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Information on EC 2.7.4.10 - nucleoside-triphosphate-adenylate kinase and Organism(s) Homo sapiens

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IUBMB Comments
Many nucleoside triphosphates can act as donors.
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This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
adenylate kinase 4, gtp:amp phosphotransferase, adenylate kinase 3, csak3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
adenylate kinase 4
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GTP: AMP phosphotra nsferase
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GTP:AMP phosphotransferase
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guanosine triphosphate-adenylate kinase
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kinase, nucleoside triphosphate-adenylate (phosphorylating)
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nucleoside triphosphate-adenosine monophosphate transphosphorylase
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-
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nucleoside triphosphate-adenylate kinase
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-
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ssozyme 3 of adenylate kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
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SYSTEMATIC NAME
IUBMB Comments
nucleoside-triphosphate:AMP phosphotransferase
Many nucleoside triphosphates can act as donors.
CAS REGISTRY NUMBER
COMMENTARY hide
9026-74-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GTP + AMP
GDP + ADP
show the reaction diagram
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-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GTP + AMP
GDP + ADP
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
in HEK-293 cells, RNA inter ference (RNAi) directed against AK4 inhibits proliferation and promotes death. RNAi directed against AK4 inhibits cell proliferation and causes death in both cell types, HEK-293 and Hep-G2, although cell cycle parameters are affected only in Hep-G2 cells. Reductions of AK4 levels are always associated with cell death
physiological function
adenylate kinase isozyme 4 belongs to a family of nucleotide monophosphate kinases involved in energy metabolism. Enzyme AK4 play a role in protection from stress. In HEK-293 cells, hypoxia increases AK4 expression but does not affect proliferation or viability. Hep-G2 cells show much higher AK4 levels, which decrease under hypoxia along with markedly reduced cell proliferation and increased cell death. AK4-mediated stress protection is not limited to one particular death scenario
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KAD4_HUMAN
223
0
25268
Swiss-Prot
Mitochondrion (Reliability: 4)
KAD3_HUMAN
227
0
25565
Swiss-Prot
Mitochondrion (Reliability: 2)
Q7Z531_HUMAN
215
0
24312
TrEMBL
other Location (Reliability: 5)
A0A384N647_HUMAN
223
0
25252
TrEMBL
Mitochondrion (Reliability: 3)
Q7Z4Y4_HUMAN
227
0
25620
TrEMBL
Mitochondrion (Reliability: 2)
A0A8I5KW96_HUMAN
223
0
25208
TrEMBL
Mitochondrion (Reliability: 4)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystallized in open conformation and co-crystallized with diguanosine pentaphosphate in closed conformation
crystallized without co-factor as a monomeric protein
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
expression of RNA interference directed against AK4
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
isozyme 3
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
HepG2 cells show high AK4 levels, which decrease under hypoxia
in HEK293 cells, hypoxia increases AK4 expression
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Xu, G.; O'Connell, P.; Stevens, J.; White, R.
Characterization of human adenylate kinase 3 (AK3) cDNA and mapping of the AK3 pseudogene to an intron of the NF1 gene
Genomics
13
537-542
1992
Homo sapiens
Manually annotated by BRENDA team
Kong, F.; Binas, B.; Moon, J.H.; Kang, S.S.; Kim, H.J.
Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells
Arch. Biochem. Biophys.
533
11-17
2013
Homo sapiens (P27144)
Manually annotated by BRENDA team
Ionescu, M.I.
Adenylate kinase a ubiquitous enzyme correlated with medical conditions
Protein J.
38
120-133
2019
Homo sapiens (P27144), Homo sapiens (Q9UIJ7)
Manually annotated by BRENDA team