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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Gallus gallus
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2.7.10.1 receptor protein-tyrosine kinaseIUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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- 2.7.10.1
- angiogenesis
- leukemia
-
nsclc
-
non-small
- myeloid
- adenocarcinoma
- tumour
- women
- subtypes
- estrogen
- vessel
-
progression-free
- mapk
- gastrointestinal
- metastases
- marrow
- node
- erk
-
angiogenic
- colorectal
- 3-kinase
-
first-line
-
resect
- mesenchymal
-
mitogen
-
hematopoietic
- phosphatidylinositol
-
clinicopathological
- gastric
- ovarian
- tumorigenesis
- progesterone
-
autocrine
-
neurotrophic
- neoplasm
-
signal-regulated
-
immunotherapy
- integrins
- sarcoma
- glioblastoma
-
radiotherapy
-
oncology
-
relapse
-
monotherapy
- analysis
- pharmacology
- synthesis
- diagnostics
- drug development
- medicine
The taxonomic range for the selected organisms is: Gallus gallus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Adhesion-related kinase
-
-
-
-
Anaplastic lymphoma kinase
-
-
-
-
AXL oncogene
-
-
-
-
Brain-specific kinase
-
-
-
-
Breathless protein
-
-
-
-
c-erbB3
-
-
-
-
c-fgr
-
-
-
-
c-fms
-
-
-
-
c-kit
-
-
-
-
c-Kit tyrosine kinase
-
-
-
-
C-mer
-
-
-
-
c-met
-
-
-
-
C-ret
-
-
-
-
C14
-
-
-
-
Cadherin 96Ca
-
-
-
-
CD115 antigen
-
-
-
-
CD117 antigen
-
-
-
-
CD135 antigen
-
-
-
-
CD136 antigen
-
-
-
-
CD140a antigen
-
-
-
-
CD140b antigen
-
-
-
-
CD167a antigen
-
-
-
-
CD202b antigen
-
-
-
-
CD220 antigen
-
-
-
-
CD221 antigen
-
-
-
-
CD246 antigen
-
-
-
-
CDW136
-
-
-
-
CEK4
-
-
-
-
Cell adhesion kinase
-
-
-
-
Derailed protein
-
-
-
-
DFGF-R1
-
-
-
-
Discoidin receptor tyrosine kinase
-
-
-
-
Doughnut protein
-
-
-
-
Dror
-
-
-
-
Drosophila relative of ERBB
-
-
-
-
DRT
-
-
-
-
EBK
-
-
-
-
EGF receptor tyrosine kinase
-
-
-
-
Egfr
-
-
-
-
EGFr TK
-
-
-
-
Egg laying defective protein 15
-
-
-
-
ELK
-
-
-
-
Embryonic brain kinase
-
-
-
-
Endothelial kinase receptor EK1
-
-
-
-
EPH-and ELK-related kinase
-
-
-
-
Epidermal growth factor receptor-related protein
-
-
-
-
Epithelial cell kinase
-
-
-
-
erbB tyrosine kinase
-
-
-
-
ErbB2 kinase
-
-
-
-
ERK
-
-
-
-
ETK
-
-
-
-
Fms proto-oncogene
-
-
-
-
GCTK
-
-
-
-
GP145-TrkB
-
-
-
-
GP145-TrkB/GP95-TrkB
-
-
-
-
GP145-TrkC
-
-
-
-
Gurken receptor
-
-
-
-
Heartless protein
-
-
-
-
HEK
-
-
-
-
HEK3
-
-
-
-
HEK4
-
-
-
-
HEK6
-
-
-
-
Heparin-binding growth factor receptor
-
-
-
-
HGF receptor
-
-
-
-
HGF-SF receptor
-
-
-
-
hydroxyaryl-protein kinase
-
-
-
-
HYK
-
-
-
-
ILP receptor
-
-
-
-
insulin receptor protein-tyrosine kinase
-
-
-
-
IR-related receptor
-
-
-
-
IRK
-
-
-
-
IRR
-
-
-
-
Keratinocyte growth factor receptor
-
-
-
-
Kinase insert domain receptor
-
-
-
-
Kinase NYK
-
-
-
-
Kinase VIK
-
-
-
-
Linotte protein
-
-
-
-
MEK4
-
-
-
-
Met proto-oncogene tyrosine kinase
-
-
-
-
Met-related kinase
-
-
-
-
MFR
-
-
-
-
MIR
-
