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Information on EC 2.7.11.1 - non-specific serine/threonine protein kinase and Organism(s) Bos taurus
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2.7.11.1 non-specific serine/threonine protein kinaseIUBMB Comments
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
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Word Map
- 2.7.11.1
- jnk
- mapks
-
signal-regulated
- rapamycin
- agonist
- necrosis
- endothelial
- cardiac
- mtor
- parkinsonism
- caspase-3
- metastasis
- bcl-2
- synaptic
- cyclin
- alzheimer
- cyclase
- hippocampal
- forskolin
- sirnas
- neurodegenerative
- autophosphorylation
-
neuroprotective
- creb
-
phorbol
- tumorigenesis
- cardiomyocytes
- wortmannin
- pten
-
cyclin-dependent
- ventricular
- gtpases
- myocytes
- cytoskeleton
-
adenylyl
- nf-kappab
- myocardial
- ischemia
-
dominant-negative
- nmda
-
hyperphosphorylation
-
postsynaptic
-
anti-apoptotic
- src
- phosphoprotein
- isoproterenol
- rhoa
- staurosporine
-
tensin
-
l-type
- medicine
- pharmacology
- molecular biology
- drug development
The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
protein kinase a, 14-3-3, camkii, p-akt, lrrk2, c-jun n-terminal kinase, serine/threonine kinase, raf-1, protein kinase b, gsk-3, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
A-kinase
-
-
-
-
A-T, mutated
-
-
-
-
A-T, mutated homolog
-
-
-
-
AMH type II receptor
-
-
-
-
Anti-sigma B factor rsbT
-
-
-
-
AP50 kinase
-
-
-
-
Ataxia telangiectasia mutated
-
-
-
-
Ataxia telangiectasia mutated homolog
-
-
-
-
ATP-protein transphosphorylase
-
-
-
-
betaIIPKC
-
-
-
-
Breast-tumor-amplified kinase
-
-
-
-
Calcium-dependent protein kinase C
-
-
-
-
Calcium/phospholipid-dependent protein kinase
-
-
-
-
cAMP-dependent protein kinase A
-
-
-
-
casein kinase
-
-
-
-
casein kinase 2
-
-
-
-
casein kinase I
-
-
-
-
casein kinase II
casein kinase-2
-
-
-
-
CDC25 suppressing protein kinase
-
-
-
-
Cell division cycle 2-like
-
-
-
-
CK-2
-
-
-
-
CK2
-
-
-
-
CK2-alpha
-
-
-
-
CKI
-
-
-
-
CKII
-
-
-
-
CLP-36 interacting kinase
-
-
-
-
cyclic monophosphate-dependent protein kinase
-
-
-
-
cyclic nucleotide-dependent protein kinase
-
-
-
-
cyclin-dependent kinase
-
-
-
-
cytidine 3',5'-cyclic monophosphate-responsive protein kinase
-
-
-
-
DNA-PKcs
-
-
-
-
DNPK1
-
-
-
-
dSTPK61
-
-
-
-
G11 protein
-
-
-
-
hARK1
-
-
-
-
histone kinase
-
-
-
-
hPDK1
-
-
-
-
Hpr kinase
-
-
-
-
hPSK
-
-
-
-
HSPK 21
-
-
-
-
HSPK 36
-
-
-
-
hydroxyalkyl-protein kinase
-
-
-
-
Kinase interacting with stathmin
-
-
-
-
kinase, casein (phosphorylating)
-
-
-
-
kinase, protamine (phosphorylating)
-
-
-
-
kinase, protein (phosphorylating)
-
-
-
-
kinase, protein, A (phosphorylating)
-
-
-
-
kinase, protein, C (phosphorylating)
-
-
-
-
Lymphocyte-oriented kinase
-
-
-
-
M phase-specific cdc2 kinase
-
-
-
-
mitogen-activated S6 kinase
-
-
-
-
mPDK1
-
-
-
-
MPSK
-
-
-
-
Myristoylated and palmitoylated serine-threonine kinase
-
-
-
-
NY-REN-55 antigen
-
-
-
-
P-CIP2
-
-
-
-
P460
-
-
-
-
p46Eg265
-
-
-
-
p46XlEg22
-
-
-
-
p82 kinase
-
-
-
-
pEg2
-
-
-
-
phosphorylase b kinase kinase
-
-
-
-
Phototropin
-
-
-
-
Pim-2h
-
-
-
-
PKA
PkB kinase
-
-
-
-
pp39-mos
-
-
-
-
Pre-mRNA protein kinase
-
-
-
-
protamine kinase
-
-
-
-
protein glutamyl kinase
-
-
-
-
protein kinase (phosphorylating)
-
-
-
-
Protein kinase B kinase
-
-
-
-
protein kinase CK2
-
-
-
-
Protein kinase Krct
-
-
-
-
Protein kinase MST
-
-
-
-
protein kinase p58
-
-
-
-
Protein kinase PKL12
-
-
-
-
protein phosphokinase
-
-
-
-
protein serine kinase
-
-
-
-
protein serine-threonine kinase
-
-
-
-
protein-aspartyl kinase
-
-
-
-
protein-cysteine kinase
-
-
-
-
protein-serine kinase
-
-
-
-
protein-serine/threonine kinase
-
-
-
-
PRP4 kinase
-
-
-
-
PRP4 pre-mRNA processing factor 4 homolog
-
-
-
-
PSK-H1
-
-
-
-
Raf kinase
-
-
-
-
Raf-1
-
-
-
-
ratAurA
-
-
-
-
ribosomal protein S6 kinase II
-
-
-
-
ribosomal S6 protein kinase
-
-
-
-
RP1 protein
-
-
-
-
S-receptor kinase
-
-
-
-
serine kinase
-
-
-
-
serine protein kinase
-
-
-
-
serine(threonine) protein kinase
-
-
-
-
serine-specific protein kinase
-
-
-
-
serine/threonine kinase
-
-
-
-
Serine/threonine kinase 15
-
-
-
-
Serine/threonine kinase Ayk1
