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Information on EC 2.6.1.40 - (R)-3-amino-2-methylpropionate-pyruvate transaminase and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC2.6.1.40
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EC Tree
IUBMB Comments
The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.22, (S)-3-amino-2-methylpropionate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.
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This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
d-3-aminoisobutyrate-pyruvate aminotransferase, d-baib aminotransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aminotransferase, D-3-aminoisobutyrate-pyruvate
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beta-aminoisobutyrate-pyruvate aminotransferase
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D-3-aminoisobutyrate-pyruvate aminotransferase
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D-3-aminoisobutyrate-pyruvate transaminase
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D-BAIB aminotransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
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SYSTEMATIC NAME
IUBMB Comments
(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase
The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.22, (S)-3-amino-2-methylpropionate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.
CAS REGISTRY NUMBER
COMMENTARY hide
37279-00-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-3-amino-2-methylpropanoate + pyruvate
2-methyl-3-oxopropanoate + L-alanine
show the reaction diagram
additional information
?
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(R)-3-amino-2-methylpropanoate + pyruvate
2-methyl-3-oxopropanoate + L-alanine
show the reaction diagram
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first step in aminoisobutyrate metabolism
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?
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
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assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
AGT2_HUMAN
514
0
57156
Swiss-Prot
Mitochondrion (Reliability: 4)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kakimoto, Y.; Taniguchi, K.; Sano, I.
D-beta-Aminoisobutyrate:pyruvate aminotransferase in mammalian liver and excretion of beta-aminoisobutyrate by man
J. Biol. Chem.
244
335-340
1969
Cavia porcellus, Homo sapiens, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team