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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Danio rerio

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EC Tree
IUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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This record set is specific for:
Danio rerio
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The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Adhesion-related kinase
-
-
-
-
Anaplastic lymphoma kinase
-
-
-
-
angiopoietin 1 receptor
-
AXL oncogene
-
-
-
-
Brain-specific kinase
-
-
-
-
Breathless protein
-
-
-
-
c-erbB3
-
-
-
-
c-fgr
-
-
-
-
c-fms
-
-
-
-
c-kit
-
-
-
-
c-Kit tyrosine kinase
-
-
-
-
C-mer
-
-
-
-
c-met
-
-
-
-
C-ret
-
-
-
-
C14
-
-
-
-
Cadherin 96Ca
-
-
-
-
CD115 antigen
-
-
-
-
CD117 antigen
-
-
-
-
CD135 antigen
-
-
-
-
CD136 antigen
-
-
-
-
CD140a antigen
-
-
-
-
CD140b antigen
-
-
-
-
CD167a antigen
-
-
-
-
CD202b antigen
-
-
-
-
CD220 antigen
-
-
-
-
CD221 antigen
-
-
-
-
CD246 antigen
-
-
-
-
CDW136
-
-
-
-
CEK4
-
-
-
-
Cell adhesion kinase
-
-
-
-
Derailed protein
-
-
-
-
DFGF-R1
-
-
-
-
Discoidin receptor tyrosine kinase
-
-
-
-
Doughnut protein
-
-
-
-
Dror
-
-
-
-
Drosophila relative of ERBB
-
-
-
-
DRT
-
-
-
-
EBK
-
-
-
-
EGF receptor tyrosine kinase
-
-
-
-
Egfr
-
-
-
-
EGFr TK
-
-
-
-
Egg laying defective protein 15
-
-
-
-
ELK
-
-
-
-
Embryonic brain kinase
-
-
-
-
Endothelial kinase receptor EK1
-
-
-
-
EPH-and ELK-related kinase
-
-
-
-
Eph-like kinase1
-
ephrin type-A receptor 3
-
Epidermal growth factor receptor-related protein
-
-
-
-
Epithelial cell kinase
-
-
-
-
erbB tyrosine kinase
-
-
-
-
ErbB2 kinase
-
-
-
-
ERK
-
-
-
-
ETK
-
-
-
-
Fms proto-oncogene
-
-
-
-
GCTK
-
-
-
-
GP145-TrkB
-
-
-
-
GP145-TrkB/GP95-TrkB
-
-
-
-
GP145-TrkC
-
-
-
-
Gurken receptor
-
-
-
-
Heartless protein
-
-
-
-
HEK
-
-
-
-
HEK3
-
-
-
-
HEK4
-
-
-
-
HEK6
-
-
-
-
Heparin-binding growth factor receptor
-
-
-
-
HGF receptor
-
-
-
-
HGF-SF receptor
-
-
-
-
hydroxyaryl-protein kinase
-
-
-
-
HYK
-
-
-
-
ILP receptor
-
-
-
-
insulin receptor protein-tyrosine kinase
-
-
-
-
IR-related receptor
-
-
-
-
IRK
-
-
-
-
IRR
-
-
-
-
Keratinocyte growth factor receptor
-
-
-
-
Kinase insert domain receptor
-
-
-
-
Kinase NYK
-
-
-
-
Kinase VIK
-
-
-
-
Linotte protein
-
-
-
-
MEK4
-
-
-
-
Met proto-oncogene tyrosine kinase
-
-
-
-
Met-related kinase
-
-
-
-
MFR
-
-
-
-
MIR
-
-
-
-
MLN 19
-
-
-
-
mROR1
-
-
-
-
mROR2
-
-
-
-
MSP receptor
-
-
-
-
NET
-
-
-
-
NEU proto-oncogene
-
-
-
-
Neurospecific receptor tyrosine kinase
-
-
-
-
NRTK
-
-
-
-
NUK
-
-
-
-
P140 TEK
-
-
-
-
p140-TrkA
-
-
-
-
p180erbB4
-
-
-
-
p185-Ron
-
-
-
-
p185erbB2
-
-
-
-
Pagliaccio
-
-
-
-
PDGF-R-alpha
-
-
-
-
PDGF-R-beta
-
-
-
-
PDGFR kinase
-
-
-
-
Protein-tyrosine kinase byk
-
-
-
-
Protein-tyrosine kinase receptor MPK-11
