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EC Tree
The taxonomic range for the selected organisms is: Homo sapiens The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
ethanolamine kinase, etnk1, etnk2, etn kinase, ethanolamine kinase 1, ethanolamine kinase 2, treki1,
more
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ethanolamine phosphokinase
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kinase, ethanolamine (phosphorylating)
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phospho group transfer
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ATP:ethanolamine O-phosphotransferase
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ATP + choline
ADP + ?
very little activity
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?
ATP + ethanolamine
ADP + O-phosphoethanolamine
additional information
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ATP + ethanolamine
ADP + O-phosphoethanolamine
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ATP + ethanolamine
ADP + O-phosphoethanolamine
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ATP + ethanolamine
ADP + O-phosphoethanolamine
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additional information
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rate-controlling step in phosphatidylethanolamine biosynthesis
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additional information
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rate-controlling step in phosphatidylethanolamine biosynthesis
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ATP + ethanolamine
ADP + O-phosphoethanolamine
additional information
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ATP + ethanolamine
ADP + O-phosphoethanolamine
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ATP + ethanolamine
ADP + O-phosphoethanolamine
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additional information
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rate-controlling step in phosphatidylethanolamine biosynthesis
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additional information
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rate-controlling step in phosphatidylethanolamine biosynthesis
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Mg2+
required
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Cardiomyopathies
Phospholipid homeostasis and lipotoxic cardiomyopathy: A matter of balance.
Eosinophilia
Novel recurrent mutations in ethanolamine kinase 1 (ETNK1) gene in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia.
Epilepsy
Structural mass spectrometry analysis of lipid changes in a Drosophila epilepsy model brain.
Fatty Liver
Complement C3 participates in the development of goose fatty liver potentially by regulating the expression of FASN and ETNK1.
Fetal Death
Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2.
Infections
Kinome siRNA screen identifies novel cell-type specific dengue host target genes.
Laryngeal Neoplasms
Radioresistance in a human laryngeal squamous cell carcinoma cell line is associated with DNA methylation changes and topoisomerase II alpha.
Leukemia
Novel recurrent mutations in ethanolamine kinase 1 (ETNK1) gene in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia.
Leukemia
Recurrent ETNK1 mutations in atypical chronic myeloid leukemia.
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Recurrent ETNK1 mutations in atypical chronic myeloid leukemia.
Leukemia, Myelomonocytic, Chronic
Novel recurrent mutations in ethanolamine kinase 1 (ETNK1) gene in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia.
Leukemia, Myelomonocytic, Chronic
Recurrent ETNK1 mutations in atypical chronic myeloid leukemia.
Lung Neoplasms
Phospholipid dynamics in ex vivo lung cancer and normal lung explants.
Mastocytosis, Systemic
Novel recurrent mutations in ethanolamine kinase 1 (ETNK1) gene in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia.
Neoplasm Metastasis
Hepatic metastasis of gastric cancer is associated with enhanced expression of ethanolamine kinase 2 via the p53-Bcl-2 intrinsic apoptosis pathway.
Neoplasm Metastasis
miR-199a-3p targets ETNK1 to promote invasion and migration in gastric cancer cells and is associated with poor prognosis.
Neoplasms
Ethanolamine kinase controls neuroblast divisions in Drosophila mushroom bodies.
Neoplasms
ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine.
Neoplasms
Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression.
Neoplasms
Hepatic metastasis of gastric cancer is associated with enhanced expression of ethanolamine kinase 2 via the p53-Bcl-2 intrinsic apoptosis pathway.
Neoplasms
Targeting Phospholipid Metabolism in Cancer.
Primary Myelofibrosis
Novel recurrent mutations in ethanolamine kinase 1 (ETNK1) gene in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia.
Stomach Neoplasms
Hepatic metastasis of gastric cancer is associated with enhanced expression of ethanolamine kinase 2 via the p53-Bcl-2 intrinsic apoptosis pathway.
Stomach Neoplasms
miR-199a-3p targets ETNK1 to promote invasion and migration in gastric cancer cells and is associated with poor prognosis.
Thrombosis
Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2.
