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Information on EC 2.7.1.68 - 1-phosphatidylinositol-4-phosphate 5-kinase and Organism(s) Caenorhabditis elegans

for references in articles please use BRENDA:EC2.7.1.68
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IUBMB Comments
This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known.
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Caenorhabditis elegans
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Word Map
The taxonomic range for the selected organisms is: Caenorhabditis elegans
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
pipkin, pip5k, pip kinase, ptdinsp, phosphatidylinositol 4-phosphate 5-kinase, phosphatidylinositol-4-phosphate 5-kinase, pipk, pipkigamma, pip5ks, pip5k1a, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Diphosphoinositide kinase
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MSS4p
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-
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phosphatidylinositol 4-phosphate kinase
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phosphatidylinositol-4-phosphate 5' kinase
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phosphatidylinositol-4-phosphate 5-kinase
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PI4P 5-kinase
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PI4P5K
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PIP kinase
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PIP-5kin
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PIP5K
PIP5Ks
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PtdIns(4)P 5-kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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PATHWAY SOURCE
PATHWAYS
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-, -
SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase
This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known.
CAS REGISTRY NUMBER
COMMENTARY hide
104645-76-3
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9032-61-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
enzyme can localize to the plasma membrane
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
O01759_CAEEL
611
0
68664
TrEMBL
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli strain HT115 (DE3)
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Xu, X.; Guo, H.; Wycuff, D.L.; Lee, M.
Role of phosphatidylinositol-4-phosphate 5 kinase (ppk-1) in ovulation of Caenorhabditis elegans
Exp. Cell Res.
313
2465-2475
2007
Caenorhabditis elegans
Manually annotated by BRENDA team
Weinkove, D.; Bastiani, M.; Chessa, T.A.; Joshi, D.; Hauth, L.; Cooke, F.T.; Divecha, N.; Schuske, K.
Overexpression of PPK-1, the Caenorhabditis elegans type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults
Dev. Biol.
313
384-397
2008
Caenorhabditis elegans (O01759), Caenorhabditis elegans
Manually annotated by BRENDA team