-
-
-
MLN 19
-
-
-
-
mROR1
-
-
-
-
mROR2
-
-
-
-
MSP receptor
-
-
-
-
NET
-
-
-
-
NEU proto-oncogene
-
-
-
-
Neurospecific receptor tyrosine kinase
-
-
-
-
NRTK
-
-
-
-
NUK
-
-
-
-
P140 TEK
-
-
-
-
p140-TrkA
-
-
-
-
p180erbB4
-
-
-
-
p185-Ron
-
-
-
-
p185erbB2
-
-
-
-
Pagliaccio
-
-
-
-
PDGF-R-alpha
-
-
-
-
PDGF-R-beta
-
-
-
-
PDGFR kinase
-
-
-
-
Protein-tyrosine kinase byk
-
-
-
-
Protein-tyrosine kinase receptor MPK-11
-
-
-
-
Proto-oncogene tyrosine-protein kinase Kit
-
-
-
-
Receptor protein-tyrosine kinase HEK11
-
-
-
-
Receptor protein-tyrosine kinase HEK5
-
-
-
-
Receptor protein-tyrosine kinase HEK7
-
-
-
-
Receptor protein-tyrosine kinase HEK8
-
-
-
-
Receptor protein-tyrosine kinase TKT
-
-
-
-
Receptor tyrosine kinase MerTK
-
-
-
-
Receptor-activated Janus kinase
-
-
-
-
RTK
-
-
-
-
SCFR
-
-
-
-
Slow nerve growth factor receptor
-
-
-
-
Stem cell-derived tyrosine kinase
-
-
-
-
Torpedo protein
-
-
-
-
TRK1 transforming tyrosine kinase protein
-
-
-
-
TrkB tyrosine kinase
-
-
-
-
TrkC tyrosine kinase
-
-
-
-
Tunica interna endothelial cell kinase
-
-
-
-
Tyrosine kinase CEK6 receptor
-
-
-
-
Tyrosine kinase DDR
-
-
-
-
Tyrosine kinase receptor HD-14
-
-
-
-
Tyrosine kinase-type cell surface receptor HER2
-
-
-
-
Tyrosine kinase-type cell surface receptor HER3
-
-
-
-
Tyrosine kinase-type cell surface receptor HER4
-
-
-
-
Tyrosine-protein kinase CAK
-
-
-
-
Tyrosine-protein kinase CEK9
-
-
-
-
Tyrosine-protein kinase DTK
-
-
-
-
Tyrosine-protein kinase FLT3
-
-
-
-
Tyrosine-protein kinase FRT
-
-
-
-
Tyrosine-protein kinase receptor CEK10
-
-
-
-
Tyrosine-protein kinase receptor CEK11
-
-
-
-
Tyrosine-protein kinase receptor CEK5
-
-
-
-
Tyrosine-protein kinase receptor CEK7
-
-
-
-
Tyrosine-protein kinase receptor CEK8
-
-
-
-
Tyrosine-protein kinase receptor CEPHA7
-
-
-
-
Tyrosine-protein kinase receptor ECK
-
-
-
-
Tyrosine-protein kinase receptor EEK
-
-
-
-
Tyrosine-protein kinase receptor EPH
-
-
-
-
Tyrosine-protein kinase receptor ESK
-
-
-
-
Tyrosine-protein kinase receptor ETK1
-
-
-
-
Tyrosine-protein kinase receptor FLT
-
-
-
-
Tyrosine-protein kinase receptor FLT3
-
-
-
-
Tyrosine-protein kinase receptor FLT4
-
-
-
-
Tyrosine-protein kinase receptor HTK
-
-
-
-
Tyrosine-protein kinase receptor PAG
-
-
-
-
Tyrosine-protein kinase receptor QEK5
-
-
-
-
Tyrosine-protein kinase receptor REK4
-
-
-
-
Tyrosine-protein kinase receptor SEK
-
-
-
-
Tyrosine-protein kinase receptor TCK
-
-
-
-
Tyrosine-protein kinase receptor TEK
-
-
-
-
Tyrosine-protein kinase receptor XEK
-
-
-
-
Tyrosine-protein kinase receptor XELK
-
-
-
-
Tyrosine-protein kinase receptor ZEK1
-
-
-
-
Tyrosine-protein kinase receptor ZEK2
-
-
-
-
Tyrosine-protein kinase receptor ZEK3
-
-
-
-
Tyrosine-protein kinase RSE
-
-
-
-
Tyrosine-protein kinase SKY
-
-
-
-
Vascular permeability factor receptor
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + protein
ADP + protein tyrosine phosphate
autophosphorylation
-
-
?
additional information
?
