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ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
ATP + 1,2-diarachidonoyl-sn-glycerol
ADP + 1,2-diarachidonoyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-dicapryl-sn-glycerol
ADP + 1,2-dicapryl-sn-glycerol 3-phosphate
about 140% of the activity with sn-1,2-dioleoylglycerol
-
-
?
ATP + 1,2-dilauroyl-sn-glycerol
ADP + 1,2-dilauroyl-sn-glycerol 3-phosphate
high activity
-
-
?
ATP + 1,2-dilinoleoyl-sn-glycerol
ADP + 1,2-dilinoleoyl-sn-glycerol
-
-
-
?
ATP + 1,2-dioleolyl-sn-glycerol
ADP + 1,2-dioleolyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-dioleoyl-sn-glycerol
ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
ATP + 1,2-dipalmitoyl-sn-glycerol
ADP + 1,2-dipalmitoyl-sn-glycerol 3-phosphate
ATP + 1,2-distearoyl-sn-glycerol
ADP + 1,2-distearoyl-sn-glycerol 3-phosphate
high activity
-
-
?
ATP + 1-arachidoyl-2-arachidonoyl-sn-glycerol
ADP + ?
isoform DGKepsilon shows about 70% activity with 0.38 mol% 1-arachidoyl-2-arachidonoyl-sn-glycerol compared to 1-stearoyl-2-arachidonoyl-sn-glycerol
-
-
?
ATP + 1-O-hexadecyl-2-oleoyl-sn-glycerol
ADP + 1-O-hexadecyl-2-oleoyl-sn-glycerol 3-phosphate
-
45.4% of the activity with 1-stearoyl-2-arachidonoyl-sn-glycerol
-
-
?
ATP + 1-O-hexadecyl-2-sn-acetyl glycerol
ADP + 1-O-hexadecyl-2-sn-acetyl glycerol 3-phosphate
-
about 12fold the rate of 1-O-hexadecyl-sn-glycerol phosphorylation, isoforms diacylglycerol kinase alpha, beta, gamma, delta1, delta1, zeta, jota, theta
-
-
?
ATP + 1-O-hexadecyl-sn-glycerol
ADP + 1-O-hexadecyl-sn-glycerol 3-phosphate
-
-
-
-
?
ATP + 1-oleoyl-2-palmitoyl-sn-glycerol
ADP + 1-palmitoyl-2-oleoyl-sn-glycerol 3-phosphate
about 85% of the activity with sn-1,2-dioleoylglycerol, DGKksi
-
-
?
ATP + 1-palmitoyl-2-arachidonoyl-sn-glycerol
ADP + 1-palmitoyl-2-arachidonoyl-sn-glycerol 3-phosphate
isoform DGKepsilon shows about 90% activity with 0.38 mol% 1-palmitoyl-2-arachidonoyl-sn-glycerol compared to 1-stearoyl-2-arachidonoyl-sn-glycerol
-
-
?
ATP + 1-palmitoyl-2-oleolyl-sn-glycerol
ADP + 1-palmitoyl-2-oleolyl-sn-glycerol 3-phosphate
high activity
-
-
?
ATP + 1-palmitoyl-2-oleoyl-sn-glycerol
ADP + 1-palmitoyl-2-oleoyl-sn-glycerol 3-phosphate
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol
ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
ATP + 1-stearoyl-2-docosahexaenoyl-sn-glycerol
ADP + 1-stearoyl-2-docosahexaenoyl-sn-glycerol 3-phosphate
ATP + 1-stearoyl-2-eicosatetraenoyl-sn-glycerol
ADP + 1-stearoyl-2-eicosatetraenoyl-sn-glycerol 3-phosphate
high activity
-
-
?
ATP + 1-stearoyl-2-linoleoyl-sn-glycerol
ADP + 1-stearoyl-2-linoleoyl-sn-glycerol 3-phosphate
ATP + 1-stearoyl-2-oleoyl-sn-glycerol
ADP + 1-stearoyl-2-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 2,3-dioleoyl-sn-glycerol
ADP + 2,3-diacyl-sn-glycerol 1-phosphate
ATP + 2-arachidonoyl-sn-glycerol
ADP + 2-arachidonoyl-sn-glycerol 3-phosphate
isoform DGKepsilon shows substrate specificity for sn-2 arachidonoyl-diacylglycerol
-
-
?
ATP + 2-monooleoyl-rac-glycerol
ADP + 2-monooleoyl-rac-glycerol 3-phosphate
-
10.7% of the activity with 1-stearoyl-2-arachidonoyl-sn-glycerol
-
-
?
ATP + sn-1,2-dioleoylglycerol
ADP + sn-1,2-dioleoylglycerol 3-phosphate
ATP + sn-1,3-dioleoylglycerol
ADP + ?
about 10% of the activity with sn-1,2-dioleoylglycerol
-
-
?
additional information
?
-
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
DGKiota may have important cellular functions in retina and brain
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
the expression of DGKeta2 is suppressed by glucocorticoid in contrast to the marked induction of DGKeta1
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
DGKgamma negatively regulates macrophage differentiation through its catalytic action operating on the cytoskeleton
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
-
r
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
i.e. phosphatidic acid
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
1,2-diacylglycerol is a second messenger
i.e. phosphatidic acid
-
?
ATP + 1,2-dioleoyl-sn-glycerol
ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
-
-
-
?
ATP + 1,2-dioleoyl-sn-glycerol
ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-dioleoyl-sn-glycerol
ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-dioleoyl-sn-glycerol
ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-dioleoyl-sn-glycerol
ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
high activity
-
-
?
ATP + 1,2-dioleoyl-sn-glycerol
ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
isoform DGKepsilon shows about 7% activity with 0.38 mol% 1,2-dioleoyl-sn-glycerol compared to 1-stearoyl-2-arachidonoyl-sn-glycerol
-
-
?
ATP + 1,2-dioleoyl-sn-glycerol
ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
about 15fold the rate of 1-O-hexadecyl-sn-glycerol phosphorylation, isoforms diacylglycerol kinase alpha, beta, gamma, delta1, delta1, zeta, jota, theta
-
-
?
ATP + 1,2-dipalmitoyl-sn-glycerol
ADP + 1,2-dipalmitoyl-sn-glycerol 3-phosphate
highest activity
-
-
?
ATP + 1,2-dipalmitoyl-sn-glycerol
ADP + 1,2-dipalmitoyl-sn-glycerol 3-phosphate
-
15% of the activity with 1-stearoyl-2-arachidonoyl-sn-glycerol
-
-
?
ATP + 1-palmitoyl-2-oleoyl-sn-glycerol
ADP + 1-palmitoyl-2-oleoyl-sn-glycerol 3-phosphate
-
96.5% of the activity with 1-stearoyl-2-arachidonoyl-sn-glycerol
-
-
?
ATP + 1-palmitoyl-2-oleoyl-sn-glycerol
ADP + 1-palmitoyl-2-oleoyl-sn-glycerol 3-phosphate
about 80% of the activity with sn-1,2-dioleoylglycerol
-
-
?
ATP + 1-palmitoyl-2-oleoyl-sn-glycerol
ADP + 1-palmitoyl-2-oleoyl-sn-glycerol 3-phosphate
about 80% of the activity with sn-1,2-dioleoylglycerol, DGKksi
-
-
?
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol
ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
-
-
-
?
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol
ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol
ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol
ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
108% of the activity with sn-1,2-dioleoylglycerol
-
-
?
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol
ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
since diacylglycerol kinase is an enzyme of the phosphatidylinositol cycle, its natural substrate could be 1-stearoyl-2-arachidonoyl-sn-glycerol, thought to be the main diacylglycerol analog generated from phosphoinositide
-
-
?
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol
ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
preferred substrate of isoform diacylglycerol kinase epsilon
-
-
?
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol
ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
isoform DGKepsilon shows 100% activity with 0.38 mol% 1-stearoyl-2-arachidonoyl-sn-glycerol
-
-
?
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol
ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
in wild-type, ratio of enzymic activity of substrates 1-stearoyl-2-linoleoyl-sn-glycerol to 1-stearoyl-2-arachidonoyl-sn-glycerol is 0.109
-
-
?
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol
ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
specific substrate of isoform DGKepsilon
-
-
?
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol
ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
specific substrate of isoform DGKepsilon
-
-
?
