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4-aminobutyrate-2-oxoglutarate transaminase deficiency
2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
4-Aminobutyrate aminotransferase (GABA-transaminase) deficiency.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
4-aminobutyrate-2-ketoglutarate aminotransferase (GABA-T) in human hair follicle.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
?-Aminobutyric acid transaminase deficiency impairs central carbon metabolism and leads to cell wall defects during salt stress in Arabidopsis roots.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
A new case of GABA transaminase deficiency facilitated by proton MR spectroscopy.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Cerebrospinal fluid as a tool in the diagnosis of neurometabolic diseases: amino acid analysis before and after acid hydrolysis.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Clinical aspects of the disorders of GABA metabolism in children.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Corrigendum: 2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Demonstration of 4-aminobutyric acid aminotransferase deficiency in lymphocytes and lymphoblasts.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
GABA Transaminase Deficiency With Survival Into Adulthood.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
GABA transaminase deficiency. Case report and literature review.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Identification of a familial mutation associated with GABA-transaminase deficiency disease.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Inherited disorders of GABA metabolism.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Metabolomics Profile in ABAT Deficiency Pre- and Post-treatment.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Paroxysmal dyskinesias with drowsiness and thalamic lesions in GABA transaminase deficiency.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Pediatric neurotransmitter diseases.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Phenotype of GABA-transaminase deficiency.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Phenotyping GABA transaminase deficiency: a case description and literature review.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Review: Normal and abnormal central nervous system GABA metabolism in childhood.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Serial Magnetic Resonance Imaging and
4-aminobutyrate-2-oxoglutarate transaminase deficiency
The pediatric neurotransmitter disorders.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
[gamma-Aminobutyric acid transaminase deficiency]
Acidosis
[The effect of chronic acidosis on the activity of renal glutamate decarboxylase and GABA-transaminase]
adenylosuccinate lyase deficiency
Cerebrospinal fluid as a tool in the diagnosis of neurometabolic diseases: amino acid analysis before and after acid hydrolysis.
alcohol dehydrogenase deficiency
Clinical aspects of the disorders of GABA metabolism in children.
Alzheimer Disease
Basic aspects of GABA-transaminase in neuropsychiatric disorders.
Alzheimer Disease
Brain aminobutyrate aminotransferase activity in Alzheimer's disease.
Alzheimer Disease
Brain gamma-aminobutyrate aminotransferase (GABA-T) and monoamine oxidase (MAO) in patients with Alzheimer's disease.
Alzheimer Disease
GABA-transaminase in brain and blood platelets: basic and clinical aspects.
Alzheimer Disease
GAD65, GAD67, and GABAT immunostaining in human brain and apparent GAD65 loss in Alzheimer's disease.
Alzheimer Disease
Implications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients.
Alzheimer Disease
Increased gamma-aminobutyrate aminotransferase activity in brain of patients with Alzheimer's disease.
Amnesia
GABAergic modulation of memory with regard to passive avoidance and conditioned suppression task in mice.
Asphyxia Neonatorum
[Experimental pathology of the asphyxia neonatorum. GABA and activities of GAD and GABA-T in the brain of newborn rats]
beta-ala-his dipeptidase deficiency
Inherited disorders of GABA metabolism.
Bradycardia
Cardiovascular effects of GABA, GABA-aminotransferase inhibitors and valproic acid following systemic administration in rats, cats and dogs: pharmacological approach to localize the site of action.
Brain Diseases
Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma.
Brain Diseases
Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies.
Brain Diseases
Enzymes of cerebral GABA metabolism and synaptosomal GABA uptake in acute liver failure in the rabbit: evidence for decreased cerebral GABA-transaminase activity.
Brain Diseases
GABA transaminase deficiency. Case report and literature review.
Brain Diseases
Metabolomics Profile in ABAT Deficiency Pre- and Post-treatment.
Brain Diseases
Phenotype of GABA-transaminase deficiency.
Brain Diseases
Serial Magnetic Resonance Imaging and
Breast Neoplasms
Human breast cancer metastases to the brain display GABAergic properties in the neural niche.
Carcinoma, Hepatocellular
Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.
Catalepsy
Graded increases in brain GABA: differential effects on feeding and other behaviours in rats.
