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ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate
-
-
phosphatidylinositol-3,4,5-triphosphate is a major product of active PI3K, and recruits Akt/PKB to the plasma membrane and the phosphorylation of Akt occurs
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
ATP + Akt
ADP + Akt phosphate
ATP + p70S6K
ADP + p70S6K phosphate
-
-
-
-
?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
-
-
-
-
?
additional information
?
-
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
p110delta controls a critical checkpoint in peripheral T cell differentiation and clonal expansion
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
PI3Kp110delta is the main source of production of 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate following antigen recognition by B cells, T cells and mast cells
-
-
?
ATP + Akt
ADP + Akt phosphate
-
-
-
-
?
ATP + Akt
ADP + Akt phosphate
-
phosphorylation at Ser473
-
-
?
additional information
?
-
-
mechanism of signal down-regulation of insulin receptor substrate mediated by monomeric p85 enzyme regulatory subunit
-
-
?
additional information
?
-
-
p110delta is an important signaling component for efficient axonal elongation in the developing and regenerating nervous system
-
-
?
additional information
?
-
p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN
-
-
?
additional information
?
-
PI3K p110delta contributes to cellular and humoral immunity. PI3K p110delta regulates the diffentiation of peripheral helper T-cells towards the Th1 and Th2 lineages. PI3K p110delta is critical to regulatory T-cell development and function
-
-
?
additional information
?
-
PI3K p110delta play a role in the regulation of RAG gene expression and thereby LC allelic/isotype exclusion
-
-
?
additional information
?
-
PI3Kgamma plays an important role in neutrophil emigration but not rolling and limited adhesion in postcapillary venules in vivo. The leukocyte but not the endothelial PI3Kgamma is critically involved in the early neutrophil emigration into the inflamed tissues. The delayed neutrophil emigration in response to neutrophil chemokines is independent of the function of PI3Lgamma but is PI3Kdelta dependent
-
-
?
additional information
?
-
PI3Kgamma plays an important role in neutrophil emigration but not rolling and limited adhesion in postcapillary venules in vivo. The leukocyte but not the endothelial PI3Kgamma is critically involved in the early neutrophil emigration into the inflamed tissues. The delayed neutrophil emigration in response to neutrophil chemokines is independent of the function of PI3Lgamma but is PI3Kdelta dependent
-
-
?
additional information
?
-
role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation
-
-
?
additional information
?
-
the delayed neutrophil emigration in response to neutrophil chemokines is independent of the function of PI3Lgamma but is PI3Kdelta dependent
-
-
?
additional information
?
-
the delayed neutrophil emigration in response to neutrophil chemokines is independent of the function of PI3Lgamma but is PI3Kdelta dependent
-
-
?
additional information
?
-
-
function of class IA phosphatidylinositol 3-kinases in the pre-T-cell receptor-controlled developmental transition of CD4-/CD8- double-negative to CD4+/CD8+ double-positive thymocytes
-
-
?
additional information
?
-
-
molecular model for the regulation of PI3K signaling by NCoR, a receptor corepressor and regulator of thyroid receptor-activated PI3K signaling
-
-
?
additional information
?
-
-
the single class 1B catalytic isoform p110gamma binds to either p101 or p84/p87 adaptors, which function to potentiate activation by betagamma-subunits of heterotrimeric GTP-binding proteins which facilitate intracellular signalling from G-protein coupled receptors
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate
-
-
phosphatidylinositol-3,4,5-triphosphate is a major product of active PI3K, and recruits Akt/PKB to the plasma membrane and the phosphorylation of Akt occurs
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
ATP + Akt
ADP + Akt phosphate
-
-
-
-
?
ATP + p70S6K
ADP + p70S6K phosphate
-
-
-
-
?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
-
-
-
-
?
additional information
?
-
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
p110delta controls a critical checkpoint in peripheral T cell differentiation and clonal expansion
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
PI3Kp110delta is the main source of production of 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate following antigen recognition by B cells, T cells and mast cells
-
-
?
additional information
?
-
-
mechanism of signal down-regulation of insulin receptor substrate mediated by monomeric p85 enzyme regulatory subunit
-
-
?
additional information
?
-
-
p110delta is an important signaling component for efficient axonal elongation in the developing and regenerating nervous system
-
-
?
additional information
?
-
p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN
-
-
?
additional information
?