ATP + 1-stearoyl-2-docosahexaenoyl-sn-glycerol
ADP + 1-stearoyl-2-docosahexaenoyl-sn-glycerol 3-phosphate
high activity
-
-
?
ATP + 1-stearoyl-2-docosahexaenoyl-sn-glycerol
ADP + 1-stearoyl-2-docosahexaenoyl-sn-glycerol 3-phosphate
no substrate for wild-type, but substrate for mutant R457Q
-
-
?
ATP + 1-stearoyl-2-linoleoyl-sn-glycerol
ADP + 1-stearoyl-2-linoleoyl-sn-glycerol 3-phosphate
-
-
-
-
?
ATP + 1-stearoyl-2-linoleoyl-sn-glycerol
ADP + 1-stearoyl-2-linoleoyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1-stearoyl-2-linoleoyl-sn-glycerol
ADP + 1-stearoyl-2-linoleoyl-sn-glycerol 3-phosphate
-
-
-
-
?
ATP + 1-stearoyl-2-linoleoyl-sn-glycerol
ADP + 1-stearoyl-2-linoleoyl-sn-glycerol 3-phosphate
in wild-type, ratio of enzymic activity of substrates 1-stearoyl-2-linoleoyl-sn-glycerol to 1-stearoyl-2-arachidonoyl-sn-glycerol is 0.109
-
-
?
ATP + 2,3-dioleoyl-sn-glycerol
ADP + 2,3-diacyl-sn-glycerol 1-phosphate
-
-
-
-
?
ATP + 2,3-dioleoyl-sn-glycerol
ADP + 2,3-diacyl-sn-glycerol 1-phosphate
-
-
isoform diacylglycerol kinase alpha 8.5%, zeta, 12%, epsilon 6% of the activity with 1,2-dioleoyl-sn-glycerol, respectively
-
?
ATP + sn-1,2-dioleoylglycerol
ADP + sn-1,2-dioleoylglycerol 3-phosphate
-
-
-
-
?
ATP + sn-1,2-dioleoylglycerol
ADP + sn-1,2-dioleoylglycerol 3-phosphate
recombinant DGKksi
-
-
?
additional information
?
-
-
the isozyme zeta interacts with phosphoinositol phosphate 5-kinase activating it via phosphatidic acid, isozyme theta associates with RhoA, complex enzyme regulation involving alternative splicing, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling
-
-
?
additional information
?
-
-
diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation
-
-
?
additional information
?
-
diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation
-
-
?
additional information
?
-
-
diacylglycerol kinase zeta plays a role in modulation of membrane trafficking. DGKzeta depletion in JURKAT cells accelerates transferrin receptor exit from the endocytic recycling compartment
-
-
?
additional information
?
-
diacylglycerol kinase zeta plays a role in modulation of membrane trafficking. DGKzeta depletion in JURKAT cells accelerates transferrin receptor exit from the endocytic recycling compartment
-
-
?
additional information
?
-
-
the enzyme plays a role in the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes
-
-
?
additional information
?
-
the enzyme plays a role in the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes
-
-
?
additional information
?
-
-
diacylglycerol kinase alpha is involved in secretion of pro-apoptotic protein Fas ligand by T-lymphocytes via the regulation of the release of lethal exosomes by the exocytic pathway
-
-
?
additional information
?
-
diacylglycerol kinase alpha is involved in secretion of pro-apoptotic protein Fas ligand by T-lymphocytes via the regulation of the release of lethal exosomes by the exocytic pathway
-
-
?
additional information
?
-
diacylglycerol kinase gamma regulates beta2-chimaerin, a GTPase-activating protein for Rac
-
-
?
additional information
?
-
-
diacylglycerol kinase zeta is involved in control of vesicle trafficking
-
-
?
additional information
?
-
diacylglycerol kinase zeta is involved in control of vesicle trafficking
-
-
?
additional information
?
-
-
diacylglycerol kinases are required for anchorage-independent growth in MDA-MB-231 cells
-
-
?
additional information
?
-
2-arachidonoyl glycerol is a very poor substrate for the epsilon isoform of diacylglycerol kinases. 2-Oleoyl glycerol is also a poor substrate for this isoform of diacylglycerol kinases
-
-
?
additional information
?
-
2-arachidonoyl glycerol is a very poor substrate for the epsilon isoform of diacylglycerol kinases. 2-Oleoyl glycerol is also a poor substrate for this isoform of diacylglycerol kinases
-
-
?
additional information
?
-
2-arachidonoyl glycerol is a very poor substrate for the zeta isoforms of diacylglycerol kinases. 2-Oleoyl glycerol is also a poor substrate for this isoform
-
-
?
additional information
?
-
2-arachidonoyl glycerol is a very poor substrate for the zeta isoforms of diacylglycerol kinases. 2-Oleoyl glycerol is also a poor substrate for this isoform
-
-
?
additional information
?
-
-
alkyl-lysophosphatidic acid can be produced in SKOV-3 cells by diacylglycerol kinase-mediated phosphorylation of 1-O-hexadecyl-sn-2-acetyl glycerol followed by deacetylation of 1-O-hexadecyl-sn-2-acetyl glycerol 3-phosphate. Production of alkyl-lysophosphatidic acid is stimulated by sphingosine and its analogues
-
-
?
additional information
?
-
the cholesterol recognition/interaction amino acid consensus domain adjacent to the lipoxygenase-like motif plays a role in acyl-chain selectivity. Despite the high degree of conservation of the amino acid sequence in this region of the protein, certain mutations result in proteins with higher activity than the wild-type protein. These mutations also result in a selective gain of acyl-chain preferences for diacylglycerols with different acyl-chain profiles. In addition to the lipoxygenase-like motif, adjacent residues also contribute to selectivity for diacylglycerols with specific acyl-chain compositions
-
-
?
additional information
?
-
water does not compete with diacylglycerol as an acceptor of the gamma-phosphate of ATP. Neither with the highly specific substrate, 1-stearoyl-2-arachidonoyl-sn-glycerol, nor with a less specific substrate, 1-stearoyl-2-linoleoyl-sn-glycerol, is there any evidence for ATP hydrolysis accompanying substrate phosphorylation
-
-
?
additional information
?
-
-
water does not compete with diacylglycerol as an acceptor of the gamma-phosphate of ATP. Neither with the highly specific substrate, 1-stearoyl-2-arachidonoyl-sn-glycerol, nor with a less specific substrate, 1-stearoyl-2-linoleoyl-sn-glycerol, is there any evidence for ATP hydrolysis accompanying substrate phosphorylation
-
-
?
additional information
?
-
the enzyme also shows 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows low 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows low 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows low 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows low 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows low 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows low 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows low 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows low 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
additional information
?
-
the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
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additional information
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the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
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additional information
?
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the enzyme also shows negligible 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
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additional information
?
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enzymatically active splice variant DGKeta3 lacks exon 26 encoding 31 amino acid residues. Splice variant DGKeta4 lacks the C-terminal half of variant DGKeta3 and has no enzymatic activity
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additional information
?
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isoform DGKepsilon is unable to phosphorylate 1-stearoyl-2-docosahexaenoyl-sn-glycerol and has essentially no activity in phosphorylating 1-monoacylglycerol substrates
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additional information
?
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isoform DGKepsilon is unable to phosphorylate 1-stearoyl-2-docosahexaenoyl-sn-glycerol and has essentially no activity in phosphorylating 1-monoacylglycerol substrates
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additional information
?
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isoform DGKzeta physically and functionally interacts with protein kinase Calpha. Diacylglycerol kinase control of protein kinase C facilitates cell-cell communication
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Acne Vulgaris
Presented at the 16(th) DGK Symposium, March 2-4, 2005, Leipzig, Germany - Received the Award for the Best Poster Presentation 1 Influencing the equilibrium of the cutaneous ecosystem to improve the properties of skin prone to acne.
Acquired Immunodeficiency Syndrome
Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and Function.
Acquired Immunodeficiency Syndrome
Role of diacylglycerol kinases in T cell development and function.
Adenocarcinoma of Lung
Survival trees for analyzing clinical outcome in lung adenocarcinomas based on gene expression profiles: identification of neogenin and diacylglycerol kinase alpha expression as critical factors.
