Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Acquired Immunodeficiency Syndrome
CTIP2 is a negative regulator of P-TEFb.
Acquired Immunodeficiency Syndrome
HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy.
Acquired Immunodeficiency Syndrome
[P-TEFb and Brd4: actors of the transcription pause release as therapeutical targets].
Adenocarcinoma of Lung
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.
Adenocarcinoma of Lung
Mechanisms underlying regulation of cell cycle and apoptosis by hnRNP B1 in human lung adenocarcinoma A549 cells.
Adenocarcinoma of Lung
P-TEFb Regulates Transcriptional Activation in Non-coding RNA Genes.
Adenocarcinoma of Lung
[Comparison of DNA-dependent protein kinase catalytic subunit expression in two lung adenocarcinoma cell lines with different radiosensitivity]
Adenocarcinoma of Lung
[Effects of hnRNP B1 on DNA-PK activity, cell cycle and apoptosis in human lung adenocarcinoma cell line A549]
Adenoma
Molecular markers of carcinogenesis for risk stratification of individuals with colorectal polyps: a case-control study.
Adenoviridae Infections
Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication.
Alzheimer Disease
DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease.
Alzheimer Disease
DNA-PK Deficiency in Alzheimer's Disease.
Anemia
An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.
Asthma
Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase.
Asthma
DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency.
Asthma
Oxidative damage and DNA damage in lungs of an ovalbumin-induced asthmatic murine model.
Astrocytoma
IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK.
Ataxia
Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.
Ataxia
Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK.
Ataxia
Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit.
Ataxia
DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).
Ataxia
Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells.
Ataxia
Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.
Ataxia
Induction of H2AX phosphorylation in tumor cells by gossypol acetic acid is mediated by phosphatidylinositol 3-kinase (PI3K) family.
Ataxia
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
Ataxia
Mechanisms of induction of cell cycle arrest and cell death by cryptolepine in human lung adenocarcinoma a549 cells.
Ataxia
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ataxia
Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): phosphoproteomic analysis.
Ataxia
Replication protein A (RPA): the eukaryotic SSB.
Ataxia
Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.
Ataxia
Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest.
Ataxia
Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated.
Ataxia
Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons.
Ataxia
The double dealing of cyclin D1.
Ataxia
The promise of DNA damage response inhibitors for the treatment of glioblastoma.
Ataxia
Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase.
Ataxia
Tying the loose ends together in DNA double strand break repair with 53BP1.
Ataxia
[Cell cycle regulation after exposure to ionizing radiation]
Ataxia Telangiectasia
A critical role for topoisomerase IIb and DNA double strand breaks in transcription.
Ataxia Telangiectasia
A flow cytometry assay that measures cellular sensitivity to DNA-damaging agents, customized for clinical routine laboratories.
Ataxia Telangiectasia
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
Ataxia Telangiectasia
Adenovirus-mediated wild-type p53 radiosensitizes human tumor cells by suppressing DNA repair capacity.
Ataxia Telangiectasia
Ataxia telangiectasia: G2 checkpoint and chromosomal damage in proliferating lymphocytes.
Ataxia Telangiectasia
Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine.
Ataxia Telangiectasia
ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.
Ataxia Telangiectasia
ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.
Ataxia Telangiectasia
ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers.
Ataxia Telangiectasia
ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells.
Ataxia Telangiectasia
BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies.
Ataxia Telangiectasia
Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism.
Ataxia Telangiectasia
Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome.
Ataxia Telangiectasia
Chemical inhibition of DNA repair kinases as a promising tool in oncology.
Ataxia Telangiectasia
Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling.
Ataxia Telangiectasia
Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK.
Ataxia Telangiectasia
Cooperative effect of BI-69A11 and celecoxib enhances radiosensitization by modulating DNA damage repair in colon carcinoma.
Ataxia Telangiectasia
DDRI-9: a novel DNA damage response inhibitor that blocks mitotic progression.
Ataxia Telangiectasia
Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents.
Ataxia Telangiectasia
Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay.
Ataxia Telangiectasia
Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.
Ataxia Telangiectasia
Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression.
Ataxia Telangiectasia
DNA damage signaling in response to double-strand breaks during mitosis.
Ataxia Telangiectasia
DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex.
Ataxia Telangiectasia
DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells.
Ataxia Telangiectasia
DNA-dependent protein kinase and Ataxia Telangiectasia Mutated (ATM) promote cell survival in response to NK314, a topoisomerase II? inhibitor.
Ataxia Telangiectasia
DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70.
Ataxia Telangiectasia
DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage.
Ataxia Telangiectasia
DNA-dependent protein kinase.
Ataxia Telangiectasia
DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks.
Ataxia Telangiectasia
DNA-PK suppresses a p53-independent apoptotic response to DNA damage.
Ataxia Telangiectasia
DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair.
Ataxia Telangiectasia
DNA-PK, ATM and MDR proteins inhibitors in overcoming fludarabine resistance in CLL cells.
Ataxia Telangiectasia
DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.
Ataxia Telangiectasia
DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress.
Ataxia Telangiectasia
DNA-PK: the major target for wortmannin-mediated radiosensitization by the inhibition of DSB repair via NHEJ pathway.
Ataxia Telangiectasia
Dose response of gamma rays and iron nuclei for induction of chromosomal aberrations in normal and repair-deficient cell lines.
Ataxia Telangiectasia
Elevated DNA damage response in pancreatic cancer.
Ataxia Telangiectasia
Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia.
Ataxia Telangiectasia
Essential and perilous: V(D)J recombination and DNA damage checkpoints in lymphocyte precursors.
Ataxia Telangiectasia
Far-infrared irradiation inhibits breast cancer cell proliferation independently of DNA damage through increased nuclear Ca2+/calmodulin binding modulated-activation of checkpoint kinase 2.
Ataxia Telangiectasia
Farnesyltransferase inhibitors induce DNA damage via reactive oxygen species in human cancer cells.
Ataxia Telangiectasia
Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit.
Ataxia Telangiectasia
Functional role for the c-Abl tyrosine kinase in meiosis I.
Ataxia Telangiectasia
Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses.
Ataxia Telangiectasia
Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.
Ataxia Telangiectasia
Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library.
Ataxia Telangiectasia
Improving Radiation Response in Glioblastoma Using ECO/siRNA Nanoparticles Targeting DNA Damage Repair.
Ataxia Telangiectasia
Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells.
Ataxia Telangiectasia
Inhibition of DNA-dependent protein kinase promotes ultrasound-induced cell death including apoptosis in human leukemia cells.
Ataxia Telangiectasia
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.
Ataxia Telangiectasia
Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine.
Ataxia Telangiectasia
Involvement of DNA-PK and ATM in radiation- and heat-induced DNA damage recognition and apoptotic cell death.
Ataxia Telangiectasia
Ionizing radiation induced signaling of DNA damage response molecules in RAW 264.7 and CD4(+) T cells.
Ataxia Telangiectasia
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
Ataxia Telangiectasia
Ionizing radiation response of primary normal human lens epithelial cells.
Ataxia Telangiectasia
It takes three to the DNA damage response tango.
Ataxia Telangiectasia
Long-term in vivo effects of cisplatin on gamma-H2AX foci signaling in peripheral lymphocytes of tumor patients after irradiation.
Ataxia Telangiectasia
Measurement of DNA-Dependent Protein Kinase Phosphorylation Using Flow Cytometry Provides a Reliable Estimate of DNA Repair Capacity.
Ataxia Telangiectasia
Mechanisms of enhancement of cytotoxicity in etoposide and ionising radiation-treated cells by the protein kinase inhibitor wortmannin.
Ataxia Telangiectasia
Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin.
Ataxia Telangiectasia
Molecular aspects of cellular responses to radiotherapy.
Ataxia Telangiectasia
Monitoring and signaling of radiation-induced damage in mammalian cells.
Ataxia Telangiectasia
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.
Ataxia Telangiectasia
Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks.
Ataxia Telangiectasia
p53 phosphorylation in mouse skin and in vitro human skin model by high-dose-radiation exposure.
Ataxia Telangiectasia
P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting.
Ataxia Telangiectasia
PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.
Ataxia Telangiectasia
PFG acted as an inducer of premature senescence in TIG-1 normal diploid fibroblast and an inhibitor of mitosis in the HeLa cells.
Ataxia Telangiectasia
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.
Ataxia Telangiectasia
Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition.
Ataxia Telangiectasia
Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.
Ataxia Telangiectasia
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
Ataxia Telangiectasia
Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.
Ataxia Telangiectasia
PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.
Ataxia Telangiectasia
Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts.
Ataxia Telangiectasia
Preclinical Risk Evaluation of Normal Tissue Injury With Novel Radiosensitizers.
Ataxia Telangiectasia
PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity.
Ataxia Telangiectasia
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ataxia Telangiectasia
Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.
Ataxia Telangiectasia
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Ataxia Telangiectasia
Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat.
Ataxia Telangiectasia
Repair of Chromosomal RAG-Mediated DNA Breaks by Mutant RAG Proteins Lacking Phosphatidylinositol 3-Like Kinase Consensus Phosphorylation Sites.
Ataxia Telangiectasia
Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.
Ataxia Telangiectasia
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.
Ataxia Telangiectasia
Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability.
Ataxia Telangiectasia
Role of CHK2 in cancer development.
Ataxia Telangiectasia
Role of DNA-dependent protein kinase in the process of radiation-induced aberration formation.
Ataxia Telangiectasia
Role of the translationally controlled tumor protein in DNA damage sensing and repair.
Ataxia Telangiectasia
Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.
Ataxia Telangiectasia
Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells.
Ataxia Telangiectasia
Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses.
Ataxia Telangiectasia
Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells.
Ataxia Telangiectasia
Synergistic Effect of a Mesothelin-Targeted 227Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models.
Ataxia Telangiectasia
Targeted cancer therapies based on the inhibition of DNA strand break repair.
Ataxia Telangiectasia
Targeting DNA Damage Repair Pathways in Pancreatic Adenocarcinoma.
Ataxia Telangiectasia
Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons.
Ataxia Telangiectasia
Targeting DNA Repair in Chronic Lymphocytic Leukemia Cells with a Novel Acyclic Nucleotide Analogue, GS-9219.
Ataxia Telangiectasia
Targeting phosphoinositide 3-kinase: moving towards therapy.
