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Information on EC 2.7.11.22 - cyclin-dependent kinase and Organism(s) Drosophila melanogaster

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EC Tree
IUBMB Comments
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
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This record set is specific for:
Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
cyclin-dependent kinase, cdk, p34cdc2, cdkl5, cdc2 kinase, cyclin-dependent kinase 5, cyclin-dependent kinase 2, cdc28, cyclin-dependent kinase 4, cyclin-dependent kinase 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cell division control protein 2 cognate
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cell division protein kinase 5 homolog
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Cyclin-dependent kinase pef1
-
-
-
-
PHO85 homolog
-
-
-
-
serine/threonine protein kinase PITSLRE
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:cyclin phosphotransferase
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
CAS REGISTRY NUMBER
COMMENTARY hide
150428-23-2
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CDK1_DROME
297
0
34439
Swiss-Prot
other Location (Reliability: 1)
CDK5_DROME
294
0
33180
Swiss-Prot
other Location (Reliability: 1)
KP58_DROME
952
0
108838
Swiss-Prot
other Location (Reliability: 1)
CDK8_DROME
454
0
53682
Swiss-Prot
other Location (Reliability: 1)
CDK2_DROME
314
0
35888
Swiss-Prot
other Location (Reliability: 1)
CDK12_DROME
1157
0
128333
Swiss-Prot
other Location (Reliability: 2)
Q24216_DROME
353
0
39673
TrEMBL
other Location (Reliability: 1)
Q7KM03_DROME
522
0
59943
TrEMBL
other Location (Reliability: 1)
Q7KM05_DROME
509
0
58517
TrEMBL
other Location (Reliability: 1)
X2J708_DROME
412
0
47316
TrEMBL
Mitochondrion (Reliability: 5)
D3PFF6_DROME
778
0
88799
TrEMBL
other Location (Reliability: 2)
Q7KM04_DROME
501
0
57741
TrEMBL
other Location (Reliability: 5)
Q9VK37_DROME
392
0
44123
TrEMBL
other Location (Reliability: 2)
M9PG50_DROME
1157
0
128333
TrEMBL
other Location (Reliability: 2)
Q7K306_DROME
317
0
36402
TrEMBL
other Location (Reliability: 3)
Q7KM08_DROME
509
0
58343
TrEMBL
other Location (Reliability: 2)
Q9VMN3_DROME
438
0
50410
TrEMBL
other Location (Reliability: 4)
M9MRD8_DROME
435
0
49881
TrEMBL
other Location (Reliability: 4)
X2JD86_DROME
421
0
48440
TrEMBL
other Location (Reliability: 4)
Q9XTK9_DROME
522
0
59768
TrEMBL
other Location (Reliability: 2)
A1Z840_DROME
387
0
43396
TrEMBL
other Location (Reliability: 1)
E1JIR3_DROME
314
0
35888
TrEMBL
other Location (Reliability: 1)
O17432_DROME
404
0
46787
TrEMBL
Mitochondrion (Reliability: 5)
M9PE01_DROME
538
0
61617
TrEMBL
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
32000
x * 32000, calculation from nucleotide sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 32000, calculation from nucleotide sequence
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
Cdk5, DNA sequence determination and analysis
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Adams, M.D.; Celniker, S.E.; Holt, R.A.; Evans, C.A.; Gocayne, J.D.; et al.
The genome sequence of Drosophila melanogaster
Science
287
2185-2195
2000
Drosophila melanogaster (Q9VPC0)
Manually annotated by BRENDA team
Biggs, W.H.; Zipursky, S.L.
Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase
Proc. Natl. Acad. Sci. USA
89
6295-6299
1992
Drosophila melanogaster (P23573), Drosophila melanogaster (Q9VPC0)
Manually annotated by BRENDA team
Sauer, K.; Weigmann, K.; Sigrist, S.; Lehner, C.F.
Novel members of the cdc2-related kinase family in Drosophila: cdk4/6, cdk5, PFTAIRE, and PITSLRE kinase
Mol. Biol. Cell
7
1759-1769
1996
Drosophila melanogaster (P48609), Drosophila melanogaster (Q9VPC0)
Manually annotated by BRENDA team
Lehner, C.F.; O'Farrell, P.H.
Drosophila cdc2 homologul: a functional homolog is coexpressed with a cognate variant
EMBO J.
9
3573-3581
1990
Xenopus laevis (P23437), Drosophila melanogaster (P23573)
Manually annotated by BRENDA team
Hellmich, M.R.; Kennison, J.A.; Hampton, L.L.; Battey, J.F.
Cloning and characterization of the Drosophila melanogaster CDK5 homolog
FEBS Lett.
356
317-321
1994
Drosophila melanogaster (P48609), Drosophila melanogaster
Manually annotated by BRENDA team
Kesavapany, S.; Li, B.S.; Amin, N.; Zheng, Y.L.; Grant, P.; Pant, H.C.
Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide
Biochim. Biophys. Acta
1697
143-153
2004
Danio rerio, Saccharomyces cerevisiae, Caenorhabditis elegans, Canis lupus familiaris, Drosophila melanogaster, Homo sapiens, Doryteuthis pealeii, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team