Aggressive Periodontitis
Alternative Splicing Generates a Diacylglycerol Kinase ? (DGK?) Transcript That Acts as a Dominant Negative Modulator of Superoxide Production in Localized Aggressive Periodontitis.
Aggressive Periodontitis
Evidence of an association between functional abnormalities and defective diacylglycerol kinase activity in peripheral blood neutrophils from patients with localized juvenile periodontitis.
Aggressive Periodontitis
Identification of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis.
Anemia, Aplastic
Dysregulated miR34a/diacylglycerol kinase ? interaction enhances T-cell activation in acquired aplastic anemia.
Arrhythmias, Cardiac
[Abstracts of the 34th Autumn Conference of the DGK and 21st Annual Convention of the Working Group for Cardiac Pacemakers and Arrhythmia. October 7-9, 2010. Nürmberg, Germany].
Arrhythmias, Cardiac
[Abstracts of the Fall Meeting of the DGK and the Annual Meeting of the Working Group for Pacemakers and Arrhythmia. October 10-12, 2013. Dresden, Germany ].
Arthritis, Juvenile
Diacylglycerol Kinase ? Regulates Macrophage Responses in Juvenile Arthritis and Cytokine Storm Syndrome Mouse Models.
Asthma
Analyses of shared genetic factors between asthma and obesity in children.
Asthma
Autocrine regulation of airway smooth muscle contraction by diacylglycerol kinase.
Asthma
Diacylglycerol kinase ? promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms.
Atrial Fibrillation
Diacylglycerol kinase zeta inhibits G(alpha)q-induced atrial remodeling in transgenic mice.
Atypical Hemolytic Uremic Syndrome
DGKE and atypical HUS.
Atypical Hemolytic Uremic Syndrome
Long-term outcomes and response to treatment in diacylglycerol kinase epsilon nephropathy.
Atypical Hemolytic Uremic Syndrome
Loss of diacylglycerol kinase ? causes thrombotic microangiopathy by impairing endothelial VEGFA signaling.
Blindness
Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA.
Brain Injuries, Traumatic
Brain trauma induces expression of diacylglycerol kinase zeta in microglia.
Breast Neoplasms
Diacylglycerol kinase is required for HGF-induced invasiveness and anchorage-independent growth of MDA-MB-231 breast cancer cells.
Breast Neoplasms
Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cells.
Carcinogenesis
DGKZ Acts as a Potential Oncogene in Osteosarcoma Proliferation Through Its Possible Interaction With ERK1/2 and MYC Pathway.
Carcinogenesis
Diacylglycerol kinase ?1 is a high affinity isozyme for diacylglycerol.
Carcinogenesis
Diacylglycerol kinases: why so many of them?
Carcinogenesis
Downregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest.
Carcinogenesis
Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion.
Carcinogenesis
Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet.
Carcinoma
Chrysin serves as a novel inhibitor of DGK?/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC).
Carcinoma
NK-cell dysfunction in human renal carcinoma reveals diacylglycerol kinase as key regulator and target for therapeutic intervention.
Carcinoma
The diacylglycerol kinase ? (DGK?)/Akt/NF-?B feedforward loop promotes esophageal squamous cell carcinoma (ESCC) progression via FAK-dependent and FAK-independent manner.
Carcinoma
The diacylglycerol kinase ?/atypical PKC/?1 integrin pathway in SDF-1? mammary carcinoma invasiveness.
Carcinoma, Hepatocellular
Combination therapy for hepatocellular carcinoma with diacylglycerol kinase alpha inhibition and anti-programmed cell death-1 ligand blockade.
Carcinoma, Hepatocellular
Diacylglycerol kinase ? predicts prognosis and functions as a tumor suppressor by negatively regulating glucose transporter 1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Diacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras-Raf-MEK-ERK pathway.
Carcinoma, Hepatocellular
Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells.
Carcinoma, Hepatocellular
Palmitic acid- and/or palmitoleic acid-containing phosphatidic acids are generated by diacylglycerol kinase ? in starved Jurkat T cells.
Carcinoma, Renal Cell
NK-cell dysfunction in human renal carcinoma reveals diacylglycerol kinase as key regulator and target for therapeutic intervention.
Carcinoma, Squamous Cell
ATP- and EGF-stimulated phosphatidulinositol synthesis by two different pathways, phospholipase D and diacylglycerol kinase, in A-431 epidermoid carcinoma cells.
Carcinosarcoma
Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022).
Cardiomegaly
Cardiac-specific overexpression of diacylglycerol kinase zeta attenuates left ventricular remodeling and improves survival after myocardial infarction.
Cardiomegaly
Cardiac-specific overexpression of diacylglycerol kinase zeta prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice.
Cardiomegaly
Diacylglycerol kinase zeta attenuates pressure overload-induced cardiac hypertrophy.
Cardiomegaly
Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.
Cardiomegaly
Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade.
Cardiomegaly
Diacylglycerol kinases as emerging potential drug targets for a variety of diseases.
Cardiomegaly
Diacylglycerol Kinases as Emerging Potential Drug Targets for a Variety of Diseases: An Update.
Cardiomegaly
Differential regulation of diacylglycerol kinase isozymes in cardiac hypertrophy.
Cardiomegaly
Role of diacylglycerol kinase in cellular regulatory processes: a new regulator for cardiomyocyte hypertrophy.
Cerebral Infarction
Brain trauma induces expression of diacylglycerol kinase zeta in microglia.
Cerebral Infarction
Diacylglycerol kinase zeta is involved in the process of cerebral infarction.
Chagas Disease
Shedding light on lipid metabolism in Kinetoplastida: A phylogenetic analysis of phospholipase D protein homologs.
Cholera
Role of protein kinase C in transforming growth factor-beta 1 induction of carcinoembryonic antigen in human colon carcinoma cells.
Colonic Neoplasms
Increased diacylglycerol kinase ? expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion.
Colonic Neoplasms
Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet.
Colonic Neoplasms
Overexpression of DGKI in Gastric Cancer Predicts Poor Prognosis.
Colorectal Neoplasms
Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer.
Cystic Fibrosis
The cubicon method for concentrating membrane proteins in the cubic mesophase.
Dental Caries
Kinase activity of the dgk gene product is involved in the virulence of Streptococcus mutans.
deoxyguanosine kinase deficiency
Abnormal neurological features predict poor survival and should preclude liver transplantation in patients with deoxyguanosine kinase deficiency.
Diabetes Mellitus
Diacylglycerol kinase zeta inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus.
Diabetes Mellitus, Type 2
Chronic administration of myristic acid improves hyperglycaemia in the Nagoya-Shibata-Yasuda mouse model of congenital type 2 diabetes.
Diabetes Mellitus, Type 2
Creatine kinase muscle type specifically interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids.
Diabetes Mellitus, Type 2
Diacylglycerol Signaling Pathway in Pancreatic ?-Cells: An Essential Role of Diacylglycerol Kinase in the Regulation of Insulin Secretion.
Diabetes Mellitus, Type 2
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.
Diabetes Mellitus, Type 2
Myristic Acid Enhances Diacylglycerol Kinase ?-Dependent Glucose Uptake in Myotubes.
Diabetes Mellitus, Type 2
Myristic acid specifically stabilizes diacylglycerol kinase ? protein in C2C12 skeletal muscle cells.
Diabetes Mellitus, Type 2
New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein.
Diabetes Mellitus, Type 2
Regulation of diacylglycerol kinase ?2 expression in C2C12 skeletal muscle cells by free fatty acids.
Diabetes Mellitus, Type 2
Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis.
Diabetes Mellitus, Type 2
Sphingomyelin synthase-related protein generates diacylglycerol via the hydrolysis of glycerophospholipids in the absence of ceramide.
Diabetic Cardiomyopathies
Diacylglycerol kinase zeta inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus.
Diabetic Nephropathies
Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice.
Diabetic Nephropathies
Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats.
