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(2R,3R)-beta-chloroalanine + 2-mercaptoethanol
3-(2-hydroxyethyl)-cysteine + HCl
(2R,3S)-beta-chloroalanine + 2-mercaptoethanol
(2R,3S)-3-(2-hydroxyethyl)-cysteine + HCl
2,4-diaminobutyric acid + 2-oxoglutarate
?
-
-
-
-
?
2-aminohexanedioic acid + 2-oxoglutarate
2-oxohexanedioic acid + L-glutamate
-
i.e. alpha-aminoadipic acid
-
-
?
3-aminopropanesulfonate + 2-oxoglutarate
?
alpha-methyl aspartate + 2-oxoglutarate
?
-
-
-
?
glycine + 2-oxoglutarate
glyoxylate + L-glutamate
-
7.7% of the activity with aspartate
-
-
?
kynurenine + 2-oxoglutarate
?
L-2-amino-4-methoxy-4-oxobutanoic acid + 2-oxoglutarate
4-methoxy-2,4-dioxobutanoic acid + L-glutamate
-
isozymes AAT1 and AAT2, the latter shows lower activity
-
-
?
L-2-amino-4-methoxy-4-oxobutanoic acid + oxaloacetate
4-methoxy-2,4-dioxobutanoic acid + L-aspartate
-
isozymes AAT1 and AAT2, low activity
-
-
?
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
L-asparagine + 2-oxoglutarate
4-amino-2,4-dioxobutanoate + L-glutamate
specific activity: 0.14 micromol/min/mg
-
-
?
L-aspartate + 2-methoxyphenylpyruvate
oxaloacetate + ?
-
67.8% conversion
-
-
?
L-aspartate + 2-oxobutyrate
oxaloacetate + 2-aminobutyrate
-
0.4% activity compared to 2-oxoglutarate
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
L-aspartate + 2-oxoisocaproate
oxaloacetate + L-leucine
-
1.0% activity compared to 2-oxoglutarate
-
-
?
L-aspartate + 3,4-dimethoxyphenylpyruvate
oxaloacetate + L-3,4-dimethoxyphenylalanine
-
72.5% conversion
-
-
?
L-aspartate + 3-methoxyphenylpyruvate
oxaloacetate + ?
-
70.2% conversion
-
-
?
L-aspartate + 4-hydroxyphenylpyruvate
oxaloacetate + L-tyrosine
Torulopsis candida
-
1.48% of the activity with 2-oxoglutarate
-
-
?
L-aspartate + 4-methoxyphenylpyruvate
oxaloacetate + ?
-
73.6% conversion
-
-
?
L-aspartate + oxaloacetate
?
relative activity compared to 2-oxoglutarate: 81.5%
-
-
?
L-aspartate + phenylpyruvate
oxaloacetate + ?
-
83.4% conversion
-
-
?
L-aspartate + phenylpyruvate
oxaloacetate + L-phenylalanine
L-aspartate + pyruvate
oxaloacetate + L-alanine
-
1.9% activity compared to 2-oxoglutarate
-
-
?
L-cysteate + 2-oxoglutarate
3-sulfopyruvate + L-glutamate
L-cysteate + oxaloacetate
?
L-cysteic acid + 2-oxoglutarate
2-oxo-3-sulfopropionate + L-glutamate
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
L-erythro-3-hydroxyaspartate + 2-oxoglutarate
erythro-3-hydroxy-2-oxoaspartate + L-glutamate
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
L-kynurenine + ?
kynurenic acid + ?
L-Lys + 2-oxo-4-phenyl-butanoic acid
L-homophenylalanine + 2-keto-6-aminocaproate
-
mutant enzyme R292E/L18H shows a 12.9fold increase in specific activity towards L-Lys and 2-oxo-4-phenylbutanoic acid
2-keto-6-aminocaproate is cyclized nonenzymatically to form DELTA1-piperideine 2-carboxylic acid in the reaction mixture. The low solubility of L-homophenylalanine and spontaneous cyclization of 2-keto-6-aminocaproate drive the reaction completely towards production of L-homophenylalanine
-
?
L-methionine + 2-oxoglutarate
L-glutamate + 4-methylsulfanyl-2-oxobutyric acid
L-Phe + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropanoate + L-glutamate
specific activity: 0.28 micromol/min/mg
-
-
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
L-proline + 2-oxoglutarate
?
16% activity compared to L-aspartate
-
-
?
L-serine + 2-oxoglutarate
3-hydroxy-2-oxopropionic acid + L-glutamate
-
7.7% of the activity with aspartate
-
-
?
L-tryptophan + 2-oxoglutarate
3-(1H-indol-3-yl)-2-oxopropanoate + L-glutamate
specific activity: 0.16 micromol/min/mg
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropionic acid + L-glutamate
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
specific activity: 0.24 micromol/min/mg
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
L-tyrosine + 2-oxoglutarate
?
27% activity compared to L-aspartate
-
-
?
oxaloacetate + L-glutamate
L-aspartate + 2-oxoglutarate
additional information
?