-
-
-
-
serine/threonine protein kinase
-
-
-
-
Serine/threonine-protein kinase NRK2
-
-
-
-
Serine/threonine-protein kinase NYD-SPK
-
-
-
-
SRK
-
-
-
-
Ste20-like kinase
-
-
-
-
STE20-like kinase MST1
-
-
-
-
STE20-like kinase MST2
-
-
-
-
STE20-like kinase MST3
-
-
-
-
Switch protein/serine kinase
-
-
-
-
T-antigen kinase
-
-
-
-
threonine-specific protein kinase
-
-
-
-
Twitchin kinase
-
-
-
-
type-2 casein kinase
-
-
-
-
additional information
casein kinase II
-
-
-
-
PKA
-
-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
catalytic mechanism and regulation of PKN
-
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (non-specific)
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
CAS REGISTRY NUMBER
COMMENTARY
191808-15-8
phosphoinositide dependent protein kinase 1
340830-03-7
-
37278-10-7
-
377752-08-4
ribosomal protein S6 kinase 2
389133-24-8
ribosomal S6 kinase 3
52660-18-1
casein kinase, protein kinase CK2
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
90698-26-3
ribosomal protein S6 kinase 1
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + Ac-LRRASLG
ADP + Ac-LRRApSLG
-
an efficient fluorescence assay for serine/threonine kinases using a peptide array is developed. Assay is based on chemical reactions specific to phosphoserine and phosphothreonine residues, that is, base-mediated beta-elimination of the phosphate group and subsequent Michael addition of a thiol-containing fluorescent reagent. This procedure enables the covalent introduction of a fluorescent moiety into the phosphorylated peptide. Novel fluorescent reagents are designed for this purpose and synthesized. As a model peptide, a well-known PKA consensus sequence Kemptide 49 is chosen
-
-
?
ATP + eukaryotic protein synthesis initiation factor
?
-
i.e. eIF-4E, 1 mol phosphate per mol eIF-4E
-
-
?
ATP + several 40S ribosomal polypeptides
?
-
e.g. S6, 2.5 mol phosphate per mol S6
-
-
?
ATP + bovine serum albumin
?
-
phosphorylated at 40-70% the rate of protamine
-
-
?
ATP + casein
?
-
phosphorylated at 5% the rate of protamine, cytosolic kinase
-
-
?
ATP + glycogen synthase
?
-
phosphorylated at 15% the rate of protamine
-
-
?
ATP + histone IIB
?
-
phosphorylated at 8% the rate of protamine, cytosolic kinase
-
-
?
ATP + protamine
ADP + O-phosphoprotamine
-
no substrates are histone H4, ovalbumin, synthetic peptide poly(Glu,Tyr) (4:1)
-
-
?
ATP + protamine
ADP + O-phosphoprotamine
-
phosphorylates little, if any activity with branched-chain alpha-keto acid dehydrogenase, pyruvate dehydrogenase, casein, ovalbumin or histone H2B
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
substrate of GSK3beta in brain
-
-
?
additional information
?
-
-
glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26, phosphorylating tau protein at serine and threonine residues
-
-
?
additional information
?
-
-
regulation mechanism and biological function of PKN
-
-
?
additional information
?
-
-
enzyme performs autophosphorylation, PKN binds several associated proteins via its ACC domain, i.e. RhoA, a small GTPase, which binds to the ACC domain of PKNalpha forming a catalytic active site
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
substrate of GSK3beta in brain
-
-
?
additional information
?
-
-
glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26, phosphorylating tau protein at serine and threonine residues
-
-
?
additional information
?
-
-
regulation mechanism and biological function of PKN
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Catalytic subunit of protein phosphatase 2A
-
Mg2+, Mn2+, Ca2+, EDTA, EGTA or vanadate does not; NaCl, diphosphate, phosphate, NaF or ATP protects
-
Protein phosphatase 2A
-
2A1 and 2; ATP; okadaic acid, microcystin-LR; phosphate or NaF prevents; specific protamine kinase inhibitors
-
Protein phosphatase 2A
-
ATP; diphosphate; Mn2+ enhances inactivation rate; okadaic acid, microcystin-LR; protein phosphatase inhibitor 2 does not protect; rate of inactivation is unaffected by EDTA, EGTA, Mg2+, Ca2+; specific protamine kinase inhibitors
-
additional information
-
heparin, Ca2+/calmodulin, phosphatidylserine and/or diolein (in the absence or presence of Ca2+); protein inhibitor of cAMP-dependent protein kinase (protamine as substrate), monoclonal antibodies to catalytic domain of protein kinase C from rat brain