-
-
-
-
Proto-oncogene tyrosine-protein kinase Kit
-
-
-
-
Receptor protein-tyrosine kinase HEK11
-
-
-
-
Receptor protein-tyrosine kinase HEK5
-
-
-
-
Receptor protein-tyrosine kinase HEK7
-
-
-
-
Receptor protein-tyrosine kinase HEK8
-
-
-
-
Receptor protein-tyrosine kinase TKT
-
-
-
-
Receptor tyrosine kinase MerTK
-
-
-
-
Receptor-activated Janus kinase
-
-
-
-
RTK
-
-
-
-
SCFR
-
-
-
-
Slow nerve growth factor receptor
-
-
-
-
Stem cell-derived tyrosine kinase
-
-
-
-
Torpedo protein
-
-
-
-
TRK1 transforming tyrosine kinase protein
-
-
-
-
TrkB tyrosine kinase
-
-
-
-
TrkC tyrosine kinase
-
-
-
-
Tunica interna endothelial cell kinase
-
-
-
-
Tyrosine kinase CEK6 receptor
-
-
-
-
Tyrosine kinase DDR
-
-
-
-
Tyrosine kinase receptor HD-14
-
-
-
-
Tyrosine kinase-type cell surface receptor HER2
-
-
-
-
Tyrosine kinase-type cell surface receptor HER3
-
-
-
-
Tyrosine kinase-type cell surface receptor HER4
-
-
-
-
Tyrosine-protein kinase CAK
-
-
-
-
Tyrosine-protein kinase CEK9
-
-
-
-
Tyrosine-protein kinase DTK
-
-
-
-
Tyrosine-protein kinase FLT3
-
-
-
-
Tyrosine-protein kinase FRT
-
-
-
-
Tyrosine-protein kinase receptor CEK10
-
-
-
-
Tyrosine-protein kinase receptor CEK11
-
-
-
-
Tyrosine-protein kinase receptor CEK5
-
-
-
-
Tyrosine-protein kinase receptor CEK7
-
-
-
-
Tyrosine-protein kinase receptor CEK8
-
-
-
-
Tyrosine-protein kinase receptor CEPHA7
-
-
-
-
Tyrosine-protein kinase receptor ECK
-
-
-
-
Tyrosine-protein kinase receptor EEK
-
-
-
-
Tyrosine-protein kinase receptor EPH
-
-
-
-
Tyrosine-protein kinase receptor ESK
-
-
-
-
Tyrosine-protein kinase receptor ETK1
-
-
-
-
Tyrosine-protein kinase receptor FLT
-
-
-
-
Tyrosine-protein kinase receptor FLT3
-
-
-
-
Tyrosine-protein kinase receptor FLT4
-
-
-
-
Tyrosine-protein kinase receptor HTK
-
-
-
-
Tyrosine-protein kinase receptor PAG
-
-
-
-
Tyrosine-protein kinase receptor QEK5
-
-
-
-
Tyrosine-protein kinase receptor REK4
-
-
-
-
Tyrosine-protein kinase receptor SEK
-
-
-
-
Tyrosine-protein kinase receptor TCK
-
-
-
-
Tyrosine-protein kinase receptor TEK
-
-
-
-
Tyrosine-protein kinase receptor XEK
-
-
-
-
Tyrosine-protein kinase receptor XELK
-
-
-
-
Tyrosine-protein kinase receptor ZEK1
-
-
-
-
Tyrosine-protein kinase receptor ZEK2
-
-
-
-
Tyrosine-protein kinase receptor ZEK3
-
-
-
-
Tyrosine-protein kinase RSE
-
-
-
-
Tyrosine-protein kinase SKY
-
-
-
-
vascular endothelial growth factor receptor 2
-
-
Vascular permeability factor receptor
-
-
-
-
VEGFR2
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
VEGFR1 and VEGFR2 are the most important receptors involved in neovascularization
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
EPA4A_DANRE
292
0
33045
Swiss-Prot
other Location (Reliability: 1)
FGFR3_DANRE
800
1
89716
Swiss-Prot
Secretory Pathway (Reliability: 1)