-
(2R,3R)-beta-chloroalanine + 2-mercaptoethanol
3-(2-hydroxyethyl)-cysteine + HCl
-
beta-substitution, reaction occurs with retention of stereochemistry
-
-
?
(2R,3R)-beta-chloroalanine + 2-mercaptoethanol
3-(2-hydroxyethyl)-cysteine + HCl
-
beta-substitution, reaction occurs with retention of stereochemistry
-
-
?
(2R,3S)-beta-chloroalanine + 2-mercaptoethanol
(2R,3S)-3-(2-hydroxyethyl)-cysteine + HCl
-
-
-
-
?
(2R,3S)-beta-chloroalanine + 2-mercaptoethanol
(2R,3S)-3-(2-hydroxyethyl)-cysteine + HCl
-
-
-
-
?
3-aminopropanesulfonate + 2-oxoglutarate
?
-
3-aminopropanesulfonate = homotaurine, lower activity compared to L-cysteate
-
-
?
3-aminopropanesulfonate + 2-oxoglutarate
?
-
3-aminopropanesulfonate = homotaurine, lower activity compared to L-cysteate
-
-
?
kynurenine + 2-oxoglutarate
?
-
-
-
?
kynurenine + 2-oxoglutarate
?
-
-
-
?
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
-
0.7% of the activity with L-aspartate
-
-
?
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
activity is not affected by the presence of formate
-
-
?
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
-
-
r
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
-
-
r
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
-
7.7% of the activity with aspartate
-
-
?
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
-
-
-
-
?
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?, r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
isozyme Asp-DEAE-1 performs preferably the reverse reaction, isozyme the forward reaction
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
relative activity L-aspartate: 100%
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?, r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
dolphin
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
dolphin
-
role in energy metabolism of diving animals
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
function in C4 acid pathway
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
30% of the activity with glutamate
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
reaction mechanism, the strain (unfavourable interaction) of the distorted internal aldimine in the unliganded enzyme is crucial for catalysis. The true driving forces are the strain energy inherent to the respective intermediates. It is described how these strain energies are generated and are used for catalysis
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
30% of the activity with glutamate
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
100% activity
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
Leptosphaeria michotii
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
enzyme plays an important role in numerous metabolic processes
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
absolute specificity for aspartate and 2-oxoglutarate and for glutamate and oxaloacetate
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
key enzyme in assimilation of C and N compounds
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?, r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
25.2% of the activity with glutamate
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
25.2% of the activity with glutamate
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?, r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
2-oxoglutarate is the best acceptor substrate
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
45% activity with L-aspartate compared to L-glutamate
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
specific activity: 2.67 micromol/min/mg
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
34% of the activity with glutamate
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
enzyme plays the most important role in amino acid metabolism
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
34% of the activity with glutamate
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
enzyme plays the most important role in amino acid metabolism
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
best amino acid donor of cytosolic enzyme
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
anti-enzyme antibodies selectively inhibit the uptake of oleate in 3T3-L1 adipocytes by 31-55%, but only poorly in fibroblasts, the antibodies have no effect on uptake of 2-deoxyglucose and octanoate
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
hyperprolinemia type II is an autosomal recessive disorder caused by severe deficiency of enzyme DELTA1-pyrroline-5-carboxylic acid dehydrogenase leading to tissue accumulation of proline. Proline has direct inhibitory effect on aspartate transaminase activity of different brain regions leading to lesser synthesis of glutamate thereby causing neurological dysfunctions
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
48% of the activity with cysteine sulfinic acid
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
aspartate aminotransferase from Sulfolobus solfataricus does not possess any arginine residue exposed to chemical modifications responsible for the binding of omega-carboxylate of the substrates
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?, r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
enzyme plays a central role in nitrogen metabolism of cells
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
enzyme can also act on neutral amino acid substrates due to a substrate-binding pocket with a more flexible conformation, Lys109 is the major determinant for the acidic substrate specificity
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?, r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
enzyme can also act on neutral amino acid substrates due to a substrate-binding pocket with a more flexible conformation, Lys109 is the major determinant for the acidic substrate specificity
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
Torulopsis candida
-
-
-
?, r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
best amino acid donor
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?, r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?, r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + phenylpyruvate
oxaloacetate + L-phenylalanine
-
no activity
-
-
?
L-aspartate + phenylpyruvate
oxaloacetate + L-phenylalanine
-
-
-
-
?
L-aspartate + phenylpyruvate
oxaloacetate + L-phenylalanine
Torulopsis candida
-
7.12% of the activity with 2-oxoglutarate
-
-
?
L-cysteate + 2-oxoglutarate
3-sulfopyruvate + L-glutamate
-
L-cysteate = (R)-cysteate
-
-
?
L-cysteate + 2-oxoglutarate
3-sulfopyruvate + L-glutamate
-
L-cysteate = (R)-cysteate
-
-
?
L-cysteate + oxaloacetate
?
-
-
-
-
?
L-cysteate + oxaloacetate
?
-
-
-
-
?
L-cysteate + pyruvate
?
-
-
-
-
?
