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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Drosophila melanogaster
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2.7.10.1 receptor protein-tyrosine kinaseIUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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- 2.7.10.1
- angiogenesis
- leukemia
-
nsclc
-
non-small
- myeloid
- adenocarcinoma
- tumour
- women
- subtypes
- estrogen
- vessel
-
progression-free
- mapk
- gastrointestinal
- metastases
- marrow
- node
- erk
-
angiogenic
- colorectal
- 3-kinase
-
first-line
-
resect
- mesenchymal
-
mitogen
-
hematopoietic
- phosphatidylinositol
-
clinicopathological
- gastric
- ovarian
- tumorigenesis
- progesterone
-
autocrine
-
neurotrophic
- neoplasm
-
signal-regulated
-
immunotherapy
- integrins
- sarcoma
- glioblastoma
-
radiotherapy
-
oncology
-
relapse
-
monotherapy
- analysis
- pharmacology
- synthesis
- diagnostics
- drug development
- medicine
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Adhesion-related kinase
-
-
-
-
Anaplastic lymphoma kinase
AXL oncogene
-
-
-
-
Brain-specific kinase
-
-
-
-
Breathless protein
-
-
-
-
c-erbB3
-
-
-
-
c-fgr
-
-
-
-
c-fms
-
-
-
-
c-kit
-
-
-
-
c-Kit tyrosine kinase
-
-
-
-
C-mer
-
-
-
-
c-met
-
-
-
-
C-ret
-
-
-
-
C14
-
-
-
-
Cadherin 96Ca
-
-
-
-
CD115 antigen
-
-
-
-
CD117 antigen
-
-
-
-
CD135 antigen
-
-
-
-
CD136 antigen
-
-
-
-
CD140a antigen
-
-
-
-
CD140b antigen
-
-
-
-
CD167a antigen
-
-
-
-
CD202b antigen
-
-
-
-
CD220 antigen
-
-
-
-
CD221 antigen
-
-
-
-
CD246 antigen
-
-
-
-
CDW136
-
-
-
-
CEK4
-
-
-
-
Cell adhesion kinase
-
-
-
-
Derailed protein
-
-
-
-
DFGF-R1
-
-
-
-
Discoidin receptor tyrosine kinase
-
-
-
-
Doughnut protein
-
-
-
-
Dror
-
-
-
-
Drosophila relative of ERBB
-
-
-
-
DRT
-
-
-
-
EBK
-
-
-
-
EGF receptor tyrosine kinase
-
-
-
-
Egfr
EGFr TK
-
-
-
-
Egg laying defective protein 15
-
-
-
-
ELK
-
-
-
-
Embryonic brain kinase
-
-
-
-
Endothelial kinase receptor EK1
-
-
-
-
EPH-and ELK-related kinase
-
-
-
-
epidermal growth factor receptor
Epidermal growth factor receptor-related protein
-
-
-
-
Epithelial cell kinase
-
-
-
-
erbB tyrosine kinase
-
-
-
-
ErbB2 kinase
-
-
-
-
ERK
ETK
-
-
-
-
fibroblast growth factor receptor homolog 2
-
Fms proto-oncogene
-
-
-
-
GCTK
-
-
-
-
GP145-TrkB
-
-
-
-
GP145-TrkB/GP95-TrkB
-
-
-
-
GP145-TrkC
-
-
-
-
Gurken receptor
-
-
-
-
Heartless protein
-
-
-
-
HEK
-
-
-
-
HEK3
-
-
-
-
HEK4
-
-
-
-
HEK6
-
-
-
-
Heparin-binding growth factor receptor
-
-
-
-
HGF receptor
-
-
-
-
HGF-SF receptor
-
-
-
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hydroxyaryl-protein kinase
-
-
-
-
HYK
-
-
-
-
ILP receptor
-
-
-
-
insulin receptor protein-tyrosine kinase
-
-
-
-
IR-related receptor
-
-
-
-
IRK
-
-
-
-
IRR
-
-
-
-
Keratinocyte growth factor receptor
-
-
-
-
Kinase insert domain receptor
-
-
-
-
Kinase NYK
-
-
-
-
Kinase VIK
-
-
-
-
Linotte protein
-
-
-
-
MEK4
-
-
-
-
Met proto-oncogene tyrosine kinase
-
-
-
-
Met-related kinase
-
-
-
-
MFR
-
-
-
-
MIR
-
-
-
-
MLN 19
-
-
-
-
mROR1
-
-
-
-
mROR2
-
-
-
-
MSP receptor
-
-
-
-
NET
-
-
-
-
NEU proto-oncogene
-
-
-
-
Neurospecific receptor tyrosine kinase
-
-
-
-
NRTK
-
-
-
-
NUK
-
-
-
-
P140 TEK
-
-
-
-
p140-TrkA
-
-
-
-
p180erbB4
-
-
-
-
p185-Ron
-
-
-
-
p185erbB2
-
-
-
-
Pagliaccio
-
-
-
-
PDGF-R-alpha
-
-
-
-
PDGF-R-beta
-
-
-
-
PDGFR kinase
-
-
-
-
Protein-tyrosine kinase byk
-
-
-
-
Protein-tyrosine kinase receptor MPK-11
-
-
-
-
Proto-oncogene tyrosine-protein kinase Kit
-
-
-
-
Receptor protein-tyrosine kinase HEK11
-
-
-
-
Receptor protein-tyrosine kinase HEK5
-
-
-
-
Receptor protein-tyrosine kinase HEK7
-
-
-
-
Receptor protein-tyrosine kinase HEK8
-
-
-
-
Receptor protein-tyrosine kinase TKT
-
-
-
-
Receptor tyrosine kinase MerTK
-
-
-
-
Receptor-activated Janus kinase
-
-
