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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Danio rerio

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EC Tree
IUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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This record set is specific for:
Danio rerio
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Word Map
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The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70 kDa zeta-associated protein
-
-
-
-
ACTR-IIB
-
-
-
-
ACTRIIA
-
-
-
-
Agammaglobulinaemia tyrosine kinase
-
-
-
-
Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
-
ATK
-
-
-
-
B cell progenitor kinase
-
-
-
-
B lymphocyte kinase
-
-
-
-
B-cell/myeloid kinase
-
-
-
-
BCR-ABL tyrosine kinase
-
-
-
-
BMK
-
-
-
-
BMP type II receptor
-
-
-
-
BMP-2/BMP-4 receptor
-
-
-
-
Bone marrow kinase BMX
-
-
-
-
BPK
-
-
-
-
Breast tumor kinase
-
-
-
-
Bruton's tyrosine kinase
-
-
-
-
c-ABL
-
-
-
-
c-FER
-
-
-
-
C-FES
-
-
-
-
C-SRC
-
-
-
-
C-SRC kinase
-
-
-
-
C-YES
-
-
-
-
CADTK
-
-
-
-
CAK beta
-
-
-
-
Calcium-dependent tyrosine kinase
-
-
-
-
Cell adhesion kinase beta
-
-
-
-
D-ash
-
-
-
-
DFer
-
-
-
-
Dsrc28C
-
-
-
-
ectoprotein kinase
-
-
-
-
Epithelial and endothelial tyrosine kinase
-
-
-
-
EPS I polysaccharide export protein epsB
-
-
-
-
focal adhesion kinase 1
-
-
-
-
gene lck protein kinase
-
-
-
-
gene lck tyrosine kinase
-
-
-
-
Hematopoietic consensus tyrosine-lacking kinase
-
-
-
-
Hemopoietic cell kinase
-
-
-
-
IL-2-inducible T-cell kinase
-
-
-
-
Itk
-
-
-
-
JAK protein tyrosine kinase
-
-
-
-
Kinase EMB
-
-
-
-
Kinase EMT
-
-
-
-
Kinase TLK
-
-
-
-
kinase, protein (phosphorylating tyrosine)
-
-
-
-
kinase, protein p56lck (phosphorylating)
-
-
-
-
L-JAK
-
-
-
-
Lck Tyrosine kinase
-
-
-
-
Leukocyte janus kinase
-
-
-
-
LSK
-
-
-
-
nonreceptor protein tyrosine kinase
-
-
-
-
NTK38
-
-
-
-
Nuclear tyrosine protein kinase RAK
-
-
-
-
ORF6
-
-
-
-
p150
-
-
-
-
p55-BLK
-
-
-
-
P55-FGR
-
-
-
-
p56-HCK
-
-
-
-
p56-HCK/p59-HCK
-
-
-
-
P56-LCK
-
-
-
-
p56lck kinase
-
-
-
-
p56lck protein kinase
-
-
-
-
p56lck protein tyrosine kinase
-
-
-
-
p56lck tyrosine kinase
-
-
-
-
P57-STK
-
-
-
-
P59-FYN
-
-
-
-
p59-HCK/p60-HCK
-
-
-
-
P60-SRC
-
-
-
-
p60-YRK
-
-
-
-
P61-YES
-
-
-
-
p94-FER
-
-
-
-
phosphotyrosyl-protein kinase
-
-
-
-
PP125FAK
-
-
-
-
Protein kinase (tyrosine-phosphorylating)
-
-
-
-
protein kinase A
-
-
-
-
Protein kinase BATK
-
-
-
-
Protein kinase HYL
-
-
-
-
Protein kinase Lck
-
-
-
-
Protein kinase NTK
-
-
-
-
Protein kinase p56-LCK
-
-
-
-
Protein kinase p56lck
-
-
-
-
Protein p56c-lck kinase
-
-
-
-
Protein p56lck tyrosine kinase
-
-
-
-
Protein tyrosine kinase
protein tyrosine kinase 2beta