Ataxia Telangiectasia
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks.
Ataxia Telangiectasia
The Ataxia Telangiectasia mutated kinase controls Ig? allelic exclusion by inhibiting secondary V?-to-J? rearrangements.
Ataxia Telangiectasia
The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect.
Ataxia Telangiectasia
The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.
Ataxia Telangiectasia
The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis.
Ataxia Telangiectasia
The Future of Radiobiology.
Ataxia Telangiectasia
The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo[def,p]chrysene on human hepatocellular cancer cell line HepG2.
Ataxia Telangiectasia
The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2.
Ataxia Telangiectasia
The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.
Ataxia Telangiectasia
The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase.
Ataxia Telangiectasia
The promise of DNA damage response inhibitors for the treatment of glioblastoma.
Ataxia Telangiectasia
The role of Ataxia telangiectasia and the DNA-dependent protein kinase in the p53-mediated cellular response to ionising radiation.
Ataxia Telangiectasia
Therapeutic effect of sodium iodide symporter gene therapy combined with external beam radiotherapy and targeted drugs that inhibit DNA repair.
Ataxia Telangiectasia
Transcriptional Regulation at DSBs: Mechanisms and Consequences.
Ataxia Telangiectasia
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction.
Autoimmune Diseases
DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity.
Autoimmune Diseases
Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation.
Blast Crisis
[Gene of DNA-dependent protein kinase catalylic subunit in chronic myeloid leukemia]
Bone Marrow Failure Disorders
Inhibition of non-homologous end joining in Fanconi Anemia cells results in rescue of survival after interstrand crosslinks but sensitization to replication associated double-strand breaks.
Breast Neoplasms
A targeted inhibition of DNA-dependent protein kinase sensitizes breast cancer cells following ionizing radiation.
Breast Neoplasms
Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients.
Breast Neoplasms
Caught in the act: binding of Ku and PARP to MARs reveals novel aspects of their functional interaction.
Breast Neoplasms
Changes in the response of MCF-7 cells to ionizing radiation after the combination of ATM and DNA-PK inhibition.
Breast Neoplasms
DDRI-9: a novel DNA damage response inhibitor that blocks mitotic progression.
Breast Neoplasms
DNA damage repair in breast cancer and its therapeutic implications.
Breast Neoplasms
DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.
Breast Neoplasms
DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin.
Breast Neoplasms
DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells.
Breast Neoplasms
Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency.
Breast Neoplasms
HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer.
Breast Neoplasms
Immunohistochemical analysis of Ku70/86 expression of breast cancer tissues.
Breast Neoplasms
Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha.
Breast Neoplasms
Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment.
Breast Neoplasms
LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.
Breast Neoplasms
Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.
Breast Neoplasms
Nuclear EGFR Suppresses Ribonuclease Activity of Polynucleotide Phosphorylase through DNAPK-mediated Phosphorylation at Serine 776.
Breast Neoplasms
Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences.
Breast Neoplasms
PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer.
Breast Neoplasms
RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy.
Breast Neoplasms
Response of breast cancer carcinoma spheroids to combination therapy with radiation and DNA-PK inhibitor: growth arrest without a change in ?/? ratio.
Breast Neoplasms
Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated.
Breast Neoplasms
Taking a Bad Turn: Compromised DNA Damage Response in Leukemia.
Breast Neoplasms
The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.
Breast Neoplasms
The molecular causes of low ATM protein expression in breast carcinoma; promoter methylation and levels of the catalytic subunit of DNA-dependent protein kinase.
Breast Neoplasms
The Yin and Yang of P-TEFb Regulation: Implications for Human Immunodeficiency Virus Gene Expression and Global Control of Cell Growth and Differentiation.
Breast Neoplasms
Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha.
Burkitt Lymphoma
Molecular properties, substrate specificity and regulation of DNA-dependent protein kinase from Raji Burkitt's lymphoma cells.
Carcinogenesis
A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.
Carcinogenesis
Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.
Carcinogenesis
Decreased expression of DNA-dependent protein kinase, a DNA repair protein, during human colon carcinogenesis.
Carcinogenesis
Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer.
Carcinogenesis
Down-regulation of Ku 70 and Ku 80 mRNA expression in transitional cell carcinomas of the urinary bladder related to tumor progression.
Carcinogenesis
Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis.
Carcinogenesis
Heterogeneous nuclear ribonucleoprotein B1 protein impairs DNA repair mediated through the inhibition of DNA-dependent protein kinase activity.
Carcinogenesis
High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase.
Carcinogenesis
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Carcinogenesis
LARP7 is a potential tumor suppressor gene in gastric cancer.
Carcinogenesis
Mechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cells.
Carcinogenesis
Multiple roles of CTDK-I throughout the cell.
Carcinogenesis
The relationship between the down-regulation of DNA-PKcs or Ku70 and the chemosensitization in human cervical carcinoma cell line HeLa.
Carcinogenesis
XPD-The Lynchpin of NER: Molecule, Gene, Polymorphisms, and Role in Colorectal Carcinogenesis.
Carcinogenesis
[The expression of ERCC1, DNA-PKcs protein and the relation to prognosis in non-small cell lung cancer.]
Carcinoma
Abnormal DNA-PKcs and Ku 70/80 expression may promote malignant pathological processes in gastric carcinoma.
Carcinoma
Altered expression of DNA double-strand repair genes Ku70 and Ku80 in carcinomas of the oral cavity.
Carcinoma
Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas.
Carcinoma
Comparison of the Radiosensitizing Effect of ATR, ATM and DNA-PK Kinase Inhibitors on Cervical Carcinoma Cells.
Carcinoma
DNA-dependent protein kinase content and activity in lung carcinoma cell lines: correlation with intrinsic radiosensitivity.
Carcinoma
DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair.
Carcinoma
DNA-PK: the major target for wortmannin-mediated radiosensitization by the inhibition of DSB repair via NHEJ pathway.
Carcinoma
Down-regulation of Ku 70 and Ku 80 mRNA expression in transitional cell carcinomas of the urinary bladder related to tumor progression.
Carcinoma
Expression of Ku70 correlates with survival in carcinoma of the cervix.
Carcinoma
Expression of Ku86 confers favorable outcome of tonsillar carcinoma treated with radiotherapy.
Carcinoma
Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma.
Carcinoma
Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation.
Carcinoma
Radioresistance in a tumour cell line correlates with radiation inducible Ku 70/80 end-binding activity.
Carcinoma
Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86.
Carcinoma
Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia.
Carcinoma
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma
Response of breast cancer carcinoma spheroids to combination therapy with radiation and DNA-PK inhibitor: growth arrest without a change in ?/? ratio.
Carcinoma
The effect of wortmannin on radiation-induced chromosome aberration formation in the radioresistant tumor cell line WiDr.
Carcinoma
Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways.
Carcinoma
Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma.
Carcinoma
[Expression and significance of DNA-dependent protein kinase in human laryngeal squamous cell carcinoma].
Carcinoma, Hepatocellular
DNA-dependent protein kinase is involved in heat shock protein-mediated accumulation of hypoxia-inducible factor-1alpha in hypoxic preconditioned HepG2 cells.
Carcinoma, Hepatocellular
NU7441 Enhances the Radiosensitivity of Liver Cancer Cells.
Carcinoma, Hepatocellular
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Hepatocellular
Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.
Carcinoma, Hepatocellular
Targeting DNA-dependent protein kinase sensitizes hepatocellular carcinoma cells to proton beam irradiation through apoptosis induction.
Carcinoma, Non-Small-Cell Lung
Co-targeting deoxyribonucleic acid-dependent protein kinase and poly(adenosine diphosphate-ribose) polymerase-1 promotes accelerated senescence of irradiated cancer cells.
Carcinoma, Non-Small-Cell Lung
Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells.
Carcinoma, Non-Small-Cell Lung
DNA-dependent protein kinase is inhibited by trifluoperazine.
Carcinoma, Non-Small-Cell Lung
DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair.
Carcinoma, Non-Small-Cell Lung
Expression of immune checkpoint PD-1 in non-small cell lung cancer is associated with tumor cell DNA-dependent protein kinase.
Carcinoma, Non-Small-Cell Lung
Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation.
Carcinoma, Non-Small-Cell Lung
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Non-Small-Cell Lung
Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines.
Carcinoma, Non-Small-Cell Lung
[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].
Carcinoma, Non-Small-Cell Lung
[The expression of DNA-PKcs in non-small cell lung cancer and its relationship with apoptosis associated proteins.]
Carcinoma, Renal Cell
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Squamous Cell
Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth.
Carcinoma, Squamous Cell
DNA double-strand break repair, DNA-PK, and DNA ligases in two human squamous carcinoma cell lines with different radiosensitivity.
Carcinoma, Squamous Cell
Expression of Ku86 confers favorable outcome of tonsillar carcinoma treated with radiotherapy.
Carcinoma, Squamous Cell
Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma.
Carcinoma, Squamous Cell
Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia.
Carcinoma, Squamous Cell
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Transitional Cell
Down-regulation of Ku 70 and Ku 80 mRNA expression in transitional cell carcinomas of the urinary bladder related to tumor progression.
Cardiomegaly
7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor.
Cardiomegaly
Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.
Cardiomegaly
Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9.
Cardiomegaly
CTIP2 is a negative regulator of P-TEFb.
Cardiomegaly
Cyclins that don't cycle--cyclin T/cyclin-dependent kinase-9 determines cardiac muscle cell size.
Cardiomegaly
HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy.
Cardiomegaly
P-TEFb as A Promising Therapeutic Target.
Cardiomegaly
Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.
Cardiomegaly
Phosphorylation of RNA polymerase II in cardiac hypertrophy: cell enlargement signals converge on cyclin T/Cdk9.
Cardiomegaly
Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy.
Cardiomegaly
Positive Transcription Elongation Factor b Activity in Compensatory Myocardial Hypertrophy is Regulated by Cardiac Lineage Protein-1.
Cardiomegaly
RNA-driven cyclin-dependent kinase regulation: when CDK9/cyclin T subunits of P-TEFb meet their ribonucleoprotein partners.
Cardiomegaly
The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2.
Cardiomegaly
The Yin and Yang of P-TEFb Regulation: Implications for Human Immunodeficiency Virus Gene Expression and Global Control of Cell Growth and Differentiation.
