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Information on EC 2.6.1.2 - alanine transaminase and Organism(s) Bos taurus

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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.2 alanine transaminase
IUBMB Comments
A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of alanine.
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Bos taurus
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
alanine aminotransferase, alanine transaminase, alat, pyruvate transaminase, glutamic-pyruvic transaminase, glutamate-pyruvate transaminase, alanine-aminotransferase, alaat, l-alanine aminotransferase, c-aat, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alanine aminotransferase
alanine-alpha-ketoglutarate aminotransferase
-
-
-
-
alanine-pyruvate aminotransferase
-
-
-
-
aminotransferase, alanine
-
-
-
-
beta-alanine aminotransferase
-
-
-
-
glutamic acid-pyruvic acid transaminase
-
-
-
-
glutamic-alanine transaminase
-
-
-
-
glutamic-pyruvic aminotransferase
-
-
-
-
glutamic-pyruvic transaminase
-
-
-
-
GPT
-
-
-
-
L-alanine aminotransferase
-
-
-
-
L-alanine transaminase
-
-
-
-
L-alanine-alpha-ketoglutarate aminotransferase
-
-
-
-
pyruvate transaminase
-
-
-
-
pyruvate-alanine aminotransferase
-
-
-
-
pyruvate-glutamate transaminase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
L-alanine:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of alanine.
CAS REGISTRY NUMBER
COMMENTARY hide
9000-86-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
show the reaction diagram
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ag+
-
-
Al3+
-
-
Citric acid
-
-
Co2+
-
-
Cu2+
-
reversed by L-cysteine and pyridoxal phosphate
EDTA
-
-
Fumaric acid
-
-
Hg2+
-
-
Maleic acid
-
-
oxalic acid
-
-
Pb2+
-
reversed by L-cysteine and pyridoxal phosphate
Zn2+
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0058 - 0.7
2-oxoglutarate
4.3
glutamate
-
pH 7.5, cytosolic alanine aminotransferase
0.59 - 30.3
L-alanine
6.6
L-glutamate
-
pH 7.5, mitochondrial alanine aminotransferase
0.4 - 0.5
pyruvate
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
-
-
7.8
-
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
cortex
Manually annotated by BRENDA team
-
stroma
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ALAT1_BOVIN
496
0
55275
Swiss-Prot
other Location (Reliability: 1)
Q7YRA0_BOVIN
309
0
34736
TrEMBL
Secretory Pathway (Reliability: 5)
A0A452DIW8_BOVIN
820
0
88209
TrEMBL
Mitochondrion (Reliability: 3)
A0A3Q1M4C5_BOVIN
546
0
60153
TrEMBL
Mitochondrion (Reliability: 2)
E1BF40_BOVIN
567
0
62156
TrEMBL
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
92000
-
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate, Sephadex G-150, DEAE-Sephadex, partial purification
-
DEAE-Sephadex
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the catalytic serum activity of the enzyme has tendency to decrease in the days 2 and 10 following experimental intoxication with Ageratum houstonianum
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Agarwal, K.
Purification and properties of L-alanine 2-oxoglutarate aminotransferase of bovine erythrocytes stroma
Indian J. Biochem. Biophys.
22
102-106
1985
Bos taurus
Manually annotated by BRENDA team
Ruscak, M.; Orlicky, J.; Zubor, V.; Hager, H.
Alanine aminotransferase in bovine brain: purification and properties
J. Neurochem.
39
210-216
1982
Bos taurus
Manually annotated by BRENDA team
Aparicio Medina, J.; Paredes Vanegas, V.
Evaluation of the catalytic activity of the enzymes aspartate transaminase and alanine transaminase in calves Holstein experimental intoxication with Ageratum houstonianum Mill (blue celestina)
Rev. Electron. Vet.
18
071701
2017
Bos taurus
-
Manually annotated by BRENDA team