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Information on EC 2.7.11.21 - polo kinase and Organism(s) Bos taurus

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.11 Protein-serine/threonine kinases
                2.7.11.21 polo kinase
IUBMB Comments
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein .
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Bos taurus
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
polo-like kinase 1, polo-like kinase, plk-1, polo kinase, polo-like kinase 4, polo-like kinase-1, tbplk, plk1 kinase, cdc5p, polo-like kinase 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
FGF-inducible kinase
-
-
-
-
Proliferation-related kinase
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (spindle-pole-dependent)
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein [2].
CAS REGISTRY NUMBER
COMMENTARY hide
149433-93-2
Polo kinase
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PLK4_BOVIN
893
0
100707
Swiss-Prot
other Location (Reliability: 1)
PLK1_BOVIN
602
0
68000
Swiss-Prot
other Location (Reliability: 5)
E1BI47_BOVIN
604
1
66339
TrEMBL
Mitochondrion (Reliability: 3)
A0A3Q1LFD8_BOVIN
576
0
64957
TrEMBL
other Location (Reliability: 5)
Q0VCE7_BOVIN
647
0
71967
TrEMBL
other Location (Reliability: 5)
E1BP17_BOVIN
685
0
78260
TrEMBL
other Location (Reliability: 1)