L-cysteate + pyruvate
?
-
-
-
-
?
L-cysteic acid + 2-oxoglutarate
2-oxo-3-sulfopropionate + L-glutamate
-
no activity
-
-
?
L-cysteic acid + 2-oxoglutarate
2-oxo-3-sulfopropionate + L-glutamate
-
i.e. 2-amino-2-sulfopropionate
-
-
?
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
-
-
-
?
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
-
-
-
?
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
-
-
-
-
?
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
-
-
-
?
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
-
-
-
?
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
-
-
-
-
?
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
-
-
-
-
?
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
-
-
-
-
?
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
-
-
-
-
?
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
-
26.2% of the activity with L-aspartate
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
-
-
-
ir
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
-
-
-
ir
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
Leptosphaeria michotii
-
only isozyme B, 27% activity compared to L-aspartate
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
-
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
-
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
63% of the activity with aspartate
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
27% activity compared to L-glutamate
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
21% of the activity with L-glutamate
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
21% of the activity with L-glutamate
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
best amino acid donor for mitochondrial enzyme
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
-
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
-
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
-
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
-
48% of the activity with L-glutamate
-
-
?
L-erythro-3-hydroxyaspartate + 2-oxoglutarate
erythro-3-hydroxy-2-oxoaspartate + L-glutamate
-
high stabilization of the quinonoid intermediate formed by L-erythro-3-hydroxyaspartate and pyridoxal 5'-phosphate at the active site via Tyr70, kinetic analysis
-
-
?
L-erythro-3-hydroxyaspartate + 2-oxoglutarate
erythro-3-hydroxy-2-oxoaspartate + L-glutamate
-
wild-type, no activity with mutant T70F
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
relative activity compared to L-aspartate: 46.7%
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
dolphin
-
L-glutamate is best amino acid donor
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
-
L-glutamate is best amino acid donor
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
binding of L-Glu to aspartate aminotransferase to form the Michaelis complex does not induce a conformational change in the enzyme. The conformational change to the closed form occurs during the transaldimination step. The hydrophobic residues of the entrance of the active site, including Tyr70, are considered to be important for promoting the transaldimination process and hence the recognition of the C5 substrate
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
-
the mechanism of the reaction at the early step of the catalysis differs significantly between the substrates L-glutamate and L-aspartate
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
-
L-glutamate is best amino acid donor
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
-
-
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
-
L-glutamate is best amino acid donor
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
-
-
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
-
L-glutamate is best amino acid donor
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
-
L-glutamate is best amino acid donor
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
-
L-glutamate is best amino acid donor
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
-
L-glutamate is best amino acid donor
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
-
L-glutamate is best amino acid donor
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
25% of the activity with cysteine sulfinic acid
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
-
-
-
-
?
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
-
-
-
-
?
L-kynurenine + ?
kynurenic acid + ?
-
-
-
-
?
L-kynurenine + ?
kynurenic acid + ?
-
-
-
-
?
L-kynurenine + ?
kynurenic acid + ?
-
-
-
-
?
L-methionine + 2-oxoglutarate
L-glutamate + 4-methylsulfanyl-2-oxobutyric acid
-
1.0% of the activity with glutamate
-
-
?
L-methionine + 2-oxoglutarate
L-glutamate + 4-methylsulfanyl-2-oxobutyric acid
-
1.0% of the activity with glutamate
-
-
?
L-methionine + 2-oxoglutarate
L-glutamate + 4-methylsulfanyl-2-oxobutyric acid
-
1.0% of the activity with glutamate
-
-
?
L-methionine + 2-oxoglutarate
L-glutamate + 4-methylsulfanyl-2-oxobutyric acid
-
0.1% activity compared to L-glutamate
-
-
?
L-methionine + 2-oxoglutarate
L-glutamate + 4-methylsulfanyl-2-oxobutyric acid
-
93% of the activity with aspartate
-
-
?
L-methionine + 2-oxoglutarate
L-glutamate + 4-methylsulfanyl-2-oxobutyric acid
-
-
-
?