-
-
RTK
SCFR
-
-
-
-
Slow nerve growth factor receptor
-
-
-
-
Stem cell-derived tyrosine kinase
-
-
-
-
Torpedo protein
-
-
-
-
TRK1 transforming tyrosine kinase protein
-
-
-
-
TrkB tyrosine kinase
-
-
-
-
TrkC tyrosine kinase
-
-
-
-
Tunica interna endothelial cell kinase
-
-
-
-
Tyrosine kinase CEK6 receptor
-
-
-
-
Tyrosine kinase DDR
-
-
-
-
Tyrosine kinase receptor HD-14
-
-
-
-
Tyrosine kinase-type cell surface receptor HER2
-
-
-
-
Tyrosine kinase-type cell surface receptor HER3
-
-
-
-
Tyrosine kinase-type cell surface receptor HER4
-
-
-
-
Tyrosine-protein kinase CAK
-
-
-
-
Tyrosine-protein kinase CEK9
-
-
-
-
Tyrosine-protein kinase DTK
-
-
-
-
Tyrosine-protein kinase FLT3
-
-
-
-
Tyrosine-protein kinase FRT
-
-
-
-
Tyrosine-protein kinase receptor CEK10
-
-
-
-
Tyrosine-protein kinase receptor CEK11
-
-
-
-
Tyrosine-protein kinase receptor CEK5
-
-
-
-
Tyrosine-protein kinase receptor CEK7
-
-
-
-
Tyrosine-protein kinase receptor CEK8
-
-
-
-
Tyrosine-protein kinase receptor CEPHA7
-
-
-
-
Tyrosine-protein kinase receptor ECK
-
-
-
-
Tyrosine-protein kinase receptor EEK
-
-
-
-
Tyrosine-protein kinase receptor EPH
-
-
-
-
Tyrosine-protein kinase receptor ESK
-
-
-
-
Tyrosine-protein kinase receptor ETK1
-
-
-
-
Tyrosine-protein kinase receptor FLT
-
-
-
-
Tyrosine-protein kinase receptor FLT3
-
-
-
-
Tyrosine-protein kinase receptor FLT4
-
-
-
-
Tyrosine-protein kinase receptor HTK
-
-
-
-
Tyrosine-protein kinase receptor PAG
-
-
-
-
Tyrosine-protein kinase receptor QEK5
-
-
-
-
Tyrosine-protein kinase receptor REK4
-
-
-
-
Tyrosine-protein kinase receptor SEK
-
-
-
-
Tyrosine-protein kinase receptor TCK
-
-
-
-
Tyrosine-protein kinase receptor TEK
-
-
-
-
Tyrosine-protein kinase receptor XEK
-
-
-
-
Tyrosine-protein kinase receptor XELK
-
-
-
-
Tyrosine-protein kinase receptor ZEK1
-
-
-
-
Tyrosine-protein kinase receptor ZEK2
-
-
-
-
Tyrosine-protein kinase receptor ZEK3
-
-
-
-
Tyrosine-protein kinase RSE
-
-
-
-
Tyrosine-protein kinase SKY
-
-
-
-
tyrosine-protein kinase transmembrane receptor Ror
-
Vascular permeability factor receptor
-
-
-
-
Anaplastic lymphoma kinase
-
-
-
-
Egfr
-
-
-
-
ERK
-
-
-
-
RTK
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
-
?
additional information
?
-
important role in neurogenesis
-
-
?
additional information
?
-
the neurotrophic receptor may function during early stages of neural development
-
-
?
additional information
?
-
Dnrk may play an important role in neural development during Drosophila embryogenesis
-
-
?
additional information
?
-
essential for migration of tracheal and specific midline glial cells
-
-
?
additional information
?
-
required for directed tracheal cell extension
-
-
?
additional information
?
-
part of a novel signal transduction cascade involved in learning and memory
-
-
?
additional information
?
-
receptor protein-tyrosine kinase involvement in key aspects of neuronal pathway recognition
-
-
?
additional information
?
-
essential for the pathfinding ability of expressing neurons, participates in a mechanism required for muscle attachment site selection
-
-
?
additional information
?
-
activity of inr gene appears to be required in the embryonic epidermis and nervous system among others, since development of the cuticle, as well as the peripheral and central nervous systems are affected by inr mutations
-
-
?
additional information
?
-
determination of anterior and posterior terminal structures of Drosophila embryos requires activation of two genes encoding putative protein kinases, torso and D-raf
-
-
?
additional information
?
-
sevenless gene determines the fate of a single photoreceptor cell type in the eye of Drosophila
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
-
?
additional information
?
-
important role in neurogenesis
-
-
?
additional information
?