Cerebellar Ataxia
A controlled study of oral vigabatrin (gamma-vinyl GABA) in patients with cerebellar ataxia.
Cerebellar Ataxia
Effect of gamma-vinyl GABA in Friedreich's ataxia.
Cerebral Infarction
Waggle needling wields preferable neuroprotective and anti-spastic effects on post-stroke spasticity rats by attenuating ?-aminobutyric acid transaminase and enhancing ?-aminobutyric acid.
Chorea
Paroxysmal dyskinesias with drowsiness and thalamic lesions in GABA transaminase deficiency.
Coma
Metabolism and brain uptake of gamma-aminobutyric acid in galactosamine-induced hepatic encephalopathy in rats.
Coma
Regional brain GABA metabolism and release during hepatic coma produced in rats chronically treated with carbon tetrachloride.
Deficiency Diseases
4-aminobutyrate-2-ketoglutarate aminotransferase (GABA-T) in human hair follicle.
Deficiency Diseases
Identification of a familial mutation associated with GABA-transaminase deficiency disease.
Dehydration
Arbuscular mycorrhiza induced putrescine degradation into ?-aminobutyric acid, malic acid accumulation, and improvement of nitrogen assimilation in roots of water-stressed maize plants.
Dehydration
Proteomic analyses unraveling water stress response in two Eucalyptus species originating from contrasting environments for aridity.
Disorders of Excessive Somnolence
Metabolomics Profile in ABAT Deficiency Pre- and Post-treatment.
Disorders of Excessive Somnolence
Phenotype of GABA-transaminase deficiency.
Drug Resistant Epilepsy
Gamma-vinyl GABA (vigabatrin): relationship between dosage, plasma concentrations, platelet GABA-transaminase inhibition, and seizure reduction in epileptic children.
Drug Resistant Epilepsy
Neuropathology of a human hippocampus following long-term treatment with vigabatrin: lack of microvacuoles.
Dyskinesias
An analysis of the cortical and striatal involvement in dyskinesia induced in rats by intracerebral injection of GABA-transaminase inhibitors and picrotoxin.
Dyskinesias
Does homocarnosine mediate the dyskinetic movements induced by gaba-transaminase inhibitors.
Dyskinesias
Suppression of haloperidol-induced oral dyskinesias in rats by vigabatrin.
Dystonia
Double-blind study of oral gamma-vinyl GABA in the treatment of dystonia.
Epilepsies, Partial
Platelet GABA-transaminase in epileptic children: influence of epilepsy and anticonvulsants.
Epilepsy
(+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway.
Epilepsy
A comparative study of the pharmacology of inhibitors of GABA-metabolism.
Epilepsy
An enhanced serum prolactin response to TRH in the presence of GABA transaminase inhibition.
Epilepsy
Antiepileptic action induced by a combination of vigabatrin and tiagabine.
Epilepsy
Basic aspects of GABA-transaminase in neuropsychiatric disorders.
Epilepsy
Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity.
Epilepsy
Clinical aspects of the disorders of GABA metabolism in children.
Epilepsy
Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions.
Epilepsy
Design, synthesis, and biological activity of a difluoro-substituted, conformationally rigid vigabatrin analogue as a potent gamma-aminobutyric acid aminotransferase inhibitor.
Epilepsy
Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma.
Epilepsy
Enhanced GABAergic inhibition preserves hippocampal structure and function in a model of epilepsy.
Epilepsy
Ethnopharmacology of Q'eqchi' Maya antiepileptic and anxiolytic plants: effects on the GABAergic system.
Epilepsy
GABA transamination regulates neuronal glutamate content in the retina.
Epilepsy
GABA-transaminase in brain and blood platelets: basic and clinical aspects.
Epilepsy
Hypersynchronisation and sedation produced by GABA-transaminase inhibitors and picrotoxin: does GABA participate in sleep control?
Epilepsy
Inactivation and inhibition of gamma-aminobutyric acid aminotransferase by conformationally restricted vigabatrin analogues.
Epilepsy
Inhibition and substrate activity of conformationally rigid vigabatrin analogues with gamma-aminobutyric acid aminotransferase.
Epilepsy
Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis.
Epilepsy
Ligand based drug design of new heterocyclic imines of GABA analogues: A molecular docking approach for the discovery of new GABA-AT inhibitors.