L-methionine + 2-oxoglutarate
L-glutamate + 4-methylsulfanyl-2-oxobutyric acid
-
-
-
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
relative activity compared to L-aspartate: 0.3%
-
-
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
-
low activity
-
-
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
-
low activity
-
-
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
-
-
i.e. phenylpyruvate
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
dolphin
-
-
-
ir
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
-
-
i.e. phenylpyruvate
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
-
-
i.e. phenylpyruvate
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
-
0.07% of the activity with L-aspartate
-
-
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
-
-
i.e. phenylpyruvate
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
-
6.9% of the activity with glutamate
i.e. phenylpyruvate
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
-
7.7% of the activity with L-aspartate
i.e. phenylpyruvate
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
-
-
i.e. phenylpyruvate
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropionic acid + L-glutamate
-
0.1% of the activity with aspartate
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropionic acid + L-glutamate
-
0.1% of the activity with aspartate
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropionic acid + L-glutamate
relative activity compared to L-aspartate: 1.7%
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropionic acid + L-glutamate
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropionic acid + L-glutamate
-
11% of the activity with glutamate
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropionic acid + L-glutamate
-
0.08% of the activity with aspartate
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropionic acid + L-glutamate
-
0.08% of the activity with L-aspartate
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropionic acid + L-glutamate
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropionic acid + L-glutamate
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropionic acid + L-glutamate
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropionic acid + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropionic acid + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
relative activity compared to L-aspartate: 0.4
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
-
low activity
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
-
low activity
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
dolphin
-
-
-
ir
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
-
-
i.e. 4-hydroxyphenylpyruvate
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
-
1.5 of the activity with glutamate
i.e. 4-hydroxyphenylpyruvate
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
-
1.5 of the activity with glutamate
i.e. 4-hydroxyphenylpyruvate
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
-
0.04% of the activity with aspartate
i.e. 4-hydroxyphenylpyruvate
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
-
0.04% of the activity with L-aspartate
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
-
1.2% of the activity with glutamate
i.e. 4-hydroxyphenylpyruvate
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
-
84.6% of the activity with aspartate
i.e. 4-hydroxyphenylpyruvate
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
-
-
i.e. 4-hydroxyphenylpyruvate
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
-
-
-
?
oxaloacetate + L-glutamate
L-aspartate + 2-oxoglutarate
-
-
-
?
oxaloacetate + L-glutamate
L-aspartate + 2-oxoglutarate
-
-
-
r
additional information
?
-
no enzyme activity is detectable in the presence of glutamine, asparagine, alanine, histidine, leucine, methionine, lysine, arginine, tryptophan, tyrosine, phenylalanine or kynureine
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
poor substrates are: glyoxylic acid, pyruvate, succinate, maleate, L-asparagine, L-glutamine, L-alanine, glycine
-
-
?
additional information
?
-
-
no activity with L-2-amino-5-methoxy-5-oxopentanoic acid, fumarate, hydroxypyruvate, glutarate, L-proline, L-arginine, and L-lysine
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
no enzyme activity is detectable in the presence of glutamine, asparagine, alanine, histidine, leucine, methionine, lysine, arginine, tryptophan, tyrosine, phenylalanine or kynureine
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
indole-3-pyruvate, p-hydroxy-phenylpyruvate, and 2-oxo-n-caproate are no substrates
-
-
?
additional information
?
-
no enzyme activity is detectable in the presence of glutamine, asparagine, alanine, histidine, leucine, methionine, lysine, arginine, tryptophan, tyrosine, phenylalanine or kynureine
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
Torulopsis candida
-
substrate specificity
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
no activity with L-cysteine, L-isoleucine, L-leucine, L-valine, L-glutamine, glycine, L-ornithine, L-lysine, L-arginine
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
no activity with L-cysteine, L-isoleucine, L-leucine, L-valine, L-glutamine, glycine, L-ornithine, L-lysine, L-arginine
-
-
?
additional information
?
-
the cytosolic isoform displays broad substrate specificity
-
-
?
additional information
?
-
the cytosolic isoform displays broad substrate specificity
-
-
?
additional information
?
-
-
the cytosolic isoform displays broad substrate specificity
-
-
?
additional information
?
-
the mitochondrial isoform is highly specific for substrates L-aspartate and 2-oxoglutarate
-
-
?
additional information
?
-
the mitochondrial isoform is highly specific for substrates L-aspartate and 2-oxoglutarate
-
-
?
additional information
?
-
-
the mitochondrial isoform is highly specific for substrates L-aspartate and 2-oxoglutarate
-
-
?
additional information
?
-
the cytosolic isoform displays broad substrate specificity
-
-
?
additional information
?
-
the cytosolic isoform displays broad substrate specificity
-
-
?
additional information
?
-
-
the cytosolic isoform displays broad substrate specificity
-
-
?
additional information
?
-
the mitochondrial isoform is highly specific for substrates L-aspartate and 2-oxoglutarate
-
-
?
additional information
?
-
the mitochondrial isoform is highly specific for substrates L-aspartate and 2-oxoglutarate
-
-
?
additional information
?