-
the neurotrophic receptor may function during early stages of neural development
-
-
?
additional information
?
-
Dnrk may play an important role in neural development during Drosophila embryogenesis
-
-
?
additional information
?
-
essential for migration of tracheal and specific midline glial cells
-
-
?
additional information
?
-
required for directed tracheal cell extension
-
-
?
additional information
?
-
part of a novel signal transduction cascade involved in learning and memory
-
-
?
additional information
?
-
receptor protein-tyrosine kinase involvement in key aspects of neuronal pathway recognition
-
-
?
additional information
?
-
essential for the pathfinding ability of expressing neurons, participates in a mechanism required for muscle attachment site selection
-
-
?
additional information
?
-
activity of inr gene appears to be required in the embryonic epidermis and nervous system among others, since development of the cuticle, as well as the peripheral and central nervous systems are affected by inr mutations
-
-
?
additional information
?
-
determination of anterior and posterior terminal structures of Drosophila embryos requires activation of two genes encoding putative protein kinases, torso and D-raf
-
-
?
additional information
?
-
sevenless gene determines the fate of a single photoreceptor cell type in the eye of Drosophila
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
spatial restriction of torso activity results from a localized activation of the torso protein at the anterior and posterior egg pole
in early embryos, DFR1 RNA expression, requiring both twist and snail proteins, is specific to mesodermal primordium and invaginated mesodermal cells. At later stages, putative muscle precursor cells and cells in the central nervous system express DFR1
expressed specifically in the developing nervous system
expressed in embryonic neuronal precursor cells including neuroblasts and CNS cells
expressed by a small subset of embryonic interneurons whose growth cones choose common pathways during development
dnt is expressed in dynamic patterns in the embryonic epidermis, at high level in epithelia adjacent to cells that are invaginating into the interior of the embryo, including ventral furrow, cephalic furrow, fore- and hindgut, optic lobe and tracheal pits
during embryogenesis, the Dnrk gene is expressed specifically in the developing nervous system
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
-
Sevenless receptor tyrosine kinase binds directly to either the suppressor of cytokine signalling SOCS36E or the adaptor protein Drk, i.e. downstream of receptor kinase. In a mechanistic model, the competition between these two proteins for binding to the same docking site results in either attenuation of the Sevenless receptor tyrosine kinase transduction in cells that should not develop R7 photoreceptors or amplification of the Ras-MAPK signal only in the R7 precursor
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). INSR_DROME
2144
0
239776
Swiss-Prot
other Location (Reliability: 4)
ROR1_DROME
685
1
78143
Swiss-Prot
Secretory Pathway (Reliability: 2)
ROR2_DROME
724
2
81837
Swiss-Prot
Secretory Pathway (Reliability: 3)
EGFR_DROME
1426
3
159718
Swiss-Prot
Secretory Pathway (Reliability: 2)
TORSO_DROME
923
0
105201
Swiss-Prot
Secretory Pathway (Reliability: 2)
7LESS_DROME
2554
1
287025
Swiss-Prot
other Location (Reliability: 2)
RYK1_DROME
610
1
68312
Swiss-Prot
Secretory Pathway (Reliability: 1)
RYK2_DROME
584
1
64938
Swiss-Prot
other Location (Reliability: 5)
FGFR1_DROME
729
2
82586
Swiss-Prot
Secretory Pathway (Reliability: 2)
FGFR2_DROME
1052
2
117813
Swiss-Prot
Secretory Pathway (Reliability: 1)
CAD96_DROME
773
2
86220
Swiss-Prot
Mitochondrion (Reliability: 3)
Q6SAK9_DROME
1325
2
147953
TrEMBL
other Location (Reliability: 5)
D0UY70_DROME
2049
1
229578
TrEMBL
other Location (Reliability: 1)
