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Information on EC 2.7.11.21 - polo kinase and Organism(s) Sus scrofa

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.11 Protein-serine/threonine kinases
                2.7.11.21 polo kinase
IUBMB Comments
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein .
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This record set is specific for:
Sus scrofa
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Word Map
The taxonomic range for the selected organisms is: Sus scrofa
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
polo-like kinase 1, polo-like kinase, plk-1, polo kinase, polo-like kinase 4, polo-like kinase-1, tbplk, plk1 kinase, cdc5p, polo-like kinase 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
FGF-inducible kinase
-
-
-
-
Plk1
-
-
Polo-like kinase 1
-
-
Proliferation-related kinase
-
-
-
-
additional information
-
the enzyme belongs to the family of polo-like kinases
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (spindle-pole-dependent)
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein [2].
CAS REGISTRY NUMBER
COMMENTARY hide
149433-93-2
Polo kinase
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
the enzyme is involved in regulation of cytokinesis and microtubule polymerization modulation during oocyte meiotic maturation, fertilization and early embryonic mitosis
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
the enzyme is involved in regulation of cytokinesis and microtubule polymerization modulation during oocyte meiotic maturation, fertilization and early embryonic mitosis
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
additional information
-
enzyme quantity is stable during meiotic maturation
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
accumulation of Plk1 in germinal vesicle stage oocytes
Manually annotated by BRENDA team
-
after fertilization, female and male
Manually annotated by BRENDA team
-
middle region, at anaphase-telophase I and anaphase-telophase II stages
Manually annotated by BRENDA team
-
after germinal vesicle breakdown, at metaphase I stage, and in MII spindle pole
Manually annotated by BRENDA team
additional information
-
localization changes with embryonal development, colchicine inhibits spindle pole localization of the enzyme, taxol treatment leads to localization in the cytoplasm
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A8D0UEP4_PIG
561
0
63042
TrEMBL
other Location (Reliability: 5)
A0A8D0NB86_PIG
604
0
68168
TrEMBL
other Location (Reliability: 4)
A0A8D1DX49_PIG
923
0
104074
TrEMBL
other Location (Reliability: 3)
A0A8D1WN35_PIG
916
0
102853
TrEMBL
other Location (Reliability: 2)
A0A8D2BL13_PIG
578
1
64493
TrEMBL
Mitochondrion (Reliability: 3)
A0A8D0W8W9_PIG
610
0
67273
TrEMBL
other Location (Reliability: 4)
A0A8D0JGF3_PIG
610
0
67282
TrEMBL
other Location (Reliability: 4)
A0A4X1SGK8_PIG
670
0
76704
TrEMBL
other Location (Reliability: 1)
A0A8D0QCQ5_PIG
537
0
60325
TrEMBL
other Location (Reliability: 5)
Q9BDP8_PIG
526
0
60400
TrEMBL
other Location (Reliability: 4)
A0A4X1VD15_PIG
963
0
108297
TrEMBL
other Location (Reliability: 1)
A0A4X1W400_PIG
647
0
71806
TrEMBL
other Location (Reliability: 3)
F1SLJ2_PIG
685
0
78361
TrEMBL
other Location (Reliability: 1)
A0A8D1JBZ3_PIG
604