-
-
the mitochondrial isoform is highly specific for substrates L-aspartate and 2-oxoglutarate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
dolphin
-
role in energy metabolism of diving animals
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
function in C4 acid pathway
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
Leptosphaeria michotii
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
enzyme plays an important role in numerous metabolic processes
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
key enzyme in assimilation of C and N compounds
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
enzyme plays the most important role in amino acid metabolism
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
enzyme plays the most important role in amino acid metabolism
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
anti-enzyme antibodies selectively inhibit the uptake of oleate in 3T3-L1 adipocytes by 31-55%, but only poorly in fibroblasts, the antibodies have no effect on uptake of 2-deoxyglucose and octanoate
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
hyperprolinemia type II is an autosomal recessive disorder caused by severe deficiency of enzyme DELTA1-pyrroline-5-carboxylic acid dehydrogenase leading to tissue accumulation of proline. Proline has direct inhibitory effect on aspartate transaminase activity of different brain regions leading to lesser synthesis of glutamate thereby causing neurological dysfunctions
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
enzyme plays a central role in nitrogen metabolism of cells
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
Torulopsis candida
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2-chloro-6-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)(2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)copper
-
-
(2-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)(2-hydroxyethyl)(2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)cuprate(1-)
-
-
(S)-4-amino-4,5-dihydro-2-furancarboxylic acid
crystal structures of the Escherichi coli aspartate aminotransferase with (S)-4-amino-4,5-dihydro-2-furancarboxylic acid bound to the active site are obtained via cocrystallization at pH 7.5 and 8. The complex structures suggest that (S)-4-amino-4,5-dihydro-2-furancarboxylic acid inhibits the transamination reaction by forming adducts with the catalytic lysine 246 via a covalent bond while producing 1 equivalent of pyridoxamine 5'-phosphate
1-(2,4-dichlorophenyl)-3-[2-(1H-indol-3-yl)ethyl]urea
-
1-(4-chlorophenyl)-3-[2-(1H-indol-3-yl)ethyl]urea
-
1-biphenyl-2-yl-3-[2-(1H-indol-3-yl)ethyl]urea
-
1-[2-(1H-indol-3-yl)ethyl]-3-phenylurea
-
1-[2-(1H-indol-3-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]urea
-
1-[2-(1H-indol-3-yl)ethyl]-3-[4-(trifluoromethyl)phenyl]urea
-
2-methyl-DL-aspartate
binds to the pyridoxal 5'-phosphate form of the enzyme, formation of an external aldimine complex
2-oxoglutaconic acid dimethyl ester
-
15% inhibition at 25°C, pH 7.0, 10 mM, after 2 h; pyridoxal 5'-phosphate enzyme form, cytosolic isozyme
4-(1H-indazol-4-yl)-N-phenylpiperazine-1-carboxamide
-
4-(1H-indol-4-yl)-N-(2-methylphenyl)piperazine-1-carboxamide
-
4-(1H-indol-4-yl)-N-(3-methylphenyl)piperazine-1-carboxamide
-
4-(1H-indol-4-yl)-N-(3-phenoxyphenyl)piperazine-1-carboxamide
-
4-(1H-indol-4-yl)-N-(4-methylphenyl)piperazine-1-carboxamide
-
4-(1H-indol-4-yl)-N-(propan-2-yl)piperazine-1-carboxamide
-
4-(1H-indol-4-yl)-N-(pyridazin-4-yl)piperazine-1-carboxamide
-
4-(1H-indol-4-yl)-N-(pyridin-3-yl)piperazine-1-carboxamide
-
4-(1H-indol-4-yl)-N-(pyrimidin-5-yl)piperazine-1-carboxamide
-
4-(1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
-
4-(1H-indol-4-yl)-N-[2-(trifluoromethyl)phenyl]piperazine-1-carboxamide
-
4-(1H-indol-4-yl)-N-[3-(methylcarbamoyl)phenyl]piperazine-1-carboxamide
-
4-(1H-indol-4-yl)-N-[3-(trifluoromethyl)phenyl]piperazine-1-carboxamide
-
4-(1H-indol-4-yl)-N-[4-(methylcarbamoyl)phenyl]piperazine-1-carboxamide
-
4-(1H-indol-4-yl)-N-[4-(trifluoromethyl)phenyl]piperazine-1-carboxamide
-
4-(3-methoxyphenyl)-N-phenylpiperazine-1-carboxamide
-
4-(5-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
-
4-(6-chloro-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
-
4-(6-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
-