Q6SAM9_DROME
1325
2
147918
TrEMBL
other Location (Reliability: 5)
Q6SAG6_DROME
1325
2
148046
TrEMBL
other Location (Reliability: 5)
Q6SAI2_DROME
1325
2
147720
TrEMBL
other Location (Reliability: 4)
Q6SAM2_DROME
1325
2
147335
TrEMBL
Mitochondrion (Reliability: 5)
E3CTT7_DROME
845
0
97462
TrEMBL
other Location (Reliability: 2)
Q6SAA1_DROME
1325
2
148164
TrEMBL
other Location (Reliability: 5)
Q86NZ2_DROME
1322
2
147700
TrEMBL
other Location (Reliability: 5)
E1JHB6_DROME
1528
1
171797
TrEMBL
Secretory Pathway (Reliability: 1)
Q9VFE2_DROME
868
0
98350
TrEMBL
Secretory Pathway (Reliability: 2)
Q6SAR2_DROME
1325
2
147517
TrEMBL
Mitochondrion (Reliability: 4)
Q6SAP7_DROME
1325
2
147957
TrEMBL
other Location (Reliability: 5)
Q6SAK8_DROME
1325
1
147761
TrEMBL
other Location (Reliability: 5)
Q6SAB9_DROME
1325
2
147914
TrEMBL
other Location (Reliability: 5)
Q6SAG2_DROME
1325
2
147985
TrEMBL
other Location (Reliability: 5)
Q6SAL5_DROME
1325
2
147870
TrEMBL
other Location (Reliability: 5)
D0UY99_DROME
2050
1
229730
TrEMBL
other Location (Reliability: 1)
Q6SAF1_DROME
1325
2
147966
TrEMBL
other Location (Reliability: 5)
Q6SAI6_DROME
1325
2
148005
TrEMBL
other Location (Reliability: 5)
Q6SAC8_DROME
1325
2
148123
TrEMBL
other Location (Reliability: 5)
C7C415_DROME
2144
0
239838
TrEMBL
other Location (Reliability: 4)
Q7KT06_DROME
1235
2
138721
TrEMBL
Secretory Pathway (Reliability: 3)
Q6SAN1_DROME
1325
2
147974
TrEMBL
other Location (Reliability: 5)
Q6SAL4_DROME
1325
2
148003
TrEMBL
Mitochondrion (Reliability: 5)
M9PCX2_DROME
1568
1
176174
TrEMBL
Secretory Pathway (Reliability: 1)
Q6SAD0_DROME
1325
2
147830
TrEMBL
other Location (Reliability: 5)
Q6SAF2_DROME
1325
2
148341
TrEMBL
other Location (Reliability: 5)
Q6SAE6_DROME
1325
2
148034
TrEMBL
other Location (Reliability: 5)
E1JHB8_DROME
1474
1
166205
TrEMBL
Secretory Pathway (Reliability: 1)
Q6SAE4_DROME
1325
2
147885
TrEMBL
other Location (Reliability: 5)
Q6SAB4_DROME
1325
2
147884
TrEMBL
other Location (Reliability: 5)
D0UY94_DROME
2049
1
229521
TrEMBL
other Location (Reliability: 1)
Q6SAK5_DROME
1244
1
138748
TrEMBL
other Location (Reliability: 5)
Q6SAA7_DROME
1325
2
147483
TrEMBL
Mitochondrion (Reliability: 5)
D0UY97_DROME
2049
1
229588
TrEMBL
other Location (Reliability: 1)
Q6SAQ3_DROME
1325
2
147992
TrEMBL
other Location (Reliability: 5)
D0UYA9_DROME
2051
1
229864
TrEMBL
other Location (Reliability: 1)
E1JHA2_DROME
380
0
42142
TrEMBL
other Location (Reliability: 5)
Q6SAN0_DROME
1325
2
147953
TrEMBL
other Location (Reliability: 5)
Q6SAM0_DROME
1325
2
147894
TrEMBL
other Location (Reliability: 5)
Q6SAA8_DROME
1325
2
148052
TrEMBL
other Location (Reliability: 5)
D0UYA5_DROME
2040
1
228468
TrEMBL
other Location (Reliability: 1)
E1JHB7_DROME
1577
1
177277
TrEMBL
Secretory Pathway (Reliability: 1)
C7C416_DROME
2148
0
240160
TrEMBL
other Location (Reliability: 4)
Q8MLW0_DROME
1377
2
153602
TrEMBL
Secretory Pathway (Reliability: 1)
Q7KTI8_DROME
1503
1
169512
TrEMBL
Secretory Pathway (Reliability: 1)
Q8IPG1_DROME
1509
1
170104
TrEMBL
Secretory Pathway (Reliability: 1)
Q6SAG0_DROME
1325
2
147895
TrEMBL
other Location (Reliability: 5)
Q8IMC2_DROME
1047
1
117946
TrEMBL
Mitochondrion (Reliability: 3)
D0UY95_DROME
2049
1
229527
TrEMBL
other Location (Reliability: 1)
Q6SAE0_DROME
1325
2
148358
TrEMBL
other Location (Reliability: 5)
Q6SAL8_DROME
1325
2
147910
TrEMBL
other Location (Reliability: 5)
D1YSF9_DROME
1005
1
112949
TrEMBL
Mitochondrion (Reliability: 3)
Q6SAJ9_DROME
1325
2
147968
TrEMBL
other Location (Reliability: 5)
D0UY88_DROME
2049
1
229534
TrEMBL
other Location (Reliability: 1)
Q9XZL6_DROME
1035
1
116505
TrEMBL
Secretory Pathway (Reliability: 1)
Q6SAC1_DROME
1325
2
148164
TrEMBL
other Location (Reliability: 5)
Q6SAI7_DROME
1325
2
147947
TrEMBL
other Location (Reliability: 5)
Q59DQ4_DROME
1080
1
121678
TrEMBL
other Location (Reliability: 3)
Q6SAJ5_DROME
1325
2
147923
TrEMBL