-
-
-
-
Protein tyrosine kinase lck
-
-
-
-
Protein tyrosine kinase p56lck
-
-
-
-
Protein tyrosine kinase pp56lck
-
-
-
-
protein-tyrosine kinase
-
-
Protein-tyrosine kinase C-TKL
-
-
-
-
Protein-tyrosine kinase CYL
-
-
-
-
PTK-RL-18
-
-
-
-
PTK70
-
-
-
-
Quek1
-
-
-
-
Related adhesion focal tyrosine kinase
-
-
-
-
Resting lymphocyte kinase
-
-
-
-
Rlk/Txk
-
-
-
-
S-domain receptor-like protein kinase
-
-
-
-
SLK
-
-
-
-
Spleen tyrosine kinase
-
-
-
-
src-kinase
-
-
-
-
SRC-related intestinal kinase
-
-
-
-
Syk-related tyrosine kinase
-
-
-
-
SYN
-
-
-
-
T cell-specific protein-tyrosine kinase
-
-
-
-
T-cell-specific kinase
-
-
-
-
Tyrosine kinase
-
-
-
-
Tyrosine kinase ARG
-
-
-
-
Tyrosine kinase lck
-
-
-
-
Tyrosine kinase p56lck
-
-
-
-
Tyrosine phosphokinase
-
-
-
-
Tyrosine protein kinase
-
-
-
-
Tyrosine protein kinase p56lck
-
-
-
-
Tyrosine-protein kinase brk
-
-
-
-
Tyrosine-protein kinase CTK
-
-
-
-
tyrosine-protein kinase JAK1
-
Tyrosine-protein kinase Lyk
-
-
-
-
Tyrosine-protein kinase TYRO 10
-
-
-
-
Tyrosine-specific protein kinase
-
-
-
-
Tyrosylprotein kinase
-
-
-
-
v-fps Protein-tyrosine kinase
-
-
-
-
WEE1hu
-
-
-
-
Wnt11
-
-
Yes kinase
-
YES related kinase
-
-
-
-
additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY hide
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + peptide
ADP + phospho-L-tyrosinyl-peptide
show the reaction diagram
-
PTKs phosphorylate substrates in a sequence-specific manner, relatively short peptide sequences determine selectivity, substrate specificity analysis using 144 different peptides, overview
-
-
?
ATP + [FAK]-L-tyrosine
ADP + [FAK]-L-tyrosine phosphate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + [FAK]-L-tyrosine
ADP + [FAK]-L-tyrosine phosphate
show the reaction diagram
activation of FAK during epiboly and gastrulation by dynamic phosphorylation at Tyr861
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine
i.e. pp2, inhibits Src family PTKs, inhibition of zebrafish egg/embryo development by Yes kinase inhibition
4-amino-7-phenylpyrazolo[3,4-d] pyrimidine
i.e. pp3, inhibits Src family PTKs, slight inhibition of zebrafish egg/embryo development by Yes kinase inhibition
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.2
assay at
7.5
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
JAK1_DANRE
1153
0
132481
Swiss-Prot
other Location (Reliability: 2)
SRC_DANRE
534
0
60147
Swiss-Prot
other Location (Reliability: 2)
BAZ1B_DANRE
1536
0
176213
Swiss-Prot
other Location (Reliability: 3)
YES_DANRE
546
0
61269
Swiss-Prot
other Location (Reliability: 2)
FYNA_DANRE
537
0
60569
Swiss-Prot
other Location (Reliability: 1)
FYNB_DANRE
544
0
61030
Swiss-Prot
other Location (Reliability: 1)
WEE2_DANRE
532
0
59774
