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Information on EC 2.7.1.81 - hydroxylysine kinase and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC2.7.1.81
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EC Tree
IUBMB Comments
Both the natural 5-hydroxy-L-lysine and its 5-epimer act as acceptors.
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This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
agphd1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase
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hydroxylysine kinase (phosphorylating)
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kinase, hydroxylysine (phosphorylating)
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
GTP:5-hydroxy-L-lysine O-phosphotransferase
Both the natural 5-hydroxy-L-lysine and its 5-epimer act as acceptors.
CAS REGISTRY NUMBER
COMMENTARY hide
9073-58-9
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 5-hydroxy-L-lysine
ADP + O-phosphohydroxy-L-lysine
show the reaction diagram
catalytic efficiency is 22fold higher with GTP than with ATP
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?
GTP + 5-hydroxy-D-lysine
GDP + O-phosphohydroxy-D-lysine
show the reaction diagram
best substrate is the physiological form 5-hydroxy-L-lysine but human enzyme can also phosphorylate at a lower rate at least one other isomer
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?
GTP + 5-hydroxy-L-lysine
GDP + O-phosphohydroxy-L-lysine
show the reaction diagram
best substrate is the physiological form 5-hydroxy-L-lysine but human enzyme can also phosphorylate at a lower rate at least one other isomer
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?
additional information
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0076 - 0.28
5-hydroxy-L-lysine
0.81
ATP
pH 7.1, 30°C
0.0035
GTP
pH 7.1, 30°C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
12 - 45
5-hydroxy-L-lysine
5
ATP
pH 7.1, 30°C
110
GTP
pH 7.1, 30°C
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HYKK_HUMAN
373
0
41933
Swiss-Prot
other Location (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Veiga-da-Cunha, M.; Hadi, F.; Balligand, T.; Stroobant, V.; Van Schaftingen, E.
Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine
J. Biol. Chem.
287
7246-7255
2012
Homo sapiens (A2RU49), Homo sapiens
Manually annotated by BRENDA team