other Location (Reliability: 5)
G7H807_DROME
882
1
97224
TrEMBL
other Location (Reliability: 3)
D0UYA1_DROME
2048
1
229448
TrEMBL
other Location (Reliability: 1)
B6IDV6_DROME
1468
1
165612
TrEMBL
Secretory Pathway (Reliability: 1)
D0UY98_DROME
2050
1
229753
TrEMBL
other Location (Reliability: 1)
D0UYA4_DROME
2050
1
229700
TrEMBL
other Location (Reliability: 1)
Q6SAM3_DROME
1325
2
147959
TrEMBL
other Location (Reliability: 5)
A0A0B4LF75_DROME
1019
2
113000
TrEMBL
Secretory Pathway (Reliability: 3)
Q6SAB0_DROME
1325
2
147860
TrEMBL
other Location (Reliability: 5)
Q6SAH2_DROME
1325
2
147740
TrEMBL
other Location (Reliability: 5)
D0UYA8_DROME
2051
1
229825
TrEMBL
other Location (Reliability: 1)
Q6SAF5_DROME
1325
2
147914
TrEMBL
other Location (Reliability: 5)
D0UYA0_DROME
2049
1
229575
TrEMBL
other Location (Reliability: 1)
Q6SAA4_DROME
1325
2
148011
TrEMBL
other Location (Reliability: 5)
D0UYA7_DROME
2054
1
230227
TrEMBL
other Location (Reliability: 1)
Q6SAA0_DROME
1325
2
147960
TrEMBL
other Location (Reliability: 5)
Q6SAA2_DROME
1325
2
147840
TrEMBL
other Location (Reliability: 5)
C7C411_DROME
2143
0
239655
TrEMBL
other Location (Reliability: 4)
Q9U5Y2_DROME
1198
0
133904
TrEMBL
other Location (Reliability: 1)
Q6SAL6_DROME
1174
0
130237
TrEMBL
other Location (Reliability: 1)
Q7KJ08_DROME
1701
2
185579
TrEMBL
Secretory Pathway (Reliability: 1)
D0UY75_DROME
2049
1
229543
TrEMBL
other Location (Reliability: 1)
Q6SAJ8_DROME
1325
2
147964
TrEMBL
other Location (Reliability: 5)
D0UY86_DROME
2049
1
229614
TrEMBL
other Location (Reliability: 1)
O96435_DROME
1019
1
114885
TrEMBL
Secretory Pathway (Reliability: 1)
D0UY81_DROME
2049
1
229579
TrEMBL
other Location (Reliability: 1)
D0UY89_DROME
2049
1
229560
TrEMBL
other Location (Reliability: 1)
D0IQ92_DROME
848
1
94204
TrEMBL
Secretory Pathway (Reliability: 1)
Q6SAL9_DROME
1325
2
147873
TrEMBL
other Location (Reliability: 5)
Q9Y1J0_DROME
1080
1
121506
TrEMBL
other Location (Reliability: 3)
Q6SAM5_DROME
1325
2
147877
TrEMBL
other Location (Reliability: 5)
Q6SAM7_DROME
1325
2
147941
TrEMBL
other Location (Reliability: 5)
Q6SAL3_DROME
1325
2
147921
TrEMBL
other Location (Reliability: 5)
Q6SAH8_DROME
1325
2
147630
TrEMBL
other Location (Reliability: 5)
Q6SAR7_DROME
1325
2
147815
TrEMBL
other Location (Reliability: 5)
Q6SAR4_DROME
1325
2
147855
TrEMBL
other Location (Reliability: 5)
Q6SAE2_DROME
1325
2
147909
TrEMBL
other Location (Reliability: 5)
M9MRE1_DROME
1500
1
169001
TrEMBL
Secretory Pathway (Reliability: 1)
Q6SA99_DROME
1325
2
147920
TrEMBL
other Location (Reliability: 5)
Q6SAJ2_DROME
1325
2
147498
TrEMBL
other Location (Reliability: 5)
Q6SAG1_DROME
1325
2
147954
TrEMBL
other Location (Reliability: 5)
Q6SAB6_DROME
1325
2
147956
TrEMBL
other Location (Reliability: 5)
D0UY85_DROME
2049
1
229590
TrEMBL
other Location (Reliability: 1)
Q6SAK0_DROME
1325
2
147029
TrEMBL
Mitochondrion (Reliability: 5)
C7C410_DROME
2143
0
239629
TrEMBL
other Location (Reliability: 4)
Q6SAF4_DROME
1325
0
147427
TrEMBL
Secretory Pathway (Reliability: 5)
Q6SAC9_DROME
1325
2
147928
TrEMBL
other Location (Reliability: 5)
Q6SAM1_DROME
1325
2
148056
TrEMBL
other Location (Reliability: 5)
Q6SAD7_DROME
1325
2
147891
TrEMBL
other Location (Reliability: 5)
Q6SAI5_DROME
1325
2
147575
TrEMBL
other Location (Reliability: 5)
Q6SAI8_DROME
1325
2
147875
TrEMBL
other Location (Reliability: 5)
Q6SAE8_DROME
1325
0
147990
TrEMBL
other Location (Reliability: 5)
Q6SAQ8_DROME
883
1
98985
TrEMBL
other Location (Reliability: 5)
Q6SAD5_DROME
1325
2
148234
TrEMBL
other Location (Reliability: 5)
Q6SAE1_DROME
1325
2
147948
TrEMBL
other Location (Reliability: 5)
Q6SAH3_DROME
1325
2
147717
TrEMBL
other Location (Reliability: 5)
Q9VZA8_DROME
1233
3
135077
TrEMBL
other Location (Reliability: 5)
D0UY91_DROME
2049
1
229539
TrEMBL
other Location (Reliability: 1)
Q6SAQ7_DROME
1325
2
147828
TrEMBL
other Location (Reliability: 5)
C7C412_DROME
2143
0