-
PI3K p110delta contributes to cellular and humoral immunity. PI3K p110delta regulates the diffentiation of peripheral helper T-cells towards the Th1 and Th2 lineages. PI3K p110delta is critical to regulatory T-cell development and function
-
-
?
additional information
?
-
PI3K p110delta play a role in the regulation of RAG gene expression and thereby LC allelic/isotype exclusion
-
-
?
additional information
?
-
PI3Kgamma plays an important role in neutrophil emigration but not rolling and limited adhesion in postcapillary venules in vivo. The leukocyte but not the endothelial PI3Kgamma is critically involved in the early neutrophil emigration into the inflamed tissues. The delayed neutrophil emigration in response to neutrophil chemokines is independent of the function of PI3Lgamma but is PI3Kdelta dependent
-
-
?
additional information
?
-
PI3Kgamma plays an important role in neutrophil emigration but not rolling and limited adhesion in postcapillary venules in vivo. The leukocyte but not the endothelial PI3Kgamma is critically involved in the early neutrophil emigration into the inflamed tissues. The delayed neutrophil emigration in response to neutrophil chemokines is independent of the function of PI3Lgamma but is PI3Kdelta dependent
-
-
?
additional information
?
-
role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation
-
-
?
additional information
?
-
the delayed neutrophil emigration in response to neutrophil chemokines is independent of the function of PI3Lgamma but is PI3Kdelta dependent
-
-
?
additional information
?
-
the delayed neutrophil emigration in response to neutrophil chemokines is independent of the function of PI3Lgamma but is PI3Kdelta dependent
-
-
?
additional information
?
-
-
function of class IA phosphatidylinositol 3-kinases in the pre-T-cell receptor-controlled developmental transition of CD4-/CD8- double-negative to CD4+/CD8+ double-positive thymocytes
-
-
?
additional information
?
-
-
molecular model for the regulation of PI3K signaling by NCoR, a receptor corepressor and regulator of thyroid receptor-activated PI3K signaling
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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metabolism
-
Rac1 regulates peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway
malfunction
-
binding of thyroid receptor to p85alpha activates PI3K/AKT signaling promoting thyroid carcinogenesis by increasing cell proliferation and tumor metastasis
malfunction
-
individual class I PI3K isoforms are strongly linked with the regulation of oncogenes and tumorigenesis. PI3Ka is upregulated and/or mutated in a variety of carcinomas, and in particular lung tumours, and is associated with an elevation in activation and signalling of the serine-threonine kinase Akt, overview
malfunction
-
PI3K is involved in non-small cell lung cancer and is PI3K is required for malignant progression in lung cancer, regulation mechanisms, overview
malfunction
-
PI3Ks constitute important regulators of various signaling pathways with relevance in cancer. Activation of PI3K by membrane localization of subunit p110alpha predisposes mammary glands to neoplastic transformation
malfunction
p110delta deficiency did not affect vascular remodeling in vivo
malfunction
-
Plasmodium berghei ANKA-infected PI3Kgamm knockout mice show greater survival despite similar parasitemia levels in comparison with infected wild-type mice. Histopathological analysis demonstrates reduced hemorrhage, leukocyte accumulation and vascular obstruction in the brain of infected PI3Kgamma null mice. PI3Kgamma deficiency also causes lower microglial activation and T cell cytotoxicity in the brain. On day 6 post-infection, CD3+/CD8+ T cells are significantly reduced in the brain of infected PI3Kgamma null mice when compared to infected wild-type mice and expression of CD44 in CD8+ T cell population in the brain tissue and levels of phospho-IkappaB-alpha in the whole brain are also markedly lower in infected PI3Kgamma null mice, phenotype, overview
physiological function
-
activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9
physiological function
-
isozyme PI3Kgamma is involved in inteleukin-8-induced increase of endothelial monolayer permeability and is able to limit neovascularization and choroidal edema, as well as macrophage infiltration, therefore contributes to reduce laser-induced retinal damage
physiological function
-
phosphatidylinositol 3-kinase is a key mediator of oncogenic K-ras
physiological function
-
PI3K activation results in increased cell proliferation, motility, migration, and metastasis. Inhibition of PI3K signaling delays tumor progression and blocks metastasis of thyroid cancer
physiological function
-
