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Information on EC 2.7.11.30 - receptor protein serine/threonine kinase and Organism(s) Danio rerio

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IUBMB Comments
The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].
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Danio rerio
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The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Synonyms
ripk1, bmpr2, ripk3, tgf-beta receptor, tbetarii, alk-1, acvrl1, bmpr-ii, bmprii, tbetar-ii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ESK2
-
-
-
-
MIS type II receptor
-
-
-
-
MISRII
-
-
-
-
MRII
-
-
-
-
Serine/threonine-protein kinase receptor R1
-
-
-
-
Serine/threonine-protein kinase receptor R4
-
-
-
-
Serine/threonine-protein kinase receptor R5
-
-
-
-
Serine/threonine-protein kinase receptor R6
-
-
-
-
SKR1
-
-
-
-
SKR2
-
-
-
-
SKR3
-
-
-
-
SKR4
-
-
-
-
SKR5
-
-
-
-
SKR6
-
-
-
-
TGF-beta type I receptor
-
-
-
-
TGF-beta type II receptor
-
-
-
-
TSK-7L
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[receptor-protein] phosphotransferase
The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].
CAS REGISTRY NUMBER
COMMENTARY hide
146702-86-5
-
152060-53-2
-
154907-75-2
-
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q66HY1_DANRE
534
2
59781
TrEMBL
Secretory Pathway (Reliability: 1)
Q32LW6_DANRE
495
1
55787
TrEMBL
Secretory Pathway (Reliability: 1)
F1QAH4_DANRE
590
1
65780
TrEMBL
Secretory Pathway (Reliability: 1)
Q9W629_DANRE
530
2
60190
TrEMBL
Secretory Pathway (Reliability: 1)
Q8JFB0_DANRE
499
2
56448
TrEMBL
Secretory Pathway (Reliability: 1)
A9CAY1_DANRE
508
0
57405
TrEMBL
Secretory Pathway (Reliability: 1)
F1RC58_DANRE
504
1
57213
TrEMBL
other Location (Reliability: 2)
A0A8M1PCF6_DANRE
527
2
59576
TrEMBL
Secretory Pathway (Reliability: 1)
F1Q6M3_DANRE
489
1
55650
TrEMBL
other Location (Reliability: 1)
O73736_DANRE
506
1
56727
TrEMBL
Secretory Pathway (Reliability: 1)
X1WG85_DANRE
493
1
55664
TrEMBL
Secretory Pathway (Reliability: 1)
B3DIP3_DANRE
1071
1
116433
TrEMBL
Secretory Pathway (Reliability: 2)
P79689_DANRE
505
1
56633
TrEMBL
Secretory Pathway (Reliability: 2)
E7F998_DANRE
645
1
72419
TrEMBL
other Location (Reliability: 5)
E7F0I3_DANRE
491
0
55163
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0R4IZG7_DANRE
535
2
59912
TrEMBL
Secretory Pathway (Reliability: 1)
B0S6E3_DANRE
500
1
56216
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0R4ISZ9_DANRE
439
1
49549
TrEMBL
other Location (Reliability: 2)
A0A0R4I9Y4_DANRE
535
2
60591
TrEMBL
Secretory Pathway (Reliability: 1)
Q1RLX1_DANRE
527
2
59576
TrEMBL
Secretory Pathway (Reliability: 1)
B3DJ37_DANRE
505
1
56450
TrEMBL
Secretory Pathway (Reliability: 2)
Q498X0_DANRE
499
2
56526
TrEMBL
Secretory Pathway (Reliability: 1)
B0V0H4_DANRE
1071
1
116462
TrEMBL
Secretory Pathway (Reliability: 2)
F1QLL7_DANRE
509
0
57966
TrEMBL
Secretory Pathway (Reliability: 1)
B0EXP7_DANRE
505
1
56891
TrEMBL
Secretory Pathway (Reliability: 1)
O93243_DANRE
527
2
59657
TrEMBL
Secretory Pathway (Reliability: 1)
B0EXP6_DANRE
500
1
56235
TrEMBL
Secretory Pathway (Reliability: 1)
F1QQ20_DANRE
505
1
56890
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0G2KN81_DANRE
511
1
57847
TrEMBL
Secretory Pathway (Reliability: 1)
Q288P2_DANRE
1071
1
116365
TrEMBL
Secretory Pathway (Reliability: 2)
A9CAY0_DANRE
514
0
57927
TrEMBL
Secretory Pathway (Reliability: 2)
F1QL23_DANRE
517
1
57872
TrEMBL
other Location (Reliability: 2)
Q4V965_DANRE
509
0
57481
TrEMBL
Secretory Pathway (Reliability: 1)
Q56E96_DANRE
495
1
56036
TrEMBL
other Location (Reliability: 1)
Q288P3_DANRE
1003
2
109350
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1NG95_DANRE
514
1
57904
TrEMBL
Secretory Pathway (Reliability: 2)
F1QH44_DANRE
502
2
56850
TrEMBL
Secretory Pathway (Reliability: 1)
F1QG01_DANRE
514
1
57904
TrEMBL
Secretory Pathway (Reliability: 2)
Q9DGI6_DANRE
506
1
56714
TrEMBL
Secretory Pathway (Reliability: 1)
F1QKF4_DANRE
556
1
63481
TrEMBL
Secretory Pathway (Reliability: 1)
C0L3D6_DANRE
535
2
60639
TrEMBL
Secretory Pathway (Reliability: 1)
F1QZF0_DANRE
498
1
56089
TrEMBL
Secretory Pathway (Reliability: 2)
F1R4D0_DANRE
538
1
60622
TrEMBL
Secretory Pathway (Reliability: 2)
F1QXI5_DANRE
1003
2
109391
TrEMBL
Secretory Pathway (Reliability: 1)
Q58EQ1_DANRE
556
1
63437
TrEMBL
Secretory Pathway (Reliability: 1)
B3DJG0_DANRE
526
2
59505
TrEMBL
Secretory Pathway (Reliability: 1)
Q9YGU4_DANRE
509
0
57479
TrEMBL
Secretory Pathway (Reliability: 1)
Q7ZZU8_DANRE
556
1
63482
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1NHT6_DANRE
151
1
16731
TrEMBL
Secretory Pathway (Reliability: 1)