-
additional information
-
cGMP, heat-stable inhibitor of cAMP-dependent protein kinase; EGTA, calmodulin; heparin, Ca2+/calmodulin, phosphatidylserine and/or diolein (in the absence or presence of Ca2+); no inhibition by cAMP
-
additional information
-
EGTA, calmodulin; heparin, Ca2+/calmodulin, phosphatidylserine and/or diolein (in the absence or presence of Ca2+)
-
additional information
-
protein phosphatase 2B, 2C, catalytic subunit of protein phosphatase 1, protein tyrosine phosphatases (PTPase 1B and T-cell PTPase), pyruvate dehydrogenase phosphatase
-
additional information
-
PKN possesses an autoinhibitory site at the C-terminal C2 domain, which also binds activating arachidonic acid
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
arachidonic acid
-
activates in vitro, binds at the autoinhibitory site at the C-terminus
protein 14-3-3
-
a dimeric scaffold protein, protein is absolutely required for connection by simultaneous binding of glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex
-
RhoA
-
small GTPase, binds to the ACC domain and activates isozymes PKNalpha and PRK2/PKNgamma/PAK-2
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.8 - 8.8
-
about 85% of maximal activity at pH 5.8 and about 80% of maximal activity at pH 8.8, protamine as substrate
6.6 - 6.8
-
about half-maximal activity at pH 6.6 and pH 6.8, bovine serum albumin as substrate
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
at least 3 different isozymes PKNalpha/PKN-1/PAK-1, PKNbeta, and PRK2/PKNgamma/PAK-2
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). IKKB_BOVIN
756
0
86647
Swiss-Prot
other Location (Reliability: 2)
KC1A_BOVIN
325
0
37567
Swiss-Prot
other Location (Reliability: 3)
SGK1_BOVIN
431
0
49026
Swiss-Prot
other Location (Reliability: 5)
HASP_BOVIN
781
0
86411
Swiss-Prot
Mitochondrion (Reliability: 4)
PK3CA_BOVIN
1068
0
124328
Swiss-Prot
Secretory Pathway (Reliability: 5)
RAF1_BOVIN
648
0
72874
Swiss-Prot
other Location (Reliability: 2)
STK25_BOVIN
426
0
48035
Swiss-Prot
other Location (Reliability: 4)
AKT1_BOVIN
480
0
55748
Swiss-Prot
other Location (Reliability: 3)
AURKA_BOVIN
402
0
45462
Swiss-Prot
other Location (Reliability: 2)
AURKB_BOVIN
344
0
39442
Swiss-Prot
other Location (Reliability: 3)
CDK5_BOVIN
292
0
33288
Swiss-Prot
other Location (Reliability: 1)
GWL_BOVIN
883
0
98072
Swiss-Prot
other Location (Reliability: 2)
RIOK3_BOVIN
519
0
58928
Swiss-Prot
other Location (Reliability: 2)
STK10_BOVIN
966
0
111615
Swiss-Prot
Mitochondrion (Reliability: 2)
IRAK1_BOVIN
718
0
77397
Swiss-Prot
other Location (Reliability: 3)
LIMK2_BOVIN
638
0
72165
Swiss-Prot
other Location (Reliability: 2)
ILK_BOVIN
452
0
51447
Swiss-Prot
other Location (Reliability: 2)
RIPK2_BOVIN
540
0
61106
Swiss-Prot
other Location (Reliability: 3)
ROCK1_BOVIN
441
0
52386
Swiss-Prot
other Location (Reliability: 1)
ROCK2_BOVIN
1388
0
160800
Swiss-Prot
other Location (Reliability: 3)
VRK1_BOVIN
396
0
45358
Swiss-Prot
Mitochondrion (Reliability: 4)
MKNK1_BOVIN
420
0
46700
Swiss-Prot
other Location (Reliability: 1)
TSSK1_BOVIN
367
0
41569
Swiss-Prot
other Location (Reliability: 2)
ACK1_BOVIN
1039
0
114868
Swiss-Prot
other Location (Reliability: 3)
CSK22_BOVIN
350
0
41270
Swiss-Prot
Mitochondrion (Reliability: 4)
STK40_BOVIN
436
0
48929
Swiss-Prot
Mitochondrion (Reliability: 5)
STK4_BOVIN
487
0
55587
Swiss-Prot
other Location (Reliability: 2)
AAK1_BOVIN
957
0
103089
Swiss-Prot
other Location (Reliability: 2)
CSK21_BOVIN
391
0
45144
Swiss-Prot
other Location (Reliability: 5)
IRAK4_BOVIN
461
0
51575
Swiss-Prot
other Location (Reliability: 5)
KPSH1_BOVIN
424
0
48009
Swiss-Prot
other Location (Reliability: 1)
MAPK3_BOVIN
384
0
43316
Swiss-Prot
other Location (Reliability: 1)
PIM1_BOVIN
313
0
35630
Swiss-Prot
other Location (Reliability: 3)
STK33_BOVIN
486
0
54627
Swiss-Prot
other Location (Reliability: 3)
STK38_BOVIN
465
0
54176
Swiss-Prot
other Location (Reliability: 4)
KC1G3_BOVIN
276
0
31510
Swiss-Prot
Mitochondrion (Reliability: 5)
KS6B1_BOVIN
527
0
59352
Swiss-Prot
other Location (Reliability: 4)
PAK1_BOVIN
544
0
60546
Swiss-Prot
