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Information on EC 2.7.11.9 - Goodpasture-antigen-binding protein kinase and Organism(s) Homo sapiens

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IUBMB Comments
This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the alpha3 chain of collagen IV and is involved in autoimmune disease.
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Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
stard11, gpbp-1, gpbpdelta26, gpbpdelta26/cert, gpbp kinase, goodpasture antigen-binding protein-1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CERT
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a splicing variant of Goodpasture antigen-binding protein
Collagen type IV alpha 3 binding protein
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Goodpasture antigen-binding protein kinase
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goodpasture-antigen-binding protein kinase
GPBP kinase
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GPBPDELTA26/CERT
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StAR-related lipid transfer protein 11
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StARD11
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START domain-containing protein 11
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[Goodpasture antigen-binding protein] phosphotransferase
This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the alpha3 chain of collagen IV and is involved in autoimmune disease.
CAS REGISTRY NUMBER
COMMENTARY hide
230316-19-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + goodpasture antigen
ADP + phosphorylated goodpasture antigen
show the reaction diagram
ATP + membrane type IV collagen
ADP + phopshorylated membrane type IV collagen
show the reaction diagram
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
show the reaction diagram
additional information
?
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Goodpasture antigen-binding protein binds to human serum amyloid P component specifically in its physiological conformations, i.e. pentamers and decamers. Collagen IV binds to serum amyloid P and to Goodpasture antigen-binding protein, the latter also binds laminin, binding studies and kinetics, overview
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + goodpasture antigen
ADP + phosphorylated goodpasture antigen
show the reaction diagram
enzyme is involved in autoimmune pathogenesis. Enzyme expression is up-regulated in the striated muscle of a Goodpasture patient and in other autoimmune conditions including cutaneous lupus erythematosus, pemphigoid, and lichen planus
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?
ATP + membrane type IV collagen
ADP + phopshorylated membrane type IV collagen
show the reaction diagram
GPBP serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus. The 91-kDa GPBP splicing variants regulates the levels of 77-kDa GPBP variant, i.e. GPBPDELTA26/CERT, in the extracellular compartment
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?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
show the reaction diagram
additional information
?
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Goodpasture antigen-binding protein binds to human serum amyloid P component specifically in its physiological conformations, i.e. pentamers and decamers. Collagen IV binds to serum amyloid P and to Goodpasture antigen-binding protein, the latter also binds laminin, binding studies and kinetics, overview
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
binding of collagen IV to Goodpasture antigen-binding protein is independent of the presence of Ca2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
human biliverdin reductase
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i.e. hBVR, inhibits GPBP kinase activity, and hBVR decreases GPBP autophosphorylation in a concentration-dependent manner. A 7-residue peptide, KKRILHC281, corresponding to the core of the consensus D(delta)-Box motif in the interacting domain of hBVR, is as effective as the intact 296-residue hBVR polypeptide in inhibiting GPBP kinase activity. The D(delta)-Box motif is a common feature of kinases in the MAPK signaling cascade
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
TNF-alpha
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stimulates the autophosphorylation of Goodpasture antigen-binding protein
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additional information
expression of the Goodpasture antigen-binding protein is induced by tumor necrosis factor
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
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assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Goodpasture antigen-binding protein is present in brain amyloid plaques