Cardiomegaly
[Misregulation of P-TEFb activity: pathological consequences].
Cockayne Syndrome
Analysis of Drosophila p8 and p52 mutants reveals distinct roles for the maintenance of TFIIH stability and male germ cell differentiation.
Cockayne Syndrome
Analysis of U1 small nuclear RNA interaction with cyclin H.
Cockayne Syndrome
Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.
Cockayne Syndrome
Cockayne syndrome protein A is a transcription factor of RNA polymerase I and stimulates ribosomal biogenesis and growth.
Cockayne Syndrome
DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development.
Cockayne Syndrome
Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases.
Cockayne Syndrome
Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression.
Cockayne Syndrome
Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein.
Cockayne Syndrome
Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly.
Cockayne Syndrome
Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio).
Cockayne Syndrome
Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.
Cockayne Syndrome
Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome.
Cockayne Syndrome
RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components xeroderma pigmentosum B and p62.
Cockayne Syndrome
TFIIH is an elongation factor of RNA polymerase I.
Cockayne Syndrome
TFIIH Subunit Alterations Causing Xeroderma Pigmentosum and Trichothiodystrophy Specifically Disturb Several Steps during Transcription.
Cockayne Syndrome
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
Cockayne Syndrome
TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair.
Cockayne Syndrome
The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.
Cockayne Syndrome
The cryo-electron microscopy structure of human transcription factor IIH.
Cockayne Syndrome
The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor.
Cockayne Syndrome
Transcription by RNA polymerase II: a process linked to DNA repair.
Cockayne Syndrome
Transcription elongation and human disease.
Cockayne Syndrome
Transcription factor IIH - the protein complex with multiple functions.
Cockayne Syndrome
Transcription factor TFIIH and DNA endonuclease Rad2 constitute yeast nucleotide excision repair factor 3: implications for nucleotide excision repair and Cockayne syndrome.
Cockayne Syndrome
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Cockayne Syndrome
Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome.
Cockayne Syndrome
TTDA: Big impact of a small protein.
Cockayne Syndrome
UVB induces a genome-wide acting negative regulatory mechanism that operates at the level of transcription initiation in human cells.
Cockayne Syndrome
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
Cockayne Syndrome
XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients.
Coinfection
Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways.
Colonic Neoplasms
Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells.
Colorectal Neoplasms
Radioresistance in a tumour cell line correlates with radiation inducible Ku 70/80 end-binding activity.
Colorectal Neoplasms
The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.
Colorectal Neoplasms
Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.
Communicable Diseases
P-TEFb as A Promising Therapeutic Target.
Cysts
Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.
Dengue
Chemoproteomic profiling identifies changes in DNA-PK as markers of early dengue virus infection.
Dengue
Positive transcription elongation factor b (P-TEFb) contributes to dengue virus-stimulated induction of interleukin-8 (IL-8).
Diabetes Mellitus, Type 2
DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.
DNA Virus Infections
A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus.
Epstein-Barr Virus Infections
Epstein-Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle.
Equine Infectious Anemia
An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.
Esophageal Neoplasms
DNA-dependent protein kinase activity correlates with Ku70 expression and radiation sensitivity in esophageal cancer cell lines.
Esophageal Neoplasms
Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium.
Fanconi Anemia
Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.
Fanconi Anemia
Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest.
Fibrosarcoma
Allotype imbalance or microsatellite mutation in low-grade soft tissue sarcomas of the extremities in adults.
Frontotemporal Lobar Degeneration
DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis.
Genetic Diseases, Inborn
Both XPD alleles contribute to the phenotype of compound heterozygote xeroderma pigmentosum patients.
Genetic Diseases, Inborn
Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations.
Genetic Diseases, Inborn
Genomic organization and promoter characterization of two human UHS keratin genes.
Genetic Diseases, Inborn
GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy.
Genetic Diseases, Inborn
It takes three to the DNA damage response tango.
Genetic Diseases, Inborn
Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH.
Genetic Diseases, Inborn
RNA polymerase II 140wimp mutant and mutations in the TFIIH subunit XPB differentially affect homeotic gene expression in Drosophila.
Genetic Diseases, Inborn
TFIIH: a link between transcription, DNA repair and cell cycle regulation.
Genetic Diseases, Inborn
The cryo-electron microscopy structure of human transcription factor IIH.
Genetic Diseases, Inborn
The long unwinding road: XPB and XPD helicases in damaged DNA opening.
Genetic Diseases, Inborn
Transcription factor IIH - the protein complex with multiple functions.
Genetic Diseases, Inborn
XPD mutations prevent TFIIH-dependent transactivation by nuclear receptors and phosphorylation of RARalpha.
Glioblastoma
Activation Mechanism of Protein Kinase B by DNA-dependent Protein Kinase Involved in the DNA Repair System.
Glioblastoma
Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.
Glioblastoma
Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells.
Glioblastoma
CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-?B pathway in multidrug-resistant glioblastoma cells in vitro.
Glioblastoma
Complementation of the radiosensitive M059J cell line.
Glioblastoma
Differential role of hydrogen peroxide and staurosporine in induction of cell death in glioblastoma cells lacking DNA-dependent protein kinase.
Glioblastoma
DNA-dependent protein kinase (DNA-PK)-deficient human glioblastoma cells are preferentially sensitized by Zebularine.
Glioblastoma
DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency.
Glioblastoma
DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif.
Glioblastoma
DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells.
Glioblastoma
Glioblastoma cells deficient in DNA-dependent protein kinase are resistant to cell death.
Glioblastoma
Human polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination.
Glioblastoma
IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
Glioblastoma
Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme.
Glioblastoma
Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice.
Glioblastoma
Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells.
Glioblastoma
Novel survivin inhibitor YM155 elicits cytotoxicity in glioblastoma cell lines with normal or deficiency DNA-dependent protein kinase activity.
Glioblastoma
Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3.
Glioblastoma
Radiation-Induced Micro-RNA Modulation in Glioblastoma Cells Differing in DNA-Repair Pathways.
Glioblastoma
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Glioblastoma
Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells.
Glioblastoma
Role of DNA-PK in the process of aberration formation as studied in irradiated human glioblastoma cell lines M059K and M059J.
Glioblastoma
Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.
Glioblastoma
SAPSR1 is a bidentate anchor for targeting protein phosphatase-6 to DNA-PK.
Glioblastoma
The ATM protein is required for sustained activation of NF-kappaB following DNA damage.
Glioblastoma
The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network.
Glioblastoma
The DNA-PK inhibitor VX-984 enhances the radiosensitivity of glioblastoma cells grown in vitro and as orthotopic xenografts.
Glioblastoma
The repair of gamma-radiation-induced DNA damage is inhibited by microcystin-LR, the PP1 and PP2A phosphatase inhibitor.
Glioblastoma
Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways.
Glioblastoma
Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.
Glioma
Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line.
Glioma
Activities of DNA-PK and Ku86, but not Ku70, may predict sensitivity to cisplatin in human gliomas.
Glioma
Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells.
Glioma
cDNA expression array analysis of DNA repair genes in human glioma cells that lack or express DNA-PK.
Glioma
Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK-deleted human glioma M059J cells.
Glioma
Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors.
Glioma
Differential gene expression in human glioma cells: correlation with presence or absence of DNA-dependent protein kinase.
Glioma
Differential stability of the DNA-activated protein kinase catalytic subunit mRNA in human glioma cells.
Glioma
DNA-dependent protein kinase acts upstream of p53 in response to DNA damage.
Glioma
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.
Glioma
DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus.
Glioma
DNA-PK is essential only for coding joint formation in V(D)J recombination.
Glioma
Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice.
Glioma
Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells.
Glioma
Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy.
Glioma
Intact G2-phase checkpoint in cells of a human cell line lacking DNA-dependent protein kinase activity.
Glioma
Ku70/Ku80 protein complex inhibits the binding of nucleotide excision repair proteins on linear DNA in vitro.
Glioma
Lack of correlation between DNA-dependent protein kinase activity and tumor cell radiosensitivity.
Glioma
Low and high LET radiation-induced apoptosis in M059J and M059K cells.
Glioma
Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.
Glioma
Radiation-Induced Micro-RNA Modulation in Glioblastoma Cells Differing in DNA-Repair Pathways.
Glioma
Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells.
Glioma
The role of autophagy in sensitizing malignant glioma cells to radiation therapy.
Glioma
[Correlation of DNA-PK activity with anti-cancer drug-sensitivity in human gliomas]
Head and Neck Neoplasms
Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth.
Head and Neck Neoplasms
Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.
Head and Neck Neoplasms
The immunohistochemical expression of DNA-PKCS and Ku (p70/p80) in head and neck cancers: relationships with radiosensitivity.
Hepatitis B
Hepatitis B virus pX targets TFIIB in transcription coactivation.
Hepatitis B
Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH.
Hepatitis B
Hepatitis B virus X protein does not influence essential steps of nucleotide excision repair effected by human liver extracts.
Hepatitis B
Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH.
Hepatitis B
Transcriptional regulation of the TFIIH transcription repair components XPB and XPD by the hepatitis B virus x protein in liver cells and transgenic liver tissue.
Hepatitis C
Hepatitis C virus-core protein facilitates the degradation of Ku70 and reduces DNA-PK activity in hepatocytes.
Herpes Simplex
Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0.
Herpes Simplex
Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53.
Herpes Simplex
Herpes simplex virus 1 ICP22 inhibits the transcription of viral gene promoters by binding to and blocking the recruitment of P-TEFb.
Herpes Simplex
Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase.
Herpes Simplex
The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase.
Herpesviridae Infections
Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity.
HIV Infections
Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR.
HIV Infections
Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.
HIV Infections
The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency.
HIV Infections
The Yin and Yang of P-TEFb Regulation: Implications for Human Immunodeficiency Virus Gene Expression and Global Control of Cell Growth and Differentiation.
Hypersensitivity
Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3.
Hypersensitivity
Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype.
Hypersensitivity
Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation.
Hypersensitivity
Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle.
Hypersensitivity
KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity.
Hypersensitivity
P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress.
Hypersensitivity
Saccharomyces cerevisiae RNA polymerase II is affected by Kluyveromyces lactis zymocin.
Hypersensitivity
The life and death of DNA-PK.
Hypersensitivity
Transcription-dependent activation of ataxia telangiectasia-mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison.