Epilepsy
Mechanism of Inactivation of ?-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115).
Epilepsy
Neurotoxic effects of GABA-transaminase inhibitors in the treatment of epilepsy: ocular perfusion and visual performance.
Epilepsy
Pediatric neurotransmitter diseases.
Epilepsy
Pharmacokinetics of the S(+) and R(-) enantiomers of vigabatrin during chronic dosing in a patient with renal failure.
Epilepsy
Pinellia Total Alkaloids Modulate the GABAergic System in Hippocampal Formation on Pilocarpine-Induced Epileptic Rats.
Epilepsy
Platelet GABA-transaminase in epileptic children: influence of epilepsy and anticonvulsants.
Epilepsy
Pregabalin peptides: conformational comparison of ?3- and ?4-substituted ?-amino acids in ????? pentapeptides.
Epilepsy
Regulation of GABA level in rat brain synaptosomes: fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies.
Epilepsy
Sodium valproate at therapeutic concentrations changes Ca2+ response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells.
Epilepsy
Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase.
Epilepsy
Synergistic anticonvulsant effects of GABA-T inhibitors and glycine.
Epilepsy
Syntheses and evaluation of fluorinated conformationally restricted analogues of GABA as potential inhibitors of GABA aminotransferase.
Epilepsy
Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase.
Epilepsy
Synthesis of Functionalized Pyrrolidin-2-ones and (S)-Vigabatrin from Pyrrole.
Epilepsy
Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina.
Epilepsy
Vigabatrin-associated visual field defects in children.
Epilepsy, Absence
Hypersynchronisation and sedation produced by GABA-transaminase inhibitors and picrotoxin: does GABA participate in sleep control?
Epilepsy, Absence
Starting and stopping mechanisms of absence epileptic seizures are revealed by hazard functions.
Epilepsy, Absence
Uptake of GABA and activity of GABA transaminase in blood platelets from children with absence epilepsy.
Epilepsy, Generalized
GABA and epilepsy: their complex relationship and the evolution of our understanding.
Epilepsy, Reflex
Catalytic inhibitors of GABA-transaminase as anticonvulsants in baboons with photosensitive epilepsy [proceedings]
Epileptic Syndromes
Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients.
Friedreich Ataxia
A controlled study of oral vigabatrin (gamma-vinyl GABA) in patients with cerebellar ataxia.
Friedreich Ataxia
Effect of gamma-vinyl GABA in Friedreich's ataxia.
Gastroesophageal Reflux
4-aminobutyrate aminotransferase (ABAT): genetic and pharmacological evidence for an involvement in gastro esophageal reflux disease.
Genetic Diseases, Inborn
Inherited disorders of GABA metabolism.
Glioma
[Changes in GAT-3 and GABA-T mRNA expression of C6 glioma cells in response to a 2-week treatment with sodium valproate and withdrawal]
Glucose Intolerance
A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity.
glutamate decarboxylase deficiency
The pediatric neurotransmitter disorders.
Hepatic Encephalopathy
Enzymes of cerebral GABA metabolism and synaptosomal GABA uptake in acute liver failure in the rabbit: evidence for decreased cerebral GABA-transaminase activity.
Hepatic Encephalopathy
Metabolism and brain uptake of gamma-aminobutyric acid in galactosamine-induced hepatic encephalopathy in rats.
Hepatic Encephalopathy
Regional brain GABA metabolism and release during hepatic coma produced in rats chronically treated with carbon tetrachloride.
Herpes Zoster
Distribution of GABA-T-intensive neurons in the rat forebrain and midbrain.
Herpes Zoster
Presumptive gamma-aminobutyric acid pathways from the midbrain to the superior colliculus studied by a combined horseradish peroxidase-gamma-aminobutyric acid transaminase pharmacohistochemical method.
Huntington Disease
Abnormalities of neurotransmitter enzymes in Huntington's chorea.
Huntington Disease
Failure of aminooxyacetic acid therapy in Huntington disease.
Huntington Disease
Isoniazid therapy of Huntington disease.
Huntington Disease
Reduced GABA transaminase activity in the Huntington's disease putamen.
Huntington Disease
The biochemical genetics of human gamma-aminobutyric acid transaminase.