Diabetic Nephropathies
Screening of subtype specific activators and inhibitors for diacylglycerol kinase.
diacylglycerol kinase (atp) deficiency
Deoxyguanosine kinase deficiency presenting as neonatal hemochromatosis.
diacylglycerol kinase (atp) deficiency
Deoxynucleoside salvage enzymes and tissue specific mitochondrial DNA depletion.
diacylglycerol kinase (atp) deficiency
Deoxyribonucleoside kinases in mitochondrial DNA depletion.
diacylglycerol kinase (atp) deficiency
Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.
diacylglycerol kinase (atp) deficiency
Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.
diacylglycerol kinase (atp) deficiency
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.
diacylglycerol kinase (atp) deficiency
Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.
diacylglycerol kinase (atp) deficiency
Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus.
diacylglycerol kinase (atp) deficiency
Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity.
diacylglycerol kinase (atp) deficiency
Mitochondrial deoxyribonucleotide pools in deoxyguanosine kinase deficiency.
diacylglycerol kinase (atp) deficiency
Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes.
diacylglycerol kinase (atp) deficiency
Neonatal liver failure due to deoxyguanosine kinase deficiency.
diacylglycerol kinase (atp) deficiency
The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase.
Diffuse Cerebral Sclerosis of Schilder
Defects in maintenance of mitochondrial DNA are associated with intramitochondrial nucleotide imbalances.
Dirofilariasis
Development of New Recombinant DgK Antigen for Diagnosis of Dirofilaria immitis Infections in Dogs Using ELISA Technique and Its Comparison to Molecular Methods
Dyslexia
SNP variations in the 7q33 region containing DGKI are associated with dyslexia in the Finnish and German populations.
Encephalomyelitis
The expression of diacylglycerol kinase isoforms ? and ? correlates with the progression of experimental autoimmune encephalomyelitis in rats.
Encephalomyelitis, Autoimmune, Experimental
The expression of diacylglycerol kinase isoforms ? and ? correlates with the progression of experimental autoimmune encephalomyelitis in rats.
Endometrial Neoplasms
Diacylglycerol kinase ? mediates 17-?-estradiol-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell line through the G protein-coupled estrogen receptor GPR30.
Epilepsy
Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum.
Epilepsy
Diacylglycerol kinases as emerging potential drug targets for a variety of diseases.
Epilepsy
Diacylglycerol Kinases as Emerging Potential Drug Targets for a Variety of Diseases: An Update.
Epilepsy
Endocannabinoids and diacylglycerol kinase activity.
Escherichia coli Infections
Irreversible severe kidney injury and anuria in a 3-month-old girl with atypical haemolytic uraemic syndrome under administration of eculizumab.
Esophageal Squamous Cell Carcinoma
Chrysin serves as a novel inhibitor of DGK?/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC).
Esophageal Squamous Cell Carcinoma
The diacylglycerol kinase ? (DGK?)/Akt/NF-?B feedforward loop promotes esophageal squamous cell carcinoma (ESCC) progression via FAK-dependent and FAK-independent manner.
Eye Diseases
Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene.
Fragile X Syndrome
New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein.
Glioblastoma
CRISPR/Cas9-Mediated Knockout of DGK Improves Antitumor Activities of Human T Cells.
Glioblastoma
DGK? Plays Crucial Roles in the Proliferation and Tumorigenicity of Human glioblastoma.
Glioblastoma
Diacylglycerol kinase ? is a critical signaling node and novel therapeutic target in glioblastoma and other cancers.
Glioblastoma
Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha.
Glioma
Diacylglycerol molecular species in plasma membrane and microsomes change transiently with endothelin-1 treatment of glioma cells.
Glioma
Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells.
Glomerulonephritis, Membranoproliferative
Long-term outcomes and response to treatment in diacylglycerol kinase epsilon nephropathy.
Glomerulonephritis, Membranoproliferative
The Phenotypic Spectrum of Nephropathies Associated with Mutations in Diacylglycerol Kinase ?.
glycerol kinase deficiency
Glycerol hypersensitivity in a Drosophila model for glycerol kinase deficiency is affected by mutations in eye pigmentation genes.
Glycogen Storage Disease Type V
Muscle glycogenosis and mitochondrial hepatopathy in an infant with mutations in both the myophosphorylase and deoxyguanosine kinase genes.
Heart Diseases
Diacylglycerol kinases: at the hub of cell signalling.
Heart Failure
Diacylglycerol Kinase ? Inhibits Ventricular Tachyarrhythmias in a Mouse Model of Heart Failure.
Heart Failure
Diacylglycerol kinase zeta inhibits G(alpha)q-induced atrial remodeling in transgenic mice.
Heart Failure
Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.
Heart Failure
Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade.
Heart Failure
Role of diacylglycerol kinase in cellular regulatory processes: a new regulator for cardiomyocyte hypertrophy.
Hemolytic-Uremic Syndrome
Outcome of diacylglycerol kinase epsilon-mediated hemolytic uremic syndrome in an infant.
Herpes Simplex
Cloning and expression of human deoxyguanosine kinase cDNA.
Herpes Simplex
Stereoisomeric selectivity of human deoxyribonucleoside kinases.
Herpes Zoster
Expression and localization of the diacylglycerol kinase family and of phosphoinositide signaling molecules in adrenal gland.
Hyperglycemia
d-Alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity.
Hypersensitivity
Altered Lipid Synthesis by Lack of Yeast Pah1 Phosphatidate Phosphatase Reduces Chronological Life Span.
Hypersensitivity
Disruption of Glycerol Metabolism by RNAi Targeting of Genes Encoding Glycerol Kinase Results in a Range of Phenotype Severity in Drosophila.
Hypersensitivity
Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans.
Hypertension
A central role for protein kinase C overactivity in diabetic glomerulosclerosis: implications for prevention with antioxidants, fish oil, and ACE inhibitors.
Hypertension
Diacylglycerol kinases as emerging potential drug targets for a variety of diseases.
Hypertension
Diacylglycerol Kinases as Emerging Potential Drug Targets for a Variety of Diseases: An Update.
Hypospadias
Association between diacylglycerol kinase kappa variants and hypospadias susceptibility in a Han Chinese population.
Hypospadias
Common variants in DGKK are strongly associated with risk of hypospadias.
Hypospadias
DGKK Variants and hypospadias in Han Chinese: association and meta-analysis.
Hypospadias
Diacylglycerol kinase K variants impact hypospadias in a California study population.
Hypospadias
Expression Analysis of DGKK during External Genitalia Formation.
Hypospadias
Further Evidence of the Association of the Diacylglycerol Kinase Kappa (DGKK) Gene With Hypospadias.
Hypospadias
The role of genetic variation in DGKK on moderate and severe hypospadias.
Hypospadias
[Single nucleotide polymorphisms of the DGKK gene and hypospadias in Chinese children].
Infarction, Middle Cerebral Artery
Diacylglycerol kinase zeta is involved in the process of cerebral infarction.
Infections
Development of New Recombinant DgK Antigen for Diagnosis of Dirofilaria immitis Infections in Dogs Using ELISA Technique and Its Comparison to Molecular Methods
Infections
Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.
Infections
Diacylglycerol kinases in immune cell function and self-tolerance.
Infections
Irreversible severe kidney injury and anuria in a 3-month-old girl with atypical haemolytic uraemic syndrome under administration of eculizumab.
Infections
Phospholipase C/diacylglycerol kinase-mediated signalling is required for benzothiadiazole-induced oxidative burst and hypersensitive cell death in rice suspension-cultured cells.
Infections
Selective immunostaining of Mehlis' gland of Opisthorchis viverrini by antibody against rat diacylglycerol kinase.
Infections
Unexpected positive control of NF?B and miR-155 by DGK? and ? ensures effector and memory CD8+ T Cell differentiation.
Insulin Resistance
Complementary measures for promoting insulin sensitivity in skeletal muscle.
Insulin Resistance
Diacylglycerol kinase as a possible therapeutic target for neuronal diseases.
Insulin Resistance
Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors.
Insulin Resistance
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.
Insulin Resistance
Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGK? gene knockout.
Insulin Resistance
Knockdown of diacylglycerol kinase delta inhibits adipocyte differentiation and alters lipid synthesis.
Insulin Resistance
mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance.
Insulin Resistance
Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis.
Intellectual Disability
Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons.
Kearns-Sayre Syndrome
Neuropathology of mitochondrial diseases.
Leishmaniasis
Shedding light on lipid metabolism in Kinetoplastida: A phylogenetic analysis of phospholipase D protein homologs.
Lethargy
Calcium/calmodulin-dependent protein kinase II regulates Caenorhabditis elegans locomotion in concert with a G(o)/G(q) signaling network.
