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IUBMB CommentsD-Glucose 6-phosphate can act as acceptor, forming alpha-D-glucose 1,6-bisphosphate.
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
pgm2l1, phosphoglucomutase 2, glucose-1,6-bisphosphate synthase,
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glucose 1,6-diphosphate synthase
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glucose-1,6-bisphosphate synthetase
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phospho group transfer
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3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase
D-Glucose 6-phosphate can act as acceptor, forming alpha-D-glucose 1,6-bisphosphate.
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2,3-bisphosphoglycerate
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0.2 mM, strong inhibitor
D-Glucose 1,6-bisphosphate
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0.01 mM, 50% inhibition
glycerol 3-phosphate
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0.2 mM, strong inhibitor
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glucose-1,6-bisphosphate synthase deficiency
Impaired glucose-1,6-biphosphate production due to bi-allelic PGM2L1 mutations is associated with a neurodevelopmental disorder.
Sarcoma
Mapping the sheep genome: production of characterized sheep x hamster cell hybrids.
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PGM2L_HUMAN
622
0
70442
Swiss-Prot
other Location (Reliability: 1)
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expression in Escherichia coli as fusion protein with a polyHis tag at their N-terminus
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Maliekal, P.; Sokolova, T.; Vertommen, D.; Veiga-da-Cunha, M.; Van Schaftingen, E.
Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family
J. Biol. Chem.
282
31844-31851
2007
Homo sapiens
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