Huntington Disease
Treatment of Huntington disease with gamma-acetylenic GABA an irreversible inhibitor of GABA-transaminase: increased CSF GABA and homocarnosine without clinical amelioration.
Hyperglycemia
A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity.
Hyperglycinemia, Nonketotic
The pediatric neurotransmitter disorders.
Hyperinsulinism
A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity.
Hyperprolactinemia
Estriol affects prolactin and LH secretion in rats.
Hyperprolactinemia
GABAergic biochemical parameters of the tuberoinfundibular neurons following chronic hyperprolactinemia.
Hypersensitivity
?-Aminobutyric acid transaminase deficiency impairs central carbon metabolism and leads to cell wall defects during salt stress in Arabidopsis roots.
Hypertension
Cardiovascular effects of GABA system activating drugs injected into the caudal ventrolateral medulla of the rat.
Hypertension, Pulmonary
A study on the involvement of GABA-transaminase in MCT induced pulmonary hypertension.
Hypoglycemia
Aminobutyrate aminotransferase and succinate semialdehyde dehydrogenase in regions of rat brain after insulin-induced hypoglycemia.
Hypoglycemia
Comparison of results obtained with different methods for estimating GABA turnover in rat neostriatum.
Hypotension
Cardiovascular effects of GABA, GABA-aminotransferase inhibitors and valproic acid following systemic administration in rats, cats and dogs: pharmacological approach to localize the site of action.
Infections
Effect of Plasmodium yoelii infection on GABA metabolism of mouse brain.
Insulin Resistance
A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity.
Intellectual Disability
2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis.
Iron Deficiencies
Effect of iron deficiency on developing rat brain.
Iron Deficiencies
Effects of iron deficiency on iron distribution and gamma-aminobutyric acid (GABA) metabolism in young rat brain tissues.
Language Development Disorders
GABA-transaminase, the liver and infantile autism.
Lethargy
Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia.
Liver Failure
Enzymes of cerebral GABA metabolism and synaptosomal GABA uptake in acute liver failure in the rabbit: evidence for decreased cerebral GABA-transaminase activity.
Liver Failure, Acute
Enzymes of cerebral GABA metabolism and synaptosomal GABA uptake in acute liver failure in the rabbit: evidence for decreased cerebral GABA-transaminase activity.
Medulloblastoma
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination.
Migraine Disorders
Peripheral GABAA receptor-mediated effects of sodium valproate on dural plasma protein extravasation to substance P and trigeminal stimulation.
Movement Disorders
2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis.
Movement Disorders
Hypersomnolence-hyperkinetic movement disorder in a child with compound heterozygous mutation in 4-aminobutyrate aminotransferase (ABAT) gene.
Muscle Hypotonia
Metabolomics Profile in ABAT Deficiency Pre- and Post-treatment.
Muscle Hypotonia
Serial Magnetic Resonance Imaging and
Muscle Spasticity
Influence of aminooxyacetic acid, a gamma-aminobutyrate transaminase inhibitor, on hereditary spastic defect in the mouse.
Myelodysplastic Syndromes
High methylation of the 4-aminobutyrate aminotransferase gene predicts a poor prognosis in patients with myelodysplastic syndrome.
Myoclonus
A functional interaction between GABA and 5-HT in inhibiting picrotoxin-induced myoclonus in rats.
Myoclonus
Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, gamma-acetylenic GABA (4-amino-hex-5-ynoic acid) and gamma-vinyl GABA (4-amino-hex-5-enoic acid).
Myoclonus
The antimyoclonic action of clonazepam through a GABA--independent mechanism.
Neoplasm Metastasis
Human breast cancer metastases to the brain display GABAergic properties in the neural niche.
Neoplasms
Comparative metabolomics of estrogen receptor positive and estrogen receptor negative breast cancer: alterations in glutamine and beta-alanine metabolism.
Neoplasms
Gamma-aminobutyric acid transaminase genetic polymorphism is a candidate locus for responsiveness to opioid analgesics in patients with cancer pain: An exploratory study.
Neoplasms
In search of druggable targets for GBM amino acid metabolism.
Neoplasms
Loss of ABAT-Mediated GABAergic System Promotes Basal-Like Breast Cancer Progression by Activating Ca2+-NFAT1 Axis.
