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Information on EC 2.7.1.67 - 1-phosphatidylinositol 4-kinase and Organism(s) Plasmodium falciparum

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EC Tree
IUBMB Comments
This reaction is catalysed by at least two different isoforms.
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Select one or more organisms in this record: ?
This record set is specific for:
Plasmodium falciparum
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Word Map
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The taxonomic range for the selected organisms is: Plasmodium falciparum
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
phosphatidylinositol kinase, pi kinase, pi4kb, pi 4-kinase, ptdins 4-kinase, pi4kiialpha, pi4ka, pi4kbeta, phosphatidylinositol-4-kinase, pik1p, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
kinase, phosphatidylinositol (phosphorylating)
-
-
-
-
phosphatidylinositol 4-kinase
phosphatidylinositol 4-kinase IIIbeta
-
phosphatidylinositol kinase
-
-
-
-
phosphatidylinositol-4-kinase
-
-
PI 4-kinase
-
-
-
-
PI kinase
-
-
-
-
PtdIns 4-kinase
-
-
-
-
type II phosphatidylinositol kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase
This reaction is catalysed by at least two different isoforms.
CAS REGISTRY NUMBER
COMMENTARY hide
37205-54-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
10 mM used in assay conditions
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1'R)-2'-acetyl-N-(2-fluorophenyl)-1'-(hydroxymethyl)-7'-methoxy-1',2',3',9'-tetrahydrospiro[piperidine-4,4'-pyrido[3,4-b]indole]-1-carboxamide
-
BRD73842
(1R)-3-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]cyclopentan-1-ol
-
-
(3-aminopyrrolidin-1-yl)(4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]phenyl)methanone
-
-
(3R)-1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]pyrrolidin-3-ol
-
-
(4-[3-[4-(methanesulfonyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]phenyl)(piperazin-1-yl)methanone
-
-
(4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)(3-hydroxypyrrolidin-1-yl)methanone
-
-
(4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)(piperazin-1-yl)methanone
-
-
(4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)[(3R)-3-hydroxypyrrolidin-1-yl]methanone
-
-
(4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)[(3S)-3-hydroxypyrrolidin-1-yl]methanone
-
-
(4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]phenyl)(piperazin-1-yl)methanone
-
-
(4-[6-[3-(methanesulfonyl)phenyl]imidazo[1,2-b]pyridazin-3-yl]phenyl)(piperazin-1-yl)methanone
-
-
1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]piperidin-4-ol
-
-
2-(4-methylpiperazin-1-yl)-8-(pyridin-4-yl)-1,5-naphthyridine
-
-
2-([3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]sulfonyl)ethanol
-
-
2-ethoxy-6'-methoxy-5-[4-(methylsulfonyl)phenyl]-3,3'-bipyridine
-
-
2-fluoro-5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
-
2-iodo-6'-methoxy-5-[4-(methylsulfonyl)phenyl]-3,3'-bipyridine
-
-
2-[3-(benzylsulfanyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
-
2-[3-(methylsulfonyl)phenyl]-8-(piperazin-1-yl)-1,5-naphthyridine
-
-
2-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
-
2-[3-(phenylsulfanyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
-
2-[3-(piperidine-1-sulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
-
2-[3-[(3R,5S)-3,5-dimethylpiperazine-1-sulfonyl]phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
-
2-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
-
2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide
-
BQR695
3-(1-methyl-1H-benzimidazol-5-yl)-6-[3-(propane-2-sulfonyl)phenyl]imidazo[1,2-b]pyridazine
-
-
3-(6-methoxypyridin-3-yl)-5-[4-(methylsulfonyl)-2-(trifluoromethyl)phenyl]pyrazin-2-amine
-
-
3-(6-methoxypyridin-3-yl)-5-[4-(methylsulfonyl)phenyl]pyrazin-2-amine
-
-
3-(6-methoxypyridin-3-yl)-5-[4-(trifluoromethoxy)phenyl]pyrazin-2-amine
-
-
3-(8-phenyl-1,5-naphthyridin-2-yl)benzenesulfonamide
-
-
3-[4-(methylsulfonyl)phenyl]-6-[2-(trifluoromethyl)pyridin-4-yl]imidazo[1,2-b]pyridazine
-
-
3-[4-(methylsulfonyl)phenyl]-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine
-
-
3-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
-
3-[8-(3-fluoropyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
-
3-[8-(4-benzylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
-
3-[8-(4-methylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
-
3-[8-(6-methylpyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
-
3-[8-(pyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
-
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]-N-[2-(pyrrolidin-1-yl)ethyl]benzene-1-sulfonamide
-
-
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]aniline
-
-
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
-
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
-
3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzenesulfonamide
-
-