4-(7-chloro-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
-
4-(7-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
-
4-(methylsulfonyl)-N-phenylpiperazine-1-carboxamide
-
4-acetyl-N-phenylpiperazine-1-carboxamide
-
alpha-aminoadipate
-
IC50: 1.5 mM
aminoguanidine
-
competes with the enzyme for pyridoxal 5'-phosphate, forms complexes with pyridoxal 5'-phosphate, 70% enzyme inhibition at 1 mM
aminooxyacetic acid hemihydrochloride
aqua[2-([[3-bromo-6-(hydroxy-kappaO)cyclohexa-2,4-dien-1-yl]methylidene]amino-kappaN)benzoato(2-)-kappaO]cuprate(1-)
-
-
aqua[2-([[3-chloro-6-(hydroxy-kappaO)cyclohexa-2,4-dien-1-yl]methylidene]amino-kappaN)benzoato(2-)-kappaO]cuprate(1-)
-
-
bis[4-chloro-2-[(phenylimino-kappaN)methyl]phenolato-kappaO]copper
-
-
bis[4-nitro-2-[(phenylimino-kappaN)methyl]phenolato-kappaO]copper
-
-
chymoptrypsin
-
cytosolic isozyme at 1 mg/ml, no inhibition of mitochondrial isozyme
-
cysteine
dokcing sturdy with wild-type and mutant enzymes
diaqua[2-chloro-6-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]-4-(hydroxymethyl)phenolato-kappaO](2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)copper
-
-
diaqua[3-([[2-(carboxy-kappaO)phenyl]imino-kappaN]methyl)-4-(hydroxy-kappaO)cyclohexa-1,5-dien-1-yl](hydroxy)oxoammoniumato(2-)copper
-
-
gamma-Acetylenic GABA
-
-
Hadacidin
-
i.e. N-formylhydroxyaminoacetic acid
hydroxylamine
inhibition of PfAspAT abolishes all glutamate oxaloacetate transamination activity in the cytoplasm of cultured parasites, demonstrating that no other enzyme within the cytoplasm can complement PfAspAT activity
isonicotinic acid hydrazine
L-2-amino-5-methoxy-5-oxopentanoic acid
-
only isozyme AAT2, competitive against L-asparate
L-Cycloserine
-
cytosolic isozyme, weak inhibition only after 24 h incubation, 1 mM
L-cysteic acid
-
competitive
L-cysteine
-
10 mM, 30% inactivation
L-cysteine sulfinic acid
-
weak, competitive to 2-oxoglutarate
L-histidine
-
inhibition is relieved by high concentrations of substrates
L-serine O-sulfate
-
inhibition of cytosolic enzyme, no inhibition of mitochondrial enzyme
Methylacetimidate
-
complete inhibition at 50 mM
N,4-diphenylpiperazine-1-carboxamide
-
N-(1,3-benzothiazol-5-yl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
-
N-(2,4-dichlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
-
N-(2-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
-
N-(3,5-dichlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
-
N-(3-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
-
N-(4-benzoylphenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
-
N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
-
N-5'-phosphopyridoxyl L-aspartate
-
cofactor analogue binds covalently to the enzyme
N-ethylmaleimide
-
alkylation of cysteine residues
N-phenyl-4-(propan-2-yl)piperazine-1-carboxamide
-
N-phenyl-4-(pyridin-4-yl)piperazine-1-carboxamide
-
N-phenyl-4-(quinolin-5-yl)piperazine-1-carboxamide
-
p-hydroxymercuribenzoate
-
-
phosphate
-
inhibition of cofactor binding to the apoenzyme, cytosolic and mitochondrial isozymes
Pro
-
hyperprolinemia type II is an autosomal recessive disorder caused by severe deficiency of enzyme DELTA1-pyrroline-5-carboxylic acid dehydrogenase leading to tissue accumulation of proline. Proline has direct inhibitory effect on aspartate transaminase activity of different brain regions leading to lesser synthesis of glutamate thereby causing neurological dysfunctions
protein-binding copper complex 10
-
-
protein-binding copper complex 11
-
-
protein-binding copper complex 9
-
-
proteinase K
-
both cytosolic and mitochondrial isozymes
-
quisqualate
-
6 mM, 90% inhibition
Sodium mersalyl
-
cytosolic isozyme, 40% inhibition after 60 min at 5 mM and 30°C
Subtilisin
-
only cytosolic isozyme
-
Trypsin
-
weak inhibition of mitochondrial isozyme
-
2-oxoglutaconate
-
injection into mice leads to inhibition of the kidney enzyme
2-oxoglutaconate
-
2-oxoglutarate protects against inhibition, L-glutamate enhances the inhibitory effect; 30% inhibition at 25°C, pH 7.2, 10 mM, after 2 h; cytosolic and mitochondrial isozymes
2-oxoglutaconate
-
2-oxoglutarate protects against inhibition, L-glutamate enhances the inhibitory effect; 30% inhibition at 25°C, pH 7.2, 10 mM, after 2 h; binds the active site of the pyridoxal 5'-phosphate enzyme form, cytosolic isozyme
2-oxoglutarate
-
