Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide
ADP + beta-nicotinamide D-ribonucleotide
-
-
-
?
ATP + amphiphysin I
ADP + phosphorylated amphiphysin
-
-
-
?
ATP + B-cell lymphoma protein 2
ADP + phosphorylated B-cell lymphoma protein 2
-
B-cell lymphoma protein 2 is phosphorylated at Ser70, Cdk5-mediated B-cell lymphoma protein 2 phosphorylation is pivotal for the antiapoptotic effect of Bcl-2 and contributes to the maintenance of neuronal survival by Cdk5
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
ATP + collapsing response mediator protein
ADP + phosphorylated collapsing response mediator protein
-
-
-
-
?
ATP + dynamin I
ADP + phosphorylated dynamin
-
-
-
?
ATP + ephexin 1
ADP + phosphorylated ephexin 1
-
-
-
-
?
ATP + ErbB2
ADP + phosphorylated ErbB2
ATP + ErbB3
ADP + phosphorylated ErbB3
ATP + high-molecular-weight neurofilament
ADP + phosphorylated high-molecular-weight neurofilament
-
-
-
?
ATP + histone 1
ADP + phosphorylated histone 1
-
-
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
ATP + huntingtin
ADP + phosphorylated huntingtin
ATP + MAP1B
ADP + phosphorylated MAP1B
-
-
-
-
?
ATP + MAP2
ADP + phosphorylated MAP2
-
-
-
-
?
ATP + MEF2
ADP + phosphorylated MEF2
-
-
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
ATP + MEP50 protein
ADP + MEP50 phosphoprotein
-
a PRMT5 co-regulatory factor
-
-
?
ATP + microtubule-associated tau
ADP + phosphorylated microtubule-associated tau
-
-
-
?
ATP + neuregulin receptor ErbB2
ADP + phosphorylated neuregulin receptor ErbB2
ATP + neuregulin receptor ErbB3
ADP + phosphorylated neuregulin receptor ErbB3
ATP + neurofilament heavy chain
ADP + phosphorylated neurofilament heavy chain
-
-
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
ATP + NF-M
ADP + phosphorylated NF-M
ATP + Pak1
ADP + phosphorylated Pak1
-
-
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
ATP + pre-synaptic P/Q-type voltage-dependent calcium channel
ADP + phosphorylated pre-synaptic P/Q-type voltage-dependent calcium channel
-
-
-
?
ATP + protein
ADP + phosphoprotein
ATP + PSD-95
ADP + phosphorylated PSD-95
-
-
-
-
?
ATP + RasGRF1
ADP + phosphorylated RasGRF1
-
-
-
-
?
ATP + RasGRF2
ADP + phosphorylated RasGRF2
-
-
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
ATP + RNA polymerase II
ADP + phosphorylated RNA polymerase II
-
-
-
?
ATP + Sept5 protein
ADP + phosphorylated Sept5 protein
-
Sept5 protein is phosphorylated at Ser17
-
-
?
ATP + septine 5
ADP + phosphorylated septine 5
-
Ser327 is the major phosphorylation site for Cdk5 in presence of activator p35
-
-
?
ATP + STAT3
ADP + phosphorylated STAT3
ATP + steroidogenic factor 1
ADP + phosphorylated steroidogenic factor 1
also known as Ad4BP, systematic name NR5A1, the phosphorylation site is at Ser203
-
-
?
ATP + synaptojanin I
ADP + phosphorylated synaptojanin I
-
-
-
?
ATP + syntaxin-1
ADP + phosphorylated syntaxin-1
-
-
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
ATP + WAVE1
ADP + phosphorylated WAVE1
-
-
-
-
?
ATP + [tau protein]
ADP + O-phospho-[tau-protein]
-
Cdk5-p25 or Cdk5-p35, see also EC 2.7.11.26
-
-
?
ATP + [tau protein]
ADP + [O-phospho-tau protein]
ATP + [tau-protein]
ADP + O-phospho -[tau-protein]
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
additional information
?
-
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation at Thr131
-
-
?
ATP + ErbB2
ADP + phosphorylated ErbB2
-
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
-
-
?
ATP + ErbB2
ADP + phosphorylated ErbB2
-
phosphorylation at Thr871
-
-
?
