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Information on EC 2.7.11.24 - mitogen-activated protein kinase and Organism(s) Bos taurus

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EC Tree
IUBMB Comments
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline . A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
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Bos taurus
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
mapk, p38, erk1/2, p38 mapk, mitogen-activated protein kinase, map kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, p38mapk, p38 map kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
c-Jun N-terminal kinase
-
-
cp38a
-
-
-
-
cp38b
-
-
-
-
CSAID binding protein
-
-
-
-
CSBP
-
-
-
-
Cytokine suppressive anti-inflammatory drug binding protein
-
-
-
-
ERK5
-
-
-
-
JNK
-
-
MAP kinase
-
-
MAP kinase MXI2
-
-
-
-
MAP kinase p38 beta
-
-
-
-
MAP kinase p38 delta
-
-
-
-
MAP kinase p38 gamma
-
-
-
-
MAP kinase p38a
-
-
-
-
MAP kinase p38alpha
-
-
-
-
MAP kinase p38b
-
-
-
-
mitogen-activated kinase
-
-
mitogen-activated protein kinase
-
-
-
-
Mitogen-activated protein kinase p38 beta
-
-
-
-
Mitogen-activated protein kinase p38 delta
-
-
-
-
Mitogen-activated protein kinase p38 gamma
-
-
-
-
Mitogen-activated protein kinase p38a
-
-
-
-
Mitogen-activated protein kinase p38alpha
-
-
-
-
Mitogen-activated protein kinase p38b
-
-
-
-
p38b
-
-
-
-
SAPK2A
-
-
-
-
stress-activated protein kinase 2a
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (MAPKK-activated)
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
CAS REGISTRY NUMBER
COMMENTARY hide
142243-02-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
show the reaction diagram
-
activity assay
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
Ca2+ dependent activation of JNK in vascular smooth muscle cells
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
anthra[1-9-cd]pyrazol-6(2H)-one
-
SP600125
Butyrolactone
-
BLI, MAPK is indirectly inhibited by the CDK inhibitor BLI
nobiletin
-
inhibits angiotensin II-induced activation of JNK
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
angiotensin II
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
-
obtained from thoracic aorta
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MK07_BOVIN
781
0
84832
Swiss-Prot
other Location (Reliability: 1)
MK13_BOVIN
366
0
42229
Swiss-Prot
other Location (Reliability: 4)
NLK_BOVIN
534
0
59339
Swiss-Prot
Mitochondrion (Reliability: 5)
MK01_BOVIN
360
0
41376
Swiss-Prot
other Location (Reliability: 3)
A0A3Q1LJU7_BOVIN
424
0
48297
TrEMBL
other Location (Reliability: 1)
G3X793_BOVIN
364
0
41428
TrEMBL
Mitochondrion (Reliability: 4)
G5E577_BOVIN
722
0
82698
TrEMBL
other Location (Reliability: 1)
A0A3Q1MNN7_BOVIN
362
0
41497
TrEMBL
other Location (Reliability: 2)
Q5E9Q6_BOVIN
366
0
42217
TrEMBL
other Location (Reliability: 4)
Q2KI72_BOVIN
339
0
38226
TrEMBL
other Location (Reliability: 1)
Q2KI27_BOVIN
520
0
60102
TrEMBL
other Location (Reliability: 1)
A0A3Q1LWJ8_BOVIN
437
0
50634
TrEMBL
other Location (Reliability: 3)
A6QLR9_BOVIN
360
0
41493
TrEMBL
other Location (Reliability: 3)
A0A3Q1LU59_BOVIN
633
0
67928
TrEMBL
Mitochondrion (Reliability: 4)
A0A3Q1LX81_BOVIN
493
0
54644
TrEMBL
Mitochondrion (Reliability: 4)
F1MVV5_BOVIN
588
0
65895
TrEMBL
other Location (Reliability: 1)
A0A3Q1LTT9_BOVIN
571
0
63696
TrEMBL
other Location (Reliability: 5)
A0A3Q1LXD7_BOVIN
339
0
38095
TrEMBL
other Location (Reliability: 2)
A0A3Q1MG18_BOVIN
437
0
50426
TrEMBL
other Location (Reliability: 3)
H2XJE9_BOVIN
527
0
58283
TrEMBL
Mitochondrion (Reliability: 4)
F6PU21_BOVIN
326
0
37563
TrEMBL
other Location (Reliability: 3)
E1B8P9_BOVIN
456
0
52515
TrEMBL
other Location (Reliability: 2)
A0A3Q1M9F7_BOVIN
586
0
62798
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1LVH0_BOVIN
424
0
48125
TrEMBL
other Location (Reliability: 1)
Q05B47_BOVIN
406
0
46574
TrEMBL
other Location (Reliability: 1)
A0A3Q1M8H8_BOVIN
571
0
63896
TrEMBL
other Location (Reliability: 5)
A0A3Q1MF91_BOVIN
374
0
41104
TrEMBL
Secretory Pathway (Reliability: 5)
Q0II77_BOVIN
359
0
40219
TrEMBL
other Location (Reliability: 1)
A0A3Q1M7B5_BOVIN
417
0
47995
TrEMBL
other Location (Reliability: 2)
A0A3Q1MGB3_BOVIN
356
0
41096
TrEMBL
other Location (Reliability: 4)
A4FV00_BOVIN
426
0
48128
TrEMBL
other Location (Reliability: 2)
F1MM73_BOVIN
384
0
44023
TrEMBL
other Location (Reliability: 3)
A1A4H8_BOVIN
351
0
39945
TrEMBL
Mitochondrion (Reliability: 4)
A5PJL3_BOVIN
367
0
41955
TrEMBL
other Location (Reliability: 5)
Q29S06_BOVIN
536
0
57962
TrEMBL
other Location (Reliability: 4)
A0A3Q1M517_BOVIN
350
0
40287
TrEMBL
other Location (Reliability: 3)
A0A3Q1LRM6_BOVIN
426
0
47900
TrEMBL
other Location (Reliability: 2)
A0A3Q1NK45_BOVIN
432
0
48990
TrEMBL
other Location (Reliability: 3)
A0A3Q1M757_BOVIN
356
0
41197
TrEMBL
other Location (Reliability: 3)
A0A3Q1LKQ5_BOVIN
350
0
40104
TrEMBL
other Location (Reliability: 5)
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
-
inhibition of JNK by nobiletin may imply its usefulness for the treatment of cardiovascular diseases relevant to vascular smooth muscle cells growth
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhou, C.H.; Wu, X.H.; Wu, Y.Q.
Nobiletin, a dietary phytochemical, inhibits vascular smooth muscle cells proliferation via calcium-mediated c-Jun N-terminal kinases pathway
Eur. J. Pharmacol.
615
55-60
2009
Bos taurus
Manually annotated by BRENDA team
Quetglas, M.D.; Adona, P.R.; de Bem, T.H.; Pires, P.R.; Leal, C.L.
Effect of cyclin-dependent kinase (CDK) inhibition on expression, localization and activity of maturation promoting factor (MPF) and mitogen activated protein kinase (MAPK) in bovine oocytes
Reprod. Domest. Anim.
45
1074-1081
2010
Bos taurus
Manually annotated by BRENDA team