FGFR4_DANRE
922
1
103465
Swiss-Prot
Secretory Pathway (Reliability: 1)
VGFR2_DANRE
1357
1
153042
Swiss-Prot
Secretory Pathway (Reliability: 1)
VGFR3_DANRE
1357
1
153178
Swiss-Prot
Secretory Pathway (Reliability: 3)
VGFR4_DANRE
1302
0
146950
Swiss-Prot
Secretory Pathway (Reliability: 1)
EPHA3_DANRE
981
1
109655
Swiss-Prot
Secretory Pathway (Reliability: 1)
LTK_DANRE
1530
2
165479
Swiss-Prot
Secretory Pathway (Reliability: 2)
KITA_DANRE
976
2
109280
Swiss-Prot
Secretory Pathway (Reliability: 2)
PGFRA_DANRE
1059
2
118211
Swiss-Prot
other Location (Reliability: 3)
TYRO3_DANRE
874
2
97599
Swiss-Prot
Secretory Pathway (Reliability: 2)
EPB4A_DANRE
987
1
109669
Swiss-Prot
Secretory Pathway (Reliability: 2)
EPB4B_DANRE
976
1
108231
Swiss-Prot
Secretory Pathway (Reliability: 1)
ALK_DANRE
1705
0
186696
Swiss-Prot
Secretory Pathway (Reliability: 1)
FGFR2_DANRE
817
1
91388
Swiss-Prot
Secretory Pathway (Reliability: 1)
CSF1R_DANRE
977
1
110188
Swiss-Prot
Secretory Pathway (Reliability: 1)
EPHB3_DANRE
500
1
55911
Swiss-Prot
other Location (Reliability: 2)
FGR1A_DANRE
810
1
91041
Swiss-Prot
Secretory Pathway (Reliability: 1)
TIE1_DANRE
184
0
21190
Swiss-Prot
other Location (Reliability: 2)
TIE2_DANRE
1116
1
122361
Swiss-Prot
Secretory Pathway (Reliability: 1)
Q5ZEW1_DANRE
986
2
110341
TrEMBL
Secretory Pathway (Reliability: 1)
Q6NZS1_DANRE
984
1
109181
TrEMBL
Secretory Pathway (Reliability: 2)
C8XT57_DANRE
738
1
82966
TrEMBL
Secretory Pathway (Reliability: 2)
G1K2P7_DANRE
766
2
86308
TrEMBL
Secretory Pathway (Reliability: 2)
F1RBT3_DANRE
815
1
91198
TrEMBL
Secretory Pathway (Reliability: 1)
F8W2E2_DANRE
840
1
93853
TrEMBL
Secretory Pathway (Reliability: 5)
E9QC99_DANRE
1426
2
158652
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1NI86_DANRE
1135
0
123711
TrEMBL
other Location (Reliability: 2)
A0A0R4IGP2_DANRE
1433
1
161463
TrEMBL
other Location (Reliability: 3)
B3DGN7_DANRE
868
2
96715
TrEMBL
Secretory Pathway (Reliability: 2)
Q1LVG4_DANRE
1348
2
152605
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0R4IRF5_DANRE
651
0
72683
TrEMBL
other Location (Reliability: 2)
A0A0B5JQ80_DANRE
645
1
70175
TrEMBL
Secretory Pathway (Reliability: 1)
A2CEJ3_DANRE
989
1
110850
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0R4ILA2_DANRE
799
1
89734
TrEMBL
Secretory Pathway (Reliability: 3)
Q90ZN8_DANRE
923
1
101720
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1NUU1_DANRE
799
1
89734
TrEMBL
Secretory Pathway (Reliability: 3)
B3DHL0_DANRE
977
1
110188
TrEMBL
Secretory Pathway (Reliability: 1)
Q8UUY9_DANRE
515
1
57342
TrEMBL
other Location (Reliability: 5)
F8W3W7_DANRE
1319
2
147257
TrEMBL
Secretory Pathway (Reliability: 2)
A0A0R4IFV9_DANRE
1191
1
132487
TrEMBL
Secretory Pathway (Reliability: 2)
E7F533_DANRE
979
1
108930
TrEMBL
Secretory Pathway (Reliability: 5)
A0A8M1PBP7_DANRE