ATP + ErbB3
ADP + phosphorylated ErbB3
-
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
-
-
?
ATP + ErbB3
ADP + phosphorylated ErbB3
-
phosphorylation at Ser1120
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
-
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
preferred substrate of cdk5 associated with p35
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
commercial substrate, Cdk5
-
-
?
ATP + huntingtin
ADP + phosphorylated huntingtin
-
-
-
-
?
ATP + huntingtin
ADP + phosphorylated huntingtin
-
huntingtin is phosphorylated by Cdk5 at Ser1181 and Ser1201
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
phosphorylation at Thr286
-
-
?
ATP + neuregulin receptor ErbB2
ADP + phosphorylated neuregulin receptor ErbB2
-
phosphorylation at Ser1176 by Cdk5
-
-
?
ATP + neuregulin receptor ErbB2
ADP + phosphorylated neuregulin receptor ErbB2
-
phosphorylation at Ser1176 in the sequence RPKTLSPGKN by Cdk5
-
-
?
ATP + neuregulin receptor ErbB3
ADP + phosphorylated neuregulin receptor ErbB3
-
phosphorylation at Thr871 and Ser1120 in the consensus sequence RSRSPR by Cdk5, Cdk5 associates with Erb3 in vivo
-
-
?
ATP + neuregulin receptor ErbB3
ADP + phosphorylated neuregulin receptor ErbB3
-
phosphorylation at Thr871 in the sequence AKTPIKWAL and Ser1120 in the consensus sequence RSRSPR by Cdk5, weak phosphorylation of Ser1204 in the proline-rich sequence RRGSPPRPPR
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + protein
ADP + phosphoprotein
serine/threonine-specific protein kinase
-
-
?
ATP + protein
ADP + phosphoprotein
receptor protein tyrosine kinase
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
the phosphorylation site is at Ser795
-
-
?
ATP + STAT3
ADP + phosphorylated STAT3
-
-
-
-
?
ATP + STAT3
ADP + phosphorylated STAT3
-
specific phosphorylation at Ser727 by CDK5-p35, CDK5 is involved in regulation of the signal transducer and transcription activator STAT3 in brain and muscle
-
-
?
ATP + STAT3
ADP + phosphorylated STAT3
-
specific phosphorylation at Ser727 by CDK5-p35
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
-
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
hyperactivated Cdk5-p25
-
-
?
ATP + [tau protein]
ADP + [O-phospho-tau protein]
-
substrate of CDK5 in the central nervous system, see also EC 2.7.11.26, tau hyperphosphorylation is involved in neurodegeneration and Alzheimer's disease, tau protein phosphorylation by CDK5 is involved in apoptosis in cortical cells
-
-
?
ATP + [tau protein]
ADP + [O-phospho-tau protein]
-
substrate of CDK5 in the central nervous system, see also EC 2.7.11.26, phosphorylation at the PHF-1 epitope, not the Tau-1 epitope, of tau protein by CDK5-p25
-
-
?
ATP + [tau-protein]
ADP + O-phospho -[tau-protein]
-
cdk5 substrate in brain, cdk5 associated with p39, tau is a microtubule-associated and developmentally regulated protein involved in axonal development in neurons, tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules, reaction of EC 2.7.11.26
-
-
?
ATP + [tau-protein]
ADP + O-phospho -[tau-protein]
-
preferred substrate of cdk5 associated with p39, recombinant bacterially expressed human tau protein as substrate, phosphorylation at Ser202 and Thr205, reaction of EC 2.7.11.26
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
-
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
activity in organisms with mutated APP and tau, not in wild-type, overview
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
hyperphosphorylation of tau by CDK5 is involved in apoptosis and neurodegeneration in Alzheimer's disease, overview
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
phosphorylation of the PHF-1 epitope at Ser396 and Ser404 by CDK5
-
-
?
additional information
?
-
the cdc2 protein kinase plays a role in transcriptional regulation
-
-
?
additional information
?
-
potential function in sensory cells
-
-
?
additional information
?
-
enzyme may have a critical function during normal embryonic development and continues to be expressed in differentiated adult tissues
-
-
?
additional information
?