PI3K, via p85alpha and p85beta subunit isoforms, plays dual regulatory roles in the induction of IFN responses by controlling both IFNalpha- and IFNgamma-dependent transcriptional regulation of IFN-sensitive genes and simultaneously regulating the subsequent initiation of mRNA translation for such genes
physiological function
-
selective regulation of CD8 effector T cell migration by the p110gamma catalytic subunit isoform of phosphatidylinositol 3-kinase
physiological function
-
the p110gamma isoform of phosphatidylinositol 3-kinase regulates chemokine receptor-mediated migration of effector CD4 T lymphocytes into peripheral inflammatory sites. Although p110gamma does not regulate antigen-dependent CD4 T cell activation and proliferation, it plays a crucial role in regulating CD4 effector T cell migration, overview
physiological function
-
the signalling pathways regulated by class 1 PI3K signalling are central in many of the fundamental cellular processes associated with PI3K signalling including cell growth, proliferation, migration and survival, signaling pathway overview
physiological function
-
isoform PI3Kdelta is responsible for phosphorylation of colony-stimulating factor CSF-1 receptor phosphorylation in response to CSF-1 added to intact cells or isolated nuclei and its triggering of the phosphorylation of Akt and p27 inside the nucleus. Translocation of exogenous CSF-1 to the nucleus-associated CSF-1 receptors correlates with a prominent role of isoform PI3Kdelta in activation of the Rab5 GTPase
physiological function
class Ia phosphatidylinositol 3-kinase isoform p110alpha is crucial for receptor tyrosine kinases signaling, thus affecting proliferation, migration, and survival of smooth muscle cells, Receptor tyrosine kinasesinduced phosphatidylinositol 3'-kinase signaling via the p110alpha isoform plays a central role for vascular remodeling
physiological function
class Ia phosphatidylinositol 3-kinase isoform p110delta is disensible for receptor tyrosine kinases signaling, p110delta exerts noncatalytic functions in smooth muscle cell proliferation, but had no effect on migration
physiological function
non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells. The interaction between the gamm isozyme and alpha subunit of cyclic nucleotide-gated channel, CNGA1, through its RA domain does not appear to play a role in regulation of CNG channel activity, but phosphatidylinositol 3-kinase gamma uses CNGA1 as an anchoring module to achieve close proximity to its substrate to generate D3-phosphoinositides. CNGA1-associated PI3Kgamma activity is independent of dark and light conditions, as well as insulin receptor impairment in rods. The RA domain of isozyme PI3Kgamma interacts strongly with CTR-CNGA1, compared with the RA domain of isozyme PI3Kalpha in retinal photoreceptor cells
physiological function
-
phosphatidylinositol 3-kinase gamma is central in signaling diverse cellular functions. Relevance of isozyme PI3Kgamma for the outcome and the neuroinflammatory process triggered by Plasmodium berghei ANKA infection
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M582V
-
site-directed mutagenesis, the full-length p85alpha isoform inter-SH2 domain mutation enables the mutant PI3K to bind influenza A virus NS1 protein leading to activation of the mutant PI3K enzyme activity, molecular modeling, overview
V573M
-
site-directed mutagenesis, the p85beta isoform inter-SH2 domain mutation abrogates mutant PI3K binding to influenza A virus NS1 protein, molecular modeling, overview
D910A
-
site-directed mutagenesis of isoform p110delta, catalytically inactive. Interleukin is unable to induce hyper-responsiveness in tissues expressing the mutant
D910A
-
mice with an inactivating knock-in mutation in the p110delta isoform of PI3K, p110deltaD910A, generated on Leishmanina major resistant and susceptible genetic backgrounds. The mutant mice show severely impaired T cell responses, but the mutant mice also show more robust resistance to Leishmanina major infection manifested as significantly reduced lesion size and accelerated parasite clearance. Cells from p110D910A mice were significantly impaired in their ability to make cytokines, particularly IFN-gamma, interleukin-10, and TNF, phenotypes, overview
additional information
expression of regulatory protein p85 102 amino acid binding domain plus catalytic subunit p110 leads to fully active enzyme complex
additional information
-
expression of regulatory protein p85 102 amino acid binding domain plus catalytic subunit p110 leads to fully active enzyme complex
additional information
-
heterozygous disruption of p85alpha regulatory subunit, increase in enzyme activity and decrease in apoptosis by insulin-like growth factor 1 through upregulated phosphatidylinositol (3,4,5)-triphosphate production. Complete depletion of regulatory subunit p85alpha results in significantly increased apoptosis due to reduced enzyme-dependent signaling
additional information
-