Swiss-Prot
other Location (Reliability: 1)
Q6TPQ4_DANRE
503
0
57504
TrEMBL
other Location (Reliability: 1)
A0A0R4ICU5_DANRE
1004
0
115513
TrEMBL
other Location (Reliability: 1)
A0A2R8RWH2_DANRE
1085
0
123948
TrEMBL
other Location (Reliability: 1)
F1R5C7_DANRE
1153
0
132482
TrEMBL
other Location (Reliability: 2)
Q4V958_DANRE
584
0
65951
TrEMBL
other Location (Reliability: 3)
Q08BY6_DANRE
511
0
58174
TrEMBL
other Location (Reliability: 1)
F1QWX8_DANRE
1095
0
125100
TrEMBL
other Location (Reliability: 2)
F8W3B7_DANRE
640
0
73825
TrEMBL
other Location (Reliability: 2)
A0A8M1PFN7_DANRE
525
0
59156
TrEMBL
other Location (Reliability: 4)
F1QBS0_DANRE
827
0
95578
TrEMBL
other Location (Reliability: 2)
A0A8M1NIX1_DANRE
492
0
56607
TrEMBL
other Location (Reliability: 2)
A0A2R8RQT2_DANRE
532
0
59778
TrEMBL
other Location (Reliability: 1)
Q8AWF1_DANRE
525
0
59156
TrEMBL
other Location (Reliability: 4)
A0A2R8QG88_DANRE
839
0
96318
TrEMBL
other Location (Reliability: 2)
A0A0R4IYB8_DANRE
1182
0
127887
TrEMBL
other Location (Reliability: 3)
C0SPC5_DANRE
1153
0
132562
TrEMBL
other Location (Reliability: 2)
A0A8M1N7F0_DANRE
485
0
55644
TrEMBL
other Location (Reliability: 1)
Q503P3_DANRE
604
0
68703
TrEMBL
other Location (Reliability: 2)
A0A2R8QMF1_DANRE
1063
0
120204
TrEMBL
other Location (Reliability: 3)
B3DGP9_DANRE
1045
0
118711
TrEMBL
other Location (Reliability: 3)
A0A2R8QB38_DANRE
447
0
50215
TrEMBL
Mitochondrion (Reliability: 4)
Q8JHU4_DANRE
584
0
66125
TrEMBL
other Location (Reliability: 3)
X1WHM4_DANRE
492
0
56607
TrEMBL
other Location (Reliability: 2)
F8W3Q8_DANRE
393
0
45143
TrEMBL
other Location (Reliability: 2)
F1Q7D7_DANRE
518
0
59005
TrEMBL
other Location (Reliability: 1)
F8W3J0_DANRE
841
0
96461
TrEMBL
other Location (Reliability: 2)
A0A0H2UKT8_DANRE
621
0
71516
TrEMBL
other Location (Reliability: 2)
A0A8M1P766_DANRE
612
0
68518
TrEMBL
other Location (Reliability: 5)
Q1LYE1_DANRE
612
0
68518
TrEMBL
other Location (Reliability: 5)
A0A2R8QJ75_DANRE
582
0
67647
TrEMBL
other Location (Reliability: 5)
E7F1M5_DANRE
512
0
58469
TrEMBL
other Location (Reliability: 2)
A0A2R8PV98_DANRE
444
0
50195
TrEMBL
other Location (Reliability: 2)
F8W425_DANRE
826
0
94532
TrEMBL
other Location (Reliability: 1)
A2CES6_DANRE
842
0
96648
TrEMBL
other Location (Reliability: 2)
A0A2R8RR02_DANRE
1101
0
124276
TrEMBL
other Location (Reliability: 3)
A0A8M1N787_DANRE
253
4
28203
TrEMBL
Secretory Pathway (Reliability: 1)
B2GS52_DANRE
534
0
60137
TrEMBL
other Location (Reliability: 2)
Q7T2V4_DANRE
1045
0
118812
TrEMBL
other Location (Reliability: 3)
O93596_DANRE
1095
0
125172
TrEMBL
other Location (Reliability: 2)
E9QFU7_DANRE
585
0
67517
TrEMBL
other Location (Reliability: 2)
M9MM92_DANRE
604
0
68761
TrEMBL