819
2
91737
TrEMBL
Secretory Pathway (Reliability: 4)
Q64GK4_DANRE
1382
1
154243
TrEMBL
Secretory Pathway (Reliability: 1)
F6NI62_DANRE
845
1
96043
TrEMBL
Secretory Pathway (Reliability: 1)
F1QEJ3_DANRE
694
1
77933
TrEMBL
other Location (Reliability: 4)
Q6QMR6_DANRE
625
0
68770
TrEMBL
Secretory Pathway (Reliability: 2)
F1QSK6_DANRE
1305
2
145689
TrEMBL
Secretory Pathway (Reliability: 2)
B0R0Q2_DANRE
1380
1
155940
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2R8QSE0_DANRE
1324
1
149711
TrEMBL
Secretory Pathway (Reliability: 3)
A0A8M1NB85_DANRE
733
0
83773
TrEMBL
other Location (Reliability: 2)
Q90ZN9_DANRE
976
1
109479
TrEMBL
Secretory Pathway (Reliability: 1)
A4JYH8_DANRE
696
1
77772
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1N9P7_DANRE
1016
2
114062
TrEMBL
Secretory Pathway (Reliability: 1)
A4JYQ2_DANRE
802
1
89911
TrEMBL
Secretory Pathway (Reliability: 1)
Q8AYP3_DANRE
815
1
91243
TrEMBL
Secretory Pathway (Reliability: 1)
F1R5F3_DANRE
833
1
91552
TrEMBL
other Location (Reliability: 3)
A0A8M1NUM7_DANRE
740
1
83240
TrEMBL
Secretory Pathway (Reliability: 2)
Q4JDD5_DANRE
1272
0
142634
TrEMBL
Secretory Pathway (Reliability: 5)
A0A2R8QG72_DANRE
887
1
98943
TrEMBL
other Location (Reliability: 1)
A0A2R8QR15_DANRE
1245
2
140143
TrEMBL
Secretory Pathway (Reliability: 1)
A8E7C6_DANRE
1106
1
125045
TrEMBL
Secretory Pathway (Reliability: 1)
A0A891XJP9_DANRE
811
1
91211
TrEMBL
Secretory Pathway (Reliability: 1)
Q5G254_DANRE
1429
2
158993
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0A0MPK4_DANRE
1392
2
156023
TrEMBL
Secretory Pathway (Reliability: 1)
Q8JID1_DANRE
439
0
49025
TrEMBL
other Location (Reliability: 2)
E7FFT8_DANRE
868
1
98935
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8M1NPF4_DANRE
957
2
107797
TrEMBL
Secretory Pathway (Reliability: 1)
F1R532_DANRE
964
0
108822
TrEMBL
other Location (Reliability: 5)
Q4VBK2_DANRE
888
1
99721
TrEMBL
Secretory Pathway (Reliability: 1)
G1K2H0_DANRE
1122
1
125114
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1N529_DANRE
1272
0
142626
TrEMBL
Secretory Pathway (Reliability: 5)
A0A2R8Q3T0_DANRE
1144
1
127433
TrEMBL
other Location (Reliability: 2)
A0A2R8RS29_DANRE
994
2
111578
TrEMBL
Secretory Pathway (Reliability: 1)
O73879_DANRE
880
1
98863
TrEMBL
other Location (Reliability: 2)
A0A8M1PIE3_DANRE
585
0
67517
TrEMBL
other Location (Reliability: 2)
B7SNG4_DANRE
1353
1
153264
TrEMBL
Secretory Pathway (Reliability: 2)
A0A0R4IML5_DANRE
883
1
99793
TrEMBL
other Location (Reliability: 5)
F1QNY7_DANRE
1456
2
163198
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0R4IYW2_DANRE
873
1
98847
TrEMBL
Secretory Pathway (Reliability: 4)
A0A0R4IML4_DANRE
740
1
82180
TrEMBL
other Location (Reliability: 3)
Q4KMK2_DANRE
937
2
104810
TrEMBL
Secretory Pathway (Reliability: 1)
F1REV2_DANRE
1380
2
154941