Hypersensitivity
[DNA-dependent protein kinase: a major protein involved in the cellular response to ionizing radiation]
Hypertrophy, Left Ventricular
Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice.
Ichthyosis
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.
Ichthyosis
Analysis of U1 small nuclear RNA interaction with cyclin H.
Ichthyosis
Distinct roles for the helicases of TFIIH in transcript initiation and promoter escape.
Ichthyosis
New clinico-genetic classification of trichothiodystrophy.
Ichthyosis
Suppression of UV-induced apoptosis by the human DNA repair protein XPG.
Ichthyosis
Trypanosoma brucei harbours a divergent XPB helicase paralogue that is specialized in nucleotide excision repair and conserved among kinetoplastid organisms.
Infections
Activation of P-TEFb (CycT1/CDK9) at sites of dual HIV/TB infection, and inhibition of MTB-induced HIV transcriptional activation by the inhibitor of CDK9, Indirubin-3'-monoxime.
Infections
Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0.
Infections
Baculovirus Transduction in Mammalian Cells Is Affected by the Production of Type I and III Interferons, Which Is Mediated Mainly by the cGAS-STING Pathway.
Infections
Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK.
Infections
Chemoproteomic profiling identifies changes in DNA-PK as markers of early dengue virus infection.
Infections
Computational analysis of retrovirus-induced scid cell death.
Infections
Different views of the dynamic landscape covered by the 5'-hairpin of the 7SK small nuclear RNA.
Infections
DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage.
Infections
DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing.
Infections
Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase.
Infections
HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration.
Infections
Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication.
Infections
Induction of a Cellular DNA Damage Response by Porcine Circovirus Type 2 Facilitates Viral Replication and Mediates Apoptotic Responses.
Infections
Measles Virus Infection Inactivates Cellular Protein Phosphatase 5 with Consequent Suppression of Sp1 and c-Myc Activities.
Infections
P-TEFb kinase complex phosphorylates histone H1 to regulate expression of cellular and HIV-1 genes.
Infections
Phosphorylation Targets of DNA-PK and Their Role in HIV-1 Replication.
Infections
Positive transcription elongation factor b (P-TEFb) contributes to dengue virus-stimulated induction of interleukin-8 (IL-8).
Infections
Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection.
Infections
Role of Noncoding RNAs in the Regulation of P-TEFb Availability and Enzymatic Activity.
Infections
Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity.
Infections
Targeting the DNA-PK complex: Its rationale use in cancer and HIV-1 infection.
Infections
TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus.
Infections
Transcription elongation and human disease.
Infections
XPB mediated retroviral cDNA degradation coincides with entry to the nucleus.
Influenza, Human
Evidence for a novel mechanism of influenza A virus host adaptation modulated by PB2-627.
Insulin Resistance
BRD4 regulates adiponectin gene induction by recruiting the P-TEFb complex to the transcribed region of the gene.
Insulin Resistance
Turning back the clock.
Latent Infection
Latent HIV-1 Infection Occurs in Multiple Subsets of Hematopoietic Progenitor Cells and Is Reversed by NF-?B Activation.
Leukemia
A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.
Leukemia
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.
Leukemia
A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70.
Leukemia
DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia.
Leukemia
ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair.
Leukemia
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
Leukemia
Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia.
Leukemia
HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.
Leukemia
Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin.
Leukemia
Inhibition of DNA-dependent protein kinase promotes ultrasound-induced cell death including apoptosis in human leukemia cells.
Leukemia
Phosphorylation of RNA helicase A by DNA-dependent protein kinase is indispensable for expression of the MDR1 gene product P-glycoprotein in multidrug-resistant human leukemia cells.
Leukemia
Potentiation of chemosensitivity in multidrug-resistant human leukemia CEM cells by inhibition of DNA-dependent protein kinase using wortmannin.
Leukemia
Resistance against Friend leukemia virus-induced leukemogenesis in DNA-dependent protein kinase (DNA-PK)-deficient scid mice associated with defective viral integration at the Spi-1 and Fli-1 site.
Leukemia
Taking MLL through the MudPIT: identification of novel complexes that bring together MLL-fusion proteins and transcription elongation factors.
Leukemia
The little elongation complex regulates small nuclear RNA transcription.
Leukemia
The super elongation complex (SEC) and MLL in development and disease.
Leukemia
Transcription elongation and human disease.
Leukemia
[Expression of DNA-dependent protein kinase catalylic subunit in adult acute leukemia and its significance].
Leukemia, Lymphocytic, Chronic, B-Cell
DNA-Dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia lymphocytes to nitrogen mustards.
Leukemia, Lymphocytic, Chronic, B-Cell
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
DNA-PK, ATM and MDR proteins inhibitors in overcoming fludarabine resistance in CLL cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Potentiation of chlorambucil cytotoxicity in B-cell chronic lymphocytic leukemia by inhibition of DNA-dependent protein kinase activity using wortmannin.
Leukemia, Lymphocytic, Chronic, B-Cell
Regulation of DNA-dependent protein kinase activity in leukemic cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pharmacologic targeting of the P-TEFb complex as a therapeutic strategy for chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Gene of DNA-dependent protein kinase catalylic subunit in chronic myeloid leukemia]
Leukemia, Myeloid
A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70.
Leukemia, Myeloid, Acute
DNA-PK Inhibitor, M3814, as a New Combination Partner of Mylotarg in the Treatment of Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Transcription elongation and human disease.
Leukemia-Lymphoma, Adult T-Cell
NK314 potentiates antitumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase II{alpha} and DNA-dependent protein kinase.
Liver Neoplasms
The effect of inhibitors of phosphatidylinositol 3-kinase-related kinases on dibenzo[def,p]chrysene genotoxicity measured by ?H2AX levels and neutral comet assay in HepG2 human hepatocellular cancer cells.
Liver Neoplasms
The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo[def,p]chrysene on human hepatocellular cancer cell line HepG2.
Liver Neoplasms
The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2.
Lung Neoplasms
Co-targeting deoxyribonucleic acid-dependent protein kinase and poly(adenosine diphosphate-ribose) polymerase-1 promotes accelerated senescence of irradiated cancer cells.
Lung Neoplasms
Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells.
Lung Neoplasms
DNA-dependent protein kinase is inhibited by trifluoperazine.
Lung Neoplasms
Expression of immune checkpoint PD-1 in non-small cell lung cancer is associated with tumor cell DNA-dependent protein kinase.
Lung Neoplasms
M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells.
Lung Neoplasms
Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation.
Lung Neoplasms
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Lung Neoplasms
Reduced DNA-dependent protein kinase activity is associated with lung cancer.
Lung Neoplasms
Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines.
Lung Neoplasms
Targeting DNA-PK overcomes acquired resistance to third-generation EGFR-TKI osimertinib in non-small-cell lung cancer.
Lung Neoplasms
[Effect of Viqi Chutan Recipe on Caspase-4 and DNA-PK of Cell Apoptosis Approach in Transplanted Lung Cancer A549 Cells in Nude Mice].
Lung Neoplasms
[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].
Lung Neoplasms
[The expression of DNA-PKcs in non-small cell lung cancer and its relationship with apoptosis associated proteins.]
Lupus Erythematosus, Systemic
Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis.
Lymphatic Metastasis
Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients.
Lymphatic Metastasis
Protein predictive signatures for lymph node metastasis of gastric cancer.
Lymphoma
Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination.
Lymphoma
The double dealing of cyclin D1.
Lymphoma, B-Cell
Association of ERCC2 Gene Polymorphisms with Susceptibility to Diffuse Large B-Cell Lymphoma.
Lymphoma, B-Cell
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Lymphoma, Large B-Cell, Diffuse
Association of ERCC2 Gene Polymorphisms with Susceptibility to Diffuse Large B-Cell Lymphoma.
Lymphoma, Large B-Cell, Diffuse
Mechanisms of JP-8 jet fuel toxicity. I. Induction of apoptosis in rat lung epithelial cells.
Lymphoma, Mantle-Cell
The double dealing of cyclin D1.
Lymphoma, Non-Hodgkin
Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies.
Malaria
Topological polar surface area: a useful descriptor in 2D-QSAR.
Melanoma
A Multikinase and DNA-PK Inhibitor Combination Immunomodulates Melanomas, Suppresses Tumor Progression, and Enhances Immunotherapies.
Melanoma
Increased Non-Homologous End Joining Makes DNA-PK a Promising Target for Therapeutic Intervention in Uveal Melanoma.
Melanoma
Relationship between antiapoptotic molecules and metastatic potency and the involvement of DNA-dependent protein kinase in the chemosensitization of metastatic human cancer cells by epidermal growth factor receptor blockade.
Melanoma
The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.
Mouth Neoplasms
Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma.
Mouth Neoplasms
Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells.
Multiple Myeloma
Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies.
Multiple Myeloma
Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma.
Multiple Myeloma
Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma.
Muscular Atrophy, Spinal
Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK.
Muscular Diseases
Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity.
Nasopharyngeal Carcinoma
DNA-dependent protein kinase activity and radiosensitivity of nasopharyngeal carcinoma cell lines CNE1/CNE2.
Nasopharyngeal Carcinoma
Expressions of Ku70 and DNA-PKcs as prognostic indicators of local control in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Knockdown of Annexin A1 Enhances Radioresistance and Inhibits Apoptosis in Nasopharyngeal Carcinoma.
Nasopharyngeal Carcinoma
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Neoplasm Metastasis
Analysis and results of Ku and XRCC4 expression in hypopharyngeal cancer tissues treated with chemoradiotherapy.
Neoplasm Metastasis
Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients.
Neoplasm Metastasis
DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer.
Neoplasm Metastasis
DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions.
Neoplasm Metastasis
Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma.
Neoplasm Metastasis
LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.
Neoplasm Metastasis
Protein predictive signatures for lymph node metastasis of gastric cancer.
Neoplasm Metastasis
The lost intrinsic fragmentation of MAT1 protein during granulopoiesis promotes the growth and metastasis of leukemic myeloblasts.
Neoplasms
15-Lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity.
Neoplasms
7SK small nuclear RNA inhibits cancer cell proliferation through apoptosis induction.
Neoplasms
7SK small nuclear RNA transcription level down-regulates in human tumors and stem cells.
Neoplasms
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.
Neoplasms
A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer.
Neoplasms
A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours.
Neoplasms
A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.