Leukemia
Ceramide is a competitive inhibitor of diacylglycerol kinase in vitro and in intact human leukemia (HL-60) cells.
Leukemia
Characterization of a ceramide kinase activity from human leukemia (HL-60) cells. Separation from diacylglycerol kinase activity.
Leukemia
Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling.
Leukemia
Real-time quantitative PCR assays for deoxycytidine kinase, deoxyguanosine kinase and 5'-nucleotidase mRNA measurement in cell lines and in patients with leukemia.
Leukemia
Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells.
Leukemia
[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.
Leukemia, Erythroblastic, Acute
Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression.
Leukemia, Myeloid, Acute
Knockdown of diacylglycerol kinase zeta (DGKZ) induces apoptosis and G2/M phase arrest in human acute myeloid leukemia HL-60 cells through MAPK/survivin/caspase pathway.
Liver Failure
Neonatal liver failure due to deoxyguanosine kinase deficiency.
Liver Neoplasms
Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGK? gene knockout.
Lung Neoplasms
Diacylglycerol kinase ? modulates oncogenic properties of lung cancer cells.
Lung Neoplasms
High-throughput functional genomic methods to analyze the effects of dietary lipids.
Lymphoma
Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling.
Lymphoma, T-Cell
Phosphatidic acid is required for the constitutive ruffling and macropinocytosis of phagocytes.
Lymphoproliferative Disorders
Diacylglycerol Kinase alpha in X Linked Lymphoproliferative Disease Type 1.
Melanoma
Combined inhibition/silencing of diacylglycerol kinase ? and ? simultaneously and synergistically enhances interleukin-2 production in T cells and induces cell death of melanoma cells.
Melanoma
Diacylglycerol kinase ?-selective inhibitors induce apoptosis and reduce viability of melanoma and several other cancer cell lines.
Melanoma
Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation.
Melanoma
Nucleoside Analog Activity in Malignant Melanoma Cell Lines.
Melanoma
Palmitic acid- and/or palmitoleic acid-containing phosphatidic acids are generated by diacylglycerol kinase ? in starved Jurkat T cells.
Muscular Diseases
Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes.
Myocardial Infarction
Cardiac-specific overexpression of diacylglycerol kinase zeta attenuates left ventricular remodeling and improves survival after myocardial infarction.
Myocardial Infarction
Gene expression and in situ localization of diacylglycerol kinase isozymes in normal and infarcted rat hearts: effects of captopril treatment.
Myocardial Infarction
Role of diacylglycerol kinase in cellular regulatory processes: a new regulator for cardiomyocyte hypertrophy.
Neoplasms
A novel diacylglycerol kinase ?-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response.
Neoplasms
Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase.
Neoplasms
Alteration of AKAP220, an upstream component of the Rb pathway, in oral carcinogenesis.
Neoplasms
Analytical Method for Diacylglycerol Kinase ? Activity in Cells Using Protein Myristoylation and Liquid Chromatography-Tandem Mass Spectrometry.
Neoplasms
Assignment of 20 microsatellite markers to the porcine linkage map.
Neoplasms
Biological regulation of diacylglycerol kinases in normal and neoplastic tissues: New opportunities for cancer immunotherapy.
Neoplasms
Combination therapy for hepatocellular carcinoma with diacylglycerol kinase alpha inhibition and anti-programmed cell death-1 ligand blockade.
Neoplasms
Combined inhibition/silencing of diacylglycerol kinase ? and ? simultaneously and synergistically enhances interleukin-2 production in T cells and induces cell death of melanoma cells.
Neoplasms
CRISPR/Cas9-Mediated Knockout of DGK Improves Antitumor Activities of Human T Cells.
Neoplasms
Diacylglycerol kinase ? (DGK?) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGK?-deficient mice have increased T cell activation and tumor clearance.
Neoplasms
Diacylglycerol kinase ? controls RCP-dependent integrin trafficking to promote invasive migration.
Neoplasms
Diacylglycerol kinase ? is a critical signaling node and novel therapeutic target in glioblastoma and other cancers.
Neoplasms
Diacylglycerol kinase ? predicts prognosis and functions as a tumor suppressor by negatively regulating glucose transporter 1 in hepatocellular carcinoma.
Neoplasms
Diacylglycerol kinase ? promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.
Neoplasms
Diacylglycerol kinase ?-selective inhibitors induce apoptosis and reduce viability of melanoma and several other cancer cell lines.
Neoplasms
Diacylglycerol kinase alpha enhances protein kinase Czeta-dependent phosphorylation at Ser311 of p65/RelA subunit of nuclear factor-kappaB.
Neoplasms
Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation.
Neoplasms
Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression.
Neoplasms
Diacylglycerol kinase control of protein kinase C.
Neoplasms
Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling.
Neoplasms
Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors.
Neoplasms
Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.
Neoplasms
Diacylglycerol kinases as emerging potential drug targets for a variety of diseases.
Neoplasms
Diacylglycerol Kinases as Emerging Potential Drug Targets for a Variety of Diseases: An Update.
Neoplasms
Diacylglycerol kinases in cancer.
Neoplasms
Diacylglycerol kinases: at the hub of cell signalling.
Neoplasms
Downregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest.
Neoplasms
Dual activities of ritanserin and R59022 as DGK? inhibitors and serotonin receptor antagonists.
Neoplasms
Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion.
Neoplasms
Haemolytic uraemic syndrome.
Neoplasms
Immune checkpoint blockade opens a new way to cancer immunotherapy.
Neoplasms
Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet.
Neoplasms
Molecular Pathways: Targeting Diacylglycerol Kinase Alpha in Cancer.
Neoplasms
New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein.
Neoplasms
NK-cell dysfunction in human renal carcinoma reveals diacylglycerol kinase as key regulator and target for therapeutic intervention.
Neoplasms
Not expecting the unexpected: diacylglycerol kinase alpha as a cancer target.
Neoplasms
Overexpression of DGKI in Gastric Cancer Predicts Poor Prognosis.
Neoplasms
Protein kinase C mediates human neutrophil cytotoxicity.
Neoplasms
Role of diacylglycerol kinases in T cell development and function.
Neoplasms
Role of protein kinase C in chick embryo skeletal myoblast fusion.
Neoplasms
Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022).
Neoplasms
Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases.
Neoplasms
Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta.
Neoplasms
T cells deficient in diacylglycerol kinase-? are resistant to PD-1 inhibition and help create persistent host immunity to leukemia.
Neoplasms
Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha.
Neoplasms
Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cells.
Neoplasms
Where do substrates of diacylglycerol kinases come from? Diacylglycerol kinases utilize diacylglycerol species supplied from phosphatidylinositol turnover-independent pathways.
Nephrotic Syndrome
Long-term outcomes and response to treatment in diacylglycerol kinase epsilon nephropathy.
Neuroblastoma
Diacylglycerol kinase ? generates dipalmitoyl-phosphatidic acid species during neuroblastoma cell differentiation.
Neuroblastoma
Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells.
Neuroblastoma
Induction of filopodia-like protrusions in N1E-115 neuroblastoma cells by diacylglycerol kinase ? independent of its enzymatic activity: potential novel function of the C-terminal region containing the catalytic domain of diacylglycerol kinase ?.
Neuroblastoma
Phosphoinositide-derived diacylglycerol conversion to phosphatidic acid is a receptor-dependent and compartmentalized phenomenon in human neuroblastoma.
Obesity
An in vivo screen for neuronal genes involved in obesity identifies Diacylglycerol kinase as a regulator of insulin secretion.
Obesity
Analyses of shared genetic factors between asthma and obesity in children.
Obesity
Deletion of diacylglycerol kinase ? confers susceptibility to obesity via reduced lipolytic activity in murine adipocytes.
Obesity
Diacylglycerol kinase zeta in hypothalamus interacts with long form leptin receptor. Relation to dietary fat and body weight regulation.
Obesity
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.
Obesity
mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance.
Obesity
Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis.
Optic Atrophy, Autosomal Dominant
Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1).
Ovarian Neoplasms
DGKA Provides Platinum Resistance in Ovarian Cancer Through Activation of c-JUN-WEE1 Signaling.
Pancreatic Neoplasms
Enhanced cytotoxicity of nucleoside analogs by overexpression of mitochondrial deoxyguanosine kinase in cancer cell lines.
