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Information on EC 2.7.7.1 - nicotinamide-nucleotide adenylyltransferase and Organism(s) Arabidopsis thaliana

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IUBMB Comments
Nicotinate nucleotide can also act as acceptor. See also EC 2.7.7.18 nicotinate-nucleotide adenylyltransferase.
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This record set is specific for:
Arabidopsis thaliana
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Synonyms
nmnat2, nmnat, nmnat1, nmnat3, nicotinamide mononucleotide adenylyltransferase, nmn adenylyltransferase, nicotinamide mononucleotide adenylyltransferase 1, nicotinamide mononucleotide adenylyltransferase 2, namnat, hnmnat-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
adenosine triphosphate-nicotinamide mononucleotide transadenylase
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adenylyltransferase, nicotinamide mononucleotide
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Arabidopsis thaliana nicotinate/nicotinamide mononucleotide adenyltransferase
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ATP:NMN adenylyltransferase
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diphosphopyridine nucleotide pyrophosphorylase
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NAD+ pyrophosphorylase
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nicotinamide adenine dinucleotide pyrophosphorylase
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nicotinamide mononucleotide adenylyltransferase
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nicotinate/nicotinamide mononucleotide adenyltransferase
NMN adenylyltransferase
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NMN/NaMN adenylyltransferase
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NMNAT
PNAT
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pyridine nucleotide adenylyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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PATHWAY SOURCE
PATHWAYS
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-, -
SYSTEMATIC NAME
IUBMB Comments
ATP:nicotinamide-nucleotide adenylyltransferase
Nicotinate nucleotide can also act as acceptor. See also EC 2.7.7.18 nicotinate-nucleotide adenylyltransferase.
CAS REGISTRY NUMBER
COMMENTARY hide
9032-70-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
show the reaction diagram
ATP + nicotinate mononucleotide
diphosphate + nicotinate adenine dinucleotide
show the reaction diagram
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-
-
-
?
nicotinate mononucleotide + ATP
nicotinate adenine dinucleotide + diphosphate
show the reaction diagram
Preiss–Handler-dependent pathway
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-
?
nicotinic acid mononucleotide + ATP
nicotinic acid adenine dinucleotide + diphosphate
show the reaction diagram
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-
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r
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
show the reaction diagram
Preiss–Handler-independent pathway
-
-
?
nicotinate mononucleotide + ATP
nicotinate adenine dinucleotide + diphosphate
show the reaction diagram
Preiss–Handler-dependent pathway
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-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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detected in the differentiated stomatal guard cells of the leaf surface
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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absisic acid-induced oxidative stress causes stomatal cell death in a nicotinamide mononucleotide adenyltransferase mutant. Stomata partially lose their ability to close leading to drought susceptibility and the stomata are less responsive to opening cues
physiological function
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the enzyme is essential for the maintenance of NAD homeostasis enabling sustainable stomatal movement. The enzyme is responsible for tolerance to stressful signalling in guard cells during stomatal closure
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NMNAT_ARATH
238
0
26923
Swiss-Prot
other Location (Reliability: 2)
A0A5S9YEI5_ARATH
238
0
26918
TrEMBL
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
24500
-
x * 24500, calculated: 24528
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 24500, calculated: 24528
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hashida, S.N.; Takahashi, H.; Kawai-Yamada, M.; Uchimiya, H.
Arabidopsis thaliana nicotinate/nicotinamide mononucleotide adenyltransferase (AtNMNAT) is required for pollen tube growth
Plant J.
49
694-703
2007
Arabidopsis thaliana (F4K687), Arabidopsis thaliana
Manually annotated by BRENDA team
Lau, C.; Niere, M.; Ziegler, M.
The NMN/NaMN adenylyltransferase (NMNAT) protein family
Front. Biosci.
14
410-431
2009
Arabidopsis thaliana, Escherichia coli (P0A752), Saccharomyces cerevisiae (P53204), Homo sapiens (Q96T66), Homo sapiens
Manually annotated by BRENDA team
Hashida, S.N.; Itami, T.; Takahashi, H.; Takahara, K.; Nagano, M.; Kawai-Yamada, M.; Shoji, K.; Goto, F.; Yoshihara, T.; Uchimiya, H.
Nicotinate/nicotinamide mononucleotide adenyltransferase-mediated regulation of NAD biosynthesis protects guard cells from reactive oxygen species in ABA-mediated stomatal movement in Arabidopsis
J. Exp. Bot.
61
3813-3825
2010
Arabidopsis thaliana
Manually annotated by BRENDA team