other Location (Reliability: 2)
Q910A2_DANRE
586
0
67647
TrEMBL
other Location (Reliability: 2)
A0A2R8QJ02_DANRE
1189
0
134352
TrEMBL
other Location (Reliability: 4)
A0A2R8Q7T0_DANRE
826
0
94664
TrEMBL
other Location (Reliability: 1)
Q66HZ1_DANRE
528
0
59612
TrEMBL
other Location (Reliability: 4)
E9QHC5_DANRE
992
0
110707
TrEMBL
other Location (Reliability: 2)
A0A8M1P7D1_DANRE
447
1
50010
TrEMBL
other Location (Reliability: 4)
F1Q6A2_DANRE
1126
0
129529
TrEMBL
other Location (Reliability: 1)
Q1RLY5_DANRE
503
0
57505
TrEMBL
other Location (Reliability: 1)
Q7SXJ2_DANRE
570
0
62280
TrEMBL
other Location (Reliability: 1)
F1QT14_DANRE
1050
0
118792
TrEMBL
other Location (Reliability: 3)
Q7ZU16_DANRE
1153
0
132515
TrEMBL
other Location (Reliability: 2)
A0A8M1NXI9_DANRE
826
0
94664
TrEMBL
other Location (Reliability: 1)
A0A0R4ICT0_DANRE
977
2
111247
TrEMBL
other Location (Reliability: 3)
A9ULT3_DANRE
622
0
71802
TrEMBL
other Location (Reliability: 2)
A0A8M1P9M0_DANRE
1807
0
208501
TrEMBL
other Location (Reliability: 3)
F1QB24_DANRE
733
0
83773
TrEMBL
other Location (Reliability: 2)
A0A2R8RU01_DANRE
619
0
71602
TrEMBL
other Location (Reliability: 2)
E7FCB4_DANRE
895
0
102460
TrEMBL
other Location (Reliability: 3)
F8W5Q8_DANRE
1062
0
117348
TrEMBL
other Location (Reliability: 2)
F1QFN4_DANRE
608
0
69976
TrEMBL
other Location (Reliability: 2)
C0SPC6_DANRE
1113
0
127668
TrEMBL
Mitochondrion (Reliability: 4)
E7F667_DANRE
1156
0
129703
TrEMBL
other Location (Reliability: 1)
E7F0I7_DANRE
489
0
55692
TrEMBL
other Location (Reliability: 1)
B0V237_DANRE
1103
0
126079
TrEMBL
other Location (Reliability: 1)
A0A0R4IH27_DANRE
1078
0
121634
TrEMBL
Mitochondrion (Reliability: 5)
A0A2R8Q5G0_DANRE
1088
0
122968
TrEMBL
other Location (Reliability: 3)
E7F063_DANRE
480
0
55610
TrEMBL
other Location (Reliability: 2)
F8W4H3_DANRE
1165
0
131703
TrEMBL
other Location (Reliability: 4)
Q66I04_DANRE
510
0
58258
TrEMBL
other Location (Reliability: 1)
Q7T2P8_DANRE
1004
0
113993
TrEMBL
other Location (Reliability: 2)
X1WHN6_DANRE
1103
0
126057
TrEMBL
other Location (Reliability: 1)
K7DYB9_DANRE
485
0
54642
TrEMBL
other Location (Reliability: 1)
B3DKK9_DANRE
1050
0
118769
TrEMBL
other Location (Reliability: 3)
A0A2R8QKV3_DANRE
1095
0
123807
TrEMBL
other Location (Reliability: 3)
F1R4V1_DANRE
441
0
49849
TrEMBL
other Location (Reliability: 1)
A0JMN4_DANRE
450
0
51018
TrEMBL
other Location (Reliability: 1)
O42200_DANRE
616
0
71620
TrEMBL
other Location (Reliability: 4)
B0UXN6_DANRE
587
0
66012
TrEMBL
other Location (Reliability: 2)
A0A0R4J755_DANRE
499
0
56694
TrEMBL
other Location (Reliability: 1)
Q6DRI0_DANRE
612
0
68535
TrEMBL
other Location (Reliability: 5)
Q98SN4_DANRE
1050
0
118776
TrEMBL
other Location (Reliability: 3)
A5WWJ6_DANRE
528
0