genetic deletion or selective inhibition of isoform PI3Kdelta diminishes joint erosion to a level comparable to its PI3Kgamma counterpart. The induction and progression of joint destruction is profoundly reduced in the absence of both PI3K isoforms and correlates with a limited ability of neutrophils to migrate into tissue in response to leukotriene B4. fMLP-induced neutrophil extravasation is primarily reliant on PI3Kgamma
additional information
-
construction of chimeras of 85alpha and p85beta iSH2 domain by overlapping PCR using mouse p85beta and bovine p85alpha as templates
additional information
-
generation of different transgenic lines expressing myristoylated p110A protein under the control of the epithelial-specific mouse mammary tumor virus promoter, i.e. myrp110A transgenic mice. The membrane localization of p110alpha predisposes mammary glands to neoplastic transformation, young female mutant mice show delayed mammary gland involution and morphologic changes of the mammary ducts, which is more pronounced in old animals, especially in mutiparous females, in which increased ductal branching, alveolar hyperplasia, and intraductal neoplasia are observed, phenotype, overview
additional information
-
generation of p110gamma knockout mice. p110gamma-deficient effector CD8 T cells exhibit impaired migration in vitro and exhibit reduced migration into the inflamed peritoneum following vaccinia virus challenge in vivo. Furthermore, p110gamma-/- mice exhibit reduced influx in response to virus-induced peritonitis and exhibit increased susceptibility to vaccinia virus infection when compared with wild-type mice, phenotype, overview
additional information
-
mRNA translation of IFN-responsive genes is defective in cells with targeted disruption of both the p85alpha and p85beta subunits of PI3K
additional information
-
mutations in catalytic subunit PI3Kdelta, PI3KdD910/A910 mice display impaired B cell development and differentiation including a reduction in B cell progenitor cells and an increase in the ratio of pre-(CD43-IgM+) to pro-(CD43+ IgM-) B cells. T cell differentiation into Th1, Th2 and Treg lineages are also impaired in PI3KdD910/A910 mice by a mechanism involving reduced T cell receptor activation of Akt and FOXO
additional information
-
p110-/- CD4 lymphocytes are phenotypically identical to their wild-type counterparts and do not exhibit any defects in TCR-mediated calcium mobilization or Erk activation. p110gamma-deficient CD4 OT.II T cells become activated and proliferate comparably with WT cells in response to antigen in vivo. But antigen-experienced p110gamma-deficient CD4 OT.II lymphocytes exhibit dramatic defects in their ability to traffic to peripheral inflammatory sites in vivo and exhibit impaired F-actin polarization and migration in response to stimulation ex vivo with the CCR4 ligand CCL22
additional information
generation of a mouse model of smooth muscle cellspecific p110alpha deficiency. Targeted deletion of p110alpha in sm-p110alpha-/- mice blunts growth factorinduced cellular responses and abolishes neointima formation after balloon injury of the carotid artery in mice. p110 Subunit knockdown via specific siRNA application
additional information
generation of a mouse model of smooth muscle cellspecific p110alpha deficiency. Targeted deletion of p110alpha in sm-p110alpha-/- mice blunts growth factorinduced cellular responses and abolishes neointima formation after balloon injury of the carotid artery in mice. p110 Subunit knockdown via specific siRNA application
additional information
-
generation of a mouse model of smooth muscle cellspecific p110alpha deficiency. Targeted deletion of p110alpha in sm-p110alpha-/- mice blunts growth factorinduced cellular responses and abolishes neointima formation after balloon injury of the carotid artery in mice. p110 Subunit knockdown via specific siRNA application
additional information
generation of a mouse model of smooth muscle cellspecific p110delta deficiency. Targeted deletion of p110delta doe not affect vascular remodeling in vivo. p110 Subunit knockdown via specific siRNA application
additional information
generation of a mouse model of smooth muscle cellspecific p110delta deficiency. Targeted deletion of p110delta doe not affect vascular remodeling in vivo. p110 Subunit knockdown via specific siRNA application
additional information
-
generation of a mouse model of smooth muscle cellspecific p110delta deficiency. Targeted deletion of p110delta doe not affect vascular remodeling in vivo. p110 Subunit knockdown via specific siRNA application
additional information
-
generation of PI3Kgamma-deficient mice
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Hawkins, P.T.; Jackson, T.R.; Stephens, L.R.
Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase
Nature
358
157-159
1992
Mus musculus
brenda
Klippel, A.; Escobedo, J.A.; Hirano, M.; Williams, L.T.
