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Information on EC 2.7.11.23 - [RNA-polymerase]-subunit kinase and Organism(s) Bos taurus

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EC Tree
IUBMB Comments
The enzyme appears to be distinct from other protein kinases. It brings about multiple phosphorylations of the unique C-terminal repeat domain of the largest subunit of eukaryotic DNA-directed RNA polymerase (EC 2.7.7.6). The enzyme does not phosphorylate casein, phosvitin or histone.
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Bos taurus
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Synonyms
dna-pk, tfiih, p-tefb, dna-dependent protein kinase, positive transcription elongation factor b, ctd kinase, kin28, srb10, ctdk-i, tfiih kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C-terminal repeat domain kinase
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CTD kinase
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kinase, ribonucleate nucleotidyltransferase II C-terminal domain (phosphorylating)
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kinase, ribonucleate nucleotidyltransferase isozyme II IIa subunit (phosphorylating)
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RNA polymerase II CTD kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[DNA-directed RNA polymerase] phosphotransferase
The enzyme appears to be distinct from other protein kinases. It brings about multiple phosphorylations of the unique C-terminal repeat domain of the largest subunit of eukaryotic DNA-directed RNA polymerase (EC 2.7.7.6). The enzyme does not phosphorylate casein, phosvitin or histone.
CAS REGISTRY NUMBER
COMMENTARY hide
122097-00-1
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CDK1_BOVIN
297
0
34025
Swiss-Prot
other Location (Reliability: 1)
CDK9_BOVIN
372
0
42748
Swiss-Prot
other Location (Reliability: 1)
CDK12_BOVIN
1264
0
140642
Swiss-Prot
other Location (Reliability: 1)
CDK13_BOVIN
1512
0
164717
Swiss-Prot
other Location (Reliability: 2)
Q08DX5_BOVIN
346
0
38946
TrEMBL
other Location (Reliability: 2)