239641
TrEMBL
other Location (Reliability: 4)
Q6SAC2_DROME
1325
2
147906
TrEMBL
other Location (Reliability: 5)
D0UY96_DROME
2049
1
229588
TrEMBL
other Location (Reliability: 1)
Q6SAQ9_DROME
1325
2
147801
TrEMBL
other Location (Reliability: 5)
Q6SAJ0_DROME
1325
2
147151
TrEMBL
Mitochondrion (Reliability: 5)
Q6SAG9_DROME
1325
0
148434
TrEMBL
other Location (Reliability: 5)
Q6SAI9_DROME
1325
2
148005
TrEMBL
other Location (Reliability: 5)
D0UY78_DROME
2049
1
229579
TrEMBL
other Location (Reliability: 1)
Q6SAA9_DROME
1325
2
147882
TrEMBL
other Location (Reliability: 5)
Q6SAC7_DROME
1325
2
147780
TrEMBL
other Location (Reliability: 5)
Q6SAL0_DROME
1325
2
147980
TrEMBL
other Location (Reliability: 5)
Q6SAH7_DROME
1325
2
147920
TrEMBL
Mitochondrion (Reliability: 5)
C7C413_DROME
2143
0
239615
TrEMBL
other Location (Reliability: 4)
Q6SAJ7_DROME
1325
2
147865
TrEMBL
other Location (Reliability: 5)
Q6SAH9_DROME
1325
2
147991
TrEMBL
other Location (Reliability: 5)
Q6SAM6_DROME
1325
2
147693
TrEMBL
other Location (Reliability: 5)
D0UYA6_DROME
2043
1
228871
TrEMBL
other Location (Reliability: 1)
Q6SAB5_DROME
1325
1
147691
TrEMBL
other Location (Reliability: 5)
Q9VJ04_DROME
946
1
109382
TrEMBL
Secretory Pathway (Reliability: 1)
D0UY80_DROME
2049
1
229565
TrEMBL
other Location (Reliability: 1)
Q59DZ7_DROME
1054
1
116547
TrEMBL
other Location (Reliability: 5)
Q6SAB3_DROME
1325
2
147861
TrEMBL
other Location (Reliability: 4)
Q7KTI7_DROME
1499
1
168872
TrEMBL
Secretory Pathway (Reliability: 1)
Q6SAE3_DROME
1325
2
147905
TrEMBL
other Location (Reliability: 5)
Q6SAA3_DROME
1325
0
147456
TrEMBL
Mitochondrion (Reliability: 5)
Q6SAI0_DROME
359
0
40506
TrEMBL
other Location (Reliability: 5)
Q6SAH6_DROME
1325
1
147810
TrEMBL
other Location (Reliability: 5)
Q6SAB8_DROME
1325
2
147871
TrEMBL
other Location (Reliability: 5)
Q6SAI4_DROME
1325
2
147811
TrEMBL
other Location (Reliability: 5)
Q6SAH4_DROME
1325
2
147932
TrEMBL
other Location (Reliability: 5)
Q6SAC6_DROME
1325
2
147901
TrEMBL
other Location (Reliability: 5)
E3CTP2_DROME
839
0
94708
TrEMBL
other Location (Reliability: 3)
Q6SAD1_DROME
1325
2
147912
TrEMBL
other Location (Reliability: 5)
D0UY77_DROME
2049
1
229612
TrEMBL
other Location (Reliability: 1)
D9PTS3_DROME
685
1
78143
TrEMBL
Secretory Pathway (Reliability: 2)
A0A7T4WRU1_DROME
2143
0
239638
TrEMBL
other Location (Reliability: 4)
Q9VLQ8_DROME
1509
1
170321
TrEMBL
Secretory Pathway (Reliability: 1)
Q6SAL2_DROME
1325
2
147980
TrEMBL
other Location (Reliability: 5)
Q6SAK7_DROME
1325
2
147731
TrEMBL
other Location (Reliability: 4)
Q6SAD8_DROME
1325
2
147627
TrEMBL
other Location (Reliability: 5)
M9PCJ1_DROME
1499
1
169088
TrEMBL
Secretory Pathway (Reliability: 1)
Q6SAK4_DROME
1325
2
147870
TrEMBL
other Location (Reliability: 5)
Q6SAD3_DROME
1325
2
148236
TrEMBL
other Location (Reliability: 5)
Q6SAK3_DROME
1325
2
148003
TrEMBL
other Location (Reliability: 5)
Q6SAG8_DROME
1325
2
147992
TrEMBL
other Location (Reliability: 5)
Q8SWV4_DROME
1158
1
126109
TrEMBL
other Location (Reliability: 2)
Q6SAH0_DROME
1325
2
147933
TrEMBL
other Location (Reliability: 5)
C7C414_DROME
2143
0
239666
TrEMBL
other Location (Reliability: 4)
Q6SAF6_DROME
1222
3
136712
TrEMBL
other Location (Reliability: 5)
Q9V4E5_DROME
1096
1
123282
TrEMBL
other Location (Reliability: 3)
Q6SAD9_DROME
1325
2
147901
TrEMBL
other Location (Reliability: 5)
Q0KIF4_DROME
1080
1
121490
TrEMBL
other Location (Reliability: 3)
Q6SAG5_DROME
1325
2
147883
TrEMBL
other Location (Reliability: 5)
D0UY84_DROME
2049
1
229562
TrEMBL
other Location (Reliability: 1)
Q6SAJ3_DROME
1325
2
148001
TrEMBL
other Location (Reliability: 5)
C7C417_DROME
2148
0
240120
TrEMBL
other Location (Reliability: 4)
Q6SAQ5_DROME
1325
2
147917
TrEMBL
other Location (Reliability: 5)
Q6SAF7_DROME
1325
2
148211
TrEMBL
other Location (Reliability: 5)
Q6SAK6_DROME
1233
1
138169
TrEMBL
other Location (Reliability: 5)
Q6SAG3_DROME
