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Information on EC 2.7.11.30 - receptor protein serine/threonine kinase and Organism(s) Gallus gallus

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IUBMB Comments
The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].
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Gallus gallus
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Word Map
The taxonomic range for the selected organisms is: Gallus gallus
The enzyme appears in selected viruses and cellular organisms
Synonyms
ripk1, bmpr2, ripk3, tgf-beta receptor, tbetarii, alk-1, acvrl1, bmpr-ii, bmprii, tbetar-ii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
activin receptor-like kinase 2
-
-
activin receptor-like kinase 5
-
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ESK2
-
-
-
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MIS type II receptor
-
-
-
-
MISRII
-
-
-
-
MRII
-
-
-
-
receptor-interacting serine/threonine kinase 1
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isoform
receptor-interacting serine/threonine kinase 3
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isoform
rIPK1
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isoform
RIPK3
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isoform
Serine/threonine-protein kinase receptor R1
-
-
-
-
Serine/threonine-protein kinase receptor R4
-
-
-
-
Serine/threonine-protein kinase receptor R5
-
-
-
-
Serine/threonine-protein kinase receptor R6
-
-
-
-
SKR1
-
-
-
-
SKR2
-
-
-
-
SKR3
-
-
-
-
SKR4
-
-
-
-
SKR5
-
-
-
-
SKR6
-
-
-
-
TGF-beta receptor I
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-
TGF-beta receptor II
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TGF-beta type I receptor
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-
-
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TGF-beta type II receptor
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-
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transforming growth factor-beta receptor I
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transforming growth factor-beta receptor II
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TSK-7L
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-
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-
SYSTEMATIC NAME
IUBMB Comments
ATP:[receptor-protein] phosphotransferase
The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].
CAS REGISTRY NUMBER
COMMENTARY hide
146702-86-5
-
152060-53-2
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154907-75-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + [receptor-protein]
ADP + [receptor-protein] phosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + [receptor-protein]
ADP + [receptor-protein] phosphate
show the reaction diagram
-
-
-
-
?
additional information
?
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-
TGF-beta signals via its receptor type I and type II, ALK5 mediates most of the TGF-beta signaling, misexpression of ALK2, being constitutively active, in nontransforming ventricular, endocardial cells causes epithelial-mesenchymal transformation, EMT, which can be inhibited by Smad6, since ALK2 alone is sufficient to cause EMT, overview
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-
?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
TGF-beta
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-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
ALK2, nontransforming ventricular, misexpression of LAK2 in endocardial cells
Manually annotated by BRENDA team
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ALK2 and ALK5, atrioventricular cushion of developing heart
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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isoforms RIPK1 and RIPK3 are involved in the injury process of chicken lungs after infection with Pasteurella multocida. The proinflammatory response involving isoforms RIPK1 and RIPK3 suggests histopathological changes associated with heterophilic granulocytes that are associated with host response to Pasteurella multocida infection in the lung
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
AVR2B_CHICK
512
1
57776
Swiss-Prot
Secretory Pathway (Reliability: 1)
BMR1B_CHICK
502
1
56766
Swiss-Prot
other Location (Reliability: 2)
TGFR2_CHICK
557
1
63308
Swiss-Prot
Secretory Pathway (Reliability: 3)
AVR2A_CHICK
513
1
58092
Swiss-Prot
Secretory Pathway (Reliability: 1)
ACVR1_CHICK
504
1
56225
Swiss-Prot
Secretory Pathway (Reliability: 2)
A0A1Z1XG83_CHICK
512
1
57739
TrEMBL
Secretory Pathway (Reliability: 1)
Q06900_CHICK
503
1
56509
TrEMBL
Secretory Pathway (Reliability: 4)
A0A1I7Q417_CHICK
671
1
76255
TrEMBL
Secretory Pathway (Reliability: 3)
F1NTD3_CHICK
502
1
56776
TrEMBL
other Location (Reliability: 2)
O42124_CHICK
1031
1
114639
TrEMBL
other Location (Reliability: 3)
F6RIN4_CHICK
970
1
107931
TrEMBL
Secretory Pathway (Reliability: 2)
A0A1D5P3Z7_CHICK
482
1
54069
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1D5PT02_CHICK
512
2
57185
TrEMBL
Secretory Pathway (Reliability: 3)
F1P3H0_CHICK
533
1
60269
TrEMBL
Secretory Pathway (Reliability: 2)
E1BQF4_CHICK
678
1
76388
TrEMBL
other Location (Reliability: 5)
A0A452J852_CHICK
514
1
57282
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1D5P2D8_CHICK
524
1
58427
TrEMBL
Secretory Pathway (Reliability: 4)
A0A1D5P214_CHICK
493
1
54975
TrEMBL
other Location (Reliability: 2)
A0A3Q2U3H9_CHICK
363
0
41208
TrEMBL
other Location (Reliability: 2)
Q788N3_CHICK
104
0
12141
TrEMBL
other Location (Reliability: 2)
A0A1D5PCF0_CHICK
519
2
58570
TrEMBL
Secretory Pathway (Reliability: 1)
Q90754_CHICK
533
1
60283
TrEMBL
Secretory Pathway (Reliability: 2)
Q5MJE3_CHICK
99
0
11571
TrEMBL
other Location (Reliability: 3)
F1NCI7_CHICK
512
1
57762
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q2UBZ9_CHICK
364
1
40388
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q2TVB0_CHICK
501
2
55612
TrEMBL
Secretory Pathway (Reliability: 3)
A0A3Q2U6N1_CHICK
416
1
44489
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1J1LVG5_CHICK
370
1
40994
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q2U1G8_CHICK
796
1
86560
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q2TUT8_CHICK
495
2
54881
TrEMBL
Secretory Pathway (Reliability: 1)
Q5DLU7_CHICK
78
0
8588
TrEMBL
other Location (Reliability: 1)
A0A1Z1XG81_CHICK
512
1
57808
TrEMBL
Secretory Pathway (Reliability: 1)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
misexpression of ALK2 in nontransforming ventricular, endocardial cells causes epithelial-mesenchymal transformation, EMT, which can be decreased by overexpression of inhibitor Smad6
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
transient expression of ALK2 and ALK5 in C3H10T1/2 cells using the adenovirus transfection system
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
apoptosis activates isoforms RIPK1 and RIPK3
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Desgrosellier, J.S.; Mundell, N.A.; McDonnell, M.A.; Moses, H.L.; Barnett, J.V.
Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation
Dev. Biol.
280
201-210
2005
Gallus gallus
Manually annotated by BRENDA team
Li, W.; Tang, Q.; Dai, N.; Feng, W.; Xie, C.; Cheng, G.; Liu, X.; Zhang, W.; Hu, X.; Gu, C.
Receptor-interacting serine/threonine kinase 1- and 3-dependent inflammation induced in lungs of chicken infected with Pasteurella multocida
Sci. Rep.
10
6340
2020
Gallus gallus
Manually annotated by BRENDA team