Neoplasms
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination.
Neoplasms
[Effects of 3-methylcholanthrene and 3-methylcholanthrene plus piracetam on the gamma-amino-butyric acid (GABA) content of several cerebral regions (author's transl)]
Nervous System Diseases
Bicyclic ?-amino acids as inhibitors of ?-aminobutyrate aminotransferase.
Nervous System Diseases
Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity.
Nervous System Diseases
Brain gamma-aminobutyrate aminotransferase (GABA-T) and monoamine oxidase (MAO) in patients with Alzheimer's disease.
Nervous System Diseases
Mechanism of Inactivation of ?-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115).
Nervous System Diseases
Site-directed mutagenesis of human brain GABA transaminase: lysine-357 is involved in cofactor binding at the active site.
Neuroblastoma
Effect of GABA and isogabaculine on ornithine decarboxylase and putrescine metabolism.
Neuroblastoma
Primary structure and tissue distribution of human 4-aminobutyrate aminotransferase.
Neurodegenerative Diseases
Enhancement of neuronal protection from oxidative stress by glutamic acid decarboxylase delivery with a defective herpes simplex virus vector.
Neuroinflammatory Diseases
Pergularia daemia hydro-ethanolic extract protects against pentylenetetrazole kindling-induced seizures, oxidative stress, and neuroinflammation in mice.
Obesity
Anorectic potency of inhibiting GABA transaminase in brain: studies of hypothalamic, dietary and genetic obesities.
Osteoarthritis
Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice.
Pituitary ACTH Hypersecretion
Effects of valproic acid, naloxone and hydrocortisone in Nelson's syndrome and cushing's disease.
Propionic Acidemia
Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia.
Reflex, Abnormal
Serial Magnetic Resonance Imaging and
Respiratory Insufficiency
Neuropharmacological aspects of central respiratory regulation. An experimental study in the rat.
Seizures
(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent ?-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction.
Seizures
(4S)-4-amino-5,6-heptadienoic acid (MDL 72483): a potent anticonvulsant GABA-T inhibitor.
Seizures
2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis.
Seizures
4-Aminobutyrate aminotransferase (GABA-transaminase) deficiency.
Seizures
Amygdaloid kindling and the GABA system.
Seizures
An overview of third-generation antiseizure drugs: Clobazam, lacosamide, rufinamide, and vigabatrin.
Seizures
Anticonvulsant activity of muscimol and gamma-aminobutyric acid against pyridoxal phosphate-induced epileptic seizures.
Seizures
Anticonvulsant and biochemical effects of inhibitors of GABA aminotransferase and valproic acid during subchronic treatment in mice.
Seizures
Audiogenic seizure protection by elevated brain GABA concentration in mice: effects of gamma-acetylenic gaba and gamma-vinyl GABA, two irreversible GABA-T inhibitors.
Seizures
Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, gamma-acetylenic GABA (4-amino-hex-5-ynoic acid) and gamma-vinyl GABA (4-amino-hex-5-enoic acid).
Seizures
Coadministration of vigabatrin and valproate in children with refractory epilepsy.
Seizures
Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models.
Seizures
Correlation between alterations in brain GABA metabolism and seizure excitability following administration of GABA aminotransferase inhibitors and valproic acid-a re-evaluation.
Seizures
Developmental regulation of regional functionality of substantial nigra GABAA receptors involved in seizures.
Seizures
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
Seizures
Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system.
Seizures
Double-blind study of gamma-vinyl GABA in patients with refractory epilepsy.
Seizures
Effect of depth electrode implantation with or without subsequent kindling on GABA turnover in various rat brain regions.
Seizures
Effect of elevated brain GABA concentrations on the actions of bicuculline and picrotoxin in mice.
Seizures
Effects of vigabatrin intake on brain GABA activity as monitored by spectrally edited magnetic resonance spectroscopy and positron emission tomography.
Seizures
Evidence implicating substantia nigra in regulation of kindled seizure threshold.
Seizures
Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo.
Seizures
Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures.
Seizures
Functional anatomy of pentylenetetrazol and electroshock seizures in the rat brainstem.
Seizures
Further evidence of involvement of substantia nigra GABAB receptors in seizure suppression in developing rats.