Parkinson Disease
Analysis of the genotype of diacylglycerol kinase delta single-nucleotide polymorphisms in Parkinson disease in the Han Chinese population.
Parkinson Disease
Association study of MCCC1/LAMP3 and DGKQ variants with Parkinson's disease in patients of Malay ancestry.
Peanut Hypersensitivity
Diacylglycerol kinase ? deficiency in a non-CD4(+) T-cell compartment leads to increased peanut hypersensitivity.
plasmin deficiency
HUS and atypical HUS.
Pre-Eclampsia
Analysis of the Epigenome in Multiplex Pre-eclampsia Families Identifies SORD, DGKI, and ICA1 as Novel Candidate Risk Genes.
Proteinuria
Podocyte dysfunction in atypical haemolytic uraemic syndrome.
Purpura, Thrombotic Thrombocytopenic
Complement activation in diseases presenting with thrombotic microangiopathy.
Purpura, Thrombotic Thrombocytopenic
Irreversible severe kidney injury and anuria in a 3-month-old girl with atypical haemolytic uraemic syndrome under administration of eculizumab.
Radiation Fibrosis Syndrome
BET-bromodomain inhibitors modulate epigenetic patterns at the diacylglycerol kinase alpha enhancer associated with radiation-induced fibrosis.
Radiation Fibrosis Syndrome
Diacylglycerol Kinase Alpha in Radiation-Induced Fibrosis: Potential as a Predictive Marker or Therapeutic Target.
Radiation Fibrosis Syndrome
Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response.
Radiation Fibrosis Syndrome
Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis.
Retinal Degeneration
A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus.
Retinal Degeneration
Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene.
Retinal Degeneration
Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA.
Retinal Degeneration
Diacylglycerol kinase defect in a Drosophila retinal degeneration mutant rdgA.
Retinal Degeneration
Drosophila retinal degeneration A gene encodes an eye-specific diacylglycerol kinase with cysteine-rich zinc-finger motifs and ankyrin repeats.
Retinal Degeneration
Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant.
Retinal Degeneration
Immunolocalization of Drosophila eye-specific diacylgylcerol kinase, rdgA, which is essential for the maintenance of the photoreceptor.
Retinal Degeneration
Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1).
Retinal Neovascularization
Diacylglycerol Kinase (DGK) Inhibitor II (R59949) Could Suppress Retinal Neovascularization and Protect Retinal Astrocytes in an Oxygen-Induced Retinopathy Model.
Retinitis Pigmentosa
Characterization of the human diacylglycerol kinase epsilon gene and its assessment as a candidate for inherited retinitis pigmentosa.
Retinitis Pigmentosa
The cloning and characterization of a novel human diacylglycerol kinase, DGKiota.
Retinoblastoma
Nuclear diacylglycerol kinase-zeta is a negative regulator of cell cycle progression in C2C12 mouse myoblasts.
Retinoblastoma
Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression.
Retinoblastoma
Protein kinase C inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein.
Retinoblastoma
The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta.
Retinoblastoma
TIS21/BTG2/PC3 and cyclin D1 are key determinants of nuclear diacylglycerol kinase-zeta-dependent cell cycle arrest.
Retinoblastoma
Tis21/btg2/pc3 and cyclin d1 are key determinants of nuclear diacylglycerol kinase-zeta-dependent cell cycle arrest.
Sarcoma, Avian
Phosphatidylinositol kinase activities in normal and Rous sarcoma virus-transformed cells.
Seizures
Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum.
Seizures
Diacylglycerol kinase epsilon modulates rapid kindling epileptogenesis.
Seizures
Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoyl- inositol lipid signaling.
Seizures
Diacylglycerol kinases as emerging potential drug targets for a variety of diseases.
Seizures
Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice.
Seizures
Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus.
Seizures
Excitotoxicity by kainate-induced seizure causes diacylglycerol kinase ? to shuttle from the nucleus to the cytoplasm in hippocampal neurons.
Seizures
Lipid signaling in experimental epilepsy.
Shock, Septic
Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.
Starvation
Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila.
Tachycardia
Diacylglycerol Kinase ? Inhibits Ventricular Tachyarrhythmias in a Mouse Model of Heart Failure.
Tachycardia, Ventricular
Diacylglycerol Kinase ? Inhibits Ventricular Tachyarrhythmias in a Mouse Model of Heart Failure.
Thrombotic Microangiopathies
Long-term outcomes and response to treatment in diacylglycerol kinase epsilon nephropathy.
Thrombotic Microangiopathies
Loss of diacylglycerol kinase ? causes thrombotic microangiopathy by impairing endothelial VEGFA signaling.
Toxoplasmosis
Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.
Toxoplasmosis
Diacylglycerol kinases in immune cell function and self-tolerance.
Trypanosomiasis
Shedding light on lipid metabolism in Kinetoplastida: A phylogenetic analysis of phospholipase D protein homologs.
Tuberculosis
M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs).
Tuberculosis
[Developmental metabolism of Mycobacterium tuberculosis of H37Rv and L strains, cultured on DGK medium; general metabolic characteristics of Mycobacterium tuberculosis.]
Tuberculosis
[Microcultures of Mycobacterium tuberculosis obtained on the synthetic medium DGK.]
Tuberculosis
[Organic catabolites of strain H37Rv Mycobacterium tuberculosis cultured in DGK medium.]
Tyrosinemias
Deoxyguanosine kinase deficiency presenting as neonatal hemochromatosis.
Uterine Cervical Neoplasms
Downregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest.
Vesicular Stomatitis
Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains.
Whooping Cough
Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals.
Whooping Cough
Inositol 1,4,5-trisphosphate-independent Ca(2+) mobilization triggered by a lipid factor isolated from vitreous body.
Whooping Cough
Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells.
Whooping Cough
Role of protein kinase C in transforming growth factor-beta 1 induction of carcinoembryonic antigen in human colon carcinoma cells.
Wilms Tumor
New frontiers on the molecular underpinnings of hypospadias according to severity.
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Schaap, D.; de Widt, J.; van der Wal, J.; Vandekerckhove, J.; van Damme, J.; Gussow, D.; Ploegh, H.L.; van Blitterswijk, W.J.; van der Bend, R.L.
Purification, cDNA-cloning and expression of human diacylglycerol kinase
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Escherichia coli, Homo sapiens
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1980
Homo sapiens
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Yada, Y.; Ozeki, T.; Kanoh, H.; Nozawa, Y.
Purification and characterization of cytosolic diacylglycerol kinases of human platelets
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Homo sapiens
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Yamada, K.; Sakane, F.; Imai, S.; Tsushima, S.; Murakami, T.; Kanoh, H.
Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells
Biochem. Biophys. Res. Commun.
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2003
Homo sapiens
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Hurttia, H.; Leino, L.
Subcellular localization of diacylglycerol kinase activity in stimulated and unstimulated human peripheral blood lymphocytes and neutrophils
Biochem. Mol. Biol. Int.
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1996
Homo sapiens
brenda
Tabellini, G.; Bortul, R.; Santi, S.; Riccio, M.; Baldini, G.; Cappellini, A.; Billi, A.M.; Berezney, R.; Ruggeri, A.; Cocco, L.; Martelli, A.M.
Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus
Exp. Cell Res.
287
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2003
Homo sapiens, Rattus norvegicus
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Sakane, F.; Kanoh, H.
Molecules in focus: diacylglycerol kinase
Int. J. Biochem. Cell Biol.
29
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1997
Homo sapiens, Mesocricetus auratus, Rattus norvegicus, Sus scrofa
brenda
Caricasole, A.; Bettini, E.; Sala, C.; Roncarati, R.; Kobayashi, N.; Caldara, F.; Goto, K.; Terstappen, G.C.
Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties
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277
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2002
Homo sapiens (Q9Y6T7), Homo sapiens
brenda
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Molecular cloning and characterization of a novel human diacylglycerol kinase zeta
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271
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Homo sapiens (Q13574), Homo sapiens
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Yamada, K.; Sakane, F.; Matsushima, N.; Kanoh, H.
EF-hand motifs of alpha, beta and gamma isoforms of diacylglycerol kinase bind calcium with different affinities and conformational changes
Biochem. J.
