Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.7.4.6 - nucleoside-diphosphate kinase and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC2.7.4.6
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Pseudomonas aeruginosa
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
hide
The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The enzyme appears in selected viruses and cellular organisms
Synonyms
nm23-h1, nucleoside diphosphate kinase, ndp kinase, nm23-h2, ndpk-b, ndpk2, nucleoside diphosphokinase, ndk-1, nucleoside-diphosphate kinase, nucleoside diphosphate kinase a, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
kinase, nucleoside diphosphate (phosphorylating)
-
-
-
-
nucleoside 5'-diphosphate kinase
-
-
-
-
nucleoside diphosphate (UDP) kinase
-
-
-
-
nucleoside diphosphate kinase
-
nucleoside diphosphokinase
-
-
-
-
nucleotide phosphate kinase
-
-
-
-
UDP kinase
-
-
-
-
uridine diphosphate kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:nucleoside-diphosphate phosphotransferase
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.
CAS REGISTRY NUMBER
COMMENTARY hide
9026-51-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
NTP + nucleoside diphosphate
NDP + NTP
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
nucleoside diphosphate kinase and flagellin from Pseudomonas aeruginosa induce interleukin 1 expression via the Akt/NF-kappaB signaling pathways
physiological function
nucleoside diphosphate kinase mediates bacterially induced toxicity against eukaryotic cells. Bacterial Ndk, with the aid of an additional bacterial factor, flagellin, induces expression of the proinflammatory cytokines interleukin-1alpha and -1beta in human host cells A-549. Cytokine induction appears to be dependent on the kinase activity of Ndk and is mediated via the NF-kappaB signaling pathway. Flagellin is required for the induction of the IL-1alpha and IL-1beta genes. Ndk activates the Akt signaling pathway, which acts upstream of NF-kappaB, as well as caspase-1, which is a key component of inflammasome
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A069Q6F8_PSEAI
143
0
15592
TrEMBL
-
Q9ZFQ0_PSEAI
150
0
16347
TrEMBL
-
A0A8G5T3K1_PSEAI
143
0
15606
TrEMBL
-
A0A8G6ZYZ2_PSEAI
143
0
15608
TrEMBL
-
A0A8G7DES6_PSEAI
143
0
15620
TrEMBL
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
N-terminal sequence homology of kinases from different organisms
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H117Q
site-directed mutagenesis, inactive mutant
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene ndk, recombinant expression of wild-type and mutant enzymes, quantitative real-time PCR expression analysis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kavanaugh-Black, A.; Connolly, D.M.; Chugani, S.A.; Chakrabarty, A.M.
Characterization of nucleoside-diphosphate kinase from Pseudomonas aeruginosa: Complex formation with succinyl-CoA synthetase
Proc. Natl. Acad. Sci. USA
91
5883-5887
1994
Pseudomonas aeruginosa, Pseudomonas aeruginosa 8822
Manually annotated by BRENDA team
Kim, Y.J.; Lee, J.H.; Lee, Y.; Jia, J.; Paek, S.H.; Kim, H.B.; Jin, S.; Ha, U.H.
Nucleoside diphosphate kinase and flagellin from Pseudomonas aeruginosa induce interleukin 1 expression via the Akt/NF-kappaB signaling pathways
Infect. Immun.
82
3252-3260
2014
Pseudomonas aeruginosa (Q59636), Pseudomonas aeruginosa
Manually annotated by BRENDA team
Lim, S.; Park, B.; Kim, D.; Park, S.; Yang, J.; Jung, J.; Lee, J.; Lee, J.
Cloning and functional characterization of dihydroflavonol 4-reductase gene involved in anthocyanin biosynthesis of chrysanthemum
Int. J. Mol. Sci.
21
1-17
2020
Pseudomonas aeruginosa, Acinetobacter baumannii (B0VKS3), Acinetobacter baumannii (D0CAF1), Acinetobacter baumannii (V5VIC4), Neisseria gonorrhoeae (B4RMG0), Helicobacter pylori (B5Z9W9), Vibrio cholerae (C3LT09), Burkholderia thailandensis (Q2SWE7), Halomonas sp. 593 (Q83WH5), Campylobacter jejuni subsp. jejuni (Q9PIG7), Helicobacter pylori G27 (B5Z9W9), Burkholderia thailandensis ATCC 700388 (Q2SWE7), Campylobacter jejuni subsp. jejuni ATCC 700819 (Q9PIG7), Neisseria gonorrhoeae NCCP11945 (B4RMG0), Vibrio cholerae M66-2 (C3LT09), Acinetobacter baumannii ATCC 19606 (D0CAF1), Acinetobacter baumannii SDF (B0VKS3)
Manually annotated by BRENDA team