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Information on EC 2.7.4.14 - UMP/CMP kinase and Organism(s) Drosophila melanogaster

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IUBMB Comments
This eukaryotic enzyme is a bifunctional enzyme that catalyses the phosphorylation of both CMP and UMP with similar efficiency. dCMP can also act as acceptor. Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, (d)CMP kinase and EC 2.7.4.22, UMP kinase.
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This record set is specific for:
Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
+
=
+
Synonyms
cmpk2, cmpk, cmp kinase, ump-cmp kinase, cmpk1, ump/cmp kinase, cytidylate kinase, pyrimidine nucleoside monophosphate kinase, cytidine monophosphate kinase, cytidine/uridine monophosphate kinase 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ATP:UMP-CMP phosphotransferase
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CMP kinase
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-
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CMPK
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-
-
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CTP:CMP phosphotransferase
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-
-
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cytidine monophosphate kinase
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-
-
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cytidylate kinase
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kinase, cytidylate (phosphorylating)
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MssA protein
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P25
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pyrimidine nucleoside monophosphate kinase
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UCK
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UMP-CMP kinase
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UMP/CMP kinase
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UMPK
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
-
PATHWAY SOURCE
PATHWAYS
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-, -, -
SYSTEMATIC NAME
IUBMB Comments
ATP:CMP(UMP) phosphotransferase
This eukaryotic enzyme is a bifunctional enzyme that catalyses the phosphorylation of both CMP and UMP with similar efficiency. dCMP can also act as acceptor. Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, (d)CMP kinase and EC 2.7.4.22, UMP kinase.
CAS REGISTRY NUMBER
COMMENTARY hide
37278-21-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + CMP
ADP + CDP
show the reaction diagram
-
-
-
-
?
ATP + dCMP
ADP + dCDP
show the reaction diagram
-
-
-
-
?
ATP + dUMP
ADP + dUDP
show the reaction diagram
-
-
-
-
?
ATP + UMP
ADP + UDP
show the reaction diagram
-
-
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.023
CMP
-
pH 8.0, 37°C
0.017
dCMP
-
pH 8.0, 37°C
0.43
dUMP
-
pH 8.0, 37°C
0.095
UMP
-
pH 8.0, 37°C
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
N-terminal signal targets the enzyme to mitochondria
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q9TW62_DROME
196
0
21823
TrEMBL
other Location (Reliability: 3)
Q9VBI2_DROME
253
0
27823
TrEMBL
Mitochondrion (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Curbo, S.; Amiri, M.; Foroogh, F.; Johansson, M.; Karlsson, A.
The Drosophila melanogaster UMP-CMP kinase cDNA encodes an N-terminal mitochondrial import signal
Biochem. Biophys. Res. Commun.
311
440-445
2003
Drosophila melanogaster
Manually annotated by BRENDA team