other Location (Reliability: 2)
PRP4B_BOVIN
1008
0
116646
Swiss-Prot
other Location (Reliability: 1)
KC1B_BOVIN
336
0
38754
Swiss-Prot
other Location (Reliability: 5)
KC1D_BOVIN
415
0
47330
Swiss-Prot
other Location (Reliability: 4)
KC1G1_BOVIN
457
0
52620
Swiss-Prot
other Location (Reliability: 2)
A0A3Q1NM57_BOVIN
1430
0
159941
TrEMBL
other Location (Reliability: 1)
Q1JQD5_BOVIN
466
0
51600
TrEMBL
other Location (Reliability: 1)
A0A3Q1LNM0_BOVIN
746
0
84101
TrEMBL
Mitochondrion (Reliability: 4)
A0A3Q1M7K8_BOVIN
449
0
51169
TrEMBL
other Location (Reliability: 2)
F1MAZ8_BOVIN
811
0
90720
TrEMBL
Secretory Pathway (Reliability: 1)
E1BN61_BOVIN
790
0
88667
TrEMBL
other Location (Reliability: 1)
F6RIL9_BOVIN
2069
0
219380
TrEMBL
other Location (Reliability: 2)
A6QP95_BOVIN
1417
0
156570
TrEMBL
other Location (Reliability: 4)
A0A3Q1MF85_BOVIN
1660
0
181404
TrEMBL
other Location (Reliability: 5)
G5E5D4_BOVIN
795
0
88921
TrEMBL
other Location (Reliability: 2)
E1B902_BOVIN
820
0
91447
TrEMBL
other Location (Reliability: 3)
A0A3Q1M2S6_BOVIN
2511
0
284933
TrEMBL
other Location (Reliability: 3)
F1MF50_BOVIN
1356
0
158648
TrEMBL
other Location (Reliability: 1)
E1B793_BOVIN
1315
0
144068
TrEMBL
other Location (Reliability: 2)
A5PJP5_BOVIN
588
0
64017
TrEMBL
Mitochondrion (Reliability: 2)
A0A3Q1LTG2_BOVIN
1300
0
146518
TrEMBL
other Location (Reliability: 2)
F1MXE2_BOVIN
1362
0
149744
TrEMBL
other Location (Reliability: 4)
F1MYV9_BOVIN
527
0
57927
TrEMBL
other Location (Reliability: 1)
A0A3Q1MLF0_BOVIN
645
0
72484
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1MW77_BOVIN
1440
0
167266
TrEMBL
other Location (Reliability: 4)
F6RP02_BOVIN
311
0
34315
TrEMBL
other Location (Reliability: 3)
A0A452DI16_BOVIN
795
0
89004
TrEMBL
other Location (Reliability: 3)
E1B754_BOVIN
1711
0
186821
TrEMBL
Mitochondrion (Reliability: 2)
E1B8W0_BOVIN
1577
0
175100
TrEMBL
other Location (Reliability: 4)
A0A3Q1MQ21_BOVIN
508
0
56067
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1M9L7_BOVIN
846
0
95089
TrEMBL
other Location (Reliability: 2)
A0A3Q1MA37_BOVIN
1646
0
182407
TrEMBL
other Location (Reliability: 4)
F1N2U3_BOVIN
846
0
95119
TrEMBL
other Location (Reliability: 2)
A0A3Q1LXB1_BOVIN
720
0
81773
TrEMBL
other Location (Reliability: 1)
A0A3Q1MUZ6_BOVIN
774
0
84796
TrEMBL
Mitochondrion (Reliability: 1)
A0A3Q1LQP3_BOVIN
921
0
102463
TrEMBL
other Location (Reliability: 1)
G3X7B2_BOVIN
422
0
48747
TrEMBL
other Location (Reliability: 1)
A0A3Q1MDE3_BOVIN
2402
0
250293
TrEMBL
other Location (Reliability: 3)
A0A3Q1MZG6_BOVIN
2516
0
285968
TrEMBL
other Location (Reliability: 4)
A0A3Q1LLT7_BOVIN
873
0
98983
TrEMBL
other Location (Reliability: 2)
A0A3Q1LPM2_BOVIN
2196
0
231475
TrEMBL
other Location (Reliability: 2)
E1BH31_BOVIN
816
0
89775
TrEMBL
other Location (Reliability: 3)
Q2KIV5_BOVIN
327
0
37888
TrEMBL
other Location (Reliability: 4)
G3MXU2_BOVIN
3126
0
343401
TrEMBL
Mitochondrion (Reliability: 3)
V6F977_BOVIN
1314
0
144038
TrEMBL
other Location (Reliability: 4)
A0A3Q1MAF4_BOVIN
855
0
94066
TrEMBL
Secretory Pathway (Reliability: 5)
A0A3Q1M3B4_BOVIN
813
0
90971
TrEMBL
other Location (Reliability: 2)
E1B7J7_BOVIN
536
0
59899
TrEMBL
other Location (Reliability: 2)
A0A3Q1LXL6_BOVIN
401
0
46105
TrEMBL
other Location (Reliability: 1)
A0A3Q1M6X3_BOVIN
1136
0
124492
TrEMBL
other Location (Reliability: 5)
A0A3Q1LJY9_BOVIN
1422
0
164960
TrEMBL
other Location (Reliability: 4)
A0A3Q1NFZ3_BOVIN
815
0
92084
TrEMBL
other Location (Reliability: 2)
A0A3Q1MRS0_BOVIN
837
0
91873
TrEMBL
other Location (Reliability: 3)
A0A3Q1LKV4_BOVIN
862
0
95162
TrEMBL
other Location (Reliability: 1)
A0A3Q1LLF0_BOVIN
1256
0
141477
TrEMBL
other Location (Reliability: 2)
A0A3Q1LK61_BOVIN
745
0
83841
TrEMBL
Mitochondrion (Reliability: 5)
F1MLY7_BOVIN
2640
0
301463
TrEMBL
other Location (Reliability: 2)
G3N2F6_BOVIN
326
0
35945
TrEMBL
other Location (Reliability: 3)
G3X7B5_BOVIN
480
0
55743
TrEMBL
other Location (Reliability: 3)
A0A3Q1LPS6_BOVIN
796
0
88911
TrEMBL
Secretory Pathway (Reliability: 1)
Q17QZ0_BOVIN
593
0
64284
TrEMBL
other Location (Reliability: 4)
A0A3Q1LMD4_BOVIN
865
0
97023
TrEMBL
other Location (Reliability: 2)
F1MBN7_BOVIN
551
0
63397
TrEMBL
other Location (Reliability: 4)
