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Information on EC 2.7.1.154 - phosphatidylinositol-4-phosphate 3-kinase and Organism(s) Drosophila melanogaster

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EC Tree
IUBMB Comments
This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date.
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This record set is specific for:
Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
phosphoinositide 3-kinases, pi3k-c2alpha, pi3k-c2beta, class ii pi3k, pik3c2g, class ii phosphoinositide 3-kinase, pi3kc2beta, pi3kc2a, pi3kc2b, phosphatidylinositol-4-phosphate 3-kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C2-domain-containing phosphoinositide 3-kinase
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C2-PI3K
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class I phosphoinositide 3-kinase
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class II phosphoinositide 3-kinase
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class II phosphoinositide 3-kinase C2alpha
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class II phosphoinositide 3-kinase C2beta
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class III phosphoinositide 3-kinase
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HsC3-PI3K
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kinase (phosphorylating), phosphatidylinositol 4-phosphate 3-
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p170
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phosphoinositide 3-kinase
phosphoinositide 3-kinase C2beta
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phosphoinositide 3-kinase-C2-beta
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phosphoinositide 3-kinase-C2-gamma
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PI 3-kinase C2alpha
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PI 3-kinase C2beta
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PI 3-kinase C2gamma
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PI3K-C2alpha
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PI3K-C2beta
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PI3K-C2gamma
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PtdIns-3-kinase C2alpha
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PtdIns-3-kinase C2beta
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PtdIns-3-kinase C2gamma
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type II phosphoinositide 3-kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho-group transfer
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase
This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date.
CAS REGISTRY NUMBER
COMMENTARY hide
141176-94-5
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67053-99-0
cf. EC 2.7.1.137
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
show the reaction diagram
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?
ATP + 1-phosphatidyl-1D-myo-inositol-4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
show the reaction diagram
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?
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
show the reaction diagram
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?
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
show the reaction diagram
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?
additional information
?
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the isozymes interact with and effect patterning of receptor signaling pathways, overview
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?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
the enzyme strictly requires the presence of Mg2+, inactive in presence of Mn2+
additional information
inactive in presence of Mn2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Wortmannin
IC50: 11 nM
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000011
Wortmannin
Drosophila melanogaster
IC50: 11 nM
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
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isozyme expression pattern and phenotype, Drk adaptor protein might be involved in localization of the isozymes, overview
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q95RR5_DROME
366
0
39670
TrEMBL
other Location (Reliability: 1)
P91634_DROME
1088
0
127006
TrEMBL
other Location (Reliability: 2)
Q7K3H0_DROME
1876
0
210475
TrEMBL
other Location (Reliability: 1)
Q7JNX6_DROME
1876
0
210506
TrEMBL
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Q9W1M7_DROME
949
0
107889
TrEMBL
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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the catalytically inactive mutant of class II isozyme PI3K_68D can bind the Drk adaptor protein in vitro
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in COS-7 cells. Specific activity of the enzyme purified from Drosophila lysate is significantly higher than that of Cpk derived from exogenous expression in COS-7 cells
expression of class I isozyme Dp110 enhances organ size by increasing the size of cells without perturbing patterning, ectopic expression of wild-type and catalytically inactive mutant of class II isozyme PI3K_68D in different patterns during Drosophila melanogaster disk development, phenotype analysis of adult cuticle
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Molz, L.; Chen, Y.W.; Hirano, M.; Williams, L.T.
CpK is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain
J. Biol. Chem.
271
13892-13899
1996
Drosophila melanogaster (Q7JNX6), Mus musculus (Q61194)
Manually annotated by BRENDA team
MacDougall, L.K.; Gagou, M.E.; Leevers, S.J.; Hafen, E.; Waterfield, M.D.
Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways
Mol. Cell. Biol.
24
796-808
2004
Drosophila melanogaster
Manually annotated by BRENDA team
Falasca, M.; Maffucci, T.
Role of class II phosphoinositide 3-kinase in cell signalling
Biochem. Soc. Trans.
35
211-214
2007
Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team