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Information on EC 2.7.11.17 - Ca2+/calmodulin-dependent protein kinase and Organism(s) Drosophila melanogaster

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EC Tree
IUBMB Comments
Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
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This record set is specific for:
Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
caldesmon, cam kinase ii, camkiv, cam kinase, calcium/calmodulin-dependent protein kinase ii, calmodulin-dependent protein kinase, camkk2, calcium/calmodulin-dependent protein kinase, ca2+/calmodulin-dependent protein kinase, camk ii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+/calmodulin-dependent protein kinase II
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calcium-independent calcium/calmodulin-dependent protein kinase II
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calcium/calmodulin-dependent protein kinase
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calcium/calmodulin-dependent protein kinase II
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calcium/calmodulin-dependent protein kinase type II alpha chain
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caldesmon
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Calspermin
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-
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CaM kinase II
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CAM kinase-GR
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-
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CMPK
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-
-
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kinase, caldesmon (phosphorylating)
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-
-
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kinase, microtubule-associated protein 2 (phosphorylating)
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-
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MAP kinase
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-
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MAP-2 kinase
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-
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MAP-2 protein serine kinase
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-
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microtubule associated protein kinase
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-
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microtubule-associated protein 2 kinase
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-
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peripheral plasma membrane protein CaMGUK
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (Ca2+/calmodulin-dependent)
Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
CAS REGISTRY NUMBER
COMMENTARY hide
141467-21-2
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93229-57-3
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97350-82-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + protein
ADP + phosphoprotein
show the reaction diagram
autophosphorylation
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Calmodulin
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
neuronal Ca2+/calmodulin-dependent protein kinase II is a major component in neurons
Manually annotated by BRENDA team
expressed at much higher levels in the fly head than in the body
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KCC2A_DROME
530
0
59920
Swiss-Prot
other Location (Reliability: 1)
CSKP_DROME
898
0
100911
Swiss-Prot
other Location (Reliability: 1)
A4V110_DROME
390
0
43465
TrEMBL
other Location (Reliability: 1)
L0MLP2_DROME
504
0
57090
TrEMBL
other Location (Reliability: 1)
Q7JMV3_DROME
405
0
45114
TrEMBL
other Location (Reliability: 1)
A0A0B4KG35_DROME
8255
0
923798
TrEMBL
other Location (Reliability: 2)
D1YSG7_DROME
530
0
59920
TrEMBL
other Location (Reliability: 1)
D1YSG8_DROME
531
0
59991
TrEMBL
other Location (Reliability: 1)
Q0KIF7_DROME
284
0
31476
TrEMBL
other Location (Reliability: 1)
A0A0B4KF84_DROME
8216
0
919345
TrEMBL
other Location (Reliability: 4)
L0MNA2_DROME
482
0
54668
TrEMBL
other Location (Reliability: 1)
A1ZA73_DROME
1918
0
215065
TrEMBL
other Location (Reliability: 1)
A0A0B4JCU1_DROME
602
0
67243
TrEMBL
other Location (Reliability: 5)
A4V134_DROME
509
0
57569
TrEMBL
other Location (Reliability: 1)
A0A0B4JD64_DROME
913
0
100097
TrEMBL
other Location (Reliability: 5)
Q8MYR8_DROME
576
0
64369
TrEMBL
other Location (Reliability: 5)
A1ZA72_DROME
7944
0
890943
TrEMBL
other Location (Reliability: 2)
A4V133_DROME
490
0
55482
TrEMBL
other Location (Reliability: 1)
L0MLR4_DROME
522
0
59048
TrEMBL
other Location (Reliability: 1)
A1ZA70_DROME
732
0
80500
TrEMBL
other Location (Reliability: 2)
A0A0B4JD82_DROME
7905
0
886491
TrEMBL
other Location (Reliability: 4)
A1ZA69_DROME
929
0
101986
TrEMBL
other Location (Reliability: 4)
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
-
the enzyme performs Ca2+/calmodulin-dependent autophosphorylation, which renders the enzyme independent on Ca2+ and calmodulin
additional information
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
T287D
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site-directed mutagenesis, the Ca2+-independent mutant expression leads to reduced viability of flies, the toxic effect can be rescued by tetracycline, expression of the mutant in brain mushroom bodies does not affect the immediate memory, overview
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
CaMKII, DNA and amino acid sequence determination and analysis, gene structure and genomic organization
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cho, K.O.; Wall, J.B.; Pugh, P.C.; Ito, M.; Mueller, S.A.; Kennedy, M.B.
The alpha subunit of type II Ca2+/calmodulin-dependent protein kinase is highly conserved in Drosophila
Neuron
7
439-450
1991
Drosophila melanogaster (Q00168)
Manually annotated by BRENDA team
Griffith, L.C.; Greenspan, R.J.
The diversity of calcium/calmodulin-dependent protein kinase II isoforms in Drosophila is generated by alternative splicing of a single gene
J. Neurochem.
61
1534-1537
1993
Drosophila melanogaster (Q00168)
Manually annotated by BRENDA team
Ohsako, S.; Nishida, Y.; Ryo, H.; Yamauchi, T.
Molecular characterization and expression of the Drosophila Ca2+/calmodulin-dependent protein kinase II gene. Identification of four forms of the enzyme generated from a single gene by alternative splicing
J. Biol. Chem.
268
2052-2062
1993
Drosophila melanogaster (Q00168)
Manually annotated by BRENDA team
Dimitratos, S.D.; Woods, D.F.; Bryant, P.J.
Camguk, Lin-2, and CASK: novel membrane-associated guanylate kinase homologs that also contain CaM kinase domains
Mech. Dev.
63
127-130
1997
Drosophila melanogaster (Q24210)
Manually annotated by BRENDA team
Martin, J.R.; Ollo, R.
A new Drosophila Ca2+/calmodulin-dependent protein kinase (Caki) is localized in the central nervous system and implicated in walking speed
EMBO J.
15
1865-1876
1996
Drosophila melanogaster (Q24210)
Manually annotated by BRENDA team
Yamauchi, T.
Neuronal Ca2+/calmodulin-dependent protein kinase II - discovery, progress in a quarter of a century, and perspective: implication for learning and memory
Biol. Pharm. Bull.
28
1342-1354
2005
Drosophila melanogaster, Rattus norvegicus
Manually annotated by BRENDA team
Mehren, J.E.; Griffith, L.C.
Calcium-independent calcium/calmodulin-dependent protein kinase II in the adult Drosophila CNS enhances the training of pheromonal cues
J. Neurosci.
24
10584-10593
2004
Drosophila melanogaster
Manually annotated by BRENDA team