Neoplasms
A Multikinase and DNA-PK Inhibitor Combination Immunomodulates Melanomas, Suppresses Tumor Progression, and Enhances Immunotherapies.
Neoplasms
A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair.
Neoplasms
A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours.
Neoplasms
A Small Molecule Screen Identifies an Inhibitor of DNA Repair Inducing the Degradation of TFIIH and the Chemosensitization of Tumor Cells to Platinum.
Neoplasms
A targeted inhibition of DNA-dependent protein kinase sensitizes breast cancer cells following ionizing radiation.
Neoplasms
Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity.
Neoplasms
Abrogation of the Brd4-P-TEFb Positive Transcription Complex by the Papillomavirus E2 protein Contributes to the Viral Oncogene Repression.
Neoplasms
Activation of the DNA-dependent protein kinase by drug-induced and radiation-induced DNA strand breaks.
Neoplasms
Activities of DNA-PK and Ku86, but not Ku70, may predict sensitivity to cisplatin in human gliomas.
Neoplasms
AF4 and AF4N protein complexes: recruitment of P-TEFb kinase, their interactome and potential functions.
Neoplasms
Allotype imbalance or microsatellite mutation in low-grade soft tissue sarcomas of the extremities in adults.
Neoplasms
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.
Neoplasms
Analysis and results of Ku and XRCC4 expression in hypopharyngeal cancer tissues treated with chemoradiotherapy.
Neoplasms
Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells.
Neoplasms
Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients.
Neoplasms
Beyond DNA repair: DNA-PK function in cancer.
Neoplasms
Bioinformatic Analyses of Canonical Pathways of TSPOAP1 and its Roles in Human Diseases.
Neoplasms
Biologic characterization of a secondary glioblastoma with extracranial progression and systemic metastasis.
Neoplasms
Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK.
Neoplasms
Brd4 and HEXIM1: multiple roles in P-TEFb regulation and cancer.
Neoplasms
Camptothecin releases P-TEFb from the inactive 7SK snRNP complex.
Neoplasms
Casticin induces DNA damage and inhibits DNA repair-associated protein expression in B16F10 mouse melanoma cancer cells.
Neoplasms
CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth
Neoplasms
CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.
Neoplasms
CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38?/MYC/PD-L1 signaling in non-small cell lung cancer.
Neoplasms
cDNA analysis of gene expression associated with DNA-dependent protein kinase activity.
Neoplasms
cDNA expression array analysis of DNA repair genes in human glioma cells that lack or express DNA-PK.
Neoplasms
Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions.
Neoplasms
Cell-type specific concentration regulation of the basal transcription factor TFIIH in XPBy/y mice model.
Neoplasms
Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: implications for genomic instability and therapy.
Neoplasms
Chemo-sensitisation of HeLa cells to Etoposide by a Benzoxazine in the absence of DNA-PK inhibition.
Neoplasms
Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K.
Neoplasms
Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas.
Neoplasms
Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status.
Neoplasms
Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.
Neoplasms
Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism.
Neoplasms
Complementation of the radiosensitive M059J cell line.
Neoplasms
Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin.
Neoplasms
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production.
Neoplasms
CTIP2 is a negative regulator of P-TEFb.
Neoplasms
Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation.
Neoplasms
Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.
Neoplasms
Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum.
Neoplasms
Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.
Neoplasms
Deletion of the Proline-Rich Region of the Murine Metastasis Susceptibility Gene Brd4 Promotes Epithelial-to-Mesenchymal Transition- and Stem Cell-Like Conversion.
Neoplasms
Developments of DNA-dependent Protein Kinase Inhibitors as Anticancer Agents.
Neoplasms
Difference in the heat sensitivity of DNA-dependent protein kinase activity among mouse, hamster and human cells.
Neoplasms
Differential DNA binding of Ku antigen determines its involvement in DNA replication.
Neoplasms
Differential gene expression in human glioma cells: correlation with presence or absence of DNA-dependent protein kinase.
Neoplasms
Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer.
Neoplasms
DNA damage and the DNA-activated protein kinase.
Neoplasms
DNA damage in cancer therapeutics: a boon or a curse?
Neoplasms
DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3.
Neoplasms
DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR.
Neoplasms
DNA-dependent protein kinase (DNA-PK)-dependent cisplatin-induced loss of nucleolar facilitator of chromatin transcription (FACT) and regulation of cisplatin sensitivity by DNA-PK and FACT.
Neoplasms
DNA-dependent protein kinase and its inhibition in support of radiotherapy.
Neoplasms
DNA-dependent protein kinase in leukaemia cells and correlation with drug sensitivity.
Neoplasms
DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer.
Neoplasms
DNA-dependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs.
Neoplasms
DNA-dependent protein kinase modulates the anti-cancer properties of silver nanoparticles in human cancer cells.
Neoplasms
DNA-dependent protein kinase.
Neoplasms
DNA-dependent protein kinase: effect on DSB repair, G2/M checkpoint and mode of cell death in NSCLC cell lines.
Neoplasms
DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer.
Neoplasms
DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin.
Neoplasms
DNA-PK as an Emerging Therapeutic Target in Cancer.
Neoplasms
DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions.
Neoplasms
DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage.
Neoplasms
DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia.
Neoplasms
DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance.
Neoplasms
DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells.
Neoplasms
DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia.
Neoplasms
Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy.
Neoplasms
Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases.
Neoplasms
Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death.
Neoplasms
Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK.
Neoplasms
Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage.
Neoplasms
Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.
Neoplasms
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair.
Neoplasms
Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies.
Neoplasms
Expression of immune checkpoint PD-1 in non-small cell lung cancer is associated with tumor cell DNA-dependent protein kinase.
Neoplasms
Expression of Ku70 correlates with survival in carcinoma of the cervix.
Neoplasms
Expression of Ku86 confers favorable outcome of tonsillar carcinoma treated with radiotherapy.
Neoplasms
Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines.
Neoplasms
First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy.
Neoplasms
Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo.
Neoplasms
Frameshift mutation in PRKDC, the gene for DNA-PKcs, in the DNA repair-defective, human, glioma-derived cell line M059J.
Neoplasms
Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination.
Neoplasms
Gene Expression Associated with DNA-Dependent Protein Kinase Activity under Normoxia, Hypoxia, and Reoxygenation.
Neoplasms
Glioblastoma cells deficient in DNA-dependent protein kinase are resistant to cell death.
Neoplasms
Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium.
Neoplasms
Heterogeneous nuclear ribonucleoprotein B1 protein impairs DNA repair mediated through the inhibition of DNA-dependent protein kinase activity.
Neoplasms
HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy.
Neoplasms
Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells.
Neoplasms
Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen.
Neoplasms
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.
Neoplasms
Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of bisphenol A.
Neoplasms
Identification of Novel Interaction Partners of Ets-1: Focus on DNA Repair.
Neoplasms
Identification of phosphorylation sites in the repetitive carboxyl-terminal domain of the mouse RNA polymerase II largest subunit.
Neoplasms
Identification of proteins binding to E-Box/Ku86 sites and function of the tumor suppressor SAFB1 in transcriptional regulation of the human xanthine oxidoreductase gene.
Neoplasms
Immunohistochemical analysis of Ku70/86 expression of breast cancer tissues.
Neoplasms
Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma.
Neoplasms
Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme.
Neoplasms
Inactivation of DNA-Dependent Protein Kinase Promotes Heat-Induced Apoptosis Independently of Heat-Shock Protein Induction in Human Cancer Cell Lines.
Neoplasms
Increased expression of DNA-dependent protein kinase confers resistance to adriamycin.
Neoplasms
Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice.
Neoplasms
Inhibiting DNA-PKcs in a non-homologous end-joining pathway in response to DNA double-strand breaks.
Neoplasms
Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells.
Neoplasms
Inhibition of DNA-dependent protein kinase promotes ultrasound-induced cell death including apoptosis in human leukemia cells.
Neoplasms
Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control.
Neoplasms
Inhibition of P-TEFb by DRB suppresses SIRT1/CK2? pathway and enhances radiosensitivity of human cancer cells.
Neoplasms
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.
Neoplasms
Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia.
Neoplasms
Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment.
Neoplasms
Is TFIIH the new Achilles heel of cancer cells?
Neoplasms
Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells.
Neoplasms
Ku antigen-DNA conformation determines the activation of DNA-dependent protein kinase and DNA sequence-directed repression of mouse mammary tumor virus transcription.
Neoplasms
Lack of correlation between DNA-dependent protein kinase activity and tumor cell radiosensitivity.
Neoplasms
Local tumor control and DNA-PK activity of peripheral blood lymphocytes in prostate cancer patients receiving radiotherapy.
Neoplasms
Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from (177)Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tumor Xenografts.
Neoplasms
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
Neoplasms
Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin.
Neoplasms
MicroRNA-136 inhibits cancer stem cell activity and enhances the anti-tumor effect of paclitaxel against chemoresistant ovarian cancer cells by targeting Notch3.
Neoplasms
Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation.
Neoplasms
Molecular mechanisms of platinum resistance: still searching for the Achilles' heel.
Neoplasms
Monitoring and signaling of radiation-induced damage in mammalian cells.
Neoplasms
MTA1 Promotes Hepatocellular Carcinoma Progression by Downregulation of DNA-PK-Mediated H1.2T146 Phosphorylation.
Neoplasms
New Insights into the Control of HIV-1 Transcription: When Tat Meets the 7SK snRNP and Super Elongation Complex (SEC).
Neoplasms
NONO phase separation enhances DNA damage repair by accelerating nuclear EGFR-induced DNA-PK activation.
Neoplasms
Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair.
Neoplasms
Novel DNA targeted therapies for head and neck cancers: clinical potential and biomarkers.
Neoplasms
Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex.
Neoplasms
Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation.
Neoplasms
P-TEFb as A Promising Therapeutic Target.
Neoplasms
P-TEFb inhibitors interfere with activation of p53 by DNA-damaging agents.
Neoplasms
P-TEFb joins the family of cdks in oncology, promotes cell growth of cancer cells.
Neoplasms
Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models.
Neoplasms
Pharmacologic targeting of the P-TEFb complex as a therapeutic strategy for chronic myeloid leukemia.
Neoplasms
Phosphorylation of RNA helicase A by DNA-dependent protein kinase is indispensable for expression of the MDR1 gene product P-glycoprotein in multidrug-resistant human leukemia cells.