59638
TrEMBL
other Location (Reliability: 4)
B0UXN7_DANRE
1135
0
123711
TrEMBL
other Location (Reliability: 2)
K7DYJ3_DANRE
933
0
106435
TrEMBL
other Location (Reliability: 3)
A0A2R8RK79_DANRE
603
0
70167
TrEMBL
other Location (Reliability: 5)
C0RW38_DANRE
1126
0
129538
TrEMBL
other Location (Reliability: 1)
A0A2R8RPC3_DANRE
1099
0
124327
TrEMBL
other Location (Reliability: 4)
C4B4T7_DANRE
516
1
58872
TrEMBL
Secretory Pathway (Reliability: 2)
F8W2F9_DANRE
1081
0
119484
TrEMBL
Mitochondrion (Reliability: 4)
Q5U3D0_DANRE
436
0
48870
TrEMBL
Mitochondrion (Reliability: 2)
F1R3M1_DANRE
616
0
71583
TrEMBL
other Location (Reliability: 4)
A0A2R8QE56_DANRE
540
0
60912
TrEMBL
other Location (Reliability: 2)
E7F1F9_DANRE
1095
0
123703
TrEMBL
other Location (Reliability: 3)
A0JMM7_DANRE
732
0
83506
TrEMBL
other Location (Reliability: 2)
Q5TYU7_DANRE
485
0
55644
TrEMBL
other Location (Reliability: 1)
A0A2R8QR19_DANRE
862
0
99596
TrEMBL
other Location (Reliability: 2)
Q1JPW8_DANRE
447
0
50157
TrEMBL
Mitochondrion (Reliability: 4)
A0A8M1N268_DANRE
510
0
58258
TrEMBL
other Location (Reliability: 1)
A0A2R8QKY3_DANRE
836
0
95360
TrEMBL
other Location (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
62000
x * 62000, recombinant Yes-kinase, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 62000, recombinant Yes-kinase, SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
the Yes kinase performs autophosphorylation
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
construction of Fyn/Yes and Wnt11 knockout mutants, activity profiling and phenotype analysis, overview
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant c-Yes GST-fusion U and SH3 domains from Escherichia coli strain DH5alpha by glutathione affinity chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of c-Yes domains U and SH3 as GST-fusion proteins in Escherichia coli strain DH5alpha
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Danio rerio (O12990), Danio rerio (O93596), Mus musculus (P00520), Mus musculus (Q9R117), Drosophila melanogaster (P00528), Drosophila melanogaster (P18106), Drosophila melanogaster (Q24145), Drosophila melanogaster (Q9V9J3), Homo sapiens (P06239), Homo sapiens (Q06187), Macaca fascicularis (Q95M30), Rattus norvegicus (Q9WUD9)
Manually annotated by BRENDA team
Tsai, W.B.; Zhang, X.; Sharma, D.; Wu, W.; Kinsey, W.H.
Role of Yes kinase during early zebrafish development
Dev. Biol.
277
129-141
2005
Danio rerio (A1A5H8), Danio rerio
Manually annotated by BRENDA team
Lemeer, S.; Jopling, C.; Naji, F.; Ruijtenbeek, R.; Slijper, M.; Heck, A.J.; den Hertog, J.
Protein-tyrosine kinase activity profiling in knock down zebrafish embryos
PLoS ONE
7
581
2007
Danio rerio
-
Manually annotated by BRENDA team