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Information on EC 2.7.1.137 - phosphatidylinositol 3-kinase and Organism(s) Arabidopsis thaliana

for references in articles please use BRENDA:EC2.7.1.137
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EC Tree
IUBMB Comments
One mammalian isoform is known.
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This record set is specific for:
Arabidopsis thaliana
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Synonyms
pi3k, phosphatidylinositol 3-kinase, pi3 kinase, vps34, phosphoinositide-3-kinase, phosphatidylinositol 3 kinase, ptdins 3-kinase, pik3c3, phosphatidylinositide 3-kinase, hvps34, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
kinase (phosphorylating), phosphatidylinositol 3-
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-
-
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kinase, phosphatidylinositol 3- (phosphorylating)
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-
-
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p85/p110 phosphoinositide 3-kinase
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-
-
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phosphatidylinositol 3'-kinase
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-
-
-
phosphatidylinositol 3-kinase
phosphoinositide 3'-kinase
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-
-
-
phosphoinositide 3-kinase
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-
-
-
PI 3-kinase
PtdIns 3'-kinase
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-
-
-
vacuolar protein sorting 34
-
VPS34
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
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PATHWAY SOURCE
PATHWAYS
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-
SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
One mammalian isoform is known.
CAS REGISTRY NUMBER
COMMENTARY hide
115926-52-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
show the reaction diagram
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
show the reaction diagram
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-
?
additional information
?
-
PI3K binds to the V-ATPase subunit B2 (VHA-B2) in vitro and in vivo
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
show the reaction diagram
-
-
-
?
additional information
?
-
PI3K binds to the V-ATPase subunit B2 (VHA-B2) in vitro and in vivo
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-((3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)methyl)guanidine
i.e. idelalisib
3-Methyladenine
3-MA, a nonspecific inhibitor of PI 3-kinases
LY294002
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
PI3K type III is the only type of PI3K identified in plants
malfunction
metabolism
PI3K type III plays a vital role in the trafficking of proteins to and from vacuoles. Interactions between VHA-B2 and PI3K are possibly promoted the translocation of VHA-B2 from the TNG to the vacuole and thus improve the assembly of V-ATPase, resulting in increased V-ATPase activity
physiological function
additional information
in yeast and mammals, Vps34 homologues are found in at least two distinct PI 3-kinase complexes. The Vps34 complex I, consisting of Vps34, Vps15, autophagy-related 6 (Atg6)/Vps30, and Atg14, regulates an early step of autophagy at the site of autophagosome formation, whereas the Vps34 complex II containing Vps34, Vps15, Atg6/ Vps30, and Vps38 (or UVRAG in mammals) is involved in vacuolar protein sorting and localized to the endosome
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PI3K_ARATH
814
0
93328
Swiss-Prot
other Location (Reliability: 2)
A0A5S9WQW4_ARATH
814
0
93342
TrEMBL
other Location (Reliability: 2)
A0A654EJR0_ARATH
814
0
93328
TrEMBL
other Location (Reliability: 2)
A0A7G2E222_ARATH
908
0
103651
TrEMBL
other Location (Reliability: 2)
A0A178W243_ARATH
814
0
93411
TrEMBL
other Location (Reliability: 2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene AtVPS34, genetic structure determination, sequence determination and genotyping, overview
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
downregulation of PI3K activity accelerates leaf senescence induced by methyl jasmonate (MeJA) and suppresses the activation of vacuolar H+-ATPase (VATPase)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Welters, P.; Takegawa, K.; Emr, S.D.; Chrispeels, M.J.
AtVPS34, a phosphatidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain
Proc. Natl. Acad. Sci. USA
91
11398-11402
1994
Arabidopsis thaliana (P42339), Arabidopsis thaliana
Manually annotated by BRENDA team
Lee, Y.; Kim, E.S.; Choi, Y.; Hwang, I.; Staiger, C.J.; Chung, Y.Y.; Lee, Y.
The Arabidopsis phosphatidylinositol 3-kinase is important for pollen development
Plant Physiol.
147
1886-1897
2008
Arabidopsis thaliana (P42339)
Manually annotated by BRENDA team
Lee, Y.; Bak, G.; Choi, Y.; Chuang, W.I.; Cho, H.T.; Lee, Y.
Roles of phosphatidylinositol 3-kinase in root hair growth
Plant Physiol.
147
624-635
2008
Arabidopsis thaliana
Manually annotated by BRENDA team
Liu, J.; Ji, Y.; Zhou, J.; Xing, D.
Phosphatidylinositol 3-kinase promotes activation and vacuolar acidification and delays methyl jasmonate-induced leaf senescence
Plant Physiol.
170
1714-1731
2016
Arabidopsis thaliana (P42339)
Manually annotated by BRENDA team
Lee, H.N.; Jung, H.; Chung, T.
Subcellular Localization of PI3P in Arabidopsis
Methods Mol. Biol.
2177
109-118
2020
Arabidopsis thaliana (P42339)
Manually annotated by BRENDA team
Liu, J.; Zhou, J.; Xing, D.
A pivotal role of phosphatidylinositol 3-kinase in delaying of methyl jasmonate-induced leaf senescence
Plant Signal. Behav.
11
e1147642
2016
Arabidopsis thaliana (P42339)
Manually annotated by BRENDA team