-
-
enzyme may have a critical function during normal embryonic development and continues to be expressed in differentiated adult tissues
-
-
?
additional information
?
-
enzyme is involved in signal transduction process of pattern formation in the hindbrain
-
-
?
additional information
?
-
enzyme is involved in signal transduction process of pattern formation in the hindbrain
-
-
?
additional information
?
-
-
enzyme is involved in signal transduction process of pattern formation in the hindbrain
-
-
?
additional information
?
-
-
naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of mutants leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of mutants leads to age-dependent memory deficits
-
-
?
additional information
?
-
-
cdk5 catalyzes tau phosphorylation in brain, but cyclin-dependent phosphorylation of other proteins, EC 2.7.11.22, in different tissues
-
-
?
additional information
?
-
-
CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview
-
-
?
additional information
?
-
-
Cdk5 regulates Akt activation and cell survival through the neuregulin-mediated PI 3-kinase signaling pathway, null mutants show lower phosphatidylinositol 3-kinase activity, Cdk5-p35 mediates neuroprotection
-
-
?
additional information
?
-
-
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, and is critical for neuronal survival, deregulation of Cdk5 occurs in neurodegeneration
-
-
?
additional information
?
-
-
the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia
-
-
?
additional information
?
-
no detectable kinase activity towards CDKs, the Pol II carboxyl-terminal domain (CTD), histone H1 or myelin basic protein
-
-
?
additional information
?
-
-
Cdk5 is a modulator of spine morphogenesis
-
-
?
additional information
?
-
-
the CDK2-cyclin E complex is a inducer of S-phase entry and key factor for the initiation of centrosome duplication, that CDK4/6-cyclin D are the proteins that compensates for the loss of CDK2 in the initiation of centrosome duplication
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide
ADP + beta-nicotinamide D-ribonucleotide
-
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + ErbB2
ADP + phosphorylated ErbB2
-
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
-
-
?
ATP + ErbB3
ADP + phosphorylated ErbB3
-
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + MEP50 protein
ADP + MEP50 phosphoprotein
-
a PRMT5 co-regulatory factor
-
-
?
ATP + neuregulin receptor ErbB2
ADP + phosphorylated neuregulin receptor ErbB2
-
phosphorylation at Ser1176 by Cdk5
-
-
?
ATP + neuregulin receptor ErbB3
ADP + phosphorylated neuregulin receptor ErbB3
-
phosphorylation at Thr871 and Ser1120 in the consensus sequence RSRSPR by Cdk5, Cdk5 associates with Erb3 in vivo
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + STAT3
ADP + phosphorylated STAT3
-
specific phosphorylation at Ser727 by CDK5-p35, CDK5 is involved in regulation of the signal transducer and transcription activator STAT3 in brain and muscle
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
ATP + [tau protein]
ADP + [O-phospho-tau protein]
-
substrate of CDK5 in the central nervous system, see also EC 2.7.11.26, tau hyperphosphorylation is involved in neurodegeneration and Alzheimer's disease, tau protein phosphorylation by CDK5 is involved in apoptosis in cortical cells
-
-
?
ATP + [tau-protein]
ADP + O-phospho -[tau-protein]
-
cdk5 substrate in brain, cdk5 associated with p39, tau is a microtubule-associated and developmentally regulated protein involved in axonal development in neurons, tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules, reaction of EC 2.7.11.26
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
additional information
?
-
ATP + tau protein
ADP + phosphorylated tau protein
-
cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
hyperactivated Cdk5-p25
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
activity in organisms with mutated APP and tau, not in wild-type, overview
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
hyperphosphorylation of tau by CDK5 is involved in apoptosis and neurodegeneration in Alzheimer's disease, overview
-
-
?
additional information
?
-
the cdc2 protein kinase plays a role in transcriptional regulation
-
-
?
additional information
?
-
potential function in sensory cells
-
-
?
additional information
?
-
enzyme may have a critical function during normal embryonic development and continues to be expressed in differentiated adult tissues
-
-
?
additional information
?
-
-
enzyme may have a critical function during normal embryonic development and continues to be expressed in differentiated adult tissues
-
-
?
additional information
?
-
enzyme is involved in signal transduction process of pattern formation in the hindbrain
-
-
?
additional information
?