-
may play an important role during development and in signal transduction pathways
-
-
?
additional information
?
-
-
may play an important role during development and in signal transduction pathways
-
-
?
additional information
?
-
Cek9 plays an active role in embryonic signal transduction pathways
-
-
?
additional information
?
-
-
Cek9 plays an active role in embryonic signal transduction pathways
-
-
?
additional information
?
-
Cek8 suggests its involvement in cellular survival or cell-cell interactions for specific subpopulations of developing motoneurons
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
may play an important role during development and in signal transduction pathways
-
-
?
additional information
?
-
-
may play an important role during development and in signal transduction pathways
-
-
?
additional information
?
-
Cek9 plays an active role in embryonic signal transduction pathways
-
-
?
additional information
?
-
-
Cek9 plays an active role in embryonic signal transduction pathways
-
-
?
additional information
?
-
Cek8 suggests its involvement in cellular survival or cell-cell interactions for specific subpopulations of developing motoneurons
-
-
?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
in the skeletal muscle of the thigh a sharp decrease in Cek5 expression is detected at the time of terminal muscle differentiation
expression of chick EphA7 during segmentation of the central and peripheral nervous system EphA7 expression is restricted to prosomeres 1 and 2 in the diencephalon and all the rhombomeres in the hindbrain during segmentation stages. Later on, a superimposed pattern appears that correlates with the formation of several axonal tracts. In the somitic mesoderm, the expression correlates with segmentation and the guidance of both neural crest and motor axons through the sclerotomes
-
4fold increase in expression in vagal versus sacral neural crest cells
expression of Cek5 in the brain gradually diminishes during embryonic development
Cek5 variant is expressed in the brain, but not in other tissues of the 10-day chick embryo
expression of Cek5 in the brain gradually diminishes during embryonic development
Cek5 variant is expressed in the brain, but not in other tissues of the 10-day chick embryo
at embryonic day 2, Cek9 immunoreactivity is concentrated in the eye, the brain, the posterior region of the neural tube, and the most recently formed somites. Later in development, Cek9 expression is widespread but particularly prominent in neural tissues
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). MUSK_CHICK
947
1
105589
Swiss-Prot
Secretory Pathway (Reliability: 1)
VGFR1_CHICK
1327
0
149426
Swiss-Prot
Secretory Pathway (Reliability: 4)
FGFR3_CHICK
806
2
89730
Swiss-Prot
Secretory Pathway (Reliability: 3)
NTRK1_CHICK
778
0
87339
Swiss-Prot
Mitochondrion (Reliability: 4)
NTRK2_CHICK
818
1
91737
Swiss-Prot
Secretory Pathway (Reliability: 4)
NTRK3_CHICK
827
2
93181
Swiss-Prot
Secretory Pathway (Reliability: 1)
EGFR_CHICK
703
1
77427
Swiss-Prot
Secretory Pathway (Reliability: 2)
EPHA3_CHICK
983
1
109910
Swiss-Prot
Secretory Pathway (Reliability: 4)
EPHA4_CHICK
986
1
109483
Swiss-Prot
Secretory Pathway (Reliability: 1)
EPHA5_CHICK
1013
0
112246
Swiss-Prot
Secretory Pathway (Reliability: 2)
PGFRA_CHICK
1087
2
122941
Swiss-Prot
Secretory Pathway (Reliability: 1)
ROS1_CHICK
2311
1
260961
Swiss-Prot
Secretory Pathway (Reliability: 4)
TYRO3_CHICK
873
1
96402
Swiss-Prot
Secretory Pathway (Reliability: 2)
KIT_CHICK
960
2
107312
Swiss-Prot
Secretory Pathway (Reliability: 2)
EPHA7_CHICK
993
1
111367
Swiss-Prot
Secretory Pathway (Reliability: 2)
EPHB1_CHICK
984
1
109558
Swiss-Prot
other Location (Reliability: 1)