3-[8-[4-(trifluoromethyl)phenyl]-1,5-naphthyridin-2-yl]benzenesulfonamide
-
-
4-fluoro-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
-
4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]benzoic acid
-
-
4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
-
5-[4-(methylsulfonyl)phenyl]-3-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-amine
-
-
5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-3,3'-bipyridin-2-amine
-
MMV390048
5-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
MMV024101
5-[8-(4-cyanophenyl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
-
5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
-
5-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
-
6-(3-methylphenyl)-3-(6-methylpyridin-3-yl)imidazo[1,2-b]pyridazine
-
-
6-[3-(methylsulfonyl)phenyl]-3-[4-(methylsulfonyl)phenyl]imidazo[1,2-a]pyridine
-
-
6-[3-(methylsulfonyl)phenyl]-3-[4-(methylsulfonyl)phenyl]imidazo[1,2-a]pyrimidine
-
-
6-[3-(methylsulfonyl)phenyl]-3-[4-(methylsulfonyl)phenyl]imidazo[1,2-b]pyridazine
-
-
6-[4-(cyclopropylsulfonyl)phenyl]-3-[4-(methylsulfonyl)phenyl]imidazo[1,2-b]pyridazine
-
-
8-(pyridin-4-yl)-2-[3-(pyrrolidin-1-ylsulfonyl)phenyl]-1,5-naphthyridine
-
-
8-(pyridin-4-yl)-2-[5-(trifluoromethyl)pyridin-3-yl]-1,5-naphthyridine
-
-
artesunate
-
-
BQR695
Chloroquine
-
-
KDU691
MMV390048
N,N-dimethyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
-
N-(2-hydroxyethyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
-
N-(2-hydroxyethyl)-3-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
-
N-(3-aminopropyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
-
N-(3-hydroxypropyl)-4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
-
N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide
-
KDU691
N-(4-cyanophenyl)-N-methyl-3-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide
-
KAI407
N-benzyl-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
-
N-cyclopropyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
-
N-[(2S)-1-hydroxypropan-2-yl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
-
N-[(oxetan-3-yl)methyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
-
N-[2-(dimethylamino)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
-
N-[2-(morpholin-4-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
-
N-[2-(piperidin-1-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
-
N-[2-(pyrrolidin-1-yl)ethyl]-3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
-
N-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
-
N-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]methanesulfonamide
-
-
N-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]methanesulfonamide
-
-
NVP-BGT226
complete inhibition at 0.01 mM
[(3R)-3-aminopyrrolidin-1-yl](4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)methanone
-
-
[(3S)-3-aminopyrrolidin-1-yl](4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)methanone
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0791
ATP
at pH 7.4 and 37°C
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000021
(1'R)-2'-acetyl-N-(2-fluorophenyl)-1'-(hydroxymethyl)-7'-methoxy-1',2',3',9'-tetrahydrospiro[piperidine-4,4'-pyrido[3,4-b]indole]-1-carboxamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000187
(3R)-1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]pyrrolidin-3-ol
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000023
(4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)(piperazin-1-yl)methanone
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000029
1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]piperidin-4-ol
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.001
2-(4-methylpiperazin-1-yl)-8-(pyridin-4-yl)-1,5-naphthyridine
Plasmodium falciparum
-
IC50 above 0.001 mM, pH and temperature not specified in the publication
0.000084
2-([3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]sulfonyl)ethanol
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.001755
2-fluoro-5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.003668
2-[3-(benzylsulfanyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00091
2-[3-(methylsulfonyl)phenyl]-8-(piperazin-1-yl)-1,5-naphthyridine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000147
2-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.001432
2-[3-(piperidine-1-sulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000046
2-[3-[(3R,5S)-3,5-dimethylpiperazine-1-sulfonyl]phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.005
2-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
0.0000035
2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000719
3-(8-phenyl-1,5-naphthyridin-2-yl)benzenesulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000215 - 0.000277
3-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000091 - 0.000105
3-[8-(3-fluoropyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000728
3-[8-(4-benzylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000437 - 0.000727