Neoplasms
Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies.
Neoplasms
Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor.
Neoplasms
Potentiation of chlorambucil cytotoxicity in B-cell chronic lymphocytic leukemia by inhibition of DNA-dependent protein kinase activity using wortmannin.
Neoplasms
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.
Neoplasms
Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death.
Neoplasms
Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation.
Neoplasms
PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer.
Neoplasms
Quantification of XRCC and DNA-PK proteins in cancer cell lines and human tumors by LC-MS/MS.
Neoplasms
Radiation-Induced Micro-RNA Modulation in Glioblastoma Cells Differing in DNA-Repair Pathways.
Neoplasms
Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86.
Neoplasms
Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.
Neoplasms
Radiosensitizing activity of a novel Benzoxazine through the promotion of apoptosis and inhibition of DNA repair.
Neoplasms
Radiosensitizing effects of ectopic miR-101 on non-small-cell lung cancer cells depend on the endogenous miR-101 level.
Neoplasms
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Neoplasms
Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound.
Neoplasms
Rare diseases provide rare insights into DNA repair pathways, TFIIH, aging and cancer center.
Neoplasms
Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.
Neoplasms
Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress.
Neoplasms
Reduced DNA-dependent protein kinase activity in two cell lines derived from adult cancer patients with late radionecrosis.
Neoplasms
Regulation of cisplatin resistance and homologous recombinational repair by the TFIIH subunit XPD.
Neoplasms
Regulation of the DNA-dependent protein kinase (DNA-PK) activity in eukaryotic cells.
Neoplasms
Relationship between antiapoptotic molecules and metastatic potency and the involvement of DNA-dependent protein kinase in the chemosensitization of metastatic human cancer cells by epidermal growth factor receptor blockade.
Neoplasms
Response of heterogeneous ribonuclear proteins (hnRNP) to ionising radiation and their involvement in DNA damage repair.
Neoplasms
Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Neoplasms
Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines.
Neoplasms
Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2.
Neoplasms
Simple synthesis of carbon-11-labeled chromen-4-one derivatives as new potential PET agents for imaging of DNA-dependent protein kinase (DNA-PK) in cancer.
Neoplasms
Small molecule DNA-PK inhibitors as potential cancer therapy: a patent review (2010-present).
Neoplasms
Small molecule inhibitors of DNA-PK for tumor sensitization to anticancer therapy.
Neoplasms
Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents.
Neoplasms
Small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy.
Neoplasms
SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage.
Neoplasms
SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization.
Neoplasms
SV40 large tumor antigen nuclear import is regulated by the double-stranded DNA-dependent protein kinase site (serine 120) flanking the nuclear localization sequence.
Neoplasms
Synergistic Effect of a Mesothelin-Targeted 227Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models.
Neoplasms
Synergistic potentiation of interferon activity with maitake mushroom d-fraction on bladder cancer cells.
Neoplasms
Synergy between Prkdc and Trp53 regulates stem cell proliferation and GI-ARS after irradiation.
Neoplasms
Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer-siRNA Chimeras in Human Tumor Xenografts.
Neoplasms
Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy.
Neoplasms
Targeting DNA repair mechanisms in cancer.
Neoplasms
Targeting DNA-Dependent Protein Kinase for Cancer Therapy.
Neoplasms
Targeting DNA-PK in cancer.
Neoplasms
Targeting of the EGFR/?1 integrin connecting proteins PINCH1 and Nck2 radiosensitizes three-dimensional SCC cell cultures.
Neoplasms
Targeting the DNA-PK complex: Its rationale use in cancer and HIV-1 infection.
Neoplasms
Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells.
Neoplasms
TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.
Neoplasms
TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair.
Neoplasms
TFIIH: New Discoveries Regarding its Mechanisms and Impact on Cancer Treatment.
Neoplasms
The association of DNA-dependent protein kinase activity of peripheral blood lymphocytes with prognosis of cancer.
Neoplasms
The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.
Neoplasms
The basal transcription machinery as a target for cancer therapy.
Neoplasms
The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network.
Neoplasms
The cryo-electron microscopy structure of human transcription factor IIH.
Neoplasms
The development of ataxia telangiectasia mutated kinase inhibitors.
Neoplasms
The DNA repair complex DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy.
Neoplasms
The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition.
Neoplasms
The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila.
Neoplasms
The immunohistochemical expression of DNA-PKCS and Ku (p70/p80) in head and neck cancers: relationships with radiosensitivity.
Neoplasms
The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer.
Neoplasms
The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes quiescent but not proliferating MG-63 human osteosarcoma cells to radiation.
Neoplasms
The relationship between the down-regulation of DNA-PKcs or Ku70 and the chemosensitization in human cervical carcinoma cell line HeLa.
Neoplasms
The requirement for the basal transcription factor IIE is determined by the helical stability of promoter DNA.
Neoplasms
The role of autophagy in sensitizing malignant glioma cells to radiation therapy.
Neoplasms
The role of nitric oxide in cancer.
Neoplasms
Therapeutic Implications of p53 Status on Cancer Cell Fate Following Exposure to Ionizing Radiation and the DNA-PK Inhibitor M3814.
Neoplasms
Three targets in one complex: A molecular perspective of TFIIH in cancer therapy.
Neoplasms
Threonine 2609 phosphorylation of the DNA-dependent Protein Kinase is a critical prerequisite for epidermal growth factor receptor mediated radiation resistance.
Neoplasms
Topological polar surface area: a useful descriptor in 2D-QSAR.
Neoplasms
Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair.
Neoplasms
Transcription elongation and human disease.
Neoplasms
Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex.
Neoplasms
Transcription-induced DNA double strand breaks: both an oncogenic force and potential therapeutic target?
Neoplasms
Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha.
Neoplasms
Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage.
Neoplasms
Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.
Neoplasms
Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma.
Neoplasms
Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM by bleomycin.
Neoplasms
Wortmannin potentiates the combined effect of etoposide and cisplatin in human glioma cells.
Neoplasms
Xeroderma pigmentosum and molecular cloning of DNA repair genes.
Neoplasms
[Cell cycle regulation after exposure to ionizing radiation]
Neoplasms
[DNA-dependent protein kinase: a major protein involved in the cellular response to ionizing radiation]
Neoplasms
[Effect of Viqi Chutan Recipe on Caspase-4 and DNA-PK of Cell Apoptosis Approach in Transplanted Lung Cancer A549 Cells in Nude Mice].
Neoplasms
[Misregulation of P-TEFb activity: pathological consequences].
Neoplasms
[P-TEFb and Brd4: actors of the transcription pause release as therapeutical targets].
Neoplasms
[The expression of ERCC1, DNA-PKcs protein and the relation to prognosis in non-small cell lung cancer.]
Nervous System Diseases
Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity.
Neuroblastoma
Activation of DNA-dependent protein kinase may play a role in apoptosis of human neuroblastoma cells.
Neuroblastoma
Apoptotic human SH-SY5Y neuroblastoma cells have regularly spaced single strand DNA breaks and increased DNA-dependent protein kinase activity.
Neuroblastoma
DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.
Neuroblastoma
Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner.
Neuroblastoma
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Neuroectodermal Tumors
Upregulation of Ku expression in human neuroectodermal tumor cells after retroviral DNA integration.
Neurofibromatoses
Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress.
Neurofibromatosis 1
Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress.
Neuroinflammatory Diseases
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis.
Neuroinflammatory Diseases
Bioinformatic Analyses of Canonical Pathways of TSPOAP1 and its Roles in Human Diseases.
Neurologic Manifestations
Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition.
Neurologic Manifestations
Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH.
Nijmegen Breakage Syndrome
Role of IFI16 in DNA damage and checkpoint.
non-specific serine/threonine protein kinase deficiency
SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiency.
Obesity
DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.
Obesity
Effects of caloric restriction on peroxisome proliferator-activated receptors and positive transcription elongation factor b expression in obese rats.
Osteosarcoma
Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells.
Osteosarcoma
Targeting DNA-PKcs increased anticancer drug sensitivity by suppressing DNA damage repair in osteosarcoma cell line MG63.
Osteosarcoma
The effect of DNA-PKcs gene silencing on proliferation, migration, invasion and apoptosis, and in vivo tumorigenicity of human osteosarcoma MG-63 cells.
Ovarian Neoplasms
A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells.
Ovarian Neoplasms
Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models.
Ovarian Neoplasms
Biomarker analysis of the MITO2 phase III trial of first-line treatment in ovarian cancer: predictive value of DNA-PK and phosphorylated ACC.
Ovarian Neoplasms
DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance.
Ovarian Neoplasms
Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer cells.
Ovarian Neoplasms
Gefitinib (ZD1839) increases the efficacy of cisplatin in ovarian cancer cells.
Ovarian Neoplasms
Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities.
Ovarian Neoplasms
The involvement of Bcl-2 family proteins in AKT-regulated cell survival in cisplatin resistant epithelial ovarian cancer.
Pancreatic Neoplasms
Elevated DNA damage response in pancreatic cancer.
Pancreatic Neoplasms
Ku70 inhibits gemcitabine-induced DNA damage and pancreatic cancer cell apoptosis.
Pancreatic Neoplasms
Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer.
Papillomavirus Infections
Implications of tyrosine phosphoproteomics in cervical carcinogenesis.
Parathyroid Neoplasms
Differential expression of kinase genes in primary hyperparathyroidism: adenoma versus normal and hyperplastic parathyroid tissue.
Photophobia
Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly.
Polycystic Kidney Diseases
Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.
Polycythemia Vera
Imbalance of DNA-dependent protein kinase subunits in polycythemia vera peripheral blood stem cells.
Porcine Reproductive and Respiratory Syndrome
Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes.
Pre-Eclampsia
Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia.
Pre-Eclampsia
Nucleotide excision repair/transcription gene defects in the fetus and impaired TFIIH-mediated function in transcription in placenta leading to preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Inhibition of DNA-PK enhances chemosensitivity of B-cell precursor acute lymphoblastic leukemia cells to doxorubicin.
Prostatic Neoplasms
Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer.
Prostatic Neoplasms
Androgen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongation.
Prostatic Neoplasms
Androgen Receptor Variants Mediate DNA Repair after Prostate Cancer Irradiation.
Prostatic Neoplasms
DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway.
Prostatic Neoplasms
DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions.
