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Information on EC 2.7.7.12 - UDP-glucose-hexose-1-phosphate uridylyltransferase and Organism(s) Rattus norvegicus

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Rattus norvegicus
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The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
uridyltransferase, galt enzyme, uridyl transferase, hexose-1-phosphate uridylyltransferase, udp-glucose-hexose-1-phosphate uridylyltransferase, galactose-1-phosphate:uridyltransferase, udp-glucose:alpha-d-galactose-1-phosphate uridylyltransferase, udpglucose:alpha-d-galactose-1-phosphate uridylyltransferase, hexose 1-phosphate uridylyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexose 1-phosphate uridyltransferase
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hexose 1-phosphate uridylyltransferase
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hexose-1-phosphate uridylyltransferase
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UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase
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uridyl transferase
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uridyltransferase
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uridylyltransferase, hexose 1-phosphate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9026-21-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-glucose + alpha-D-galactose 1-phosphate
alpha-D-glucose 1-phosphate + UDP-galactose
show the reaction diagram
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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UDP-glucose consumed/h/g Hgb
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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derived from anterior pituitary gland gonadotropin-producing cells in different stages of the estrous cycle: proestrus, estrus, metestrus, and diestrus
Manually annotated by BRENDA team
additional information
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expression level of the enzyme changes during the estrous cycle in the anterior pituitary gland
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
classic galactosemia (CG) is a potentially lethal inborn error of metabolism, if untreated, that results from profound deficiency of galactose-1-phosphate. An uidylyltransferasegalactose-1-phosphate uridylyltransferase-null rat model of CG documentes phenotypes and defines the relationships among three key galactose metabolites in different tissues and across post-natal development
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GALT_RAT
379
0
43314
Swiss-Prot
other Location (Reliability: 2)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kelly, S.; Sweeney, P.; Schedlbauer, L.
Galactose-l-phosphate uridyl transferase activity in red cells of various animal species
Experientia
37
550-553
1981
Bos taurus, Capra hircus, Cavia porcellus, Cavia porcellus Hartley, Chlorocebus aethiops, Equus caballus, Homo sapiens, Oryctolagus cuniculus, Ovis aries, Rattus norvegicus
Manually annotated by BRENDA team
Daude, N.; Lestage, J.; Reichardt, J.K.; Petry, K.G.
Expression of galactose-1-phosphate uridyltransferase in the anterior pituitary of rat during the estrous cycle
Neuroendocrinology
64
42-48
1996
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Rasmussen, S.A.; Daenzer, J.M.I.; MacWilliams, J.A.; Head, S.T.; Williams, M.B.; Geurts, A.M.; Schroeder, J.P.; Weinshenker, D.; Fridovich-Keil, J.L.
A galactose-1-phosphate uridylyltransferase-null rat model of classic galactosemia mimics relevant patient outcomes and reveals tissue-specific and longitudinal differences in galactose metabolism
J. Inherit. Metab. Dis.
43
518-528
2020
Rattus norvegicus (P43424)
Manually annotated by BRENDA team