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Information on EC 2.6.1.2 - alanine transaminase and Organism(s) Mus musculus

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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.2 alanine transaminase
IUBMB Comments
A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of alanine.
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This record set is specific for:
Mus musculus
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The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
alanine aminotransferase, alanine transaminase, alat, pyruvate transaminase, glutamic-pyruvic transaminase, glutamate-pyruvate transaminase, alanine-aminotransferase, alaat, l-alanine aminotransferase, c-aat, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alanine aminotransferase
alanine-alpha-ketoglutarate aminotransferase
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-
-
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alanine-pyruvate aminotransferase
-
-
-
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aminotransferase, alanine
-
-
-
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beta-alanine aminotransferase
-
-
-
-
glutamic acid-pyruvic acid transaminase
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-
-
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glutamic-alanine transaminase
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-
-
-
glutamic-pyruvic aminotransferase
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-
-
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glutamic-pyruvic transaminase
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-
-
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L-alanine aminotransferase
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-
-
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L-alanine transaminase
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-
-
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L-alanine-alpha-ketoglutarate aminotransferase
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-
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pyruvate transaminase
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-
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pyruvate-alanine aminotransferase
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-
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pyruvate-glutamate transaminase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
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-
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SYSTEMATIC NAME
IUBMB Comments
L-alanine:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of alanine.
CAS REGISTRY NUMBER
COMMENTARY hide
9000-86-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
show the reaction diagram
pyruvate + L-glutamate
L-alanine + 2-oxoglutarate
show the reaction diagram
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-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
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-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acarbose
-
0.1% acarbose fed to diabetic mice induces a decrease of the catalytic activity to 69.6%
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1
2-oxoglutarate
pH 8.0, 20°C
26.5
L-alanine
pH 8.0, 20°C
13
L-glutamate
pH 8.0, 20°C
12.5
pyruvate
pH 8.0, 20°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
372 units/mg
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ALAT1_MOUSE
496
0
55143
Swiss-Prot
other Location (Reliability: 3)
ALAT2_MOUSE
522
0
57944
Swiss-Prot
Mitochondrion (Reliability: 2)
Q566C3_MOUSE
496
0
55143
TrEMBL
other Location (Reliability: 3)
A0A2R8VHV7_MOUSE
233
0
25829
TrEMBL
other Location (Reliability: 3)
A0A2R8VHW0_MOUSE
363
0
39986
TrEMBL
other Location (Reliability: 3)
A0A2R8VI31_MOUSE
256
0
28687
TrEMBL
other Location (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
ethanol administration causes a 3-3.5fold increase in serum ALT levels in superoxide dismutase deficient mice compared with their pair-fed controls and with wild-type ethanol-fed mice
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
agriculture
expression of AlaAT variants from diverse sources and different subcellular locations, in the wild-type Arabidopsis thaliana Col-0 background and alaat1, alaat2 knockout background under various conditions. Both the physical and physiological properties of AlaAT over-expressing transgenic plants demonstrate significant differences between plants expressing the different AlaAT enzymes under different external conditions. Plants over-expressing Mus musculus AlaAT1 and Hordeum vulgare AlaAT constitutively show increased leaf area.Pyrococcus furiosus AlaAT over-expressing cells take-up external leucine and alanine more effectively
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Petlevski, R.; Hadzija, M.; Bajalo, J.L.; Juretic, D.
Effect of acarbose on alanine aminotransferase and aspartate aminotransferase activities in the liver of control and diabetic CBA mice
Acta Pharm.
56
87-93
2006
Mus musculus
Manually annotated by BRENDA team
Curry-McCoy, T.V.; Osna, N.A.; Nanji, A.A.; Donohue, T.M.
Chronic ethanol consumption results in atypical liver injury in copper/zinc superoxide dismutase deficient mice
Alcohol. Clin. Exp. Res.
34
251-261
2010
Mus musculus
Manually annotated by BRENDA team
McAllister, C.H.; Good, A.G.
Alanine aminotransferase variants conferring diverse NUE phenotypes in Arabidopsis thaliana
PLoS ONE
10
e0121830
2015
Hordeum vulgare (P52894), Hordeum vulgare, Mus musculus (Q8QZR5), Pyrococcus furiosus (Q9P9M8)
Manually annotated by BRENDA team
McAllister, C.H.; Facette, M.; Holt, A.; Good, A.G.
Analysis of the enzymatic properties of a broad family of alanine aminotransferases
PLoS ONE
8
e55032
2013
Medicago truncatula, Arabidopsis thaliana (F4I7I0), Arabidopsis thaliana (Q9LDV4), Saccharomyces cerevisiae (P52893), Hordeum vulgare (P52894), Mus musculus (Q8QZR5), Pyrococcus furiosus (Q9P9M8)
Manually annotated by BRENDA team