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0.25
ethanolamine
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37°C, pH 8.5
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additional information
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brenda
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SwissProt
brenda
gene ek1; gene EKI1
SwissProt
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gene EKI1
SwissProt
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gene eki2, splicing variants eki2alpha and eki2beta; gene eki2, splicing variants eki2alpha and eki2beta
UniProt
brenda
gene ETNK1
SwissProt
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expression levels of splicing variant ek2alpha is repressed in the HepG2 cells
brenda
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additional information
expression profile of the enzyme in cancer cell lines, overview
brenda
additional information
expression profile of the enzyme in cancer cell lines, overview
brenda
additional information
expression profile of the enzyme in cancer cell lines, overview. Splice variant ek2beta exhibits a markedly low mRNA transcript level in all three of the cancer cell lines
brenda
additional information
expression profile of the enzyme in cancer cell lines, overview. Splice variant ek2beta exhibits a markedly low mRNA transcript level in all three of the cancer cell lines
brenda
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evolution
human ethanolamine kinase exists as three isoforms: EK1, EK2alpha and EK2beta, encoded by two separate genes; ek1, which produces the ek1 transcript variant 1, and ek2, which undergoes alternative splicing to produce ek2alpha (NCBI reference: NM_018208.2) and ek2beta (GenBank reference: AK001623.1) transcript variants. ek2alpha and ek2beta are respectively translated into EK2alpha and EK2beta
malfunction
somatic enzyme mutations targeted to two contiguous amino acids in the ETNK1 kinase domain are involved in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia, phenotypes, overview
physiological function
splicing variant ek2beta exhibits a markedly low mRNA transcript level in all three of the cancer cell lines examined, thus suggesting that transcription of the ek2beta gene may be negligible and this isoform may not have a significant role in phosphatidyletanolamine synthesis in the three cancer cell lines
metabolism
a key enzyme in cellular phospholipid synthesis
metabolism
choline kinase and ethanolamine kinase are enzymes that initiate the first step in the Kennedy pathway, resulting in the biosynthesis of phosphatidylcholine and phosphatidylethanolamine. Expression profiling of ethanolamine kinase in MCF-7, HCT-116 and Hep-G2 cells, and the transcriptional regulation by epigenetic modification
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EKI2_HUMAN
386
0
44781
Swiss-Prot
Mitochondrion (Reliability: 3 )
CHKA_HUMAN
457
0
52249
Swiss-Prot
other Location (Reliability: 3 )
CHKB_HUMAN
395
0
45271
Swiss-Prot
other Location (Reliability: 2 )
EKI1_HUMAN
452
1
50968
Swiss-Prot
Mitochondrion (Reliability: 3 )
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44000
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2 * 44000, SDS-PAGE
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dimer
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2 * 44000, SDS-PAGE
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D816V
naturally occuring mutation involved in adult systemic mastocytosis, chronic myelomonocytic leukemia, or eosinophilia
G245A
naturally occuring mutation involved in adult systemic mastocytosis,with chronic myelomonocytic leukemia and/or eosinophilia, inactive mutant
N244K
naturally occuring mutation involved in adult systemic mastocytosis, with chronic myelomonocytic leukemia and/or eosinophilia, inactive mutant
N244S
naturally occuring mutation involved in adult systemic mastocytosis, with chronic myelomonocytic leukemia and/or eosinophilia, inactive mutant
N244T
naturally occuring mutation involved in adult systemic mastocytosis, with chronic myelomonocytic leukemia and/or eosinophilia, inactive mutant
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gene eki1, a Sp site at position (-40/-31) is essential for the basal transcription of this gene, quantitative real-time PCR transcription analysis of ek1 mRNA, Identification of important regulatory regions in the ek1 gene promoter by analysis of 4 promoter constructs, trichostatin A activates basal ek1 promoter activity via Sp(-40/-31) site
gene ETNK1, overexpression of wild-type and N244S mutant enzymes in murine Ba/F3 cells
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substantial induction of splicing variant ek2alpha mRNA expression in response to trichostatin A treatment in Hep-G2 cells, the elevated ek2alpha mRNA expression may be due to the accumulation of acetylated histones H3 and H4, located around the promoter regions. Trichostatin A may also induce the recruitment of euchromatic markers and RNA polymerase II to the transcription factor complex that binds to the promoter, thus facilitating gene transcription
treatment of HCT-116 cells with trichostatin A (TSA), a histone deacetylase inhibitor, significantly upregulates the eki1 promoter activity through the Sp(-40/-31) site and increases the endogenous expression of gene eki1. Trichostatin A increases the binding of Sp1, Sp3 and RNA polymerase II to the ek1 promoter in HCT116 cells, molecular mechanism, overview. The effect of TSA on ek1 promoter activity is cell-line specific as TSA treatment does not affect ek1 promoter activity in Hep-G2 cells
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Ishidate, K.
Choline/ethanolamine kinase from mammalian tissues
Biochim. Biophys. Acta
1348
70-78
1997
Saccharomyces cerevisiae, Homo sapiens, Rattus norvegicus
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Draus, E.; Niefield, J.; Vietor, K.; Havsteen, B.
Isolation and characterization of the human liver ethanolamine kinase
Biochim. Biophys. Acta
1045
195-204
1990
Homo sapiens
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Lykidis, A.; Wang, J.; Karim, M.A.; Jackowski, S.
Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway
J. Biol. Chem.
276
2174-2179
2001
Homo sapiens (Q9HBU6), Homo sapiens
brenda
Lasho, T.L.; Finke, C.M.; Zblewski, D.; Patnaik, M.; Ketterling, R.P.; Chen, D.; Hanson, C.A.; Tefferi, A.; Pardanani, A.
Novel recurrent mutations in ethanolamine kinase 1 (ETNK1) gene in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia
Blood Cancer J.
5
e275
2015
Homo sapiens (Q9HBU6), Homo sapiens
brenda
Ling, C.S.; Yin, K.B.; Cun, S.T.; Ling, F.L.
Expression profiling of choline and ethanolamine kinases in MCF7, HCT116 and HepG2 cells, and the transcriptional regulation by epigenetic modification
Mol. Med. Rep.
11
611-618
2015
Homo sapiens (Q9HBU6), Homo sapiens (Q9NVF9)
brenda
Kuan, C.S.; See Too, W.C.; Few, L.L.
Sp1 and Sp3 are the transcription activators of human ek1 promoter in TSA-treated human colon carcinoma cells
PLoS ONE
11
e0147886
2016
Homo sapiens (Q9HBU6), Homo sapiens
brenda