A0A3Q1LV55_BOVIN
2072
0
235840
TrEMBL
Secretory Pathway (Reliability: 4)
F1MQJ7_BOVIN
557
0
63295
TrEMBL
other Location (Reliability: 4)
A0A3Q1MHS8_BOVIN
444
0
49300
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1M7Y2_BOVIN
326
0
37861
TrEMBL
other Location (Reliability: 2)
A0A3Q1M7P3_BOVIN
811
0
90514
TrEMBL
other Location (Reliability: 4)
A0A3Q1LYU9_BOVIN
513
0
58491
TrEMBL
other Location (Reliability: 2)
A0A3Q1N0B9_BOVIN
519
0
57993
TrEMBL
other Location (Reliability: 2)
A0A3Q1LRM7_BOVIN
781
0
87923
TrEMBL
other Location (Reliability: 2)
A0A3Q1M4R9_BOVIN
1332
0
145707
TrEMBL
Mitochondrion (Reliability: 5)
E1BN63_BOVIN
2379
0
247692
TrEMBL
other Location (Reliability: 3)
E1B9D1_BOVIN
438
0
50656
TrEMBL
other Location (Reliability: 2)
A0A3Q1MSM7_BOVIN
1239
0
134717
TrEMBL
other Location (Reliability: 2)
A0A3Q1NG99_BOVIN
1030
0
114627
TrEMBL
other Location (Reliability: 4)
F6PVT1_BOVIN
530
0
58419
TrEMBL
other Location (Reliability: 3)
A0A3Q1M9F0_BOVIN
1313
0
143498
TrEMBL
other Location (Reliability: 4)
A0A3Q1LYD4_BOVIN
1412
0
163680
TrEMBL
other Location (Reliability: 3)
F1MRL0_BOVIN
1440
0
161074
TrEMBL
other Location (Reliability: 1)
A0A3Q1MN73_BOVIN
2541
0
288709
TrEMBL
other Location (Reliability: 1)
F1MNR5_BOVIN
733
0
83106
TrEMBL
Mitochondrion (Reliability: 3)
A0A3Q1MH26_BOVIN
380
0
43941
TrEMBL
other Location (Reliability: 1)
A0A3Q1MBK9_BOVIN
2832
0
296459
TrEMBL
other Location (Reliability: 3)
A5D7V1_BOVIN
476
0
54471
TrEMBL
other Location (Reliability: 2)
A0A3Q1LPD6_BOVIN
1069
0
123559
TrEMBL
other Location (Reliability: 2)
A0A3Q1NHF0_BOVIN
2071
0
219402
TrEMBL
other Location (Reliability: 2)
A0A3Q1LTK5_BOVIN
468
0
52257
TrEMBL
other Location (Reliability: 5)
A0A3Q1M8V1_BOVIN
2663
0
304228
TrEMBL
other Location (Reliability: 2)
A0A3Q1N7V3_BOVIN
537
0
59039
TrEMBL
other Location (Reliability: 3)
A0A0G2USR6_BOVIN
691
0
77585
TrEMBL
other Location (Reliability: 4)
A0A3Q1MET0_BOVIN
380
0
43558
TrEMBL
Mitochondrion (Reliability: 4)
A0A3Q1MLJ1_BOVIN
487
0
55487
TrEMBL
other Location (Reliability: 2)
A0A3Q1MIU3_BOVIN
729
0
82655
TrEMBL
other Location (Reliability: 2)
A0A3Q1LNQ6_BOVIN
759
0
85632
TrEMBL
other Location (Reliability: 2)
E1BCU9_BOVIN
435
0
48915
TrEMBL
other Location (Reliability: 1)
A0A3Q1MA27_BOVIN
1613
0
182920
TrEMBL
other Location (Reliability: 3)
A0A3Q1N4A7_BOVIN
2052
0
234699
TrEMBL
Mitochondrion (Reliability: 4)
A0A3Q1M9S4_BOVIN
366
0
41083
TrEMBL
other Location (Reliability: 1)
G3X696_BOVIN
1240
0
142982
TrEMBL
other Location (Reliability: 3)
A4IFF4_BOVIN
735
0
82725
TrEMBL
other Location (Reliability: 2)
A0A3Q1MLZ6_BOVIN
1596
0
181080
TrEMBL
other Location (Reliability: 1)
A0A3Q1M353_BOVIN
766
0
84564
TrEMBL
other Location (Reliability: 2)
E1BAL6_BOVIN
1649
0
186647
TrEMBL
other Location (Reliability: 3)
E1BF05_BOVIN
1315
0
143644
TrEMBL
other Location (Reliability: 3)
A0A3Q1LR74_BOVIN
2047
0
233787
TrEMBL
other Location (Reliability: 3)
A0A3Q1LXL0_BOVIN
685
0
76664
TrEMBL
other Location (Reliability: 4)
F1MLS2_BOVIN
3028
0
339923
TrEMBL
Mitochondrion (Reliability: 4)
A0A3Q1LPW7_BOVIN
2673
0
280416
TrEMBL
other Location (Reliability: 3)
F1MBL6_BOVIN
3658
0
410232
TrEMBL
Mitochondrion (Reliability: 5)
E1BNS8_BOVIN
778
0
84282
TrEMBL
other Location (Reliability: 2)
E1BNH0_BOVIN
2167
0
229134
TrEMBL
other Location (Reliability: 2)
E1BP72_BOVIN
1664
0
188972
TrEMBL
other Location (Reliability: 3)
F6Q6K1_BOVIN
677
0
76318
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1M2S5_BOVIN
372
0
43035
TrEMBL
Mitochondrion (Reliability: 3)
A0A3Q1LWR7_BOVIN
617
0
70343
TrEMBL
other Location (Reliability: 1)
E1BJH5_BOVIN
894
0
101331
TrEMBL
other Location (Reliability: 2)
G3MXZ8_BOVIN
2229
0
235267
TrEMBL
other Location (Reliability: 2)
A0A3Q1LWQ5_BOVIN
544
0
60651
TrEMBL
other Location (Reliability: 2)
A0A3Q1LYH3_BOVIN
731
0
82578
TrEMBL
other Location (Reliability: 3)
F1MNP4_BOVIN
525
0
59110
TrEMBL
other Location (Reliability: 4)
A0A3Q1M585_BOVIN
2181
0
229808
TrEMBL
other Location (Reliability: 2)
A0A3Q1LZ53_BOVIN
733
0
82936
TrEMBL
other Location (Reliability: 3)
A0A3Q1NH21_BOVIN
481
0
55641
TrEMBL
other Location (Reliability: 3)
E1BH93_BOVIN
3144
0
345636
TrEMBL
other Location (Reliability: 2)
E1BAC4_BOVIN
618
1