1-3 mM, at pH 6.0, not at pH 8.0
2-oxoglutarate
dolphin
-
oxoglutarate production; substrate inhibition at high concentration
2-oxoglutarate
-
product and substrate inhibition
2-oxoglutarate
-
in cell extracts, alanine activity is inhibited by 50% by about 2.5 mM 2-oxoglutarate, while the aspartate activity is unaffected at this concentration. The highly purified enzyme is also inhibited by 2-oxoglutarate, but the extent of inhibition is slightly more than that in extracts. Thus, alanine activity is completely inhibited by 10 mM 2-oxoglutarate, and 36% of the aspartate activity is inhibited
2-oxoglutarate
-
competitive to L-aspartate
2-oxoglutarate
-
cytoplasmic enzyme inhibited above 0.25 mM, mitochondrial enzyme not
2-oxoglutarate
-
competitive to cysteine sulfinic acid or aspartate
2-oxoglutarate
-
substrate inhibition at high concentration
adipate
-
moderately
aminooxyacetic acid hemihydrochloride
-
inhibitor of C-S lyase, reduces renal injuries due to cisplatin in rats. On day 5 following a bolus cisplatin injection, in vivo nephrotoxic potentials are in the decreasing order of species rats > mice, rabbits, based on body surface. The levels of renal Pt residue at the nephrotoxic dose are in order of rabbits > rats > mice. The activity of endogenous basal mitochondrial aspartate aminotransferase, one of the C-S lyases, in the renal cortex of naive animals is rats > mice, rabbits. Expression of mitochondrial C-S lyase in the kidney is observed at approximately 37 kDa in all five species used. In in vitro studies, the cytotoxicity of cisplatin is dependent on the expression level of C-S lyase mRNA in the respective renal cells
aminooxyacetic acid hemihydrochloride
-
inhibitor of C-S lyase, reduces renal injuries due to cisplatin in rats. On day 5 following a bolus cisplatin injection, in vivo nephrotoxic potentials are in the decreasing order of species rats > mice, rabbits, based on body surface. The levels of renal Pt residue at the nephrotoxic dose are in order of rabbits > rats > mice. The activity of endogenous basal mitochondrial aspartate aminotransferase, one of the C-S lyases, in the renal cortex of naive animals is rats > mice, rabbits. Expression of mitochondrial C-S lyase in the kidney is observed at approximately 37 kDa in all five species used. In in vitro studies, the cytotoxicity of cisplatin is dependent on the expression level of C-S lyase mRNA in the respective renal cells
aminooxyacetic acid hemihydrochloride
inhibitor of C-S lyase, reduces renal injuries due to cisplatin in rats. On day 5 following a bolus cisplatin injection, in vivo nephrotoxic potentials are in the decreasing order of species rats > mice, rabbits, based on body surface. The levels of renal Pt residue at the nephrotoxic dose are in order of rabbits > rats > mice. The activity of endogenous basal mitochondrial aspartate aminotransferase, one of the C-S lyases, in the renal cortex of naive animals is rats > mice, rabbits. Expression of mitochondrial C-S lyase in the kidney is observed at approximately 37 kDa in all five species used. In in vitro studies, the cytotoxicity of cisplatin is dependent on the expression level of C-S lyase mRNA in the respective renal cells
CN-
-
-
CN-
-
cytosolic isoform, at 5 mM
fumarate
-
competitive
Glutarate
-
isozyme AAT1: competitive
isonicotinic acid hydrazine
-
complete inhibition at 0.3 mM, partially reversible by pyridoxyl 5'-phosphate
isonicotinic acid hydrazine
-
cytosolic isozyme, only after 24 h incubation, 1 mM
L-aspartate
-
inhibits tyrosine transamination
L-aspartate
-
weak, competitive against 2-oxoglutarate
L-glutamate
dolphin
-
forward reaction, substrate L-aspartate
L-glutamate
-
isozyme AAT1 and AAT2, product inhibition
L-glutamate
-
product inhibition, noncompetitive to 2-oxoglutarate and competitive against aspartate
L-glutamate
-
5 mM, significant inhibition
L-glutamate
-
competitive
malate
-
oxoglutarate production, oxaloacetate production
malate
dolphin
-
isozymes Asp-DEAE-1 and Asp-DEAE-2
Maleate
-
78% inhibition of cytosolic isozyme at 4 mM, competitive to 2-oxoglutarate
Maleate
binds noncovalently to the pyridoxal 5'-phosphate form of the enzyme
oxaloacetate
dolphin
-
substrate inhibition
oxaloacetate
-
isozyme AAT1 and AAT2, product inhibition
oxaloacetate
-
isozymes AAT-P1 and AAT-P2; substrate inhibition
