Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.7.1.68 - 1-phosphatidylinositol-4-phosphate 5-kinase and Organism(s) Mus musculus

for references in articles please use BRENDA:EC2.7.1.68
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Mus musculus
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
hide
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
pipkin, pip5k, pip kinase, ptdinsp, phosphatidylinositol 4-phosphate 5-kinase, phosphatidylinositol-4-phosphate 5-kinase, pipk, pipkigamma, pip5k1a, pip5ks, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Diphosphoinositide kinase
-
-
-
-
MSS4p
-
-
-
-
phosphatidylinositol 4-phosphate 5-kinase
phosphatidylinositol 4-phosphate 5-kinase alpha
phosphatidylinositol 4-phosphate 5-kinase beta
-
-
phosphatidylinositol 4-phosphate 5-kinase gamma661
-
-
phosphatidylinositol 4-phosphate 5-kinase Igamma_v6
-
-
phosphatidylinositol 4-phosphate 5-kinase-Ibeta
-
-
phosphatidylinositol 4-phosphate kinase
-
-
-
-
phosphatidylinositol 5-kinase gamma
-
-
phosphatidylinositol phosphate 5-kinase Ibeta
-
-
phosphatidylinositol phosphate kinase type I gamma
-
-
phosphatidylinositol-4-phosphate 5-kinase
phosphoinositol-4-phosphate-5-kinase
-
-
PI 4-phosphate 5-kinase
-
PI(4)P 5-kinase
-
-
PI4P 5-kinase
-
-
-
-
PI4P5K
-
-
-
-
PIP kinase
-
-
-
-
PIP-5kin
-
-
-
-
PIP5K
PIP5K type I
-
-
PIP5K-Ib
-
-
PIP5Kalpha
PIP5Kbeta
PIP5Kgamma
PIP5Kgamma661
-
-
PIP5KI gamma
-
-
PIP5KIgamma
-
-
PIP5KIgamma_v6
-
-
PIP5Ks
-
-
-
-
PIPK1gamma-87
-
-
PIPKalpha
-
-
PIPkinIgamma93
-
-
PtdIns(4)P 5-kinase
-
-
-
-
PtdIns4P5K
-
-
type I phosphatidylinositol 4-phosphate 5-kinase gamma
-
-
type I PI 4-phosphate 5-kinase
-
type Igamma phosphatidylinositol 4-phosphate 5-kinase
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
show the reaction diagram
an activation loop spanning the catalytic domain is responsible for determination of both substrate specificity and subcellular targeting
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase
This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known.
CAS REGISTRY NUMBER
COMMENTARY hide
104645-76-3
-
9032-61-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1,2-dipalmitoyl phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1,2-dipalmitoyl phosphatidyl-1D-myo-inositol 4,5-bisphosphate
show the reaction diagram
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
show the reaction diagram
ATP + 1-stearoyl-2-arachidonoyl phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-stearoyl-2-arachidonoyl phosphatidyl-1D-myo-inositol 4,5-bisphosphate
show the reaction diagram
-
-
-
-
?
ATP + 1-stearoyl-2-oleoyl phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-stearoyl-2-oleoyl phosphatidyl-1D-myo-inositol 4,5-bisphosphate
show the reaction diagram
-
-
-
-
?
