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ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
ATP + adenosine
ADP + adenosine 5'-phosphate
ATP + cytidine
ADP + cytidine 5'-phosphate
catalytic efficiency with cytidine is 45% relative to guanosine
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-
?
ATP + guanosine
ADP + GMP
ATP + guanosine
ADP + guanosine 5'-phosphate
ATP + inosine
ADP + inosine 5'-phosphate
ATP + mizoribine
ADP + mizoribine 5'-phosphate
i.e. 5-hydroxy-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide. Phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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-
?
ATP + ribavirin
ADP + ribavirin 5'-phosphate
ATP + uridine
ADP + uridine 5'-phosphate
CTP + inosine
CDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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-
?
GTP + cytidine
GDP + CMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
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-
?
GTP + guanosine
GDP + GMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
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-
?
GTP + guanosine
GDP + guanosine 5'-phosphate
phosphoryl donor specificity in order of decreasing Vmax: GTP > ATP > ITP. The catalytic efficiency of GTP is 39% compared to that of ATP
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?
GTP + inosine
GDP + IMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
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-
?
GTP + inosine
GDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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-
?
ITP + cytidine
IDP + CMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
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-
?
ITP + guanosine
IDP + GMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
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-
?
ITP + guanosine
IDP + guanosine 5'-phosphate
phosphoryl donor specificity in order of decreasing Vmax: GTP > ATP > ITP
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-
?
ITP + inosine
IDP + IMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
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-
?
ITP + inosine
IDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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-
?
TTP + inosine
TDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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-
?
UTP + inosine
UDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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-
?
additional information
?
-
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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-
?
ATP + adenosine
ADP + adenosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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-
?
ATP + adenosine
ADP + adenosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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-
?
ATP + adenosine
ADP + adenosine 5'-phosphate
catalytic efficiency with cytidine is 22% relative to guanosine
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?
ATP + cytidine
ADP + CMP
at 70°C the Vmax/Km-value for cytidine is 93% of the Vmax/Km-value for inosine. At 50°C the Vmax/Km-value for cytidine is 59% of the Vmax/Km-value for inosine. Neither ADP, acetyl phosphate, nor diphosphate can replace ATP
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?
ATP + cytidine
ADP + CMP
at 70°C the Vmax/Km-value for cytidine is 93% of the Vmax/Km-value for inosine. At 50°C the Vmax/Km-value for cytidine is 59% of the Vmax/Km-value for inosine. Neither ADP, acetyl phosphate, nor diphosphate can replace ATP
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?
ATP + guanosine
ADP + GMP
at 70°C the Vmax/Km-value for guanosine is 52% of the Vmax/Km-value for inosine. At 50°C the Vmax/Km-value for guanosine is 52% of the Vmax/Km-value for inosine. Neither ADP, acetyl phosphate, nor diphosphate can replace ATP
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?
ATP + guanosine
ADP + GMP
at 70°C the Vmax/Km-value for guanosine is 52% of the Vmax/Km-value for inosine. At 50°C the Vmax/Km-value for guanosine is 52% of the Vmax/Km-value for inosine. Neither ADP, acetyl phosphate, nor diphosphate can replace ATP
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?
ATP + guanosine
ADP + guanosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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-
?
ATP + guanosine
ADP + guanosine 5'-phosphate
phosphoryl donor specificity in order of decreasing Vmax: GTP > ATP > ITP. The catalytic efficiency of GTP is 39% compared to that of ATP
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?
ATP + inosine
ADP + IMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
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?
ATP + inosine
ADP + IMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
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?
ATP + inosine
ADP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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?
ATP + inosine
ADP + inosine 5'-phosphate
catalytic efficiency with inosine is 62% relative to guanosine
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?
ATP + ribavirin
ADP + ribavirin 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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-
?
ATP + ribavirin
ADP + ribavirin 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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-
?
ATP + uridine
ADP + uridine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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-
?
ATP + uridine
ADP + uridine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
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?
additional information
?