-
enzyme is involved in signal transduction process of pattern formation in the hindbrain
-
-
?
additional information
?
-
-
enzyme is involved in signal transduction process of pattern formation in the hindbrain
-
-
?
additional information
?
-
-
naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of mutants leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of mutants leads to age-dependent memory deficits
-
-
?
additional information
?
-
-
CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview
-
-
?
additional information
?
-
-
Cdk5 regulates Akt activation and cell survival through the neuregulin-mediated PI 3-kinase signaling pathway, null mutants show lower phosphatidylinositol 3-kinase activity, Cdk5-p35 mediates neuroprotection
-
-
?
additional information
?
-
-
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, and is critical for neuronal survival, deregulation of Cdk5 occurs in neurodegeneration
-
-
?
additional information
?
-
-
the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia
-
-
?
additional information
?
-
-
Cdk5 is a modulator of spine morphogenesis
-
-
?
additional information
?
-
-
the CDK2-cyclin E complex is a inducer of S-phase entry and key factor for the initiation of centrosome duplication, that CDK4/6-cyclin D are the proteins that compensates for the loss of CDK2 in the initiation of centrosome duplication
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Calmodulin
-
Ca2+/calmodulin induce the phosphorylation of p35 by Cdk5 after stimulation of the Ca2+-permeable cation channels NMDA receptor and kainate receptor, leading to cleavage of p35 to p25
CDC25 phosphatase
-
major activator of CDK2
-
cyclin D1
-
CDK4 is dependent on
-
neuregulin
-
activates phosphorylation of STAT3 in vivo
-
p25
-
-
-
p25
-
cyclin activator, dependent on, over 10fold increase in activity of CDK5
-
p25
-
regulatory and activating subunit, soluble localization of enzyme complex
-
p25
-
regulatory subunit and activator of Cdk5, soluble, p35 is cleaved to p25 by calpain leading to hyperactivation of Cdk5
-
p25
-
soluble cofactor of Cdk5, cleavage of p35 to p25
-
p25
-
regulatory subunit
-
p35
-
-
-
p35
-
tightly bound neuronal activators of cdk5, required for activity with regulatory function, p39 activates to a greater extent compared to p35 in vitro
-
p35
-
activation subunit, required, interacts with and activates Cdk5, laminin induces upregulation of p35, regulation of p35 expression, overview
-
p35
-
membrane-bound cofactor of Cdk5, levels in primary embryonal cortical neurons are reduced by glutamate-induced stimulation of NMDA or kainate receptors through NMDA or kainate, cleavage of p35 to p25, reduced p35 leads to inhibition of Cdk5
-
p35
-
regulatory and activating subunit, particulate localization of enzyme complex
-
p35
-
regulatory subunit and activator of Cdk5, membrane-bound, in neuronal growth cones, p35 is cleaved to p25 by calpain leading to hyperactivation of Cdk5
-
p35
-
the cyclin is the regulatory subunit, dependent on
-
p35
-
p35 knockout mice (p35-/-), which exhibit significantly decreased Cdk5 activity, show delayed responses to painful thermal stimulation compared with wild-type controls. In contrast, mice overexpressing p35, which exhibit elevated levels of Cdk5 activity, are more sensitive to painful thermal stimuli than are controls
-
p35
-
activation is dependent on non-cyclin activator p35
-
p35
-
activation of Cdk5 requires association with two noncyclin neural-specific activators p35 and p39
-
p35
principal activator
-
p35
-
regulatory subunit, p35 is cleaved to p25 by calpain
-
p39
-
tightly bound neuronal activators of cdk5, required for activity with regulatory function, p39 activates to a greater extent compared to p35 in vitro, p39 is the activator activator in vivo
-
p39
-
activation subunit, can substitute for p35, interacts with and activates Cdk5
-
p39
-
regulatory subunit and activator of Cdk5
-
p39
-
activation is dependent on non-cyclin activator p39
-
p39
-
activation of Cdk5 requires association with two noncyclin neural-specific activators p35 and p39
-
p39
principal activator
-
p39
-
regulatory subunit, Mice lacking p39 display an apparently normal phenotype
-
additional information
activation of cyclin-dependent kinase 4 by mouse MO15-associated kinase
-
additional information
-
activation of cyclin-dependent kinase 4 by mouse MO15-associated kinase
-
additional information
-
CDKs are activated by phosphorylation
-
additional information
-
thapsigargin-induced apoptosis might enhance the phosphorylation of the PHF-1 epitope of tau protein by CDK5-p25, no effect by doxycycline on enzyme expression and activity
-
additional information
cyclin H or cyclin H together with cyclin K do not activate PNQALRE
-
additional information
myocardial ischemia activates Cdk2 resulting in the phosphorylation and inactivation of the retinoblastoma gene product
-
additional information
-
Cdk5 Cdk5 requires the binding of p35, p25 (a C-terminal fragment of p35), or p39 as regulatory subunnits for activation, activation mechanism of Cdk5, overview
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Gilardi-Hebenstreit, P.; Nieto, M.A.; Frain, M.; Mattei, M.G.; Chestier, A.; Wilkinson, D.G.; Charnay, P.
