Information on EC 2.7.4.8 - guanylate kinase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
2.7.4.8
-
RECOMMENDED NAME
GeneOntology No.
guanylate kinase
PATHWAY
KEGG Link
MetaCyc Link
guanosine ribonucleotides de novo biosynthesis
-
Metabolic pathways
-
Purine metabolism
-
SYSTEMATIC NAME
IUBMB Comments
ATP:(d)GMP phosphotransferase
dGMP can also act as acceptor, and dATP can act as donor.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5'-GMP kinase
-
-
-
-
apo-EcGMPK
-
-
ATP: GMP phosphotransferase
-
-
ATP:GMP phosphotransferase
-
-
-
-
ATP:GMP phosphotransferase
-
-
CASK polypeptide
O14936
cf. EC 2.7.11.1, the protein contains a guanylate kinase domain
Cavbeta1b
-
-
Cavbeta2a
Q8VGC3
-
deoxyguanylate kinase
-
-
-
-
DLG1/SAP97
-
-
DLG1/SAP97
Q62696
-
GMK
Escherichia coli TS202A
-
-
-
GMP kinase
-
-
-
-
GMP kinase
-
-
guanosine monophosphate kinase
-
-
-
-
guanosine monophosphate kinase
-
-
guanosine monophosphate kinase (EcGMPK)
-
-
guanylate kinase
-
-
guanylate kinase
Escherichia coli TS202A
-
-
-
guanylate kinase
-
-
guanylate kinase
-
-
guanylate kinase
-
-
guanylate kinase
-
-
guanylate kinase (GK)
-
-
guanylate monophosphate kinase
-
-
kinase, guanylate (phosphorylating)
-
-
-
-
MAGUK
-
-
MAGUK
Q62696
-
MAGUK PSD-95
-
-
membrane associated guanylate kinase
-
-
membrane associated guanylate kinase protein
-
-
membrane-associated guanylate kinase
-
-
membrane-associated guanylate kinase
-
-
membrane-associated guanylate kinase
Q62696
-
membrane-associated guanylate kinase
-
-
post-synaptic density-95 membrane associated guanylate kinase
-
-
postsynaptic density protein-95 SH3 GK
-
-
PSD-95 GK
-
-
PSD-95 MAGUK
-
-
PSD-95alpha
-
-
PSD-95beta
-
-
Staphylococcus aureus guanylate monophosphate kinase
-
-
voltage-gated calcium channel beta1b
-
-
voltage-gated calcium channel beta2a
Q8VGC3
-
membrane-associated guanylate kinases
-
-
additional information
-
the enzyme belongs to the post-synaptic density-95 membrane associated guanylate kinase, MAGUK, family of scaffolding proteins,
CAS REGISTRY NUMBER
COMMENTARY
9026-59-9
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
calf
-
-
Manually annotated by BRENDA team
strain B
-
-
Manually annotated by BRENDA team
strain JE24F+, derived from W3110, uninfected or infected with RNA-phage MS2
-
-
Manually annotated by BRENDA team
strain K12
Uniprot
Manually annotated by BRENDA team
strain TS202A, guanylate-kinase-deficient
-
-
Manually annotated by BRENDA team
Escherichia coli JE24F+
strain JE24F+, derived from W3110, uninfected or infected with RNA-phage MS2
-
-
Manually annotated by BRENDA team
Escherichia coli K12
strain K12
Uniprot
Manually annotated by BRENDA team
Escherichia coli TS202A
strain TS202A, guanylate-kinase-deficient
-
-
Manually annotated by BRENDA team
Jerusalem artichoke
-
-
Manually annotated by BRENDA team
CASK polypeptide, cf. EC 2.7.11.1
SwissProt
Manually annotated by BRENDA team
mouse
-
-
Manually annotated by BRENDA team
strain H37Rv, Rv1389c gene
UniProt
Manually annotated by BRENDA team
nuclear gene VIRESCENT 2 or v2
-
-
Manually annotated by BRENDA team
Cavbeta2a
UniProt
Manually annotated by BRENDA team
female Fischer or male Buffalo rats
-
-
Manually annotated by BRENDA team
baker's yeast
-
-
Manually annotated by BRENDA team
RCSB Protein Data Bank: 1EX6, enzyme with a non-acetylated N terminus in its unligated form; RCSB Protein Data Bank: 1EX7, enzyme with a non-acetylated N terminus in a complex with GMP
Uniprot
Manually annotated by BRENDA team
pig
-
-
Manually annotated by BRENDA team
IC50 VALUE [mM]
IC50 VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.0005
-
Ap5G
P60546
The crystal structure of EcGMPK in complex with Ap5G solved at 2.5 Å resolution.
PDB
SCOP
CATH
ORGANISM
Anaplasma phagocytophilum (strain HZ)
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Plasmodium falciparum (isolate 3D7)
Plasmodium vivax (strain Salvador I)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Staphylococcus aureus (strain COL)
APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
drug development
-
the guanylate-kinase-deficient Escherichia coli strain relies on the presence of a plasmid-borne, functional guanylate kinase for viability. Such a strain will be beneficial to assess the role of specific amino acids of guanylate kinase in structure, function, drug activation, and drug resistance
medicine
P60546
GMPK from bacterial pathogens, in which this enzyme is essential, are potential targets for therapeutic inhibition.
drug development
Escherichia coli TS202A
-
the guanylate-kinase-deficient Escherichia coli strain relies on the presence of a plasmid-borne, functional guanylate kinase for viability. Such a strain will be beneficial to assess the role of specific amino acids of guanylate kinase in structure, function, drug activation, and drug resistance
-