-
in the presence of D-ribose, L-ribose, fructose, glucose, 2-deoxy-glucose, xanthosine, galactose, xylose, N-acetyl glucosamine, fructose-6-phosphate, mannose-6-phosphate and ribose-5-phosphate, the activity is below the detection limit. No activity with cytidine or thamidine
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?
additional information
?
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in the presence of D-ribose, L-ribose, fructose, glucose, 2-deoxy-glucose, xanthosine, galactose, xylose, N-acetyl glucosamine, fructose-6-phosphate, mannose-6-phosphate and ribose-5-phosphate, the activity is below the detection limit. No activity with cytidine or thamidine
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?
additional information
?
-
in the presence of D-ribose, L-ribose, fructose, glucose, 2-deoxy-glucose, xanthosine, galactose, xylose, N-acetyl glucosamine, fructose-6-phosphate, mannose-6-phosphate and ribose-5-phosphate, the activity is below the detection limit. No activity with cytidine or thamidine
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?
additional information
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the enzyme plays a role in nucleotide metabolism
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additional information
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the enzyme plays a role in nucleotide metabolism
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additional information
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adenosine, xanthosine, 2'-deoxyadenosine, uridine, and thymidine are used at low rates, the enzyme catalyses the ATP-dependent phosphorylation of D-fructose 6-phosphate at an extremely low rate
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?
additional information
?
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adenosine, xanthosine, 2'-deoxyadenosine, uridine, and thymidine are used at low rates, the enzyme catalyses the ATP-dependent phosphorylation of D-fructose 6-phosphate at an extremely low rate
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?
additional information
?
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the enzyme plays a role in nucleotide metabolism
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?
additional information
?
-
adenosine, xanthosine, 2'-deoxyadenosine, uridine, and thymidine are used at low rates, the enzyme catalyses the ATP-dependent phosphorylation of D-fructose 6-phosphate at an extremely low rate
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?
additional information
?
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negligible enzymatic activity with thymidine, uridine, and 2-deoxyadenosine. Negligible enzymatic activity is observed with UTP and TTP as phosphate donors
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?
additional information
?
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-
negligible enzymatic activity with thymidine, uridine, and 2-deoxyadenosine. Negligible enzymatic activity is observed with UTP and TTP as phosphate donors
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?
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Ota, H.; Sakasegawa, S.; Yasuda, Y.; Imamura, S.; Tamura, T.
A novel nucleoside kinase from Burkholderia thailandensis: a member of the phosphofructokinase B-type family of enzymes
FEBS J.
275
5865-5872
2008
Burkholderia thailandensis (Q2SZE4), Burkholderia thailandensis, Burkholderia thailandensis DSM 13276 (Q2SZE4)
brenda
Arnfors, L.; Hansen, T.; Schnheit, P.; Ladenstein, R.; Meining, W.
Structure of Methanocaldococcus jannaschii nucleoside kinase: an archaeal member of the ribokinase family
Acta Crystallogr. Sect. D
62
1085-1097
2006
Methanocaldococcus jannaschii (Q57849), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q57849)
brenda
Arnfors, L.; Hansen, T.; Meining, W.; Schnheit, P.; Ladenstein, R.
Expression, purification, crystallization and preliminary X-ray analysis of a nucleoside kinase from the hyperthermophile Methanocaldococcus jannaschii
Acta Crystallogr. Sect. F
61
591-594
2005
Methanocaldococcus jannaschii (Q57849), Methanocaldococcus jannaschii
brenda
Hansen, T.; Arnfors, L.; Ladenstein, R.; Schnheit, P.
The phosphofructokinase-B (MJ0406) from Methanocaldococcus jannaschii represents a nucleoside kinase with a broad substrate specificity
Extremophiles
11
105-114
2006
Methanocaldococcus jannaschii (Q57849), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q57849)
brenda
Elkin, S.R.; Kumar, A.; Price, C.W.; Columbus, L.
A broad specificity nucleoside kinase from Thermoplasma acidophilum
Proteins
81
568-582
2013
Thermoplasma acidophilum (Q9HJT3), Thermoplasma acidophilum
brenda