EPHB2_CHICK
1004
1
111963
Swiss-Prot
Secretory Pathway (Reliability: 1)
FGFR1_CHICK
819
1
91577
Swiss-Prot
Secretory Pathway (Reliability: 1)
FGFR2_CHICK
823
1
92299
Swiss-Prot
Secretory Pathway (Reliability: 1)
EPHB3_CHICK
988
1
109579
Swiss-Prot
Mitochondrion (Reliability: 3)
EPHB5_CHICK
1002
1
111947
Swiss-Prot
Secretory Pathway (Reliability: 5)
A0A1D5PNF3_CHICK
877
2
100584
TrEMBL
Secretory Pathway (Reliability: 4)
Q4PLA5_CHICK
1292
1
145119
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q3AJC5_CHICK
1300
1
141760
TrEMBL
Secretory Pathway (Reliability: 2)
F1P382_CHICK
1327
0
149442
TrEMBL
Secretory Pathway (Reliability: 4)
A0A1D5PVH7_CHICK
1363
1
154101
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1D5NZB4_CHICK
1177
1
131017
TrEMBL
Secretory Pathway (Reliability: 2)
F1NGV4_CHICK
1140
2
126536
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1D5PT01_CHICK
855
1
96954
TrEMBL
Secretory Pathway (Reliability: 3)
F1NCL8_CHICK
803
0
89965
TrEMBL
Secretory Pathway (Reliability: 1)
E1C5T2_CHICK
1404
1
153812
TrEMBL
Secretory Pathway (Reliability: 2)
F1P3V0_CHICK
974
1
106224
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1L1S0E6_CHICK
1106
2
125024
TrEMBL
other Location (Reliability: 4)
Q9YI42_CHICK
68
0
7785
TrEMBL
other Location (Reliability: 1)
F1NHC7_CHICK
995
1
111034
TrEMBL
Secretory Pathway (Reliability: 1)
Q90ZF0_CHICK
94
0
10197
TrEMBL
other Location (Reliability: 2)
Q90777_CHICK
974
1
106166
TrEMBL
Secretory Pathway (Reliability: 2)
F1NHS5_CHICK
554
0
61346
TrEMBL
other Location (Reliability: 1)
F1N870_CHICK
1087
2
122817
TrEMBL
Secretory Pathway (Reliability: 1)
F1NKN2_CHICK
1316
0
147569
TrEMBL
Secretory Pathway (Reliability: 1)
Q9YI40_CHICK
68
0
7791
TrEMBL
other Location (Reliability: 1)
F1NLU3_CHICK
558
0
61978
TrEMBL
other Location (Reliability: 5)
A0A1D5PMV1_CHICK
990
1
108525
TrEMBL
other Location (Reliability: 2)
A0A1D5PNP7_CHICK
927
1
103479
TrEMBL
other Location (Reliability: 1)
A0A1D5PUU0_CHICK
955
1
104784
TrEMBL
other Location (Reliability: 2)
A0A1D5PHZ9_CHICK
1220
1
137366
TrEMBL
other Location (Reliability: 2)
A0A1D5P6T3_CHICK
1324
1
149744
TrEMBL
other Location (Reliability: 3)
Q677M1_CHICK
1348
1
150122
TrEMBL
Secretory Pathway (Reliability: 1)
Q9PWN6_CHICK
989
1
112124
TrEMBL
other Location (Reliability: 2)
A0A1D5NWM4_CHICK
1200
2
132206
TrEMBL
other Location (Reliability: 2)
A3E346_CHICK
256
1
28478
TrEMBL
Secretory Pathway (Reliability: 4)
H9KZZ2_CHICK
1333
1
149785
TrEMBL
Secretory Pathway (Reliability: 1)
F1P4I4_CHICK
1003
1
111338
TrEMBL
Secretory Pathway (Reliability: 1)
Q8AV70_CHICK
718
1
79540
TrEMBL
other Location (Reliability: 1)
A0A1D5PKH0_CHICK
1226
2
136472
TrEMBL
Secretory Pathway (Reliability: 2)
F1NB88_CHICK
969
1
108632
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1L1RML1_CHICK
1105
0
125001
TrEMBL
Secretory Pathway (Reliability: 3)
F1N871_CHICK
1378
1
156502
TrEMBL
Secretory Pathway (Reliability: 1)
Q98TD0_CHICK
969
1
108573
TrEMBL
Secretory Pathway (Reliability: 1)
F1P258_CHICK
1276
1
143690
TrEMBL
other Location (Reliability: 2)
F1NC62_CHICK
979
1
108782
TrEMBL
Secretory Pathway (Reliability: 3)
F1NLR2_CHICK
873
1
96356
TrEMBL
Secretory Pathway (Reliability: 2)
Q08757_CHICK
1404
1
153851
TrEMBL
Secretory Pathway (Reliability: 2)
F1NIS8_CHICK
971
1
107962
TrEMBL
other Location (Reliability: 2)
F1NJX6_CHICK
983
1
109764
TrEMBL
Secretory Pathway (Reliability: 4)
A0A3Q2TWI3_CHICK
779
0
86886
TrEMBL
other Location (Reliability: 3)
Q4PLA4_CHICK
1276
1
143674
TrEMBL
other Location (Reliability: 2)
F1NHC6_CHICK
1002
1
111665
TrEMBL
Secretory Pathway (Reliability: 5)
Q90749_CHICK
824
1
92425
TrEMBL
Secretory Pathway (Reliability: 1)
Q5F3X2_CHICK
873
1
99397
TrEMBL