The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity
Mol. Cell. Biol.
14
2675-2685
1994
Mus musculus (P42337), Mus musculus
brenda
Luo, J.; Field, S.J.; Lee, J.Y.; Engelman, J.A.; Cantley, L.C.
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
J. Cell Biol.
170
455-464
2005
Mus musculus
brenda
Ueki, K.; Fruman, D.A.; Brachmann, S.M.; Tseng, Y.H.; Cantley, L.C.; Kahn, C.R.
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival
Mol. Cell. Biol.
22
965-977
2002
Mus musculus
brenda
Patton, D.T.; Garcon, F.; Okkenhaug, K.
The PI3K p110delta controls T-cell development, differentiation and regulation
Biochem. Soc. Trans.
35
167-171
2007
Mus musculus (O35904)
brenda
Liu, L.; Puri, K.D.; Penninger, J.M.; Kubes, P.
Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo
Blood
110
1191-1198
2007
Mus musculus (O35904), Mus musculus (Q9JHG7)
brenda
Papakonstanti, E.A.; Ridley, A.J.; Vanhaesebroeck, B.
The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN
EMBO J.
26
3050-3061
2007
Mus musculus (O35904)
brenda
Nashed, B.F.; Zhang, T.; Al-Alwan, M.; Srinivasan, G.; Halayko, A.J.; Okkenhaug, K.; Vanhaesebroeck, B.; Hayglass, K.T.; Marshall, A.J.
Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation
Eur. J. Immunol.
37
416-424
2007
Mus musculus (O35904)
brenda
Okkenhaug, K.; Patton, D.T.; Bilancio, A.; Garcon, F.; Rowan, W.C.; Vanhaesebroeck, B.
The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells
J. Immunol.
177
5122-5128
2006
Mus musculus (O35904)
brenda
Llorian, M.; Stamataki, Z.; Hill, S.; Turner, M.; Martensson, I.L.
The PI3K p110delta is required for down-regulation of RAG expression in immature B cells
J. Immunol.
178
1981-1985
2007
Mus musculus (O35904)
brenda
Eickholt, B.J.; Ahmed, A.I.; Davies, M.; Papakonstanti, E.A.; Pearce, W.; Starkey, M.L.; Bilancio, A.; Need, A.C.; Smith, A.J.; Hall, S.M.; Hamers, F.P.; Giese, K.P.; Bradbury, E.J.; Vanhaesebroeck, B.
Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase
PLoS ONE
2
e869
2007
Mus musculus
brenda
Okkenhaug, K.; Ali, K.; Vanhaesebroeck, B.
Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K
Trends Immunol.
28
80-87
2007
Mus musculus (O35904)
brenda
Randis, T.M.; Puri, K.D.; Zhou, H.; Diacovo, T.G.
Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils
Eur. J. Immunol.
38
1215-1224
2008
Mus musculus
brenda
Shiroki, F.; Matsuda, S.; Doi, T.; Fujiwara, M.; Mochizuki, Y.; Kadowaki, T.; Suzuki, H.; Koyasu, S.
The p85alpha regulatory subunit of class IA phosphoinositide 3-kinase regulates beta-selection in thymocyte development
J. Immunol.
178
1349-1356
2007
Mus musculus
brenda
Farghaly, H.S.; Blagbrough, I.S.; Medina-Tato, D.A.; Watson, M.L.
Interleukin 13 increases contractility of murine tracheal smooth muscle by a phosphoinositide 3-kinase p110delta-dependent mechanism
Mol. Pharmacol.
73
1530-1537
2008
Mus musculus
brenda
Geering, B.; Cutillas, P.R.; Nock, G.; Gharbi, S.I.; Vanhaesebroeck, B.
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
Proc. Natl. Acad. Sci. USA
104
7809-7814
2007
Mus musculus
brenda
Renner, O.; Blanco-Aparicio, C.; Grassow, M.; Canamero, M.; Leal, J.F.; Carnero, A.
Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation
Cancer Res.
68
9643-9653
2008
Homo sapiens, Mus musculus
brenda
Hwang, M.K.; Song, N.R.; Kang, N.J.; Lee, K.W.; Lee, H.J.
Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: its direct inhibition by quercetin
Int. J. Biochem. Cell Biol.
41
1592-1600
2009
Mus musculus
brenda
Li, Y.; Anderson, D.H.; Liu, Q.; Zhou, Y.
Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity
J. Biol. Chem.
283
23397-23409
2008
Bos taurus, Mus musculus
brenda
Martin, A.L.; Schwartz, M.D.; Jameson, S.C.; Shimizu, Y.
Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase
J. Immunol.
180
2081-2088
2008
Mus musculus, Mus musculus C57BL/6
brenda
Kaur, S.; Sassano, A.; Joseph, A.M.; Majchrzak-Kita, B.; Eklund, E.A.; Verma, A.; Brachmann, S.M.; Fish, E.N.; Platanias, L.C.
Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling
J. Immunol.
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7316-7323
2008
Mus musculus
brenda
Liu, D.; Zhang, T.; Marshall, A.J.; Okkenhaug, K.; Vanhaesebroeck, B.; Uzonna, J.E.
The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells
J. Immunol.
183
1921-1933
2009
Mus musculus
brenda
Thomas, M.S.; Mitchell, J.S.; DeNucci, C.C.; Martin, A.L.; Shimizu, Y.
The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites
J. Leukoc. Biol.
84
814-823
2008
Mus musculus
brenda
Gavard, J.; Hou, X.; Qu, Y.; Masedunskas, A.; Martin, D.; Weigert, R.; Li, X.; Gutkind, J.S.
A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability
Mol. Cell. Biol.
29
2469-2480
2009
Homo sapiens, Mus musculus
brenda
Chen, B.C.; Kang, J.C.; Lu, Y.T.; Hsu, M.J.; Liao, C.C.; Chiu, W.T.; Yeh, F.L.; Lin, C.H.
Rac1 regulates peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway
Mol. Immunol.
46
1179-1188
2009
Mus musculus
brenda
Yang, Y.; Iwanaga, K.; Raso, M.G.; Wislez, M.; Hanna, A.E.; Wieder, E.D.; Molldrem, J.J.; Wistuba, I.I.; Powis, G.; Demayo, F.J.; Kim, C.F.; Kurie, J.M.
Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer
PLoS ONE
3
e2220
2008
Mus musculus
brenda
Furuya, F.; Lu, C.; Guigon, C.J.; Cheng, S.Y.
Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors
Steroids
74
628-634
2009
Mus musculus
brenda
Marwick, J.A.; Chung, K.F.; Adcock, I.M.
Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease
Ther. Adv. Respir. Dis.
2009
1-16
2010
Homo sapiens, Mus musculus
brenda
Zwaenepoel, O.; Tzenaki, N.; Vergetaki, A.; Makrigiannakis, A.; Vanhaesebroeck, B.; Papakonstanti, E.A.
Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110delta isoform of PI 3-kinase
FASEB J.
26
691-706
2012
Mus musculus
brenda
Wu, Y.; Tan, H.; Shui, G.; Bauvy, C.; Huang, Q.; Wenk, M.; Ong, C.; Codogno, P.; Shen, H.
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase
J. Biol. Chem.
285
10850-10861
2010
Homo sapiens, Mus musculus
brenda
Vantler, M.; Jesus, J.; Leppaenen, O.; Scherner, M.; Berghausen, E.M.; Mustafov, L.; Chen, X.; Kramer, T.; Zierden, M.; Gerhardt, M.; Ten Freyhaus, H.; Blaschke, F.; Sterner-Kock, A.; Baldus, S.; Zhao, J.J.; Rosenkranz, S.
Class IA phosphatidylinositol 3-kinase isoform p110alpha mediates vascular remodeling
Arterioscler. Thromb. Vasc. Biol.
35
1434-1444
2015
Rattus norvegicus, Rattus norvegicus (A0A0G2K344), Rattus norvegicus (Q9Z1L0), Homo sapiens (O00329), Homo sapiens (P42336), Homo sapiens (P42338), Homo sapiens, Mus musculus (O35904), Mus musculus (P42337), Mus musculus
brenda
Gupta, V.K.; Rajala, A.; Rajala, R.V.
Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells
Cell Commun. Signal.
13
7-7
2015
Mus musculus (Q9JHG7)
brenda
Lacerda-Queiroz, N.; Brant, F.; Rodrigues, D.H.; Vago, J.P.; Rachid, M.A.; Sousa, L.P.; Teixeira, M.M.; Teixeira, A.L.
Phosphatidylinositol 3-kinase gamma is required for the development of experimental cerebral malaria
PLoS ONE
10
e0119633
2015
Mus musculus, Mus musculus C57BL/6
brenda