Seizures
GABA and epilepsy: their complex relationship and the evolution of our understanding.
Seizures
GABA-transaminase antisense oligodeoxynucleotide modulates cocaine- and pentylenetetrazol-induced seizures in mice.
Seizures
GABAergic modulation of lindane (gamma-hexachlorocyclohexane)-induced seizures.
Seizures
Gamma-vinyl GABA (vigabatrin): relationship between dosage, plasma concentrations, platelet GABA-transaminase inhibition, and seizure reduction in epileptic children.
Seizures
gamma-Vinyl GABA in endopiriform area suppresses kindled amygdala seizures.
Seizures
Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice.
Seizures
Glutamate decarboxylase and GABA aminotransferase levels in different regions of rat brain on the onset of Leptazol induced convulsions.
Seizures
Hippocampal electrical activity and gamma-aminobutyrate metabolism in brain tissue following administration of homocysteine.
Seizures
Hyper-beta-alaninemia associated with beta-aminoaciduria and gamma-aminobutyricaciduaia, somnolence and seizures.
Seizures
Identification of a familial mutation associated with GABA-transaminase deficiency disease.
Seizures
Identification of a median thalamic system regulating seizures and arousal.
Seizures
Influence of a GABA transaminase inhibitor on central nervous system oxygen toxicity.
Seizures
Influence of pharmacological manipulation of inhibitory and excitatory neurotransmitter systems on seizure behavior in the Mongolian gerbil.
Seizures
Inherited disorders of GABA metabolism.
Seizures
Inhibitory effects of the essential oil from SuHeXiang Wan on the central nervous system after inhalation.
Seizures
Inhibitory effects of the fragrance inhalation of essential oil from Acorus gramineus on central nervous system.
Seizures
Intranasally administered pitavastatin ameliorates pentylenetetrazol-induced neuroinflammation, oxidative stress and cognitive dysfunction.
Seizures
Involvement of GABAergic and glutamatergic systems in the anticonvulsant activity of 3-alkynyl selenophene in 21 day-old rats.
Seizures
L-cycloserine: behavioural and biochemical effects after single and repeated administration to mice, rats and cats.
Seizures
Ligand based drug design of new heterocyclic imines of GABA analogues: A molecular docking approach for the discovery of new GABA-AT inhibitors.
Seizures
Mechanism of Inactivation of ?-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115).
Seizures
Mediodorsal thalamus plays a critical role in the development of limbic motor seizures.
Seizures
Metabolomics Profile in ABAT Deficiency Pre- and Post-treatment.
Seizures
Picrotoxin convulsions and GABA metabolism after injection of anticonvulsants in chicks.
Seizures
Platelet and brain GABA-transaminase and monoamine oxidase activities in patients with complex partial seizures.
Seizures
Relationship between gamma-aminobutyric acid metabolism and antivitamin B6-induced convulsions.
Seizures
Reversible suppression of amygdaloid kindled convulsion following unilateral gabaculine injection into the substantia innominata.
Seizures
Role of nitric oxide on GABA, glutamic acid, activities of GABA-T and GAD in rat brain cerebral cortex.
Seizures
Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels.
Seizures
Seizure protection and increased nerve-terminal GABA: delayed effects of GABA transaminase inhibition.
Seizures
Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels.
Seizures
Serial Magnetic Resonance Imaging and
Seizures
Some correlations between local anesthetic-induced convulsions and gamma-aminobutyric acid in rat spinal cord.
Seizures
Starting and stopping mechanisms of absence epileptic seizures are revealed by hazard functions.
Seizures
Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase.
Seizures
Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra.
Seizures
Synergistic anticonvulsant effects of GABA-T inhibitors and glycine.
Seizures
Synthesis and Anticonvulsant Activity Evaluation of 3-alkoxy-4-(4-(hexyloxy/heptyloxy)phenyl)-4H-1,2,4 -triazole.
Seizures
The alteration of gamma-aminobutyric acid-transaminase expression in the gerbil hippocampus induced by seizure.
Seizures
The central piriform cortex: anatomical connections and anticonvulsant effect of GABA elevation in the kindling model.
Seizures
The influence in rabbits and rats of gamma-acetylenic GABA on seizures generated by pentylenetetrazol.