68106
TrEMBL
Secretory Pathway (Reliability: 4)
E1BK33_BOVIN
1572
0
170971
TrEMBL
other Location (Reliability: 4)
F1MH45_BOVIN
1719
0
195786
TrEMBL
other Location (Reliability: 2)
H2XJF0_BOVIN
936
0
107869
TrEMBL
Mitochondrion (Reliability: 2)
A0A3Q1MIZ0_BOVIN
733
0
82269
TrEMBL
Secretory Pathway (Reliability: 2)
A0A3Q1LQM0_BOVIN
615
0
68310
TrEMBL
Secretory Pathway (Reliability: 4)
A0A3Q1M334_BOVIN
967
0
111702
TrEMBL
Mitochondrion (Reliability: 2)
A0A3Q1MJ77_BOVIN
474
0
54857
TrEMBL
other Location (Reliability: 2)
A0A3Q1MBB5_BOVIN
1166
0
128135
TrEMBL
other Location (Reliability: 3)
A0A3Q1LNA9_BOVIN
559
0
62268
TrEMBL
other Location (Reliability: 2)
A5PK80_BOVIN
253
0
28172
TrEMBL
other Location (Reliability: 2)
A0A3Q1LIT6_BOVIN
757
0
84191
TrEMBL
Mitochondrion (Reliability: 4)
G3MZE2_BOVIN
479
0
53182
TrEMBL
other Location (Reliability: 2)
A0A3Q1MJ80_BOVIN
2808
0
293730
TrEMBL
other Location (Reliability: 3)
A0A3Q1M652_BOVIN
464
1
53388
TrEMBL
other Location (Reliability: 2)
A0A3Q1MNA7_BOVIN
2001
0
228761
TrEMBL
other Location (Reliability: 3)
A0A3Q1MIQ9_BOVIN
611
0
68020
TrEMBL
other Location (Reliability: 3)
A0A3Q1M2N3_BOVIN
414
1
48003
TrEMBL
other Location (Reliability: 2)
A0A3Q1MIZ9_BOVIN
1036
0
115709
TrEMBL
Mitochondrion (Reliability: 5)
F1MKW8_BOVIN
906
0
100990
TrEMBL
other Location (Reliability: 5)
G3X788_BOVIN
1743
0
192239
TrEMBL
other Location (Reliability: 1)
A0A3Q1ML34_BOVIN
2018
0
230239
TrEMBL
Mitochondrion (Reliability: 4)
E1BA03_BOVIN
681
0
74378
TrEMBL
other Location (Reliability: 5)
A0A3Q1NJ46_BOVIN
808
0
88721
TrEMBL
other Location (Reliability: 2)
F6QDN3_BOVIN
1417
0
156570
TrEMBL
other Location (Reliability: 4)
A0A3Q1NI20_BOVIN
820
0
90162
TrEMBL
other Location (Reliability: 2)
A9Q1J5_BOVIN
650
0
74252
TrEMBL
other Location (Reliability: 1)
A0A3Q1M4X3_BOVIN
744
0
83696
TrEMBL
other Location (Reliability: 1)
A0A3Q1M608_BOVIN
776
0
87592
TrEMBL
other Location (Reliability: 1)
E1BB43_BOVIN
1061
0
118026
TrEMBL
other Location (Reliability: 4)
A0A3Q1MSX1_BOVIN
818
0
91270
TrEMBL
Mitochondrion (Reliability: 4)
A6QLW1_BOVIN
1358
0
152795
TrEMBL
other Location (Reliability: 2)
A0A3Q1MLN6_BOVIN
747
0
84328
TrEMBL
other Location (Reliability: 2)
A0A3Q1N562_BOVIN
1133
0
132676
TrEMBL
other Location (Reliability: 1)
A0A3Q1LUE8_BOVIN
2410
0
273044
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1NIS1_BOVIN
972
0
103728
TrEMBL
other Location (Reliability: 2)
A0A3Q1MUI5_BOVIN
486
0
55781
TrEMBL
other Location (Reliability: 1)
A0A3Q1MC24_BOVIN
1810
0
205764
TrEMBL
other Location (Reliability: 2)
A0A3Q1MIM9_BOVIN
1836
0
199936
TrEMBL
other Location (Reliability: 5)
A0A3Q1N707_BOVIN
1233
0
133832
TrEMBL
other Location (Reliability: 2)
A0A3Q1MQ45_BOVIN
477
0
55057
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1NIF4_BOVIN
1706
0
193808
TrEMBL
other Location (Reliability: 2)
F1MPS5_BOVIN
1304
0
142712
TrEMBL
Mitochondrion (Reliability: 3)
A0A3Q1LWG3_BOVIN
1049
0
116617
TrEMBL
other Location (Reliability: 4)
F1N319_BOVIN
1388
0
160859
TrEMBL
other Location (Reliability: 3)
B3FXL6_BOVIN
461
0
51589
TrEMBL
other Location (Reliability: 5)
G5E6T0_BOVIN
3126
0
343257
TrEMBL
other Location (Reliability: 5)
A0A3Q1LYB8_BOVIN
2739
0
287170
TrEMBL
other Location (Reliability: 3)
F1MCX5_BOVIN
367
0
42204
TrEMBL
other Location (Reliability: 4)
E1BNW0_BOVIN
476
0
54394
TrEMBL
other Location (Reliability: 2)
A0A3Q1LZH6_BOVIN
2794
0
292098
TrEMBL
other Location (Reliability: 3)
A0A3Q1MNY8_BOVIN
1000
0
115824
TrEMBL
other Location (Reliability: 1)
F1MY55_BOVIN
719
0
80836
TrEMBL
other Location (Reliability: 2)
A0A3Q1M4D1_BOVIN
2060
0
235394
TrEMBL
Mitochondrion (Reliability: 4)
A0A3Q1MJ29_BOVIN
716
0
80962
TrEMBL
other Location (Reliability: 2)
A0A3Q1LXK8_BOVIN
835
0
94170
TrEMBL
Secretory Pathway (Reliability: 5)
A0A3Q1LV85_BOVIN
1797
0
204380
TrEMBL
other Location (Reliability: 2)
Q2KJA0_BOVIN
611
0
68146
TrEMBL
other Location (Reliability: 3)
A7MB90_BOVIN
414
0
47268
TrEMBL
other Location (Reliability: 2)
F1MM00_BOVIN
975
0
109683
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q1LJN0_BOVIN
796
0
89893
TrEMBL
Secretory Pathway (Reliability: 5)
A0A3Q1LP73_BOVIN
2804
0
293618
TrEMBL
other Location (Reliability: 3)
A0A3Q1LSY0_BOVIN