Secretory Pathway (Reliability: 3)
Q9PSH2_CHICK
599
0
66363
TrEMBL
other Location (Reliability: 2)
Q2HZD7_CHICK
1319
1
146222
TrEMBL
Secretory Pathway (Reliability: 3)
A0A3Q3AKW5_CHICK
845
1
96039
TrEMBL
Secretory Pathway (Reliability: 3)
F1NFQ9_CHICK
1024
2
114528
TrEMBL
Secretory Pathway (Reliability: 2)
A0A1L1S0Q6_CHICK
1233
1
139163
TrEMBL
Secretory Pathway (Reliability: 1)
P79884_CHICK
217
0
24798
TrEMBL
other Location (Reliability: 1)
M1SQS2_CHICK
1363
1
154175
TrEMBL
Secretory Pathway (Reliability: 1)
Q90975_CHICK
1382
1
154451
TrEMBL
Secretory Pathway (Reliability: 1)
F1P040_CHICK
1382
1
154381
TrEMBL
Secretory Pathway (Reliability: 1)
Q9PSD4_CHICK
1107
0
125087
TrEMBL
Secretory Pathway (Reliability: 3)
F1NSE6_CHICK
1013
0
112387
TrEMBL
Secretory Pathway (Reliability: 3)
A0A1D5PC06_CHICK
901
1
101390
TrEMBL
other Location (Reliability: 3)
A0A1D5PES4_CHICK
901
0
100276
TrEMBL
Secretory Pathway (Reliability: 3)
Q9W6F6_CHICK
1137
1
127928
TrEMBL
other Location (Reliability: 2)
Q90699_CHICK
790
0
88670
TrEMBL
Secretory Pathway (Reliability: 2)
A0A1D5P163_CHICK
861
2
97031
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1D5PXE5_CHICK
1288
1
141238
TrEMBL
other Location (Reliability: 2)
A0A3Q2U0L8_CHICK
713
0
79918
TrEMBL
Secretory Pathway (Reliability: 1)
Q2EJ72_CHICK
1235
2
135680
TrEMBL
Secretory Pathway (Reliability: 1)
H9KZZ1_CHICK
790
0
88644
TrEMBL
Secretory Pathway (Reliability: 2)
Q90601_CHICK
1064
0
120465
TrEMBL
Secretory Pathway (Reliability: 3)
A0A3Q2UKD3_CHICK
1128
1
126361
TrEMBL
Secretory Pathway (Reliability: 2)
A0A3Q2TWZ3_CHICK
1001
0
111090
TrEMBL
Secretory Pathway (Reliability: 3)
F1NQL9_CHICK
2311
1
260928
TrEMBL
Secretory Pathway (Reliability: 4)
F1NAX7_CHICK
1000
1
111749
TrEMBL
Secretory Pathway (Reliability: 4)
A0A3Q2U7B1_CHICK
616
0
68227
TrEMBL
other Location (Reliability: 2)
A0A1D5NU66_CHICK
1073
0
120219
TrEMBL
Secretory Pathway (Reliability: 2)
M1S0Z2_CHICK
1363
1
154115
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q2TWJ4_CHICK
849
0
94468
TrEMBL
Secretory Pathway (Reliability: 3)
A0A1D5NXU2_CHICK
824
1
92355
TrEMBL
Secretory Pathway (Reliability: 1)
A0M8T9_CHICK
1382
1
154400
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q2UH46_CHICK
1281
0
144019
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1D5NY91_CHICK
762
0
85126
TrEMBL
other Location (Reliability: 2)
A0A1D5NX49_CHICK
947
1
105549
TrEMBL
Secretory Pathway (Reliability: 1)
F1N869_CHICK
967
2
107786
TrEMBL
Secretory Pathway (Reliability: 1)
Q91015_CHICK
67
0
7906
TrEMBL
other Location (Reliability: 4)
F1NW21_CHICK
1348
1
150112
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1D5P7I7_CHICK
1074
1
120330
TrEMBL
Secretory Pathway (Reliability: 2)
A0A1D5PEH0_CHICK
1319
1
146324
TrEMBL
Secretory Pathway (Reliability: 3)
Q90836_CHICK
527
0
58353
TrEMBL
Secretory Pathway (Reliability: 2)
Q9YI41_CHICK
68
0
7793
TrEMBL
other Location (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
identification of a complete Cek7 receptor protein tyrosine kinase coding sequence and cDNAs of alternatively spliced transcripts
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
RET is a cell-intrinsic marker that regulates hindgut colonization by sacral neural crest cells, and has the ability to promote the enteric nervous system developmental potential of sacral neural crest cells towards that of vagal neural crest cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Rattus norvegicus (O08775), Homo sapiens (P00533), Homo sapiens (P04629), Homo sapiens (P06213), Homo sapiens (P07949), Homo sapiens (P17948), Homo sapiens (Q9UM73), Drosophila melanogaster (P04412), Caenorhabditis elegans (Q10656), Gallus gallus (Q91044), Gallus gallus (Q91987)
Araujo, M.; Nieto, M.A.