TrEMBL
other Location (Reliability: 3)
E7EYX4_DANRE
1350
2
149293
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0R4ITE7_DANRE
821
1
93078
TrEMBL
Secretory Pathway (Reliability: 1)
F1RA48_DANRE
389
0
42849
TrEMBL
Secretory Pathway (Reliability: 2)
F1Q7S3_DANRE
780
1
87892
TrEMBL
Secretory Pathway (Reliability: 1)
B3DGS5_DANRE
981
2
109769
TrEMBL
Secretory Pathway (Reliability: 2)
A5WW86_DANRE
1059
2
118399
TrEMBL
other Location (Reliability: 3)
F1Q9D9_DANRE
963
1
108090
TrEMBL
Secretory Pathway (Reliability: 1)
A0A891XJS9_DANRE
808
1
90841
TrEMBL
Secretory Pathway (Reliability: 1)
F6P1M3_DANRE
797
2
90265
TrEMBL
Secretory Pathway (Reliability: 1)
B8JKB8_DANRE
925
1
101894
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0G2L2B8_DANRE
1064
2
119648
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2R8Q9U7_DANRE
977
1
110257
TrEMBL
Secretory Pathway (Reliability: 1)
F1QU92_DANRE
1009
1
112335
TrEMBL
Secretory Pathway (Reliability: 2)
F1QPA0_DANRE
819
2
91737
TrEMBL
Secretory Pathway (Reliability: 4)
A0A286Y9P5_DANRE
1246
1
140167
TrEMBL
Secretory Pathway (Reliability: 1)
B3DJR6_DANRE
1116
1
122349
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0R4ILA5_DANRE
968
1
108368
TrEMBL
other Location (Reliability: 2)
B3DGT9_DANRE
800
1
89724
TrEMBL
Secretory Pathway (Reliability: 1)
Q8JFV0_DANRE
1161
2
124852
TrEMBL
other Location (Reliability: 2)
Q6QMR8_DANRE
389
0
42874
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8M1PBN6_DANRE
1380
1
155882
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8M1P3W6_DANRE
815
1
91198
TrEMBL
Secretory Pathway (Reliability: 1)
F1QP50_DANRE
1429
2
159019
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2R8QG87_DANRE
851
1
96647
TrEMBL
Secretory Pathway (Reliability: 4)
F8W376_DANRE
838
1
93653
TrEMBL
Secretory Pathway (Reliability: 5)
A0A2R8PYL3_DANRE
165
0
19305
TrEMBL
Mitochondrion (Reliability: 4)
F1QLR7_DANRE
1382
1
154185
TrEMBL
Secretory Pathway (Reliability: 1)
F1R5S1_DANRE
1275
3
140851
TrEMBL
Secretory Pathway (Reliability: 1)
A4JYI8_DANRE
751
2
84130
TrEMBL
other Location (Reliability: 5)
B7ZVT9_DANRE
922
1
103475
TrEMBL
Secretory Pathway (Reliability: 1)
F1QDE6_DANRE
1388
2
154828
TrEMBL
other Location (Reliability: 1)
A0A8N1Z2F3_DANRE
1106
1
125045
TrEMBL
Secretory Pathway (Reliability: 1)
A0A286Y9G6_DANRE
923
1
103546
TrEMBL
Secretory Pathway (Reliability: 1)
B8LFF6_DANRE
1414
2
157793
TrEMBL
Secretory Pathway (Reliability: 1)
A9JRD6_DANRE
526
1
58460
TrEMBL
Secretory Pathway (Reliability: 3)
A0A2R8QNM5_DANRE
696
1
77867
TrEMBL
Secretory Pathway (Reliability: 1)
Q805B9_DANRE
815
1
91147
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1P4D8_DANRE
1078
0
121634
TrEMBL
Mitochondrion (Reliability: 5)
A0A2R8QM04_DANRE
1027
1
114136
TrEMBL
Secretory Pathway (Reliability: 1)
F1QKJ0_DANRE
818
1
92694