Seizures
The mode of action of homocysteine on mouse brain glutamic decarboxylase and gamma-aminobutyrate aminotransferase.
Seizures
The pediatric neurotransmitter disorders.
Seizures
The role of gamma-aminobutyric acid in the mechanism of seizures.
Seizures
Vigabatrin as add-on therapy for adult complex partial seizures: a double-blind, placebo-controlled multicentre study. The Canadian Vigabatrin Study Group.
Seizures
Vigabatrin for refractory complex partial seizures: multicenter single-blind study with long-term follow-up.
Seizures
Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors.
Seizures, Febrile
Experimental febrile convulsions in epileptic chickens: the anticonvulsant effect of elevated gamma-aminobutyric acid concentrations.
Spasm
The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms.
Spasms, Infantile
(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent ?-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction.
Spasms, Infantile
An overview of third-generation antiseizure drugs: Clobazam, lacosamide, rufinamide, and vigabatrin.
Spasms, Infantile
Current role of vigabatrin in infantile spasms.
Spasms, Infantile
Mechanism of Inactivation of ?-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115).
Spasms, Infantile
The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms.
Starvation
[The effect of starvation on GABA-transaminase and glutamate decarboxylase activity on mitochondria of dog limbic structures during postnatal ontogenesis]
Stupor
[Characteristics of dopamine and GABA system functions in the brain of animals with different durations of ethanol sleep]
succinate-semialdehyde dehydrogenase [nad(p)+] deficiency
Inherited disorders of GABA metabolism.
succinate-semialdehyde dehydrogenase [nad(p)+] deficiency
Pediatric neurotransmitter diseases.
succinate-semialdehyde dehydrogenase [nad(p)+] deficiency
Review: Normal and abnormal central nervous system GABA metabolism in childhood.
succinate-semialdehyde dehydrogenase [nad(p)+] deficiency
The pediatric neurotransmitter disorders.
Tachycardia
Cardiovascular effects of GABA system activating drugs injected into the caudal ventrolateral medulla of the rat.
Tardive Dyskinesia
Effect of gamma-vinyl GABA in tardive dyskinesia.
Tardive Dyskinesia
Gamma-Acetylenic GABA in tardive dyskinesia.
Tardive Dyskinesia
gamma-Acetylenic GABA in tardive dyskinesia.
Tardive Dyskinesia
[Therapeutic trial of gamma-vinyl GABA, an inhibitor of GABA transaminase, in tardive dyskinesias induced by neuroleptics]
Tinnitus
Forward acoustic masking enhances the auditory brainstem response in a diotic, but not dichotic, paradigm in salicylate-induced tinnitus.
Tinnitus
PHARMACOLOGICAL TREATMENTS FOR TINNITUS: NEW AND OLD.
Tinnitus
Vigabatrin, a GABA transaminase inhibitor, reversibly eliminates tinnitus in an animal model.
Toxic Optic Neuropathy
Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use-limiting visual field defects.
Tremor
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
Vitamin B 6 Deficiency
Effect of pyridoxine deficiency and prednisolone on beta-alanine-oxoglutarate aminotransferase and D-3-aminoisobutyrate aminotransferase in rat liver and kidney.
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Cooper, A.J.L.
Glutamate-gamma-aminobutyrate transaminase
Methods Enzymol.
113
80-82
1985
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Matre, M.; Ciesielski, L.; Cash, C.; Mandel, P.
Comparison of the structural characteristics of the 4-aminobutyrate:2-oxoglutarate transaminases from rat and human brain, and of their affinities for certain inhibitors
Biochim. Biophys. Acta
522
385-399
1978
Homo sapiens, Rattus norvegicus
brenda
Cash, C.; Matre, M.; Ciesielski, L.; Mandel, P.
Purification and partial characterisation of 4-aminobutyrate 2-ketoglutarate transaminase from human brain
FEBS Lett.
47
199-203
1974
Homo sapiens
brenda
Cavallotti, D.; Artico, M.; De Santis, S.; Cavallotti, C.
Occurrence of gamma-aminobutyric acid-transaminase activity in nerve fibers of human thymus
Hum. Immunol.
