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Information on EC 2.7.6.1 - ribose-phosphate diphosphokinase and Organism(s) Drosophila melanogaster

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EC Tree
IUBMB Comments
dATP can also act as donor.
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This record set is specific for:
Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
prps1, prpp synthetase, phosphoribosylpyrophosphate synthetase, phosphoribosyl pyrophosphate synthetase, prpp synthase, prpps, prs-i, ribose-phosphate pyrophosphokinase, ppribp synthetase, 5-phosphoribosyl-1-pyrophosphate synthetase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5-phosphoribose pyrophosphorylase
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5-phosphoribosyl-1-pyrophosphate synthetase
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5-phosphoribosyl-alpha-1-pyrophosphate synthetase
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ATP:D-ribose-5-phosphate pyrophosphotransferase
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phosphoribosyl-diphosphate synthetase
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phosphoribosylpyrophosphate synthase
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phosphoribosylpyrophosphate synthetase
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PP-ribose P synthetase
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PPRibP synthetase
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PRPP synthase
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PRPP synthetase
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pyrophosphokinase, ribose phosphate
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pyrophosphoribosylphosphate synthetase
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ribophosphate pyrophosphokinase
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ribose-5-phosphate pyrophosphokinase
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ribose-phosphate pyrophosphokinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diphosphate transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:D-ribose-5-phosphate diphosphotransferase
dATP can also act as donor.
CAS REGISTRY NUMBER
COMMENTARY hide
9015-83-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
PRPS is a direct target of retinoblastoma RB/E2F transcription factor in Drosophila melanogaster
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q8IMI0_DROME
387
0
42871
TrEMBL
Mitochondrion (Reliability: 4)
F0JAG1_DROME
204
0
22219
TrEMBL
other Location (Reliability: 2)
A0A0B4KHW7_DROME
356
0
39357
TrEMBL
other Location (Reliability: 1)
Q9VA53_DROME
406
0
44821
TrEMBL
Mitochondrion (Reliability: 4)
M9PEY1_DROME
354
0
38664
TrEMBL
Mitochondrion (Reliability: 4)
Q9VT33_DROME
388
0
42696
TrEMBL
other Location (Reliability: 1)
A0A0B4KHF5_DROME
377
0
41781
TrEMBL
Mitochondrion (Reliability: 4)
Q8IGE6_DROME
372
0
40829
TrEMBL
Mitochondrion (Reliability: 4)
A0A0B4JDE3_DROME
404
0
44595
TrEMBL
other Location (Reliability: 5)
A0A0B4KHJ3_DROME
376
0
41694
TrEMBL
Mitochondrion (Reliability: 4)
M9PF46_DROME
373
0
40960
TrEMBL
Mitochondrion (Reliability: 4)
M9PHW7_DROME
373
0
40970
TrEMBL
other Location (Reliability: 1)
Q7KRU0_DROME
386
0
42484
TrEMBL
other Location (Reliability: 1)
Q961V3_DROME
367
0
40535
TrEMBL
other Location (Reliability: 1)
Q9VT32_DROME
350
0
38279
TrEMBL
Mitochondrion (Reliability: 4)
M9PEP5_DROME
369
0
40400
TrEMBL
other Location (Reliability: 1)
A0A0B4JD23_DROME
385
0
42646
TrEMBL
other Location (Reliability: 5)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Q165P
mimicks missense mutations identified in human neurological disorders such as Arts syndrome
R228W
mimicks missense mutations identified in human neurological disorders such as Arts syndrome
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
mutations Q165P and R228W mimick missense mutations identified in neurological disorders such as Arts syndrome. Mutant flies are able to develop normally, but have a shortened lifespan and locomotive defects. Patient-derived PRPS mutations result in profound defects in lipolysis, macroautophagy, and lysosome function. The nervous system of these mutant flies is affected by these defects
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Delos Santos, K.; Kim, M.; Yergeau, C.; Jean, S.; Moon, N.S.
Pleiotropic role of Drosophila phosphoribosyl pyrophosphate synthetase in autophagy and lysosome homeostasis
PLoS Genet.
15
e1008376
2019
Drosophila melanogaster (Q9VT33)
Manually annotated by BRENDA team