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1NYP8_DANRE
817
1
91494
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0R4ITX7_DANRE
801
1
89920
TrEMBL
Secretory Pathway (Reliability: 3)
A0A8M1NCR3_DANRE
604
2
67783
TrEMBL
Mitochondrion (Reliability: 3)
Q6VQA3_DANRE
1191
1
132660
TrEMBL
Secretory Pathway (Reliability: 2)
F1R376_DANRE
1064
1
120385
TrEMBL
Secretory Pathway (Reliability: 1)
Q5EBY4_DANRE
1275
3
140829
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1P2R3_DANRE
473
0
53522
TrEMBL
Secretory Pathway (Reliability: 5)
A0A0G2L6L8_DANRE
501
1
55988
TrEMBL
other Location (Reliability: 3)
F8W2R6_DANRE
1100
1
120612
TrEMBL
other Location (Reliability: 2)
F8W481_DANRE
995
2
111321
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2R8QI76_DANRE
1526
0
164961
TrEMBL
Secretory Pathway (Reliability: 3)
B3DK54_DANRE
1191
1
132562
TrEMBL
Secretory Pathway (Reliability: 2)
A2BFZ9_DANRE
665
1
74134
TrEMBL
other Location (Reliability: 2)
F1REM5_DANRE
996
1
111813
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2R8Q165_DANRE
851
1
96647
TrEMBL
Secretory Pathway (Reliability: 4)
A0A0R4IKS3_DANRE
861
1
97431
TrEMBL
other Location (Reliability: 1)
A0A2R8QED1_DANRE
1500
0
162080
TrEMBL
Secretory Pathway (Reliability: 3)
A0A2R8S059_DANRE
1210
2
134191
TrEMBL
other Location (Reliability: 1)
E7F3X9_DANRE
974
1
108010
TrEMBL
Secretory Pathway (Reliability: 1)
Q7SZF7_DANRE
1191
1
132484
TrEMBL
Secretory Pathway (Reliability: 2)
Q7SY19_DANRE
431
1
47108
TrEMBL
Secretory Pathway (Reliability: 1)
F1QMJ7_DANRE
1289
1
144087
TrEMBL
other Location (Reliability: 1)
A0A0R4IIR3_DANRE
1301
0
146821
TrEMBL
Secretory Pathway (Reliability: 1)
B3DH46_DANRE
1429
2
159095
TrEMBL
Secretory Pathway (Reliability: 1)
F1RCL1_DANRE
976
1
109487
TrEMBL
Secretory Pathway (Reliability: 1)
E7F1P1_DANRE
956
2
108651
TrEMBL
Secretory Pathway (Reliability: 1)
B3DGS3_DANRE
981
1
109569
TrEMBL
Secretory Pathway (Reliability: 1)
F1QB19_DANRE
788
2
89261
TrEMBL
Secretory Pathway (Reliability: 1)
F1QYI3_DANRE
1296
2
145776
TrEMBL
other Location (Reliability: 1)
F1RBY7_DANRE
503
0
55110
TrEMBL
Secretory Pathway (Reliability: 2)
A2BG00_DANRE
720
1
80269
TrEMBL
other Location (Reliability: 3)
A0A2R8QFJ8_DANRE
920
1
102074
TrEMBL
Secretory Pathway (Reliability: 1)
F1R4B3_DANRE
981
1
109582
TrEMBL
Secretory Pathway (Reliability: 1)
F1QPE2_DANRE
943
0
106384
TrEMBL
other Location (Reliability: 2)
Q90269_DANRE
457
0
51738
TrEMBL
other Location (Reliability: 2)
E7FG42_DANRE
630
1
69625
TrEMBL
Secretory Pathway (Reliability: 1)
F1QNX5_DANRE
1353
1
153237
TrEMBL
Secretory Pathway (Reliability: 2)
A5WW87_DANRE
1065
2
119424
TrEMBL
Secretory Pathway (Reliability: 1)
F1QSD6_DANRE
984
1
109235
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8M1P5F4_DANRE
1027
1
114136
TrEMBL
Secretory Pathway (Reliability: 1)