60
1072-1079
1999
Homo sapiens
brenda
Jeon, S.G.; Bahn, J.H.; Jang, J.S.; Park, J.; Kwon, O.S.; Cho, S.W.; Choi, S.Y.
Human brain GABA transaminase tissue distribution and molecular expression
Eur. J. Biochem.
267
5601-5607
2000
Homo sapiens
brenda
Schor, D.S.; Struys, E.A.; Hogema, B.M.; Gibson, K.M.; Jakobs, C.
Development of a stable-isotope dilution assay for gamma-aminobutyric acid (GABA) transaminase in isolated leukocytes and evidence that GABA and beta-alanine transaminases are identical
Clin. Chem.
47
525-531
2001
Homo sapiens
brenda
Yoon, C.S.; Kim, D.W.; Jang, S.H.; Lee, B.R.; Choi, H.S.; Choi, S.H.; Kim, S.Y.; An, J.J.; Kwon, O.S.; Kang, T.C.; Won, M.H.; Cho, S.W.; Lee, K.S.; Park, J.; Eum, W.S.; Choi, S.Y.
Cysteine-321 of human brain GABA transaminase is involved in intersubunit cross-linking
Mol. Cells
18
214-219
2004
Homo sapiens
brenda
Kim, D.W.; Yoon, C.S.; Eum, W.S.; Lee, B.R.; An, J.J.; Lee, S.H.; Lee, S.R.; Ahn, J.Y.; Kwon, O.S.; Kang, T.C.; Won, M.H.; Cho, S.W.; Lee, K.S.; Park, J.; Choi, S.Y.
Site-directed mutagenesis of human brain GABA transaminase: lysine-357 is involved in cofactor binding at the active site
Mol. Cells
18
314-319
2004
Homo sapiens
brenda
Tao, Y.H.; Yuan, Z.; Tang, X.Q.; Xu, H.B.; Yang, X.L.
Inhibition of GABA shunt enzymes activity by 4-hydroxybenzaldehyde derivatives
Bioorg. Med. Chem. Lett.
16
592-595
2006
Homo sapiens
brenda
Yuan, H.; Silverman, R.B.
Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase
Bioorg. Med. Chem. Lett.
17
1651-1654
2007
Homo sapiens
brenda
Tao, Y.H.; Xu, H.B.; Yang, X.L.
Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one
Bioorg. Med. Chem. Lett.
19
731-734
2009
Homo sapiens
brenda
Tsuji, M.; Aida, N.; Obata, T.; Tomiyasu, M.; Furuya, N.; Kurosawa, K.; Errami, A.; Gibson, K.M.; Salomons, G.S.; Jakobs, C.; Osaka, H.
A new case of GABA transaminase deficiency facilitated by proton MR spectroscopy
J. Inherit. Metab. Dis.
33
85-90
2010
Homo sapiens
brenda
Besse, A.; Wu, P.; Bruni, F.; Donti, T.; Graham, B.H.; Craigen, W.J.; McFarland, R.; Moretti, P.; Lalani, S.; Scott, K.L.; Taylor, R.W.; Bonnen, P.E.
The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism
Cell Metab.
21
417-427
2015
Homo sapiens (P80404)
brenda
Iftikhar, H.; Batool, S.; Deep, A.; Narasimhan, B.; Sharma, P.; Malhotra, M.
In silico analysis of the inhibitory activities of GABA derivatives on 4-aminobutyrate transaminase
Arab. J. Chem.
10
S1267-S1275
2017
Sus scrofa (P80147), Homo sapiens (P80404)
-
brenda
Chen, Y.; Zhao, G.; Li, N.; Luo, Z.; Wang, X.; Gu, J.
Role of 4-aminobutyrate aminotransferase (ABAT) and the lncRNA co-expression network in the development of myelodysplastic syndrome
Oncol. Rep.
42
509-520
2019
Homo sapiens (P80404)
brenda
Moschitto, M.J.; Silverman, R.B.
Synthesis of (S)-3-amino-4-(difluoromethylenyl)-cyclopent-1-ene-1-carboxylic acid (OV329), a potent inactivator of gamma-aminobutyric acid aminotransferase
Org. Lett.
20
4589-4592
2018
Homo sapiens (P80404)
brenda
2.6.1.19 4-aminobutyrate-2-oxoglutarate transaminase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