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
isozyme GPBPDELTA26/CERT
Manually annotated by BRENDA team
77 kDa GPBP
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Manually annotated by BRENDA team
91 kDa GPBP
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
physiological function
Goodpasture antigen-binding protein, GPBP, is a nonconventional Ser/Thr kinase for basement membrane type IV collagen
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CERT_HUMAN
624
0
70835
Swiss-Prot
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
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Goodpasture antigen-binding protein performs autophosphorylation
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
I439A/W588A
site-directed mutagenesis, the mutant shows reduced binding of serum amyloid P
N460A/Y461A
site-directed mutagenesis, the mutant shows unaltered binding of serum amyloid P
P500G/A501Q
site-directed mutagenesis, the mutant binding to serum amyloid P is abolished
V498A/W499A
site-directed mutagenesis, the mutant shows unaltered binding of serum amyloid P
Y461A/F462A
site-directed mutagenesis, the mutant shows reduced binding of serum amyloid P
additional information
immobilization of Goodpasture antigen-binding protein by human serum amyloid P component binding from solution and in plasma, overview. Serum amyloid P associates in the blood with a 37-kDa GPBP fragment containing the N-terminal region and the middle domain
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant FLAG-tagged Goodpasture antigen-binding protein from Escherichia coli strain BL21(DE3) by affinity chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA sequence determination and analysis, a TNF-responsive transcription unit that locates the enzyme in the signalling cascade of TNF, regulation of transcription, e.g. by tumor necrosis factor, via cooperation in a bidirectional transcription complex with the gene encoding the DNA polymerase kappa, NFkappaB, and a 140-bp promoter with a Sp1 site and a TATA-like element, promoter analysis, overview
expression of FLAG-tagged Goodpasture antigen-binding protein in Escherichia coli strain BL21(DE3)
expression of FLAG-tagged Goodpasture antigen-binding protein in HEK-293A cells
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gene COL4A3BP, DNA and amino acid sequence determinatio and analysis, gene COL4A3BP bears an alternative canonical translation initiation site, iMet, that extends the open reading frame of the 91-kDa polypeptide upstream by 45 residues, expression of FLAG-tagged GPBP in HeLa cells, two splicing variants GPBP and GPBPDELTA26/CERT. Native GPBP polypeptides of 91 kDa and 120 kDa are expressed insolubly associated with cellular membranes, whereas native GPBPDELTA26/CERT polypeptide of 77 kDa is expressed soluble in the cytoplasm, overview
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
TNF-alpha-mediated transcriptional activation of GPBP, not affected by human biliverdin reductase
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Raya, A.; Revert-Ros, F.; Martinez-Martinez, P.; Navarro, S.; Rosello, E.; et al.
Goodpasture antigen-binding protein, the kinase that phosphorylates the goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis
J. Biol. Chem.
275
40392-40399
2000
Mus musculus (Q9EQG9), Bos taurus (Q9GKI7), Homo sapiens (Q9Y5P4), Homo sapiens
Manually annotated by BRENDA team
Raya, A.; Revert, F.; Navarro, S.; Saus, J.
Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen
J. Biol. Chem.
274
12642-12649
1999
Homo sapiens (Q9Y5P4)
Manually annotated by BRENDA team
Granero, F.; Revert, F.; Revert-Ros, F.; Lainez, S.; Martinez-Martinez, P.; Saus, J.
A human-specific TNF-responsive promoter for Goodpasture antigen-binding protein
FEBS J.
272
5291-5305
2005
Homo sapiens (Q9Y5P4)
Manually annotated by BRENDA team
Revert, F.; Ventura, I.; Martinez-Martinez, P.; Granero-Molto, F.; Revert-Ros, F.; Macias, J.; Saus, J.
Goodpasture antigen-binding protein is a soluble exportable protein that interacts with type IV collagen: identification of novel membrane-bound isoforms
J. Biol. Chem.
283
30246-30255
2008
Homo sapiens (Q9Y5P4)
Manually annotated by BRENDA team
Miralem, T.; Gibbs, P.E.; Revert, F.; Saus, J.; Maines, M.D.
Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression
J. Biol. Chem.
285
12551-12558
2010
Homo sapiens
Manually annotated by BRENDA team
Mencarelli, C.; Bode, G.H.; Losen, M.; Kulharia, M.; Molenaar, P.C.; Veerhuis, R.; Steinbusch, H.W.; De Baets, M.H.; Nicolaes, G.A.; Martinez-Martinez, P.
Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques
J. Biol. Chem.
287
14897-14911
2012
Homo sapiens (Q9Y5P4)
Manually annotated by BRENDA team
Hanada, K.
Co-evolution of sphingomyelin and the ceramide transport protein CERT
Biochim. Biophys. Acta
1841
704-719
2014
Homo sapiens
Manually annotated by BRENDA team