The expression of chick EphA7 during segmentation of the central and peripheral nervous system
Mech. Dev.
68
173-177
1997
Gallus gallus (O42422)
Pasquale, E.B.
A distinctive family of embryonic protein-tyrosine kinase receptors
Proc. Natl. Acad. Sci. USA
87
5812-5816
1990
Gallus gallus (P18460), Gallus gallus (P18461), Gallus gallus
Lee, P.L.; Johnson, D.E.; Cousens, L.S.; Fried, V.A.; Williams, L.T.
Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor
Science
245
57-60
1989
Gallus gallus (P21804)
Pasquale, E.B.; Singer, S.J.
Identification of a developmentally regulated protein-tyrosine kinase by using anti-phosphotyrosine antibodies to screen a cDNA expression library
Proc. Natl. Acad. Sci. USA
86
5449-5453
1989
Gallus gallus (P21804), Gallus gallus
Pasquale, E.B.
Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family
Cell Regul.
2
523-534
1991
Gallus gallus (P28693), Gallus gallus
Sajjadi, F.G.; Pasquale, E.B.
Five novel avian Eph-related tyrosine kinases are differentially expressed
Oncogene
8
1807-1813
1993
Gallus gallus (P28693), Gallus gallus (P54755), Gallus gallus (Q07496), Gallus gallus (Q07497)
Sajjadi, F.G.; Pasquale, E.B.; Subramani, S.
Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor
New Biol.
3
769-778
1991
Gallus gallus (P29318), Gallus gallus, Mus musculus (P29319), Mus musculus
Siever, D.A.; Verderame, M.F.
Identification of a complete Cek7 receptor protein tyrosine kinase coding sequence and cDNAs of alternatively spliced transcripts
Gene
148
219-226
1994
Gallus gallus (P54755), Gallus gallus
Ohta, K.; Nakamura, M.; Hirokawa, K.; Tanaka, S.; Iwama, A.; Suda, T.; Ando, M.; Tanaka, H.
The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development
Mech. Dev.
54
59-69
1996
Gallus gallus (Q07496)
Soans, C.; Holash, J.A.; Pavlova, Y.; Pasquale, E.B.
Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine kinase Cek9
J. Cell Biol.
135
781-795
1996
Gallus gallus (Q07497), Gallus gallus
Sasaki, E.; Okamura, H.; Chikamune, T.; Kanai, Y.; Watanabe, M.; Naito, M.; Sakurai, M.
Cloning and expression of the chicken c-kit proto-oncogene
Gene
128
257-261
1993
Gallus gallus (Q08156), Gallus gallus
Wagh, P.K.; Peace, B.E.; Waltz, S.E.
Met-related receptor tyrosine kinase Ron in tumor growth and metastasis
Adv. Cancer Res.
100
1-33
2008
Bos taurus, Canis lupus, Gallus gallus, Equus caballus, Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus, Strongylocentrotus purpuratus, Takifugu rubripes
EXTERNAL LINKS (specific for EC-Number 2.7.10.1)
Transporter Classification Database (TCDB): 8.A.23.1.30, 8.A.23.1.29, 8.A.23.1.9, 8.A.23.1.38, 8.A.23.1.13, 8.A.23.1.39, 8.A.23.1.17, 1.A.87.2.6, 8.A.23.1.37, 8.A.23.1.7, 8.A.23.1.15, 8.A.23.1.16
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