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Information on EC 2.7.1.149 - 1-phosphatidylinositol-5-phosphate 4-kinase and Organism(s) Drosophila melanogaster

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This record set is specific for:
Drosophila melanogaster
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The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
phosphatidylinositol 4-kinase, type ii kinase, pip4k2a, type ii ptdins 4-kinase, pip4k, pip4k2b, pip4k2c, mss4p, type ii phosphatidylinositol 4-kinase, phosphatidylinositol 5-phosphate 4-kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-phosphatidylinositol-4-phosphate 5-kinase
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1-phosphatidylinositol-4-phosphate kinase
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Diphosphoinositide kinase
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phosphatidylinositol 5 phosphate 4-kinase
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phosphatidylinositol 5-phosphate 4-kinase
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PIP(4)K
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-
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PIP4KIIalpha
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PIP5KII-alpha
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-
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PIP5KIII
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-
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PIPKII
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PtdIns(4)P-5-kinase B isoform
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PtdIns(4)P-5-kinase C isoform
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type II PIP kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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PATHWAY SOURCE
PATHWAYS
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-, -
SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
104645-76-3
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247907-17-1
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
show the reaction diagram
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-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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20 mM used in assay conditions
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
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the enzyme regulates plasma-membrane phosphatidylinositol 3,4,5-trisphosphate turnover and insulin signalling. The enzyme is required to limit phosphatidylinositol 3,4,5-trisphosphate levels during insulin receptor activation
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q8SXX1_DROME
404
0
47033
TrEMBL
other Location (Reliability: 4)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D271K
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inactive
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in a enzyme-deficient mutant of Drosophila melanogaster
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gupta, A.; Toscano, S.; Trivedi, D.; Jones, D.R.; Mathre, S.; Clarke, J.H.; Divecha, N.; Raghu, P.
Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development
Proc. Natl. Acad. Sci. USA
110
5963-5968
2013
Drosophila melanogaster
Manually annotated by BRENDA team
Sharma, S.; Mathre, S.; Ramya, V.; Shinde, D.; Raghu, P.
Phosphatidylinositol 5 phosphate 4-kinase regulates plasma-membrane PIP3 turnover and insulin signaling
Cell Rep.
27
1979-1990
2019
Drosophila melanogaster
Manually annotated by BRENDA team
Kamalesh, K.; Trivedi, D.; Toscano, S.; Sharma, S.; Kolay, S.; Raghu, P.
Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis
J. Cell Sci.
130
2119-2133
2017
Drosophila melanogaster
Manually annotated by BRENDA team