321
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1997
Homo sapiens, Rattus norvegicus, Sus scrofa, Sus scrofa DGKalpha
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The cloning and characterization of a novel human diacylglycerol kinase, DGKiota
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273
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1998
Homo sapiens
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Murakami, T.; Sakane, F.; Imai, S.; Houkin, K.; Kanoh, H.
Identification and characterization of two splice variants of human diacylglycerol kinase eta
J. Biol. Chem.
278
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2003
Homo sapiens (Q86XP1), Homo sapiens
brenda
Los, A.P.; van Baal, J.; de Widt, J.; Divecha, N.; van Blitterswijk, W.J.
Structure-activity relationship of diacylglycerol kinase theta
Biochim. Biophys. Acta
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2004
Homo sapiens
brenda
Luo, B.; Regier, D.S.; Prescott, S.M.; Topham, M.K.
Diacylglycerol kinases
Cell. Signal.
16
983-989
2004
Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mammalia, no activity in Saccharomyces cerevisiae
brenda
Dicu, A.O.; Matthew, K.; Topham, K.; Ottaway, L.; Epand, R.M.
Role of the hydrophobic segment of diacylglycerol kinase epsilon
Biochemistry
46
6109-6117
2007
Homo sapiens
brenda
Tu-Sekine, B.; Ostroski, M.; Raben, D.M.
Modulation of diacylglycerol kinase theta activity by alpha-thrombin and phospholipids
Biochemistry
46
924-932
2007
Homo sapiens
brenda
Yanagisawa, K.; Yasuda, S.; kai, M.; Imai, S.i.; Yamada, K.; Yamashita, T.; JImbow, K.; Kanoh, H.; Sakane, F.
Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation
Biochim. Biophys. Acta
1771
462-474
2007
Homo sapiens, Homo sapiens (P23743)
brenda
Los, A.P.; de Widt, J.; Topham, M.K.; van Blitterswijk, W.J.; Divecha, N.
Protein kinase C inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein
Biochim. Biophys. Acta
1773
352-357
2007
Homo sapiens
brenda
Alonso, R.; Mazzeo, C.; Merida, I.; Izquierdo, M.
: A new role of diacylglycerol kinase alpha on the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes
Biochimie
89
213-221
2007
Homo sapiens, Homo sapiens (P23743)
brenda
Yasuda, S.; Kai, M.; Imai, S.; Kanoh, H.; Sakane, F.
Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor
FEBS Lett.
581
551-557
2007
Chlorocebus aethiops, Homo sapiens (P49619)
brenda
Evangelisti, C.; Bortul, R.; Fala, F.; Tabellini, G.; Goto, K.; Martelli, A.M.
Nuclear diacylglycerol kinases: emerging downstream regulators in cell signalling networks
Histol. Histopathol.
22
573-579
2007
Chlorocebus aethiops, Cricetulus griseus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Miele, C.; Paturzo, F.; Teperino, R.; Sakane, F.; Fiory, F.; Oriente, F.; Ungaro, P.; Valentino, R.; Beguinot, F.; Formisano, P.
Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localization
J. Biol. Chem.
282
3185-3143
2007
Homo sapiens
brenda
Rincon, E.; Santos, T.; Avila-Flores, A.; Albar, J.P.; Lalioti, V.; Lei, C.; Hong, W.; Merida, I.
Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein
Mol. Cell. Proteomics
6
1073-1087
2007
Homo sapiens, Homo sapiens (Q13574)
brenda
Leach, N.T.; Sun, Y.; Michaud, S.; Zheng, Y.; Ligon, K.L.; Ligon, A.H.; Sander, T.; Korf, B.R.; Lu, W.; Harris, D.J.; Gusella, J.F.; Maas, R.L.; Quade, B.J.; Cole, A.J.; Kelz, M.B.; Morton, C.C.
Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice
Am. J. Hum. Genet.
80
792-799
2007
Mus musculus, Homo sapiens (Q16760), Homo sapiens
brenda
Filigheddu, N.; Cutrupi, S.; Porporato, P.E.; Riboni, F.; Baldanzi, G.; Chianale, F.; Fortina, E.; Piantanida, P.; De Bortoli, M.; Vacca, G.; Graziani, A.; Surico, N.
Diacylglycerol kinase is required for HGF-induced invasiveness and anchorage-independent growth of MDA-MB-231 breast cancer cells
Anticancer Res.
27
1489-1492
2007
Homo sapiens
brenda
Kawasaki, T.; Kobayashi, T.; Ueyama, T.; Shirai, Y.; Saito, N.
Regulation of clathrin-dependent endocytosis by diacylglycerol kinase delta: importance of kinase activity and binding to AP2alpha
Biochem. J.
409
471-479
2008
Homo sapiens
brenda
Yasuda, S.; Kai, M.; Imai, S.; Kanoh, H.; Sakane, F.
Phorbol ester and hydrogen peroxide synergistically induce the interaction of diacylglycerol kinase gamma with the Src homology 2 and C1 domains of beta2-chimaerin
Biochem. J.
409
95-106
2008
Homo sapiens
brenda
Epand, R.M.; Shulga, Y.V.; Timmons, H.C.; Perri, A.L.; Belani, J.D.; Perinpanathan, K.; Johnson-McIntire, L.B.; Bajjalieh, S.; Dicu, A.O.; Elias, C.; Rychnovsky, S.D.; Topham, M.K.
Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase
Biochemistry
46
14225-14231
2007
Homo sapiens
brenda
Glukhov, E.; Shulga, Y.V.; Epand, R.F.; Dicu, A.O.; Topham, M.K.; Deber, C.M.; Epand, R.M.
Membrane interactions of the hydrophobic segment of diacylglycerol kinase epsilon
Biochim. Biophys. Acta
1768
2549-2558
2007
Homo sapiens (P52429)
brenda
Chibalin, A.V.; Leng, Y.; Vieira, E.; Krook, A.; Bjoernholm, M.; Long, Y.C.; Kotova, O.; Zhong, Z.; Sakane, F.; Steiler, T.; Nylen, C.; Wang, J.; Laakso, M.; Topham, M.K.; Gilbert, M.; Wallberg-Henriksson, H.; Zierath, J.R.
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance
Cell
132
375-386
2008
Mus musculus, Rattus norvegicus, Homo sapiens (Q16760), Homo sapiens
brenda
Williams, J.M.; Pettitt, T.R.; Powell, W.; Grove, J.; Savage, C.O.; Wakelam, M.J.
Antineutrophil cytoplasm antibody-stimulated neutrophil adhesion depends on diacylglycerol kinase-catalyzed phosphatidic acid formation
J. Am. Soc. Nephrol.
18
1112-1120
2007
Homo sapiens
brenda
Merino, E.; Avila-Flores, A.; Shirai, Y.; Moraga, I.; Saito, N.; Merida, I.
Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells
J. Immunol.
180
5805-5815
2008
Homo sapiens (P23743)
brenda
Decaffmeyer, M.; Shulga, Y.V.; Dicu, A.O.; Thomas, A.; Truant, R.; Topham, M.K.; Brasseur, R.; Epand, R.M.
Determination of the topology of the hydrophobic segment of mammalian diacylglycerol kinase epsilon in a cell membrane and its relationship to predictions from modeling
J. Mol. Biol.
383
797-809
2008
Homo sapiens (P52429)
brenda
Li, D.; Urs, A.N.; Allegood, J.; Leon, A.; Merrill, A.H.; Sewer, M.B.
Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17
Mol. Cell. Biol.
27
6669-6685
2007
Homo sapiens
brenda
Baum, A.E.; Akula, N.; Cabanero, M.; Cardona, I.; Corona, W.; Klemens, B.; Schulze, T.G.; Cichon, S.; Rietschel, M.; Noethen, M.M.; Georgi, A.; Schumacher, J.; Schwarz, M.; Abou Jamra, R.; Hoefels, S.; Propping, P.; Satagopan, J.; Detera-Wadleigh, S.D.; Hardy, J.; McMahon, F.J.
A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder
Mol. Psychiatry
13
197-207
2008
Homo sapiens
brenda
Los, A.; de Widt, J.; van Blitterswijk, W.; Divecha, N.
Is there a role for diacylglycerol kinase-zeta in cell cycle regulation?
Adv. Enzyme Regul.
48
31-39
2008
Homo sapiens (Q13574)
brenda
Merida, I.; Avila-Flores, A.; Garcia, J.; Merino, E.; Almena, M.; Torres-Ayuso, P.
Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression
Adv. Enzyme Regul.
49
174-188
2009
Mus musculus (O88673), Homo sapiens (P23743)
brenda
Kai, M.; Yasuda, S.; Imai, S.; Toyota, M.; Kanoh, H.; Sakane, F.
Diacylglycerol kinase alpha enhances protein kinase Czeta-dependent phosphorylation at Ser311 of p65/RelA subunit of nuclear factor-kappaB
FEBS Lett.
583
3265-3268
2009
Sus scrofa (P20192), Homo sapiens (P23743)
brenda
Yasuda, S.; Kai, M.; Imai, S.; Takeishi, K.; Taketomi, A.; Toyota, M.; Kanoh, H.; Sakane, F.
Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization
J. Biol. Chem.
284
29559-29570
2009
Homo sapiens (Q86XP1)
brenda
Lung, M.; Shulga, Y.V.; Ivanova, P.T.; Myers, D.S.; Milne, S.B.; Brown, H.A.; Topham, M.K.; Epand, R.M.
Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol
J. Biol. Chem.
284
31062-31073
2009
Homo sapiens (P52429)
brenda
Gellett, A.M.; Kharel, Y.; Sunkara, M.; Morris, A.J.; Lynch, K.R.
Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases
Biochem. Biophys. Res. Commun.
422
758-763
2012
Homo sapiens
brenda
Knight, M.J.; Joubert, M.K.; Plotkowski, M.L.; Kropat, J.; Gingery, M.; Sakane, F.; Merchant, S.S.; Bowie, J.U.
Zinc binding drives sheet formation by the SAM domain of diacylglycerol kinase delta
Biochemistry
49
9667-9676
2010
Homo sapiens
brenda
Gantayet, A.; Jegatheswaran, J.; Jayakumaran, G.; Topham, M.K.; Epand, R.M.
Endocannabinoids and diacylglycerol kinase activity
Biochim. Biophys. Acta
1808
1050-1053
2011
Homo sapiens (P52429), Homo sapiens (Q13574)
brenda
Takeuchi, M.; Sakiyama, S.; Usuki, T.; Sakai, H.; Sakane, F.
Diacylglycerol kinase delta1 transiently translocates to the plasma membrane in response to high glucose
Biochim. Biophys. Acta
1823
2210-2216
2012
Homo sapiens (Q16760), Homo sapiens
brenda
Prodeus, A.; Berno, B.; Topham, M.K.; Epand, R.M.
The basis of the substrate specificity of the epsilon isoform of human diacylglycerol kinase is not a consequence of competing hydrolysis of ATP
Chem. Phys. Lipids
166
26-30
2013
Homo sapiens (P52429), Homo sapiens
brenda
DSouza, K.; Epand, R.M.
Catalytic activity and acyl-chain selectivity of diacylglycerol kinase epsilon are modulated by residues in and near the lipoxygenase-like motif
J. Mol. Biol.
416
619-628
2012
Homo sapiens (P52429)
brenda
Gharbi, S.I.; Rincon, E.; Avila-Flores, A.; Torres-Ayuso, P.; Almena, M.; Cobos, M.A.; Albar, J.P.; Merida, I.
Diacylglycerol kinase zeta controls diacylglycerol metabolism at the immunological synapse
Mol. Biol. Cell
22
4406-4414
2011
Homo sapiens (P23743), Homo sapiens (Q13574)
brenda
Atsumi, H.; Kitada, M.; Kanasaki, K.; Koya, D.
Reversal of redox-dependent inhibition of diacylglycerol kinase by antioxidants in mesangial cells exposed to high glucose
Mol. Med. Rep.
4
923-927
2011
Homo sapiens
brenda
Sato, Y.; Murakami, C.; Yamaki, A.; Mizuno, S.; Sakai, H.; Sakane, F.
Distinct 1-monoacylglycerol and 2-monoacylglycerol kinase activities of diacylglycerol kinase isozymes
Biochim. Biophys. Acta
1864
1170-1176
2016
Homo sapiens (O75912), Homo sapiens (P49619), Homo sapiens (P52429), Homo sapiens (P52824), Homo sapiens (Q13574), Homo sapiens (Q16760), Homo sapiens (Q5KSL6), Homo sapiens (Q86XP1), Sus scrofa (P20192), Rattus norvegicus (P68403)
brenda
Saito, T.; Takahashi, D.; Sakane, F.
Expression, purification, and characterization of human diacylglycerol kinase zeta
ACS Omega
4
5540-5546
2019
Homo sapiens (Q13574), Homo sapiens
brenda
Merida, I.; Arranz-Nicolas, J.; Rodriguez-Rodriguez, C.; Avila-Flores, A.
Diacylglycerol kinase control of protein kinase C
Biochem. J.
476
1205-1219
2019
Homo sapiens (Q13574)
brenda
Jennings, W.; Doshi, S.; Hota, P.K.; Prodeus, A.; Black, S.; Epand, R.M.
Expression, purification, and properties of a human arachidonoyl-specific isoform of diacylglycerol kinase
Biochemistry
56
1337-1347
2017
Homo sapiens (P52429), Homo sapiens
brenda
Franks, C.E.; Campbell, S.T.; Purow, B.W.; Harris, T.E.; Hsu, K.L.
The ligand binding landscape of diacylglycerol kinases
Cell Chem. Biol.
24
870-880.e5
2017
Homo sapiens (P23743)
brenda
Epand, R.M.; So, V.; Jennings, W.; Khadka, B.; Gupta, R.S.; Lemaire, M.
Diacylglycerol kinase-epsilon properties and biological roles
Front. Cell Dev. Biol.
4
112
2016
Homo sapiens (P52429), Homo sapiens
brenda
Fazio, A.; Obeng, E.; Rusciano, I.; Marvi, M.; Zoli, M.; Mongiorgi, S.; Ramazzotti, G.; Follo, M.; McCubrey, J.; Cocco, L.; Manzoli, L.; Ratti, S.
Subcellular localization relevance and cancer-associated mechanisms of diacylglycerol kinases
Int. J. Mol. Sci.
21
1-19
2020
Homo sapiens (O75912), Homo sapiens (P23743), Homo sapiens (P49619), Homo sapiens (P52429), Homo sapiens (P52824), Homo sapiens (Q13574), Homo sapiens (Q16760), Homo sapiens (Q5KSL6), Homo sapiens (Q86XP1), Homo sapiens (Q9Y6T7)
brenda
Hayashi, D.; Tsumagari, R.; Liu, K.; Ueda, S.; Yamanoue, M.; Sakane, F.; Shirai, Y.
Screening of subtype-specific activators and inhibitors for diacylglycerol kinase
J. Biochem.
165
517-522
2019
Homo sapiens (O75912), Homo sapiens (P23743), Homo sapiens (P49619), Homo sapiens (P52824), Homo sapiens (Q13574), Homo sapiens (Q16760), Homo sapiens (Q5KSL6), Homo sapiens (Q86XP1), Homo sapiens (Q9Y6T7)
brenda
Poli, A.; Fiume, R.; Baldanzi, G.; Capello, D.; Ratti, S.; Gesi, M.; Manzoli, L.; Graziani, A.; Suh, P.G.; Cocco, L.; Follo, M.Y.
Nuclear localization of diacylglycerol kinase alpha in K562 cells is involved in cell cycle progression
J. Cell. Physiol.
232
2550-2557
2017
Homo sapiens (P23743), Homo sapiens
brenda
Takahashi, D.; Sakane, F.
Expression and purification of human diacylglycerol kinase alpha from baculovirus-infected insect cells for structural studies
PeerJ
6
e5449
2018
Homo sapiens (P23743), Homo sapiens
brenda
Murakami, E.; Shionoya, T.; Komenoi, S.; Suzuki, Y.; Sakane, F.
Cloning and characterization of novel testis-specific diacylglycerol kinase eta splice variants 3 and 4
PLoS ONE
11
e0162997
2016
Homo sapiens (Q86XP1)
brenda
Takahashi, D.; Suzuki, K.; Sakamoto, T.; Iwamoto, T.; Murata, T.; Sakane, F.
Crystal structure and calcium-induced conformational changes of diacylglycerol kinase alpha EF-hand domains
Protein Sci.
28
694-706
2019
Homo sapiens (P23743)
brenda