ATP + dipalmitoyl phosphatidylinositol 4-phosphate
ADP + dipalmitoylphosphatidylinositol 4,5-bisphosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
H2O2
-
the enzyme is inhibited after 20 min incubation with 0.6 mM H2O2
additional information
-
not inhibited by SP600125, SB203580, ZVAD-fmk, wortmannin or LY294002
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-diarachidonoyl phosphatidic acid
-
-
1,2-dilinoleoyl phosphatidic acid
-
-
1,2-dioleoyl phosphatidic acid
-
-
1-arachidoyl-2-arachidonoyl phosphatidic acid
-
-
1-stearoyl-2-arachidonoyl phosphatidic acid
-
-
1-stearoyl-2-oleoyl phosphatidic acid
-
-
ADP-ribosylation factor 1
-
0.001 mM
-
ADP-ribosylation factor 6
-
0.001 mM
-
Arf6
-
activates the enzyme via binding of small GTPase Rac1, regulatory function, mutant Arf6 N121I is defective for nucleotide binding, mutant Q67L is similarly active as the wild-type Arf6
-
beta2 adaptin
-
the beta2 subunit of beta2 adaptin binds to the C-terminal tail of PIP5Kgamma661 and causes activation of the enzyme
-
lysophosphatidic acid
-
mechanism overview
phosphatidic acid
small G protein ARF
-
ARF activation absolutely requires the presence of phosphatidic acid, which cannot be substituted by phosphatidylserine, phosphatidylethanolamine, or lysophosphatidic acid, but by competitive phosphatidylcholine, reconstitution of the recombinant either isozyme alpha, beta, or gamma with recombinant class II and III ARFs, ARF5 and ARF6, respectively, as well as myristoylated class I ARF in presence of GTPgammaS or GDP, and phosphatidic acid activates the isozymes
-
small G protein RHO
-
activates the enzyme in neurits, crucial in cell shapig together with the enzyme, overview
-
small GTPase Arf
-
involved in membrane receptor-mediated regulation, acts via effectors, mechanism overview
-
small GTPase ARF/phosphatidic acid
-
regulation of isozyme gamma
-
small GTPase Rho
-
involved in membrane receptor-mediated regulation, acts via effectors, mechanism overview
-
Triton X-100
-
optimal phosphatidic acid-stimulation of type I PIP5K activity occurs in the presence of Triton X-100
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.9 - 16
1-stearoyl-2-arachidonoyl phosphatidyl-1D-myo-inositol 4-phosphate
1.6 - 3.7
1-stearoyl-2-oleoyl phosphatidyl-1D-myo-inositol 4-phosphate
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
isozymes type I PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma are all expressed in BV-2 microglial cells
Manually annotated by BRENDA team
highest expression
Manually annotated by BRENDA team
-
phosphatidylinositol 4-phosphate 5-kinase Igamma_v6 splice variant
Manually annotated by BRENDA team
additional information
-
PIP5KIgamma_v6 tissue expression pattern, overview
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
co-localization of KIF2A and PIPKalpha at the tips of neurites
-
Manually annotated by BRENDA team
-
isozyme PIP5Kalpha
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
phosphorylation of 1-phosphatidyl-1D-myo-inositol 4-phosphate by the type I PI 4-phosphate 5-kinase (PIP5K) family members including PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma isoforms is the major pathway of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis in mammalian cells
physiological function
additional information
-
identification of the binding domain for His6-tagged KIF2A and GST-tagged PIPKalpha interaction, overview
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PI51A_MOUSE
546
0
60485
Swiss-Prot
other Location (Reliability: 4)
PI51B_MOUSE
539
0
60803
Swiss-Prot
other Location (Reliability: 1)
PI51C_MOUSE
661
0
72408
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
68000
-
x * 68000, isozymes alpha or beta, x * 90000, isozyme gamma
90000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
-
the enzyme is negatively regulated by, besides other mechanisms, phosphorylation, autophosphorylation is enhanced by phosphatidylinositol, isozyme alpha is phosphorylated by cAMP-dependent protein kinase at serine 214, Ca2+ induces dephosphorylation of isozyme gamma at serine 264, phosphorylation by 9,11-dideoxy-9alpha,11alpha-methanoepoxyprostaglandin U46619 is inhibited by genistein in platelets, tyrosine phosphorylation by focal adhesion kinase of isozyme gamma brain splice variant associated to the FERM domain of talin in brain
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D203A
-
catalytically inactive. Expression in Xenopus laevis oocyte has no effect on epithelial sodium channel activity
D227A
D253A
-
mutant lacking kinase activity. Overexpression compromises uropod formation and rear retraction during chemotaxis
D266A
-