An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain
Oncogene
7
2499-2506
1992
Mus musculus (P30285), Mus musculus (Q03147), Mus musculus
brenda
Th'ng, J.P.; Wright, P.S.; Hamaguchi, J.; Lee, M.G.; Norbury, C.J.; Nurse, P.; Bradbury, E.M.
The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product
Cell
63
313-324
1990
Mus musculus (P11440)
brenda
Spurr, N.K.; Gough, A.C.; Lee, M.G.
Cloning of the mouse homologue of the yeast cell cycle control gene cdc2
DNA Seq.
1
49-54
1990
Mus musculus (P11440)
brenda
Cisek, L.J.; Corden, J.L.
Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2
Nature
339
679-684
1989
Mus musculus (P11440)
brenda
Kidd, V.J.; Luo, W.; Xiang, J.L.; Tu, F.; Easton, J.; McCune, S.; Snead, M.L.
Regulated expression of a cell division control-related protein kinase during development
Cell Growth Differ.
2
85-93
1991
Mus musculus (P24788), Mus musculus
brenda
Ershler, M.; Nagorskaya, T.V.; Visser, J.W.; Belyavsky, A.V.
Novel CDC2-related protein kinases produced in murine hematopoietic stem cells
Gene
124
305-306
1993
Mus musculus (P30285), Mus musculus (P49615), Mus musculus (Q03147)
brenda
Kato, J.Y.; Matsuoka, M.; Strom, D.K.; Sherr, C.J.
Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase
Mol. Cell. Biol.
14
2713-2721
1994
Mus musculus (P30285)
brenda
Matsushime, H.; Ewen, M.E.; Strom, D.K.; Kato, J.Y.; Hanks, S.K.; Roussel, M.F.; Sherr, C.J.
Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins
Cell
71
323-334
1992
Mus musculus (P30285), Mus musculus
brenda
Ohshima, T.; Nagle, J.W.; Pant, H.C.; Joshi, J.B.; Kozak, C.A.; Brady, R.O.; Kulkarni, A.B.
Molecular cloning and chromosomal mapping of the mouse cyclin-dependent kinase 5 gene
Genomics
28
585-588
1995
Mus musculus (P49615), Mus musculus
brenda
Ino, H.; Ishizuka, T.; Chiba, T.; Tatibana, M.
Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems
Brain Res.
661
196-206
1994
Mus musculus (P49615)
brenda
Stepanova, L.; Ershler, M.A.; Belyavsky, A.V.
Sequence of the cDNA encoding murine CRK4 protein kinase
Gene
149
321-324
1994
Mus musculus (Q03147), Mus musculus
brenda
Matsuoka, M.; Kato, J.Y.; Fisher, R.P.; Morgan, D.O.; Sherr, C.J.
Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase
Mol. Cell. Biol.
14
7265-7275
1994
Mus musculus (Q03147), Mus musculus
brenda
Ershler, M.A.; Nagorskaia, T.V.; Fisser Ia, V.; Beliavskii, A.V.
Identification of new protein kinase genes, similar to kinases of the cdc2 family and expressed in murine hematopoietic stem cells
Dokl. Akad. Nauk
324
893-897
1992
Mus musculus (Q03147)
brenda
Okuda, T.; Cleveland, J.L.; Downing, J.R.
PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family
Oncogene
7
2249-2258
1992
Mus musculus (Q04735), Mus musculus (Q04899), Mus musculus
brenda
Bladt, F.; Birchmeier, C.
Characterization and expression analysis of the murine rck gene: a protein kinase with a potential function in sensory cells
Differentiation
53
115-122
1993
Mus musculus (Q04859)
brenda
Takahashi, S.; Saito, T.; Hisanaga, S.; Pant, H.C.; Kulkarni, A.B.
Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules
J. Biol. Chem.
278
10506-10515
2003
Mus musculus
brenda
Shelton, S.B.; Krishnamurthy, P.; Johnson, G.V.
Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells
J. Neurosci. Res.
76
110-120
2004
Mus musculus
brenda
Lambourne, S.L.; Sellers, L.A.; Bush, T.G.; Choudhury, S.K.; Emson, P.C.; Suh, Y.H.; Wilkinson, L.S.
Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities
Mol. Cell. Biol.
25
278-293
2005
Homo sapiens, Mus musculus
brenda
Kesavapany, S.; Li, B.S.; Amin, N.; Zheng, Y.L.; Grant, P.; Pant, H.C.
Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide
Biochim. Biophys. Acta
1697
143-153
2004
Danio rerio, Saccharomyces cerevisiae, Caenorhabditis elegans, Canis lupus familiaris, Drosophila melanogaster, Homo sapiens, Doryteuthis pealeii, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Andres, V.
Control of vascular cell proliferation and migration by cyclin-dependent kinase signalling: new perspectives and therapeutic potential
Cardiovasc. Res.
63
11-21
2004
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Li, B.S.; Ma, W.; Jaffe, H.; Zheng, Y.; Takahashi, S.; Zhang, L.; Kulkarni, A.B.; Pant, H.C.
Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival
J. Biol. Chem.
278
35702-35709
2003
Mus musculus, Rattus norvegicus
brenda
Wei, F.Y.; Tomizawa, K.; Ohshima, T.; Asada, A.; Saito, T.; Nguyen, C.; Bibb, J.A.; Ishiguro, K.; Kulkarni, A.B.; Pant, H.C.; Mikoshiba, K.; Matsui, H.; Hisanaga, S.
Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability
J. Neurochem.
93
502-512
2005
Mus musculus, Mus musculus ICR
brenda
Hisanaga, S.; Saito, T.
The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator
Neurosignals
12
221-229
2003
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Fu, A.K.; Fu, W.Y.; Ng, A.K.; Chien, W.W.; Ng, Y.P.; Wang, J.H.; Ip, N.Y.
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity
Proc. Natl. Acad. Sci. USA
101
6728-6733
2004
Mus musculus
brenda
Wohlbold, L.; Larochelle, S.; Liao, J.C.; Livshits, G.; Singer, J.; Shokat, K.M.; Fisher, R.P.
The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity
Cell Cycle
5
546-554
2006
Mus musculus (Q9JHU3)
brenda
Baatout, S.; Mueller, W.; Michaux, A.; Buset, J.; Schoonjans, W.; Jacquet, P.
Histone H1 and cdk1 kinase activities in early embryos of four mouse strains after X-irradiation
In Vivo
21
571-582
2007
Mus musculus
brenda
Pareek, T.K.; Keller, J.; Kesavapany, S.; Pant, H.C.; Iadarola, M.J.; Brady, R.O.; Kulkarni, A.B.
Cyclin-dependent kinase 5 activity regulates pain signaling
Proc. Natl. Acad. Sci. USA
103
791-796
2006
Mus musculus, Rattus norvegicus
brenda
Fukasawa, K.
P53, cyclin-dependent kinase and abnormal amplification of centrosomes
Biochim. Biophys. Acta
1786
15-23
2008
Mus musculus
brenda
Cheung, Z.H.; Ip, N.Y.
The roles of cyclin-dependent kinase 5 in dendrite and synapse development
Biotechnol. J.
2
949-957
2007
Mus musculus
brenda
Sen, A.; Thom, M.; Nikolic, M.; Sisodiya, S.M.
The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia
Dev. Neurosci.