1325
2
147967
TrEMBL
other Location (Reliability: 5)
Q6SAJ6_DROME
1325
2
148014
TrEMBL
other Location (Reliability: 5)
Q6SAA5_DROME
1325
2
148048
TrEMBL
other Location (Reliability: 5)
Q6SAH1_DROME
1325
2
147952
TrEMBL
other Location (Reliability: 5)
Q6SAC4_DROME
1316
2
146651
TrEMBL
Secretory Pathway (Reliability: 5)
Q6SAK2_DROME
1325
2
148015
TrEMBL
other Location (Reliability: 5)
PDB
SCOP
CATH
UNIPROT
ORGANISM
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
proteolytic modification
INR proreceptor of 280000 Da is processed proteolytically to generate an insulin-binding alpha subunit of 120000 Da and a beta subunit of 170000 Da with protein tyrosine kinase domain
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
a single amino acid substitution in the ATP-binding site of the putative kinase domain results in the synthesis of an inactive sev protein unable to determine cell fate
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
alternative splicing generates two distinct transcripts for the Drosophila melanogaster fibroblast growth factor receptor homolog
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
around 38% tyrosine phosphorylation events from Drosophila RTK proteins conserved on 185 human proteins are confirmed in vivo tyrosine phosphorylation events
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Rattus norvegicus (O08775), Homo sapiens (P00533), Homo sapiens (P04629), Homo sapiens (P06213), Homo sapiens (P07949), Homo sapiens (P17948), Homo sapiens (Q9UM73), Drosophila melanogaster (P04412), Caenorhabditis elegans (Q10656), Gallus gallus (Q91044), Gallus gallus (Q91987)
Adams, M.D.; Celniker, S.E.; Holt, R.A.; Evans, C.A.; Gocayne, J.D.; et al.
The genome sequence of Drosophila melanogaster
Science
287
2185-2195
2000
Drosophila melanogaster (P13368), Drosophila melanogaster (Q07407), Drosophila melanogaster (Q24488), Drosophila melanogaster (Q27324), Drosophila melanogaster (Q9v422), Drosophila melanogaster (Q9v6k3), Drosophila melanogaster (Q9vie4)
Fernandez, R.; Tabarini, D.; Azpiazu, N.; Frasch, M.; Schlessinger, J.
The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential
EMBO J.
14
3373-3384
1995
Drosophila melanogaster (P09208)
Nishida, Y.; Hata, M.; Nishizuka, Y.; Rutter, W.J.; Ebina, Y.
Cloning of a Drosophila cDNA encoding a polypeptide similar to the human insulin receptor precursor
Biochem. Biophys. Res. Commun.
141
474-481
1986
Drosophila melanogaster (P09208)
Petruzzelli, L.; Herrera, R.; Arenas-Garcia, R.; Fernandez, R.; Birnbaum, M.J.; Rosen, O.M.
Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody
Proc. Natl. Acad. Sci. USA
83
4710-4714
1986
Drosophila melanogaster (P09208)
Ruan, Y.; Chen, C.; Cao, Y.; Garofalo, R.S.
The Drosophila insulin receptor contains a novel carboxyl-terminal extension likely to play an important role in signal transduction
J. Biol. Chem.
270
4236-4243
1995
Drosophila melanogaster (P09208)
Basler, K.; Hafen, E.
Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain
Cell
54
299-311
1988
Drosophila melanogaster (P13368)
Bowtell, D.D.; Simon, M.A.; Rubin, G.M.
Nucleotide sequence and structure of the sevenless gene of Drosophila melanogaster
Genes Dev.
2
620-634
1988
Drosophila melanogaster (P13368), Drosophila melanogaster
Norton, P.A.; Hynes, R.O.; Rees, D.J.
Sevenless: seven found?
Cell
61
15-16
1990
Drosophila melanogaster (P13368)
Oates, A.C.; Wollberg, P.; Achen, M.G.; Wilks, A.F.
Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA
Biochem. Biophys. Res. Commun.
249
660-667
1998
Drosophila melanogaster (P13368), Drosophila melanogaster (Q24488), Drosophila melanogaster (Q9v6k3), Drosophila melanogaster
Sprenger, F.; Stevens, L.M.; Nusslein-Volhard, C.
The Drosophila gene torso encodes a putative receptor tyrosine kinase
Nature
338
478-483
1989
Drosophila melanogaster (P18475)
Sprenger, F.; Trosclair, M.M.; Morrison, D.K.