Prostatic Neoplasms
DNA-PK, Nuclear mTOR, and the Androgen Pathway in Prostate Cancer.
Prostatic Neoplasms
Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation.
Prostatic Neoplasms
Enhancing the apoptotic potential of insulin-like growth factor-binding protein-3 in prostate cancer by modulation of CK2 phosphorylation.
Prostatic Neoplasms
From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator.
Prostatic Neoplasms
Local tumor control and DNA-PK activity of peripheral blood lymphocytes in prostate cancer patients receiving radiotherapy.
Prostatic Neoplasms
Phenylbutyrate attenuates the expression of Bcl-X(L), DNA-PK, caveolin-1, and VEGF in prostate cancer cells.
Prostatic Neoplasms
Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3.
Prostatic Neoplasms
Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies.
Prostatic Neoplasms
Positive feedback loop mediated by protein phosphatase 1? mobilization of P-TEFb and basal CDK1 drives androgen receptor in prostate cancer.
Prostatic Neoplasms
Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound.
Prostatic Neoplasms
Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer-siRNA Chimeras in Human Tumor Xenografts.
Prostatic Neoplasms
The second largest subunit of RNA polymerase II interacts with and enhances transactivation of androgen receptor.
Prostatic Neoplasms
Transcription-induced DNA double strand breaks: both an oncogenic force and potential therapeutic target?
Pulmonary Disease, Chronic Obstructive
Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer.
Retinoblastoma
Death substrates come alive.
Retinoblastoma
DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1.
Retinoblastoma
Flavopiridol enhances human tumor cell radiosensitivity and prolongs expression of gammaH2AX foci.
Retinoblastoma
The double dealing of cyclin D1.
Rhabdomyosarcoma, Alveolar
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Rheumatic Diseases
Identification of human autoantibodies to the DNA ligase IV/XRCC4 complex and mapping of an autoimmune epitope to a potential regulatory region.
Rift Valley Fever
NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62.
Rift Valley Fever
Targeting TFIIH to inhibit host cell transcription by Rift Valley Fever Virus.
Rift Valley Fever
Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH.
Sarcoma
Allotype imbalance or microsatellite mutation in low-grade soft tissue sarcomas of the extremities in adults.
Sarcoma
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Sarcoma, Ewing
Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2.
Severe Combined Immunodeficiency
DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency.
Severe Combined Immunodeficiency
DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties.
Severe Combined Immunodeficiency
DNA-PK autophosphorylation facilitates Artemis endonuclease activity.
Severe Combined Immunodeficiency
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity.
Severe Combined Immunodeficiency
Dysfunctional mammalian telomeres join with DNA double-strand breaks.
Severe Combined Immunodeficiency
Elongated telomeres in scid mice.
Severe Combined Immunodeficiency
Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.
Severe Combined Immunodeficiency
Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair.
Severe Combined Immunodeficiency
Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.
Severe Combined Immunodeficiency
High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase.
Severe Combined Immunodeficiency
Identification of four highly conserved regions in DNA-PKcs.
Severe Combined Immunodeficiency
Involvement of DNA-dependent protein kinase in down-regulation of cell cycle progression.
Severe Combined Immunodeficiency
Irradiation-induced rescue of thymocyte differentiation and V(D)J recombination in mice lacking the catalytic subunit of DNA-dependent protein kinase.
Severe Combined Immunodeficiency
Lack of detectable defect in DNA double-strand break repair and DNA-dependent protein kinase activity in radiosensitive human severe combined immunodeficiency fibroblasts.
Severe Combined Immunodeficiency
Radiation-induced apoptosis in scid mice spleen after low dose irradiation.
Severe Combined Immunodeficiency
Regulation of the DNA-dependent protein kinase (DNA-PK) activity in eukaryotic cells.
Severe Combined Immunodeficiency
Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.
Severe Combined Immunodeficiency
Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity.
Severe Combined Immunodeficiency
The neoplastic transformation of SCID cells by radiation.
Skin Diseases
Distribution of mutations in the human xeroderma pigmentosum group A gene and their relationships to the functional regions of the DNA damage recognition protein.
Skin Neoplasms
Analysis of U1 small nuclear RNA interaction with cyclin H.
Skin Neoplasms
Comparative study of nucleotide excision repair defects between XPD-mutated fibroblasts derived from trichothiodystrophy and xeroderma pigmentosum patients.
Skin Neoplasms
Persistence of repair proteins at unrepaired DNA damage distinguishes diseases with ERCC2 (XPD) mutations: cancer-prone xeroderma pigmentosum vs. non-cancer-prone trichothiodystrophy.
Spinal Muscular Atrophies of Childhood
The gene encoding p44, a subunit of the transcription factor TFIIH, is involved in large-scale deletions associated with Werdnig-Hoffmann disease.
Squamous Cell Carcinoma of Head and Neck
Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status.
Squamous Cell Carcinoma of Head and Neck
Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth.
Squamous Cell Carcinoma of Head and Neck
Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells.
Squamous Cell Carcinoma of Head and Neck
Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia.
Squamous Cell Carcinoma of Head and Neck
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Squamous Cell Carcinoma of Head and Neck
Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons.
Squamous Cell Carcinoma of Head and Neck
The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
[Expression and significance of DNA-dependent protein kinase in human laryngeal squamous cell carcinoma].
Starvation
A transcriptional autoregulatory loop for KIN28-CCL1 and SRB10-SRB11, each encoding RNA polymerase II CTD kinase-cyclin pair, stimulates the meiotic development of S. cerevisiae.
Starvation
DNA-PKcs is activated under nutrient starvation and activates Akt, MST1, FoxO3a, and NDR1.
Starvation
The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2.
Stomach Neoplasms
Effects of dna-dependent protein kinase inhibition by NU7026 on dna repair and cell survival in irradiated gastric cancer cell line N87.
Telangiectasis
AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.
Telangiectasis
ATM phosphorylates histone H2AX in response to DNA double-strand breaks.
Telangiectasis
ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression.
Telangiectasis
ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis.
Telangiectasis
Casticin induces DNA damage and inhibits DNA repair-associated protein expression in B16F10 mouse melanoma cancer cells.
Telangiectasis
Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors.
Telangiectasis
Double-strand DNA breaks are mainly repaired by the homologous recombination pathway in early developing swine embryos.
Telangiectasis
Epstein-Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle.
Telangiectasis
Inhibition of HIV-1 replication by caffeine and caffeine-related methylxanthines.
Telangiectasis
Intersection of Two Checkpoints: Could Inhibiting the DNA Damage Response Checkpoint Rescue Immune Checkpoint-Refractory Cancer?
Telangiectasis
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
Telangiectasis
Molecular mechanisms of ionizing radiation-induced apoptosis.
Telangiectasis
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
Telangiectasis
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Telangiectasis
Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family.
Telangiectasis
Targeting DNA repair mechanisms in cancer.
Telangiectasis
The development of ataxia telangiectasia mutated kinase inhibitors.
Telangiectasis
The effect of inhibitors of phosphatidylinositol 3-kinase-related kinases on dibenzo[def,p]chrysene genotoxicity measured by ?H2AX levels and neutral comet assay in HepG2 human hepatocellular cancer cells.
Telangiectasis
Transcription-dependent activation of ataxia telangiectasia-mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison.
Thyroid Neoplasms
Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines.
Tics
Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest.
Tongue Neoplasms
Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.
Trichothiodystrophy Syndromes
A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy.
Trichothiodystrophy Syndromes
A new function of TFIIH explains the neurological symptoms in trichothiodystrophy.
Trichothiodystrophy Syndromes
A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A.
Trichothiodystrophy Syndromes
Analysis of Drosophila p8 and p52 mutants reveals distinct roles for the maintenance of TFIIH stability and male germ cell differentiation.
Trichothiodystrophy Syndromes
Analysis of U1 small nuclear RNA interaction with cyclin H.
Trichothiodystrophy Syndromes
Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice.
Trichothiodystrophy Syndromes
Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.
Trichothiodystrophy Syndromes
DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development.
Trichothiodystrophy Syndromes
Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases.
Trichothiodystrophy Syndromes
Dual functions of DNA repair genes: molecular, cellular, and clinical implications.
Trichothiodystrophy Syndromes
Dynamic partnership between TFIIH, PGC-1? and SIRT1 is impaired in trichothiodystrophy.
Trichothiodystrophy Syndromes
GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy.
Trichothiodystrophy Syndromes
Interacting partners of the Tfb2 subunit from yeast TFIIH.
Trichothiodystrophy Syndromes
Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly.
Trichothiodystrophy Syndromes
Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio).
Trichothiodystrophy Syndromes
Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing.
Trichothiodystrophy Syndromes
Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy.
Trichothiodystrophy Syndromes
Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH.
Trichothiodystrophy Syndromes
Mutations in XPD helicase prevent its interaction and regulation by p44, another subunit of TFIIH, resulting in Xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) phenotypes.
Trichothiodystrophy Syndromes
Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH.
Trichothiodystrophy Syndromes
p8/TTDA overexpression enhances UV-irradiation resistance and suppresses TFIIH mutations in a Drosophila trichothiodystrophy model.
Trichothiodystrophy Syndromes
Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy.
Trichothiodystrophy Syndromes
Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin.
Trichothiodystrophy Syndromes
Small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy.
Trichothiodystrophy Syndromes
Solution structure and self-association properties of the p8 TFIIH subunit responsible for trichothiodystrophy.
Trichothiodystrophy Syndromes
Splitting hairs--discovery of a new DNA repair and transcription factor for the human disease trichothiodystrophy.
Trichothiodystrophy Syndromes
Structural basis for group A trichothiodystrophy.
Trichothiodystrophy Syndromes
Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder.
Trichothiodystrophy Syndromes
Tfb5 is partially dispensable for Rad26 mediated transcription coupled nucleotide excision repair in yeast.
Trichothiodystrophy Syndromes
TFIIE orchestrates the recruitment of the TFIIH kinase module at promoter before release during transcription.
Trichothiodystrophy Syndromes
TFIIH Subunit Alterations Causing Xeroderma Pigmentosum and Trichothiodystrophy Specifically Disturb Several Steps during Transcription.
Trichothiodystrophy Syndromes
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
Trichothiodystrophy Syndromes
TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin.
Trichothiodystrophy Syndromes
TFIIH: a link between transcription, DNA repair and cell cycle regulation.
