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Information on EC 2.6.1.2 - alanine transaminase and Organism(s) Arabidopsis thaliana

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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.2 alanine transaminase
IUBMB Comments
A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of alanine.
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This record set is specific for:
Arabidopsis thaliana
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The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
alanine aminotransferase, alanine transaminase, alat, pyruvate transaminase, glutamic-pyruvic transaminase, glutamate-pyruvate transaminase, alanine-aminotransferase, alaat, l-alanine aminotransferase, c-aat, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alanine aminotransferase
alanine-alpha-ketoglutarate aminotransferase
-
-
-
-
alanine-pyruvate aminotransferase
-
-
-
-
ALT
-
-
-
-
aminotransferase, alanine
-
-
-
-
beta-alanine aminotransferase
-
-
-
-
glutamic acid-pyruvic acid transaminase
-
-
-
-
glutamic-alanine transaminase
-
-
-
-
glutamic-pyruvic aminotransferase
-
-
-
-
glutamic-pyruvic transaminase
-
-
-
-
GPT
-
-
-
-
L-alanine aminotransferase
-
-
-
-
L-alanine transaminase
-
-
-
-
L-alanine-alpha-ketoglutarate aminotransferase
-
-
-
-
pyruvate transaminase
-
-
-
-
pyruvate-alanine aminotransferase
-
-
-
-
pyruvate-glutamate transaminase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
L-alanine:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of alanine.
CAS REGISTRY NUMBER
COMMENTARY hide
9000-86-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
show the reaction diagram
pyruvate + L-glutamate
L-alanine + 2-oxoglutarate
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
show the reaction diagram
-
-
-
r
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1 - 1
2-oxoglutarate
2.4 - 10.4
L-alanine
2.5 - 4.9
L-glutamate
0.1 - 5.1
pyruvate
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GGT1_ARATH
481
0
53301
Swiss-Prot
other Location (Reliability: 2)
GGT2_ARATH
481
0
53444
Swiss-Prot
other Location (Reliability: 2)
ALAT1_ARATH
543
0
59821
Swiss-Prot
Mitochondrion (Reliability: 5)
ALAT2_ARATH
540
0
59511
Swiss-Prot
Mitochondrion (Reliability: 5)
A0A5S9UV58_ARATH
543
0
59804
TrEMBL
Mitochondrion (Reliability: 5)
A0A178WKD9_ARATH
543
0
59837
TrEMBL
Mitochondrion (Reliability: 5)
A0A178WF62_ARATH
498
0
55378
TrEMBL
other Location (Reliability: 2)
A0A5S9WT98_ARATH
540
0
59541
TrEMBL
Mitochondrion (Reliability: 5)
A0A178WAU5_ARATH
540
0
59513
TrEMBL
Mitochondrion (Reliability: 5)
A0A7G2E8A8_ARATH
489
0
53705
TrEMBL
other Location (Reliability: 3)
A0A178WG36_ARATH
481
0
53301
TrEMBL
other Location (Reliability: 2)
A0A5S9WRJ0_ARATH
481
0
53430
TrEMBL
other Location (Reliability: 2)
A0A654EBF0_ARATH
543
0
59821
TrEMBL
Mitochondrion (Reliability: 5)
A0A178WFM8_ARATH
481
0
53444
TrEMBL
other Location (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the enzyme expression is induced under oxygen stress
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
McAllister, C.H.; Facette, M.; Holt, A.; Good, A.G.
Analysis of the enzymatic properties of a broad family of alanine aminotransferases
PLoS ONE
8
e55032
2013
Medicago truncatula, Arabidopsis thaliana (F4I7I0), Arabidopsis thaliana (Q9LDV4), Saccharomyces cerevisiae (P52893), Hordeum vulgare (P52894), Mus musculus (Q8QZR5), Pyrococcus furiosus (Q9P9M8)
Manually annotated by BRENDA team
Diab, H.; Limami, A.
Reconfiguration of N metabolism upon hypoxia stress and recovery Roles of alanine aminotransferase (AlaAt) and glutamate dehydrogenase (GDH)
Plants (Basel)
5
345-367
2016
Glycine max, Lotus japonicus, Medicago truncatula, Arabidopsis thaliana (F4I7I0)
Manually annotated by BRENDA team