Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.7.1.67 - 1-phosphatidylinositol 4-kinase and Organism(s) Drosophila melanogaster

for references in articles please use BRENDA:EC2.7.1.67
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This reaction is catalysed by at least two different isoforms.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Drosophila melanogaster
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
phosphatidylinositol kinase, pi kinase, pi4kb, pi 4-kinase, ptdins 4-kinase, pi4kiialpha, pi4ka, pi4kbeta, phosphatidylinositol-4-kinase, pik1p, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
kinase, phosphatidylinositol (phosphorylating)
-
-
-
-
phosphatidylinositol 4-kinase
-
-
-
-
phosphatidylinositol kinase
-
-
-
-
PI 4-kinase
-
-
-
-
PI kinase
-
-
-
-
PI4K
-
-
-
-
PtdIns 4-kinase
-
-
-
-
type II phosphatidylinositol 4-kinase
-
-
type II phosphatidylinositol kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase
This reaction is catalysed by at least two different isoforms.
CAS REGISTRY NUMBER
COMMENTARY hide
37205-54-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
dynamic tubular, PI4KII
Manually annotated by BRENDA team
additional information
-
PI4KII localizes to the Golgi and to a dynamic tubular endosomal network
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
in PI4KII mutants, mucin-containing glue granules fail to reach normal size, with glue protein aberrantly accumulating in enlarged Rab7-positive late endosomes. PI4KIIDELTA mutants reveal small glue granules of grossly normal morphology, PI4KIIDELTA cells also exhibited large vacuolated structures not observed in wild-type, phenotype, overview. Retromer localization and dynamics are altered in PI4KIIDELTA mutants
metabolism
-
formation of PI4KII-containing endosomal tubules is independent of retromer or AP-3 function, but retromer dynamics at LEs depends on PI4KII
physiological function
-
phosphatidylinositol 4-phosphate is a key regulator of membrane trafficking. Specific requirement for PI4KII emerged in larval salivary glands. In the Golgi, PI4KII is required for sorting of glue granule cargo and the granule-associated SNARE Snap24. In endosomes, it is required for normal retromer dynamics and for formation of tubular endosomes that are likely to be involved in retrieving Snap24 and lysosomal enzyme receptor protein from late endosomes to the trans-Golgi network. PI4KII in flies thus reveals a role for PI4KII in regulating the fidelity of granule protein trafficking in secretory tissues, PI4KII catalytic activity is required for granule biogenesis and normal endosome size, overview
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A4D6K881_DROME
1682
0
183038
TrEMBL
other Location (Reliability: 4)
Q9W4X4_DROME
2134
0
239762
TrEMBL
other Location (Reliability: 5)
Q8I0B7_DROME
563
0
63090
TrEMBL
other Location (Reliability: 3)
A0A6F7SG83_DROME
480
0
54327
TrEMBL
other Location (Reliability: 3)
D6W4K4_DROME
382
0
43176
TrEMBL
other Location (Reliability: 3)
M9PDM4_DROME
2154
0
242034
TrEMBL
other Location (Reliability: 5)
Q8MYR7_DROME
1308
0
148333
TrEMBL
other Location (Reliability: 3)
Q9U1K8_DROME
2160
0
242389
TrEMBL
Mitochondrion (Reliability: 5)
Q8STF7_DROME
710
0
79010
TrEMBL
other Location (Reliability: 1)
Q9BKJ2_DROME
1338
0
147244
TrEMBL
Mitochondrion (Reliability: 5)
Q9VND3_DROME
710
0
78955
TrEMBL
other Location (Reliability: 1)
Q9W0R8_DROME
1674
0
181975
TrEMBL
other Location (Reliability: 4)
A0A6H2EES5_DROME
457
0
51797
TrEMBL
other Location (Reliability: 2)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Burgess, J.; Del Bel, L.M.; Ma, C.I.; Barylko, B.; Polevoy, G.; Rollins, J.; Albanesi, J.P.; Kraemer, H.; Brill, J.A.
Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila
Development
139
3040-3050
2012
Drosophila melanogaster
Manually annotated by BRENDA team