580
0
64488
TrEMBL
other Location (Reliability: 2)
A0A3Q1M614_BOVIN
409
0
45915
TrEMBL
other Location (Reliability: 4)
A0A3Q1MP11_BOVIN
1598
0
180327
TrEMBL
other Location (Reliability: 3)
E1BPU0_BOVIN
2527
0
286201
TrEMBL
other Location (Reliability: 2)
F1MF36_BOVIN
950
0
107588
TrEMBL
other Location (Reliability: 1)
F1MQV7_BOVIN
552
0
62321
TrEMBL
other Location (Reliability: 1)
A0A3Q1LL59_BOVIN
1754
0
199698
TrEMBL
other Location (Reliability: 2)
A0A8J8XJQ0_BOVIN
906
0
100990
TrEMBL
other Location (Reliability: 5)
F1MQE1_BOVIN
771
0
85457
TrEMBL
other Location (Reliability: 2)
F1MG77_BOVIN
781
0
86370
TrEMBL
Mitochondrion (Reliability: 4)
E1BEI6_BOVIN
3054
0
350217
TrEMBL
other Location (Reliability: 2)
A0JN96_BOVIN
491
0
56277
TrEMBL
other Location (Reliability: 1)
M5FMV3_BOVIN
593
0
67250
TrEMBL
other Location (Reliability: 5)
A0A3Q1MCM5_BOVIN
717
0
81073
TrEMBL
other Location (Reliability: 4)
F1MDL4_BOVIN
760
0
83870
TrEMBL
other Location (Reliability: 2)
G3MZK9_BOVIN
257
0
29982
TrEMBL
Secretory Pathway (Reliability: 3)
A0A3Q1MCB4_BOVIN
1794
0
204061
TrEMBL
other Location (Reliability: 2)
A0A3Q1LXY6_BOVIN
1412
0
163902
TrEMBL
other Location (Reliability: 4)
A6QQ50_BOVIN
847
0
93153
TrEMBL
other Location (Reliability: 3)
E1BLB6_BOVIN
4124
0
464589
TrEMBL
other Location (Reliability: 3)
F1N6C1_BOVIN
2015
0
224766
TrEMBL
other Location (Reliability: 4)
Q5BIM4_BOVIN
606
0
67690
TrEMBL
other Location (Reliability: 3)
E1BM51_BOVIN
1246
0
135343
TrEMBL
other Location (Reliability: 2)
Q08DN4_BOVIN
344
0
39408
TrEMBL
other Location (Reliability: 3)
A0A3Q1MEB9_BOVIN
2580
0
271127
TrEMBL
other Location (Reliability: 3)
A0A3Q1LJM2_BOVIN
482
0
54866
TrEMBL
other Location (Reliability: 2)
G5E5T2_BOVIN
724
0
81546
TrEMBL
other Location (Reliability: 1)
A0A3Q1ND05_BOVIN
1354
0
158301
TrEMBL
other Location (Reliability: 1)
A0A3Q1MTN4_BOVIN
437
0
50386
TrEMBL
other Location (Reliability: 2)
A0A3Q1MSM5_BOVIN
293
0
33124
TrEMBL
other Location (Reliability: 4)
A0A3Q1MEZ6_BOVIN
2528
0
286571
TrEMBL
Mitochondrion (Reliability: 5)
F1MPF0_BOVIN
1866
6
212783
TrEMBL
other Location (Reliability: 2)
F1MYJ4_BOVIN
479
0
55775
TrEMBL
other Location (Reliability: 2)
E1BFS2_BOVIN
894
0
99124
TrEMBL
other Location (Reliability: 1)
E1B8J7_BOVIN
910
0
100146
TrEMBL
Secretory Pathway (Reliability: 5)
A0A3Q1LNI9_BOVIN
1691
0
192530
TrEMBL
other Location (Reliability: 2)
E1BFB4_BOVIN
2550
0
288969
TrEMBL
Mitochondrion (Reliability: 5)
G5E5K2_BOVIN
880
0
97716
TrEMBL
other Location (Reliability: 2)
A6QNL2_BOVIN
691
0
77577
TrEMBL
other Location (Reliability: 4)
A0A3Q1M0H8_BOVIN
720
0
81270
TrEMBL
other Location (Reliability: 3)
A0A3Q1M888_BOVIN
820
0
91901
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q1M0G8_BOVIN
524
0
58047
TrEMBL
other Location (Reliability: 2)
F1MX36_BOVIN
418
0
45571
TrEMBL
other Location (Reliability: 1)
A0A3Q1LHD8_BOVIN
719
0
81812
TrEMBL
other Location (Reliability: 2)
A0A3Q1M514_BOVIN
1646
0
179976
TrEMBL
Mitochondrion (Reliability: 2)
F1MY86_BOVIN
304
0
34853
TrEMBL
Mitochondrion (Reliability: 2)
A7YW43_BOVIN
253
0
28200
TrEMBL
other Location (Reliability: 2)
A0A3S5ZPR2_BOVIN
650
0
74300
TrEMBL
other Location (Reliability: 1)
A0A3Q1MSW8_BOVIN
2388
0
249088
TrEMBL
other Location (Reliability: 3)
A0A8J8XSY8_BOVIN
1314
0
144038
TrEMBL
other Location (Reliability: 4)
A0A3Q1MDC2_BOVIN
1621
0
183533
TrEMBL
other Location (Reliability: 1)
F1MH23_BOVIN
472
0
54069
TrEMBL
other Location (Reliability: 1)
A5PJL4_BOVIN
740
0
83694
TrEMBL
other Location (Reliability: 1)
A0A3Q1LM65_BOVIN
738
0
82630
TrEMBL
other Location (Reliability: 2)
A0A3Q1LML5_BOVIN
564
0
61717
TrEMBL
other Location (Reliability: 2)
A0A3Q1MUT9_BOVIN
743
0
83784
TrEMBL
other Location (Reliability: 4)
A0A3Q1N762_BOVIN
2496
0
284600
TrEMBL
other Location (Reliability: 2)
A0A3Q1LG63_BOVIN
2331
0
266400
TrEMBL
Secretory Pathway (Reliability: 5)
A0A3Q1M8E4_BOVIN
351
0
40461
TrEMBL
other Location (Reliability: 2)
A0A3Q1M6U8_BOVIN
1729
0
195955
TrEMBL
other Location (Reliability: 2)
F1N747_BOVIN
2018
0
230889
TrEMBL
Mitochondrion (Reliability: 4)
A0A3Q1LWF1_BOVIN
753
0
84439
TrEMBL
other Location (Reliability: 2)
F1MFB2_BOVIN
1034
0
110685
TrEMBL
Mitochondrion (Reliability: 3)