O73876_DANRE
666
1
74296
TrEMBL
other Location (Reliability: 4)
A4JYH6_DANRE
692
1
77036
TrEMBL
Secretory Pathway (Reliability: 2)
B3DKP1_DANRE
1272
0
142626
TrEMBL
Secretory Pathway (Reliability: 5)
Q5VSJ4_DANRE
1016
2
114062
TrEMBL
Secretory Pathway (Reliability: 1)
B3DK52_DANRE
1405
1
158490
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0R4IZ74_DANRE
941
2
106191
TrEMBL
Secretory Pathway (Reliability: 1)
F1Q7X2_DANRE
625
0
68597
TrEMBL
Secretory Pathway (Reliability: 2)
A0A0R4IFS9_DANRE
1368
1
154408
TrEMBL
Secretory Pathway (Reliability: 3)
B8JLJ1_DANRE
784
1
88280
TrEMBL
Secretory Pathway (Reliability: 1)
F1R5P2_DANRE
657
1
74054
TrEMBL
other Location (Reliability: 2)
F1RBS5_DANRE
815
1
91294
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2R8Q844_DANRE
1278
1
143497
TrEMBL
Secretory Pathway (Reliability: 2)
B8A5K6_DANRE
957
2
107797
TrEMBL
Secretory Pathway (Reliability: 1)
Q1MT83_DANRE
665
1
74476
TrEMBL
other Location (Reliability: 2)
F8W2F8_DANRE
1376
2
154626
TrEMBL
Secretory Pathway (Reliability: 1)
A0A891XJQ6_DANRE
811
1
91185
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2R8QM53_DANRE
1277
2
143473
TrEMBL
Secretory Pathway (Reliability: 2)
Q5RID4_DANRE
1101
2
123401
TrEMBL
other Location (Reliability: 3)
Q5GIT3_DANRE
1272
0
142656
TrEMBL
Secretory Pathway (Reliability: 5)
A4JYD9_DANRE
1059
2
118381
TrEMBL
other Location (Reliability: 3)
Q6QMR7_DANRE
503
0
55196
TrEMBL
Secretory Pathway (Reliability: 2)
A0A0R4IEC7_DANRE
998
2
112050
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2R8Q3E8_DANRE
959
1
106181
TrEMBL
Secretory Pathway (Reliability: 4)
F1QJD4_DANRE
988
1
110425
TrEMBL
Secretory Pathway (Reliability: 1)
F1R671_DANRE
760
1
83379
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8N7UZS2_DANRE
1405
1
158447
TrEMBL
Secretory Pathway (Reliability: 3)
G1K2P2_DANRE
740
1
83388
TrEMBL
Secretory Pathway (Reliability: 2)
Q8AW81_DANRE
1305
2
145710
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2R8QHE8_DANRE
1072
1
120509
TrEMBL
Secretory Pathway (Reliability: 4)
E7F2W4_DANRE
983
2
110631
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2R8Q2A9_DANRE
1150
1
128116
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0R4IJK3_DANRE
960
1
106571
TrEMBL
other Location (Reliability: 2)
A0A8M1PE96_DANRE
815
1
91294
TrEMBL
Secretory Pathway (Reliability: 1)
E7EY14_DANRE
806
1
89939
TrEMBL
Secretory Pathway (Reliability: 3)
F6P3V1_DANRE
1001
1
112404
TrEMBL
Secretory Pathway (Reliability: 1)
Q5J1R9_DANRE
941
2
106260
TrEMBL
Secretory Pathway (Reliability: 1)
D9MNA7_DANRE
1064
2
119715
TrEMBL
Secretory Pathway (Reliability: 1)
O42362_DANRE
1106
1
125088
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1N221_DANRE
941
2
106260
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2R8QCP1_DANRE
844
1
94672