Trichothiodystrophy Syndromes
TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair.
Trichothiodystrophy Syndromes
The cryo-electron microscopy structure of human transcription factor IIH.
Trichothiodystrophy Syndromes
The structure of the TFIIH p34 subunit reveals a von Willebrand factor A like fold.
Trichothiodystrophy Syndromes
The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor.
Trichothiodystrophy Syndromes
Transcription by RNA polymerase II: a process linked to DNA repair.
Trichothiodystrophy Syndromes
Transcription factor IIH - the protein complex with multiple functions.
Trichothiodystrophy Syndromes
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Trichothiodystrophy Syndromes
Transcriptional changes in trichothiodystrophy cells.
Trichothiodystrophy Syndromes
Trichothiodystrophy view from the molecular basis of DNA repair/transcription factor TFIIH.
Trichothiodystrophy Syndromes
TTDA: Big impact of a small protein.
Trichothiodystrophy Syndromes
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
Trichothiodystrophy Syndromes
XPD mutations in trichothiodystrophy hamper collagen VI expression and reveal a role of TFIIH in transcription derepression.
Triple Negative Breast Neoplasms
HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer.
Urinary Bladder Neoplasms
Down-regulation of Ku 70 and Ku 80 mRNA expression in transitional cell carcinomas of the urinary bladder related to tumor progression.
Urinary Bladder Neoplasms
Expression and DNA binding activity of the Ku heterodimer in bladder carcinoma.
Uterine Cervical Neoplasms
The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.
Uveitis
T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex.
Vaccinia
A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus.
Vaccinia
Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2.
Vaccinia
DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing.
Vesicular Stomatitis
The matrix protein of vesicular stomatitis virus inhibits host-directed transcription of target genes via interaction with the TFIIH subunit p8.
Viremia
A Phase 1/2 Randomized, Placebo-Controlled Trial of Romidespin in Persons With HIV-1 on Suppressive Antiretroviral Therapy.
Viremia
A phase I/II randomized, placebo-controlled trial of romidepsin in persons with HIV-1 on suppressive antiretroviral therapy to assess safety and activation of HIV-1 expression (A5315).
Virus Diseases
Chemoproteomic profiling identifies changes in DNA-PK as markers of early dengue virus infection.
Virus Diseases
HIV-1 transcription is regulated by splicing factor SRSF1.
Virus Diseases
Interferon regulatory factor-3 is an in vivo target of DNA-PK.
Virus Diseases
Role of DNA-PK in the cellular response to DNA double-strand breaks.
Virus Diseases
Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity.
Virus Diseases
The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight.
Virus Diseases
[Misregulation of P-TEFb activity: pathological consequences].
Werner Syndrome
DNA-dependent protein kinase (DNA-PK)-dependent cisplatin-induced loss of nucleolar facilitator of chromatin transcription (FACT) and regulation of cisplatin sensitivity by DNA-PK and FACT.
Werner Syndrome
Repair of telomeric DNA prior to replicative senescence.
Werner Syndrome
Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks.
Werner Syndrome
Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase.
Wiskott-Aldrich Syndrome
IMP dehydrogenase is recruited to the transcription complex through serine 2 phosphorylation of RNA polymerase II.
Xeroderma Pigmentosum
A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription.
Xeroderma Pigmentosum
A temperature-sensitive disorder in basal transcription and DNA repair in humans.
Xeroderma Pigmentosum
Adenovirus type 12-induced fragility of the human RNU2 locus requires p53 function.
Xeroderma Pigmentosum
Affinity purification of human DNA repair/transcription factor TFIIH using epitope-tagged xeroderma pigmentosum B protein.
Xeroderma Pigmentosum
Analysis of Drosophila p8 and p52 mutants reveals distinct roles for the maintenance of TFIIH stability and male germ cell differentiation.
Xeroderma Pigmentosum
Analysis of the conserved NER helicases (XPB and XPD) and UV-induced DNA damage in Hydra.
Xeroderma Pigmentosum
Both XPD alleles contribute to the phenotype of compound heterozygote xeroderma pigmentosum patients.
Xeroderma Pigmentosum
Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.
Xeroderma Pigmentosum
Common XPD (ERCC2) polymorphisms have no measurable effect on nucleotide excision repair and basal transcription.
Xeroderma Pigmentosum
Conserved XPB Core Structure and Motifs for DNA Unwinding: Implications for Pathway Selection of Transcription or Excision Repair.
Xeroderma Pigmentosum
Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum.
Xeroderma Pigmentosum
Detection and determination of oligonucleotide triplex formation-mediated transcription-coupled DNA repair in HeLa nuclear extracts.
Xeroderma Pigmentosum
Distinct roles for the helicases of TFIIH in transcript initiation and promoter escape.
Xeroderma Pigmentosum
Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair.
Xeroderma Pigmentosum
DNA excision repair.
Xeroderma Pigmentosum
DNA quality control by a lesion sensor pocket of the xeroderma pigmentosum group D helicase subunit of TFIIH.
Xeroderma Pigmentosum
DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development.
Xeroderma Pigmentosum
Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases.
Xeroderma Pigmentosum
Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death.
Xeroderma Pigmentosum
Dual functions of DNA repair genes: molecular, cellular, and clinical implications.
Xeroderma Pigmentosum
Epstein-Barr virus co-opts TFIIH component XPB to specifically activate essential viral lytic promoters.
Xeroderma Pigmentosum
Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression.
Xeroderma Pigmentosum
GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy.
Xeroderma Pigmentosum
Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1, and TFIIH.
Xeroderma Pigmentosum
Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein.
Xeroderma Pigmentosum
Lack of CAK complex accumulation at DNA damage sites in XP-B and XP-B/CS fibroblasts reveals differential regulation of CAK anchoring to core TFIIH by XPB and XPD helicases during nucleotide excision repair.
Xeroderma Pigmentosum
Mechanism of promoter melting by the xeroderma pigmentosum complementation group B helicase of transcription factor IIH revealed by protein-DNA photo-cross-linking.
Xeroderma Pigmentosum
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
Xeroderma Pigmentosum
MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.
Xeroderma Pigmentosum
Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly.
Xeroderma Pigmentosum
Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio).
Xeroderma Pigmentosum
Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy.
Xeroderma Pigmentosum
Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH.
Xeroderma Pigmentosum
Mutations in XPB and XPD helicases found in xeroderma pigmentosum patients impair the transcription function of TFIIH.
Xeroderma Pigmentosum
Mutations in XPD helicase prevent its interaction and regulation by p44, another subunit of TFIIH, resulting in Xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) phenotypes.
Xeroderma Pigmentosum
p8/TTDA overexpression enhances UV-irradiation resistance and suppresses TFIIH mutations in a Drosophila trichothiodystrophy model.
Xeroderma Pigmentosum
Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome.
Xeroderma Pigmentosum
Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity.
Xeroderma Pigmentosum
Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy.
Xeroderma Pigmentosum
RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components xeroderma pigmentosum B and p62.
Xeroderma Pigmentosum
Selective regulation of vitamin D receptor-responsive genes by TFIIH.
Xeroderma Pigmentosum
Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF-?B and AP-1 signalling.
Xeroderma Pigmentosum
Spironolactone-induced XPB degradation requires TFIIH integrity and ubiquitin-selective segregase VCP/p97.
Xeroderma Pigmentosum
Strand- and site-specific DNA lesion demarcation by the xeroderma pigmentosum group D helicase.
Xeroderma Pigmentosum
TFIIH action in transcription initiation and promoter escape requires distinct regions of downstream promoter DNA.
Xeroderma Pigmentosum
TFIIH Subunit Alterations Causing Xeroderma Pigmentosum and Trichothiodystrophy Specifically Disturb Several Steps during Transcription.
Xeroderma Pigmentosum
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
Xeroderma Pigmentosum
TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin.
Xeroderma Pigmentosum
TFIIH: a link between transcription, DNA repair and cell cycle regulation.
Xeroderma Pigmentosum
TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair.
Xeroderma Pigmentosum
The carboxy-terminal domain of xeroderma pigmentosum complementation group C protein, involved in TFIIH and centrin binding, is highly disordered.
Xeroderma Pigmentosum
The cryo-electron microscopy structure of human transcription factor IIH.
Xeroderma Pigmentosum
The structure of the TFIIH p34 subunit reveals a von Willebrand factor A like fold.
Xeroderma Pigmentosum
The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor.
Xeroderma Pigmentosum
The XPD helicase: XPanDing archaeal XPD structures to get a grip on human DNA repair.
Xeroderma Pigmentosum
Transcription by RNA polymerase II: a process linked to DNA repair.
Xeroderma Pigmentosum
Transcription factor IIH - the protein complex with multiple functions.
Xeroderma Pigmentosum
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Xeroderma Pigmentosum
TTDA: Big impact of a small protein.
Xeroderma Pigmentosum
Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene.
Xeroderma Pigmentosum
Two new XPD patients compound heterozygous for the same mutation demonstrate diverse clinical features.
Xeroderma Pigmentosum
Xeroderma pigmentosum and molecular cloning of DNA repair genes.
Xeroderma Pigmentosum
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
Xeroderma Pigmentosum
XPD mutations prevent TFIIH-dependent transactivation by nuclear receptors and phosphorylation of RARalpha.
[rna-polymerase]-subunit kinase deficiency
DNA-dependent protein kinase defects are linked to deficiencies in DNA repair and V(D)J recombination.
[rna-polymerase]-subunit kinase deficiency
DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus.
[rna-polymerase]-subunit kinase deficiency
DNA-dependent protein kinase.
[rna-polymerase]-subunit kinase deficiency
DNA-PK Deficiency in Alzheimer's Disease.
[rna-polymerase]-subunit kinase deficiency
DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity.
[rna-polymerase]-subunit kinase deficiency
DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells.
[rna-polymerase]-subunit kinase deficiency
Dysfunctional mammalian telomeres join with DNA double-strand breaks.
[rna-polymerase]-subunit kinase deficiency
Nonhomologous-end-joining factors regulate DNA repair fidelity during Sleeping Beauty element transposition in mammalian cells.
[rna-polymerase]-subunit kinase deficiency
Role of DNA-dependent protein kinase in neuronal survival.
[rna-polymerase]-subunit kinase deficiency
Variable diversity joining recombination: nonhairpin coding ends in thymocytes of SCID and wild-type mice.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.