E1B887_BOVIN
568
0
65189
TrEMBL
other Location (Reliability: 2)
G3MX27_BOVIN
550
0
59548
TrEMBL
other Location (Reliability: 3)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
45000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
3 polypeptides detected by SDS-PAGE: alpha - 45000 Da, alpha' - 40000 Da, beta - 26000 Da
additional information
-
3 polypeptides detected by SDS-PAGE: alpha - 45000 Da, alpha' - 40000 Da, beta - 26000 Da
additional information
-
isozyme structure analysis, PKN kinase contains a catalytic domain homologous to that of protein kinase C, as well as a unique regulatory region containing antiparallel coiled-coil domain, the ACC domain, and an autoinhibitory C2 domain binding activators
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
phosphoprotein
phosphoprotein with an alkali-labile phosphate content exceeding 2 mol/mol protein
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, in 0.05 M imidazole chloride, pH 7.3, 10% glycerol, 1 mM DTT, protease inhibitors, 1 mM EDTA, at least 6 months
-
-70°C, in 0.025 M Tris-HCl, pH 7.3, 10% glycerol, 1 mM EDTA, 1 mM benzamidine, 0.1 mM PMSF, 14 mM 2-mercaptoethanol, 0.1% Triton X-100, 12 months
-
0-4°C, in 0.05 M imidazole chloride, pH 7.3, 10% glycerol, 1 mM DTT, protease inhibitors, 1 mM EDTA, up to 3 weeks
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
co-expression of glycogen synthase kinase-3 beta, tau, and 14-3-3 in COS-7 cells and in HEK-293 cells
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Coffer, P.J.; Woodgett, J.R.
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
Eur. J. Biochem.
205
1217
1992
Homo sapiens (P31749), Bos taurus (Q01314)
Coffer, P.J.; Woodgett, J.R.
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
Eur. J. Biochem.
201
475-481
1991
Homo sapiens (P31749), Homo sapiens, Bos taurus (Q01314), Bos taurus
Rowles, J.; Slaughter, C.; Moomaw, C.; Hsu, J.; Cobb, M.H.
Purification of casein kinase I and isolation of cDNAs encoding multiple casein kinase I-like enzymes
Proc. Natl. Acad. Sci. USA
88
9548-9552
1991
Bos taurus (P35507), Bos taurus (P67827), Bos taurus
Litchfield, D.W.; Lozeman, F.J.; Piening, C.; Sommercorn, J.; Takio, K.; Walsh, K.A.; Krebs, E.G.
Subunit structure of casein kinase II from bovine testis. Demonstration that the alpha and alpha' subunits are distinct polypeptides
J. Biol. Chem.
265
7638-7644
1990
Bos taurus (P20427), Bos taurus, Homo sapiens (P68400)
Damuni, Z.; Reed, L.J.
Purification and properties of a protamine kinase and a type II casein kinase from bovine kidney mitochondria
Arch. Biochem. Biophys.
262
574-584
1988
Bos taurus
Damuni, Z.; Amick, G.D.; Sneed, T.R.
Purification and properties of a distinct protamine kinase from the cytosol of bovine kidney cortex
J. Biol. Chem.
264
6412-6416
1989
Bos taurus
Amick, G.D.; Reddy, S.A.G.; Damuni, Z.
Purification and properties of a protamine kinase from bovine kidney microsomes
Arch. Biochem. Biophys.
297
80-85
1992
Bos taurus
Amick, G.D.; Reddy, S.A.G.; Damuni, Z.
Protein phosphatase 2A is a specific protamine-kinase-inactivating phosphatase
Biochem. J.
287
1019-1022
1992
Bos taurus
-
Damuni, Z.
Inactivation of bovine kidney cytosolic protamine kinase by the catalytic subunit of protein phosphatase 2A
Biochem. Biophys. Res. Commun.
166
449-456
1990
Bos taurus
Amick, G.D.; Damuni, Z.
Protamine kinase phosphorylates eukaryotic protein synthesis initiation factor 4E
Biochem. Biophys. Res. Commun.
183
431-437
1992
Bos taurus
Mukai, H.
The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC
J. Biochem.
133
17-27
2003
Asteroidea, Bos taurus, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus laevis
Agarwal-Mawal, A.; Qureshi, H.Y.; Cafferty, P.W.; Yuan, Z.; Han, D.; Lin, R.; Paudel, H.K.
14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex
J. Biol. Chem.
278
12722-12728
2003
Bos taurus
EXTERNAL LINKS (specific for EC-Number 2.7.11.1)
Transporter Classification Database (TCDB): 8.A.23.1.35, 9.B.321.1.1, 8.A.104.1.10, 1.A.87.2.4, 1.I.1.1.3, 1.A.87.2.9, 8.A.104.1.1, 1.A.87.2.6, 1.I.1.1.5, 9.A.15.1.1, 1.A.4.5.8, 1.A.4.5.1, 1.A.87.2.11, 8.A.104.1.9, 1.A.87.2.3, 8.A.104.1.5, 2.A.133.1.3
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