3-[8-(4-methylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000084
3-[8-(6-methylpyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000119 - 0.000238
3-[8-(pyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000025 - 0.000031
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]-N-[2-(pyrrolidin-1-yl)ethyl]benzene-1-sulfonamide
0.000935
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]aniline
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000745
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000122
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000063 - 0.000102
3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000265
3-[8-[4-(trifluoromethyl)phenyl]-1,5-naphthyridin-2-yl]benzenesulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.005
4-fluoro-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
Plasmodium falciparum
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
0.005
4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
0.0000034
5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-3,3'-bipyridin-2-amine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000543
5-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000424
5-[8-(4-cyanophenyl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000284 - 0.000377
5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
0.000355
5-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.001484
8-(pyridin-4-yl)-2-[3-(pyrrolidin-1-ylsulfonyl)phenyl]-1,5-naphthyridine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.001
8-(pyridin-4-yl)-2-[5-(trifluoromethyl)pyridin-3-yl]-1,5-naphthyridine
Plasmodium falciparum
-
IC50 above 0.001 mM, pH and temperature not specified in the publication
0.001
N,N-dimethyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
Plasmodium falciparum
-
IC50 above 0.001 mM, pH and temperature not specified in the publication
0.000019 - 0.000022
N-(2-hydroxyethyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000412 - 0.000457
N-(2-hydroxyethyl)-3-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.000708
N-(3-aminopropyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00618
N-(3-hydroxypropyl)-4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.0000015
N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00012
N-(4-cyanophenyl)-N-methyl-3-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000031 - 0.000065
N-benzyl-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.001
N-cyclopropyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
Plasmodium falciparum
-
IC50 above 0.001 mM, pH and temperature not specified in the publication
0.001015
N-[(2S)-1-hydroxypropan-2-yl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000203
N-[(oxetan-3-yl)methyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.002623
N-[2-(dimethylamino)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00005
N-[2-(morpholin-4-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00136
N-[2-(piperidin-1-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00002 - 0.000046
N-[2-(pyrrolidin-1-yl)ethyl]-3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.000496
N-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000087 - 0.00011
N-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]methanesulfonamide
0.005
N-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]methanesulfonamide
Plasmodium falciparum
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 40000, SDS-PAGE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H1484Y
the mutant shows reduced activity compared to the wild type enzyme
S1320L
the mutant shows reduced activity compared to the wild type enzyme
Y1356F
the mutant shows reduced activity compared to the wild type enzyme
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
HIS-Select nickel affinity gel chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Pichia pastoris
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fienberg, S.; Eyermann, C.J.; Arendse, L.; Basarab, G.S.; McPhail, J.; Burke, J.E.; Chibale, K.
Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-kinase Inhibitors
ACS Infect. Dis.
6
3048-3063
2020
Plasmodium falciparum
Manually annotated by BRENDA team
Sternberg, A.R.; Roepe, P.D.
Heterologous expression, purification, and functional analysis of the Plasmodium falciparum phosphatidylinositol 4-kinase IIIbeta
Biochemistry
59
2494-2506
2020
Plasmodium falciparum (Q8I406), Plasmodium falciparum
Manually annotated by BRENDA team
Kandepedu, N.; Gonzalez Cabrera, D.; Eedubilli, S.; Taylor, D.; Brunschwig, C.; Gibhard, L.; Njoroge, M.; Lawrence, N.; Paquet, T.; Eyermann, C.J.; Spangenberg, T.; Basarab, G.S.; Street, L.J.; Chibale, K.
Identification, characterization, and optimization of 2,8-disubstituted-1,5-naphthyridines as novel Plasmodium falciparum phosphatidylinositol-4-kinase inhibitors with in vivo efficacy in a humanized mouse model of malaria
J. Med. Chem.
61
5692-5703
2018
Plasmodium falciparum, Plasmodium vivax
Manually annotated by BRENDA team