site-directed mtagenesis, mutation of the putative ATP and 1-phosphatidyl-1D-myo-inositol 4-phosphate binding site, cells form extremely extended bipolar neurits even in presence of serum, failed to interfere with cell flattening and neurite extension
D309N
-
greatly reduced kinase activity towards 1-phosphatidyl-1D-myo-inositol 4-phosphate
D309N/R427Q
-
greatly reduced kinase activity towards 1-phosphatidyl-1D-myo-inositol 4-phosphate
D316K
-
no activity
D322A
-
isozyme PIP5Kalpha mutant that shows reduced activity compared to the wild-type enzyme
K138A
-
no activity
K181A
-
greatly reduced kinase activity towards 1-phosphatidyl-1D-myo-inositol 4-phosphate
L202I
-
the mutations of PIP5Kalpha decreases the substrate affinity and the enzyme efficiency for 1-stearoyl-2-arachidonoyl phosphatidylinositol-4-phosphate compared to the wild-type enzyme
L210I
-
the mutations of PIP5Kalpha decreases the substrate affinity and the enzyme efficiency for 1-stearoyl-2-arachidonoyl phosphatidylinositol-4-phosphate compared to the wild-type enzyme
R332H
YFP-tagged tubby mutant
R427Q
-
greatly reduced kinase activity towards 1-phosphatidyl-1D-myo-inositol 4-phosphate
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
amylose-resin column chromatography
glutathione-Sepharose chromatography
-
glutathione-Sepharose column chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning of splice variant phosphatidylinositol 4-phosphate 5-kinase Igamma_v6, expression in COS-7 cells
-
coexpression of wild-type HA-tagged isozyme alpha or HA-tagged isozyme alpha mutant D227A with HA-tagged Arf6 or HA-tagged Arf6 mutant N121I in COS-1 cells
-
expressed in Escherichia coli
-
expressed in HEK-293T cells
-
expressed in HeLa cells
-
expression in COS-7 cells
-
expression in Xenopus laevis oocyte
-
expression of HA-tagged PIP5K isozymes in COS-7 cells, expression of isozyme PIP5Kalpha mutant D322A
-
expression of isozyme PIP5Kalpha tagged with monomeric red fluorescent protein, haemagglutinin, or FLAG in HEK-293T cells
expression of mutant enzymes K181A, D309N, D309N/R429Q and R427Q in Escherichia coli, expression of mutant enzymes in human MG-63 osteosarcoma cells
-
functional complementation of a yeast Mss4-1 mutant strain YOC808 by the wild-type isozyme gamma and the deletion mutants localizing to the plasma membrane, while the deletion mutants localized to the cytosol cannot support yeast cell growth, expression of wild-type and mutant type I HA-tagged or EGFP-tagged isozymes gamma in Neuro 2A cells and in COS-1 cells
-
overexpression of isozymes alpha, beta, and gamma in HeLa cells, overexpression of isozymes alpha, beta, and gamma in CV-1 cells: isozymes alpha and beta are active, the latter shows the highest activity, isozyme gamma is not active, small interference RNA inhibition of isozyme beta expression also reduces expression of isozyme alpha, but increased expression of isozyme gamma, with a 50% loss in activity, reduction of isozyme alpha expression increases expression of isozymes beta and gamma and leaves the 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis level unaltered, inhibition of isozyme gamma increases expression of isozymes alpha and beta, overview, expression of isozyme beta increases the internalization of influenza virus hemagglutinin Y543, enzyme expression prevents the cells of disruption of their actine cytoskeleton by drugs, e.g. cytochalasin D or latrunculin, and increases the number of clathrin-coated pits
-
overexpression of mutant D266A in N1E-115 cells, expression of isozyme alpha in COS-7 cells, expression of isozyme alpha in Escherichia coli
-
overexpression of PIPKalpha in N1E-115 neuroblastoma cells, co-expression of His6-tagged KIF2A and GST-tagged PIPKalpha in Escherichia coli, binding analysis
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
treatment of BV-2 microglial cells with lipoteichoic acid increases isoform PIP5Kalpha expression in BV-2 and primary microglial cells, but not in primary cultures from Toll-like receptor 2-deficient mice
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Galiano, F.J.; Ulug, E.T.; Davis, J.N.
Overexpression of murine phosphatidylinositol 4-phosphate 5-kinase type Ibeta disrupts a phosphatidylinositol 4,5 bisphosphate regulated endosomal pathway
J. Cell. Biochem.
85
131-145
2002
Mus musculus
Manually annotated by BRENDA team
Barbieri, M.A.; Heath, C.M.; Peters, E.M.; Wells, A.; Davis, J.N.; Stahl, P.D.
Phosphatidylinositol-4-phosphate 5-kinase-1beta is essential for epidermal growth factor receptor-mediated endocytosis
J. Biol. Chem.
276
47212-47216
2001
Mus musculus
Manually annotated by BRENDA team
Coppolino, M.G.; Dierckman, R.; Loijens, J.; Collins, R.F.; Pouladi, M.; Jongstra-Bilen, J.; Schreiber, A.D.; Trimble, W.S.; Anderson, R.; Grinstein, S.
Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis
J. Biol. Chem.
277
43849-43857
2002
Mus musculus
Manually annotated by BRENDA team
Yamazaki, M.; Miyazaki, H.; Watanabe, H.; Sasaki, T.; Maehama, T.; Frohman, M.A.; Kanaho, Y.
Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling
J. Biol. Chem.
277
17226-17230
2002
Mus musculus
Manually annotated by BRENDA team
Tolias, K.F.; Hartwig, J.H.; Ishihara, H.; Shibasaki, Y.; Cantley, L.C.; Carpenter, C.L.
Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly
Curr. Biol.
10
153-156
2000
Mus musculus
Manually annotated by BRENDA team
Park, S.J.; Itoh, T.; Takenawa, T.
Phosphatidylinositol 4-phosphate 5-kinase type I is regulated through phosphorylation response by extracellular stimuli
J. Biol. Chem.
276
4781-4787
2001
Mus musculus
Manually annotated by BRENDA team
van Horck, F.P.; Lavazais, E.; Eickholt, B.J.; Moolenaar, W.H.; Divecha, N.
Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling
Curr. Biol.
12
241-245
2002
Mus musculus
Manually annotated by BRENDA team
Kanaho, Y.; Miyazaki, H.; Yamazaki, M.
Activation of PI(4)P 5-kinase by small G proteins
Adv. Enzyme Regul.
43
107-119
2003
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Arioka, M.; Nakashima, S.; Shibasaki, Y.; Kitamoto, K.
Dibasic amino acid residues at the carboxy-terminal end of kinase homology domain participate in the plasma membrane localization and function of phosphatidylinositol 5-kinase gamma
Biochem. Biophys. Res. Commun.
319
456-463
2004
Mus musculus
Manually annotated by BRENDA team
Oude Weernink, P.A.; Schmidt, M.; Jakobs, K.H.
Regulation and cellular roles of phosphoinositide 5-kinases
Eur. J. Pharmacol.
500
87-99
2004
Saccharomyces cerevisiae, Candida albicans, Homo sapiens, Mus musculus, Schizosaccharomyces pombe
Manually annotated by BRENDA team
Padron, D.; Wang, Y.J.; Yamamoto, M.; Yin, H.; Roth, M.G.
Phosphatidylinositol phosphate 5-kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis
J. Cell Biol.
162
693-701
2003
Mus musculus
Manually annotated by BRENDA team
Wong, K.W.; Isberg, R.R.
Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake
J. Exp. Med.
198
603-614
2003
Mus musculus
Manually annotated by BRENDA team
Perez-Mansilla, B.; Ha, V.L.; Justin, N.; Wilkins, A.J.; Carpenter, C.L.; Thomas, G.M.
The differential regulation of phosphatidylinositol 4-phosphate 5-kinases and phospholipase D1 by ADP-ribosylation factors 1 and 6
Biochim. Biophys. Acta
1761
1429-1442
2006
Mus musculus
Manually annotated by BRENDA team
Halstead, J.R.; van Rheenen, J.; Snel, M.H.; Meeuws, S.; Mohammed, S.; DSantos, C.S.; Heck, A.J.; Jalink, K.; Divecha, N.
A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis
Curr. Biol.
16
1850-1856
2006
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Nakano-Kobayashi, A.; Yamazaki, M.; Unoki, T.; Hongu, T.; Murata, C.; Taguchi, R.; Katada, T.; Frohman, M.A.; Yokozeki, T.; Kanaho, Y.
Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis
EMBO J.
26
1105-1116
2007
Mus musculus
Manually annotated by BRENDA team
Giudici, M.L.; Lee, K.; Lim, R.; Irvine, R.F.
The intracellular localisation and mobility of Type Igamma phosphatidylinositol 4P 5-kinase splice variants
FEBS Lett.
580
6933-6937
2006
Mus musculus
Manually annotated by BRENDA team
Jarquin-Pardo, M.; Fitzpatrick, A.; Galiano, F.J.; First, E.A.; Davis, J.N.
Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4-phosphate 5-kinase-Ibeta for phosphatidylinositol-4-phosphate
J. Cell. Biochem.
100
112-128
2007
Mus musculus
Manually annotated by BRENDA team
Gong, L.W.; Di Paolo, G.; Diaz, E.; Cestra, G.; Diaz, M.E.; Lindau, M.; De Camilli, P.; Toomre, D.
Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion
Proc. Natl. Acad. Sci. USA
102
5204-5209
2005
Mus musculus
Manually annotated by BRENDA team
Weixel, K.M.; Edinger, R.S.; Kester, L.; Guerriero, C.J.; Wang, H.; Fang, L.; Kleyman, T.R.; Welling, P.A.; Weisz, O.A.; Johnson, J.P.
Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells
J. Biol. Chem.
282
36534-36542
2007
Mus musculus
Manually annotated by BRENDA team
Lokuta, M.A.; Senetar, M.A.; Bennin, D.A.; Nuzzi, P.A.; Chan, K.T.; Ott, V.L.; Huttenlocher, A.
Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis
Mol. Biol. Cell
18
5069-5080
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Xia, Y.; Irvine, R.F.; Giudici, M.L.
Phosphatidylinositol 4-phosphate 5-kinase Igamma_v6, a new splice variant found in rodents and humans
Biochem. Biophys. Res. Commun.
411
416-420
2011
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Hasegawa, H.; Noguchi, J.; Yamashita, M.; Okada, R.; Sugimoto, R.; Furuya, M.; Unoki, T.; Funakoshi, Y.; Baba, T.; Kanaho, Y.
Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis
Biol. Reprod.
86:136
1-12
2012
Mus musculus
Manually annotated by BRENDA team
Shulga, Y.V.; Anderson, R.A.; Topham, M.K.; Epand, R.M.
Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator
J. Biol. Chem.
287
35953-35963
2012
Mus musculus
Manually annotated by BRENDA team
Nguyen, T.T.; Kim, Y.M.; Kim, T.D.; Le, O.T.; Kim, J.J.; Kang, H.C.; Hasegawa, H.; Kanaho, Y.; Jou, I.; Lee, S.Y.
Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location
J. Biol. Chem.
288
5645-5659
2013
Homo sapiens, Mus musculus (P70182)
Manually annotated by BRENDA team
Noda, Y.; Niwa, S.; Homma, N.; Fukuda, H.; Imajo-Ohmi, S.; Hirokawa, N.
Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKalpha) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches
Proc. Natl. Acad. Sci. USA
109
1725-1730
2012
Mus musculus
Manually annotated by BRENDA team
Sakagami, H.; Katsumata, O.; Hara, Y.; Tamaki, H.; Fukaya, M.
Preferential localization of type I phosphatidylinositol 4-phosphate 5-kinase gamma at the periactive zone of mouse photoreceptor ribbon synapses
Brain Res.
1586
23-33
2014
Mus musculus
Manually annotated by BRENDA team
Hara, Y.; Fukaya, M.; Tamaki, H.; Sakagami, H.
Type I phosphatidylinositol 4-phosphate 5-kinase gamma is required for neuronal migration in the mouse developing cerebral cortex
Eur. J. Neurosci.
38
2659-2671
2013
Mus musculus
Manually annotated by BRENDA team
Yamazaki, M.; Yamauchi, Y.; Goshima, Y.; Kanaho, Y.
Phosphatidylinositol 4-phosphate 5-kinase beta regulates growth cone morphology and semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons
Neurosci. Lett.
547
59-64
2013
Mus musculus
Manually annotated by BRENDA team
Nguyen, T.T.N.; Seo, E.; Choi, J.; Le, O.T.T.; Kim, J.Y.; Jou, I.; Lee, S.Y.
Phosphatidylinositol 4-phosphate 5-kinase alpha contributes to toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid
Cell. Signal.
38
159-170
2017
Mus musculus
Manually annotated by BRENDA team
Khrongyut, S.; Rawangwong, A.; Pidsaya, A.; Sakagami, H.; Kondo, H.; Hipkaeo, W.
Localization of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) alpha, beta, gamma in the three major salivary glands in situ of mice and their response to beta-adrenoceptor stimulation
J. Anat.
234
502-514
2019
Mus musculus (O70161), Mus musculus (P70181), Mus musculus (P70182)
Manually annotated by BRENDA team