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Information on EC 2.7.11.21 - polo kinase and Organism(s) Xenopus tropicalis

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.11 Protein-serine/threonine kinases
                2.7.11.21 polo kinase
IUBMB Comments
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein .
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Xenopus tropicalis
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Word Map
The taxonomic range for the selected organisms is: Xenopus tropicalis
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
polo-like kinase 1, polo-like kinase, plk-1, polo kinase, polo-like kinase 4, polo-like kinase-1, tbplk, plk1 kinase, cdc5p, polo-like kinase 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
FGF-inducible kinase
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-
-
-
Proliferation-related kinase
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (spindle-pole-dependent)
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein [2].
CAS REGISTRY NUMBER
COMMENTARY hide
149433-93-2
Polo kinase
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PLK4_XENTR
946
0
105883
Swiss-Prot
other Location (Reliability: 2)
PLK1_XENTR
598
0
68121
Swiss-Prot
other Location (Reliability: 2)
A0A6I8R8K4_XENTR
633
0
71626
TrEMBL
other Location (Reliability: 1)
F6ZDC6_XENTR
661
0
74435
TrEMBL
other Location (Reliability: 1)
A0A8J0SI64_XENTR
660
0
74335
TrEMBL
other Location (Reliability: 1)
A0A6I8QT48_XENTR
982
0
109921
TrEMBL
other Location (Reliability: 2)
A0A6I8R203_XENTR
741
1
84724
TrEMBL
other Location (Reliability: 2)
A0A6I8Q7X4_XENTR
753
1
86380
TrEMBL
other Location (Reliability: 3)
A0A6I8RZG9_XENTR
622
0
69639
TrEMBL
other Location (Reliability: 1)
A0A6I8RXX7_XENTR
788
1
90119
TrEMBL
other Location (Reliability: 2)
A4QNQ0_XENTR
663
0
76007
TrEMBL
other Location (Reliability: 2)
A0A6I8RKR0_XENTR
706
1
80985
TrEMBL
other Location (Reliability: 2)
F6T9D0_XENTR
631
0
72588
TrEMBL
other Location (Reliability: 2)
A0A6I8S7H6_XENTR
638
0
72962
TrEMBL
other Location (Reliability: 2)
F6VBJ2_XENTR
609
0
70531
TrEMBL
other Location (Reliability: 1)
A0A8J0SFJ5_XENTR
978
0
109445
TrEMBL
other Location (Reliability: 2)
A0A6I8QS72_XENTR
946
0
105943
TrEMBL
other Location (Reliability: 2)