Biochemical analysis of torso and D-raf during Drosophila embryogenesis: implications for terminal signal transduction
Mol. Cell. Biol.
13
1163-1172
1993
Drosophila melanogaster (P18475)
Ito, M.; Matsui, T.; Taniguchi, T.; Chihara, K.
Alternative splicing generates two distinct transcripts for the Drosophila melanogaster fibroblast growth factor receptor homolog
Gene
139
215-218
1994
Drosophila melanogaster (Q07407), Drosophila melanogaster
Shishido, E.; Higashijima, S.; Emori, Y.; Saigo, K.
Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos
Development
117
751-761
1993
Drosophila melanogaster (Q07407), Drosophila melanogaster (Q09147)
Glazer, L.; Shilo, B.Z.
The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell extension
Genes Dev.
5
697-705
1991
Drosophila melanogaster (Q09147)
Klambt, C.; Glazer, L.; Shilo, B.Z.
breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells
Genes Dev.
6
1668-1678
1992
Drosophila melanogaster (Q09147)
Shishido, E.; Emori, Y.; Saigo, K.
Identification of seven novel protein-tyrosine kinase genes of Drosophila by the polymerase chain reaction
FEBS Lett.
289
235-238
1991
Drosophila melanogaster (Q07407), Drosophila melanogaster (Q09147), Drosophila melanogaster
Wilson, C.; Goberdhan, D.C.; Steller, H.
Dror, a potential neurotrophic receptor gene, encodes a Drosophila homolog of the vertebrate Ror family of Trk-related receptor tyrosine kinases
Proc. Natl. Acad. Sci. USA
90
7109-7113
1993
Drosophila melanogaster (Q24488)
Callahan, C.A.; Bonkovsky, J.L.; Scully, A.L.; Thomas, J.B.
Derailed is required for muscle attachment site selection in Drosophila
Development
122
2761-2767
1996
Drosophila melanogaster (Q27324)
Callahan, C.A.; Muralidhar, M.G.; Lundgren, S.E.; Scully, A.L.; Thomas, J.B.
Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member
Nature
376
171-174
1995
Drosophila melanogaster (Q27324)
Dura, J.M.; Taillebourg, E.; Preat, T.
The Drosophila learning and memory gene linotte encodes a putative receptor tyrosine kinase homologous to the human RYK gene product
FEBS Lett.
370
250-254
1995
Drosophila melanogaster (Q27324)
Taillebourg, E.; Dura, J.M.
A novel mechanism for P element homing in Drosophila
Proc. Natl. Acad. Sci. USA
96
6856-6861
1999
Drosophila melanogaster (Q27324)
Oates, A.C.; Bonkovsky, J.L.; Irvine, D.V.; Kelly, L.E.; Thomas, J.B.; Wilks, A.F.
Embryonic expression and activity of doughnut, a second RYK homolog in Drosophila
Mech. Dev.
78
165-169
1998
Drosophila melanogaster (Q9v422)
Savant-Bhonsale, S.; Friese, M.; McCoon, P.; Montell, D.J.
A Drosophila derailed homolog, doughnut, expressed in invaginating cells during embryogenesis
Gene
231
155-161
1999
Drosophila melanogaster (Q9v422)
Oishi, I.; Sugiyama, S.; Liu, Z.J.; Yamamura, H.; Nishida, Y.; Minami, Y.
A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling
J. Biol. Chem.
272
11916-11923
1997
Drosophila melanogaster (Q9v6k3)
Sugaya, R.; Ishimaru, S.; Hosoya, T.; Saigo, K.; Emori, Y.
A Drosophila homolog of human proto-oncogene ret transiently expressed in embryonic neuronal precursor cells including neuroblasts and CNS cells
Mech. Dev.
45
139-145
1994
Drosophila melanogaster (Q9vie4)
Bazigou, E.; Apitz, H.; Johansson, J.; Loren, C.E.; Hirst, E.M.; Chen, P.L.; Palmer, R.H.; Salecker, I.
Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila
Cell
128
961-975
2007
Drosophila melanogaster
Hubbard, S.R.; Miller, W.T.
Receptor tyrosine kinases: mechanisms of activation and signaling
Curr. Opin. Cell Biol.
19
117-123
2007
Drosophila melanogaster, Homo sapiens
Mason, J.M.; Morrison, D.J.; Basson, M.A.; Licht, J.D.
Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling
Trends Cell Biol.
16
45-54
2006
Drosophila melanogaster, Homo sapiens, Mus musculus
Krishnamoorthy, S.
Receptor tyrosine kinase (RTK) mediated tyrosine phosphor-proteome from Drosophila S2 (ErbB1) cells reveals novel signaling networks
PLoS ONE
3
e2877
2008
Drosophila melanogaster (P09208), Homo sapiens (P35916), Homo sapiens
EXTERNAL LINKS (specific for EC-Number 2.7.10.1)
Transporter Classification Database (TCDB): 8.A.23.1.30, 8.A.23.1.29, 8.A.23.1.9, 8.A.23.1.38, 8.A.23.1.13, 8.A.23.1.39, 8.A.23.1.17, 1.A.87.2.6, 8.A.23.1.37, 8.A.23.1.7, 8.A.23.1.15, 8.A.23.1.16
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