30
96-104
2008
Mus musculus (P49615)
brenda
Taniguchi, M.; Taoka, M.; Itakura, M.; Asada, A.; Saito, T.; Kinoshita, M.; Takahashi, M.; Isobe, T.; Hisanaga, S.
Phosphorylation of adult type Sept5 (CDCrel-1) by cyclin-dependent kinase 5 inhibits interaction with syntaxin-1
J. Biol. Chem.
282
7869-7876
2007
Mus musculus
brenda
Liem, D.A.; Zhao, P.; Angelis, E.; Chan, S.S.; Zhang, J.; Wang, G.; Berthet, C.; Kaldis, P.; Ping, P.; Maclellan, W.R.
Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury
J. Mol. Cell. Cardiol.
45
610-616
2008
Mus musculus (P97377)
brenda
Anne, S.L.; Saudou, F.; Humbert, S.
Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons
J. Neurosci.
27
7318-7328
2007
Mus musculus, Rattus norvegicus
brenda
Paoletti, P.; Vila, I.; Rife, M.; Lizcano, J.M.; Alberch, J.; Gines, S.
Dopaminergic and glutamatergic signaling crosstalk in Huntingtons disease neurodegeneration: the role of p25/cyclin-dependent kinase 5
J. Neurosci.
28
10090-10101
2008
Mus musculus, Homo sapiens (Q00535), Homo sapiens
brenda
Amin, N.D.; Zheng, Y.L.; Kesavapany, S.; Kanungo, J.; Guszczynski, T.; Sihag, R.K.; Rudrabhatla, P.; Albers, W.; Grant, P.; Pant, H.C.
Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis
J. Neurosci.
28
3631-3643
2008
Mus musculus, Rattus norvegicus
brenda
Cheung, Z.H.; Gong, K.; Ip, N.Y.
Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2
J. Neurosci.
28
4872-4877
2008
Mus musculus
brenda
Lewis, A.E.; Rusten, M.; Hoivik, E.A.; Vikse, E.L.; Hansson, M.L.; Wallberg, A.E.; Bakke, M.
Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7
Mol. Endocrinol.
22
91-104
2008
Homo sapiens (P50613), Mus musculus (Q03147)
brenda
Lin, H.; Hu, G.X.; Dong, L.; Dong, Q.; Mukai, M.; Chen, B.B.; Holsberger, D.R.; Sottas, C.M.; Cooke, P.S.; Lian, Q.Q.; Li, X.K.; Ge, R.S.
Increased proliferation but decreased steroidogenic capacity in Leydig cells from mice lacking cyclin-dependent kinase inhibitor 1B
Biol. Reprod.
80
1232-1238
2009
Mus musculus
brenda
Jhou, R.S.; Sun, K.H.; Sun, G.H.; Wang, H.H.; Chang, C.I.; Huang, H.C.; Lu, S.Y.; Tang, S.J.
Inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduces lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor kappaB
Cell Prolif.
42
141-149
2009
Mus musculus
brenda
Hao, Y.; Pan, D.; Zhang, M.; Xu, J.; Li, L.; Wei, J.; Wang, X.
The neuroprotective effects of cyclin-dependent kinase-5 inhibition in mice with Niemann-Pick disease type C
J. Huazhong Univ. Sci. Technol. Med. Sci.
29
324-329
2009
Mus musculus
brenda
Aggarwal, P.; Vaites, L.P.; Kim, J.K.; Mellert, H.; Gurung, B.; Nakagawa, H.; Herlyn, M.; Hua, X.; Rustgi, A.K.; McMahon, S.B.; Diehl, J.A.
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase
Cancer Cell
18
329-340
2010
Homo sapiens, Mus musculus
brenda
Hisanaga, S.; Endo, R.
Regulation and role of cyclin-dependent kinase activity in neuronal survival and death
J. Neurochem.
115
1309-1321
2010
Homo sapiens, Mus musculus
brenda
Oi, A.; Katayama, S.; Hatano, N.; Sugiyama, Y.; Kameshita, I.; Sueyoshi, N.
Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)
Biochem. Biophys. Res. Commun.
482
239-245
2017
Mus musculus (Q3UTQ8), Mus musculus
brenda