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1PBC2_DANRE
868
2
96715
TrEMBL
Secretory Pathway (Reliability: 2)
J7GVC9_DANRE
876
1
97973
TrEMBL
other Location (Reliability: 2)
O73877_DANRE
490
1
55081
TrEMBL
other Location (Reliability: 4)
A0A2R8QQ09_DANRE
1417
2
157879
TrEMBL
other Location (Reliability: 4)
A0A0H2UKW5_DANRE
813
1
92083
TrEMBL
Secretory Pathway (Reliability: 1)
F1QWE3_DANRE
952
2
106154
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8N7UZE5_DANRE
1368
1
154408
TrEMBL
Secretory Pathway (Reliability: 3)
Q91407_DANRE
168
0
18996
TrEMBL
other Location (Reliability: 1)
A0A2R8QJK4_DANRE
857
1
95637
TrEMBL
Secretory Pathway (Reliability: 3)
D0FH56_DANRE
936
1
105533
TrEMBL
Secretory Pathway (Reliability: 1)
B3DGZ3_DANRE
619
1
70090
TrEMBL
other Location (Reliability: 2)
A0A8M1PAD1_DANRE
351
1
38939
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2R8RJX9_DANRE
958
1
106321
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2R8QE85_DANRE
1116
1
124431
TrEMBL
other Location (Reliability: 2)
A0A2R8Q206_DANRE
1348
1
152360
TrEMBL
other Location (Reliability: 3)
A4JYH7_DANRE
822
1
91691
TrEMBL
Secretory Pathway (Reliability: 2)
P79726_DANRE
1106
1
125125
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1P5Y5_DANRE
797
2
90265
TrEMBL
Secretory Pathway (Reliability: 1)
A4QN31_DANRE
728
1
81771
TrEMBL
Secretory Pathway (Reliability: 1)
Q5J1R8_DANRE
676
3
77015
TrEMBL
Secretory Pathway (Reliability: 1)
F1QIM7_DANRE
937
2
104940
TrEMBL
Secretory Pathway (Reliability: 1)
Q1LWJ4_DANRE
1405
1
158420
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1P2M2_DANRE
818
1
92694
TrEMBL
Secretory Pathway (Reliability: 1)
Q5RIU8_DANRE
804
1
91430
TrEMBL
Mitochondrion (Reliability: 2)
A0A286Y8S1_DANRE
986
2
110313
TrEMBL
Secretory Pathway (Reliability: 1)
F1RCR4_DANRE
1015
1
113545
TrEMBL
other Location (Reliability: 3)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
0.1 mM trans-3,5,4'-trimethoxystilbene downregulates VEGFR2 mRNA expression 4fold
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bovenkamp, D.E.; Greer, P.
Novel Eph-family receptor tyrosine kinase is widely expressed in the developing zebrafish nervous system
Dev. Dyn.
209
166-181
1997
Danio rerio (O13146), Danio rerio
Manually annotated by BRENDA team
Lyons, M.S.; Bell, B.; Stainier, D.; Peters, K.G.
Isolation of the zebrafish homologues for the tie-1 and tie-2 endothelium-specific receptor tyrosine kinases
Dev. Dyn.
212
133-140
1998
Danio rerio (O73791), Danio rerio
Manually annotated by BRENDA team
Alex, D.; Leong, E.C.; Zhang, Z.J.; Yan, G.T.; Cheng, S.H.; Leong, C.W.; Li, Z.H.; Lam, K.H.; Chan, S.W.; Lee, S.M.
Resveratrol derivative, trans-3,5,4-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation
J. Cell. Biochem.
109
339-346
2010
Danio rerio
Manually annotated by BRENDA team