0
68198
TrEMBL
other Location (Reliability: 4)
A0A8D0QIT6_PIG
592
0
66198
TrEMBL
other Location (Reliability: 3)
A0A8D1Q011_PIG
576
0
65046
TrEMBL
other Location (Reliability: 4)
A0A4X1W9W4_PIG
752
0
81616
TrEMBL
other Location (Reliability: 3)
A0A8D0SCF1_PIG
667
0
74980
TrEMBL
other Location (Reliability: 4)
A0A480IQ39_PIG
606
0
68830
TrEMBL
other Location (Reliability: 1)
A0A8D0IY09_PIG
671
0
76743
TrEMBL
other Location (Reliability: 1)
A0A4X1VTV9_PIG
611
0
67427
TrEMBL
other Location (Reliability: 5)
A0A8D1VPL6_PIG
610
0
67243
TrEMBL
other Location (Reliability: 4)
A0A8D0K0A0_PIG
852
0
95980
TrEMBL
other Location (Reliability: 3)
A0A8D0JMN6_PIG
647
0
72482
TrEMBL
other Location (Reliability: 5)
A0A480IKH6_PIG
567
0
62719
TrEMBL
other Location (Reliability: 3)
A0A8D0XVM6_PIG
552
0
62361
TrEMBL
other Location (Reliability: 4)
A0A8D1N5R2_PIG
611
0
67453
TrEMBL
other Location (Reliability: 5)
A0A8D1CXT9_PIG
615
0
68395
TrEMBL
other Location (Reliability: 3)
A0A8D1ZPG2_PIG
932
0
104678
TrEMBL
other Location (Reliability: 1)
A0A8D1HGX0_PIG
964
0
108411
TrEMBL
other Location (Reliability: 1)
I3LII4_PIG
601
0
67406
TrEMBL
other Location (Reliability: 4)
A0A8D0Y425_PIG
932
0
104692
TrEMBL
other Location (Reliability: 1)
A0A4X1VVK8_PIG
585
0
64739
TrEMBL
other Location (Reliability: 5)
A0A8D0W2A8_PIG
611
0
67837
TrEMBL
other Location (Reliability: 3)
A0A4X1V9A9_PIG
931
0
104579
TrEMBL
other Location (Reliability: 1)
F1RRA8_PIG
916
0
102853
TrEMBL
other Location (Reliability: 2)
A0A8D2CFG2_PIG
964
0
108396
TrEMBL
other Location (Reliability: 1)
A0A8D1JF84_PIG
579
1
64659
TrEMBL
Mitochondrion (Reliability: 4)
A0A4X1WB13_PIG
703
0
77294
TrEMBL
other Location (Reliability: 3)
A0A8D0PK30_PIG
685
0
78361
TrEMBL
other Location (Reliability: 1)
A0A8D1ADC9_PIG
619
0
68884
TrEMBL
other Location (Reliability: 3)
A0A4X1SGX8_PIG
684
0
78264
TrEMBL
other Location (Reliability: 1)
A0A480V3H2_PIG
893
0
100316
TrEMBL
other Location (Reliability: 1)
A0A287BE28_PIG
964
0
108411
TrEMBL
other Location (Reliability: 1)
A0A5G2QG88_PIG
671
0
76801
TrEMBL
other Location (Reliability: 1)
A0A8D0XVW6_PIG
667
0
74969
TrEMBL
other Location (Reliability: 4)
F1S348_PIG
647
0
71806
TrEMBL
other Location (Reliability: 3)
A0A8D0YHF9_PIG
671
0
76801
TrEMBL
other Location (Reliability: 1)
A0A8D0QCQ1_PIG
611
0
67409
TrEMBL
other Location (Reliability: 5)
A0A4X1UWP2_PIG
552
0
62391
TrEMBL
other Location (Reliability: 4)
A0A8D1YVG9_PIG
667
0
74999
TrEMBL
other Location (Reliability: 4)
A0A5G2QN48_PIG
932
0
104692
TrEMBL
other Location (Reliability: 1)
A0A5G2QFG4_PIG
619
0
68219
TrEMBL
other Location (Reliability: 3)
F1SDI4_PIG
611
0
67508
TrEMBL
other Location (Reliability: 5)
A0A8D1ZS13_PIG
916
0
102839
TrEMBL
other Location (Reliability: 2)
A0A8D0LLQ4_PIG
685
0
78303
TrEMBL
other Location (Reliability: 2)
A0A4X1UYN5_PIG
604
0
68179
TrEMBL
other Location (Reliability: 4)
A0A8D1DKX4_PIG
611
0
67508
TrEMBL
other Location (Reliability: 5)
A0A8D0QC98_PIG
560
0
62769
TrEMBL
other Location (Reliability: 5)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yao, L.J.; Fan, H.Y.; Tong, C.; Chen, D.Y.; Schatten, H.; Sun, Q.Y.
Polo-like kinase-1 in porcine oocyte meiotic maturation, fertilization and early embryonic mitosis
Cell. Mol. Biol.
49
399-405
2003
Sus scrofa
Manually annotated by BRENDA team