p-chloromercuribenzoate
-
complete inhibition at 0.15 mM
p-chloromercuribenzoate
-
cytosolic isozyme, 50% inhibition after 10 min at 30°C, 1 mM
succinate
dolphin
-
forward reaction
additional information
-
no inhibition by 4-aminobutyric acid
-
additional information
-
no substrate inhibition
-
additional information
the enzyme is not influenced by EDTA
-
additional information
-
cytosolic isozyme, no inhibition by L-cysteine and EDTA
-
additional information
-
the activities with 2 mM aspartate or alanine are not inhibited by 10 mM isoleucine, phenylalanine, arginine, asparagine, glutamine, glycine, lysine, methionine, proline, serine, and threonine
-
additional information
-
acarbose causes no changes in the specific and total activities of AST
-
additional information
-
no inhibition by dipropylacetic acid, vinyl-GABA
-
additional information
-
insensitive to glutamine
-
additional information
-
no inhibition by Cd2+, Pb2+ and Cu2+
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5.84 - 12.07
2-methoxyphenylpyruvate
0.77 - 0.86
2-oxo-4-phenyl-butanoic acid
0.007 - 6.9
2-oxoglutarate
1.01 - 10.32
3,4-dimethoxyphenylpyruvate
-
4.92 - 11.56
3-methoxyphenylpyruvate
4.12 - 10.14
4-methoxyphenylpyruvate
29.4
kynurenine
at pH 7.4 and 37°C
4.1 - 20.3
L-2-amino-4-methoxy-4-oxobutanoic acid
29
L-Asp
pH 8, mutant enzyme A12T/P13T/N34D/T109S/G261A/S285G/A293D/N297S
2.05
L-cysteine sulfinic acid
-
pH 8.5, 60°C, recombinant enzyme
0.724
L-kynurenine
-
at pH 7.4
0.3
L-Phe
pH 8, mutant enzyme A12T/P13T/N34D/T109S/G261A/S285G/A293D/N297S
1.1 - 6.6
L-phenylalanine
0.92 - 4.24
phenylpyruvate
0.00025
pyridoxyl 5'-phosphate
-
pH 7.6, 25°C
additional information
additional information
-
5.84
2-methoxyphenylpyruvate
-
mutant enzyme N165Y/R316H/A381T/P399L, at pH 8.0 and 40°C
12.07
2-methoxyphenylpyruvate
-
wild type enzyme, at pH 8.0 and 40°C
0.77
2-oxo-4-phenyl-butanoic acid
-
wild-type enzyme
0.86
2-oxo-4-phenyl-butanoic acid
-
mutant enzyme R292E/L18H
0.007
2-oxoglutarate
-
recombinant deletion mutant, pH 7.5, 25°C
0.062
2-oxoglutarate
-
30°C
0.07
2-oxoglutarate
-
isozyme pAspAT, gamma-form, pH 8.0, 25°C
0.071
2-oxoglutarate
-
pH 7.6, 25°C
0.075
2-oxoglutarate
-
isozyme pAspAT, beta-form, pH 8.0, 25°C
0.08
2-oxoglutarate
-
recombinant mutant C166S, pH 7.5, 25°C
0.08
2-oxoglutarate
-
isozyme Asp-DEAE-1, pH 8.0
0.087
2-oxoglutarate
-
isozyme pAspAT, alpha-form, pH 8.0, 25°C
0.088 - 0.095
2-oxoglutarate
-
pH 7.4, 30°C
0.093
2-oxoglutarate
-
cytosolic isozyme, pH 7.4, 25°C
0.098
2-oxoglutarate
-
mitochondrial isozyme, pH 7.4, 25°C
0.105
2-oxoglutarate
-
isoenzyme AAT-2, pH 7.8, 37°C
0.11
2-oxoglutarate
-
pH 8.3, 25°C
0.11
2-oxoglutarate
-
isoenzyme AAT-1, pH 7.8, 37°C
0.12
2-oxoglutarate
-
isozyme Asp-DEAE-2, pH 8.0
0.13
2-oxoglutarate
-
isozyme mAspAT, pH 8.0, 25°C
0.13
2-oxoglutarate
allozyme AAT-2b, pH 7.5, 25°C
0.13
2-oxoglutarate
allozyme AAT-2c, pH 7.5, 25°C
0.13
2-oxoglutarate
allozyme AAT-3a, pH 7.5, 25°C
0.14
2-oxoglutarate
-
isozyme cAspAT, beta-form, pH 8.0, 25°C
0.17
2-oxoglutarate
-
pH 7.4, 25°C
0.17
2-oxoglutarate
-
isozyme cAspAT, alpha-form, pH 8.0, 25°C
0.17
2-oxoglutarate
allozyme AAT-2a, pH 7.5, 25°C
0.18
2-oxoglutarate
allozyme AAT-3c, pH 7.5, 25°C
0.2
2-oxoglutarate
-
pH 7.5, 37°C
0.2
2-oxoglutarate
-
pH 8.0, 45°C
0.2
2-oxoglutarate
-
isozyme AAT-P2, pH 7.6, 25°C
0.2
2-oxoglutarate
-
isozyme AspAT-3, 25°C, pH 8.0
0.2
2-oxoglutarate
-
isozyme cAspAT, gamma-form, pH 8.0, 25°C
0.22
2-oxoglutarate
-
pH 8.5, 60°C, recombinant enzyme
0.23
2-oxoglutarate
-
isozyme AspAT-1, 25°C, pH 8.0
0.24
2-oxoglutarate
-
25°C, pH 8.0
0.25
2-oxoglutarate
allozyme AAT-3b, pH 7.5, 25°C
0.26
2-oxoglutarate
-
isozyme AAT-P1, pH 7.6, 25°C
0.3
2-oxoglutarate
pH 8.0, 45°C
0.3
2-oxoglutarate
-
recombinant isozyme mAspAT, pH 7.5, 25°C
0.3
2-oxoglutarate
-
cytosolic isozyme, pH 8.0, 37°C
0.33
2-oxoglutarate
-
recombinant premature isozyme pmAspAT, pH 7.5, 25°C
0.39
2-oxoglutarate
-
isozyme AAT-2, including forms 2a, 2b and 2c, pH 8.0
0.46
2-oxoglutarate
pH 7.5, 25°C, recombinant mutant T84V
0.48
2-oxoglutarate
pH 8, cosubstrate: L-Phe, mutant enzyme A12T/P13T/N34D/T109S/G261A/S285G/A293D/N297S
0.5
2-oxoglutarate
-
pH 7.5, 37°C
0.55
2-oxoglutarate
-
pH 7.8, 25°C
0.55
2-oxoglutarate
-
isozyme AAT-1, pH 8.0
0.59
2-oxoglutarate
-
wild-type, pH 8.4, 25°C
0.67
2-oxoglutarate
-
isozyme AST II, 37°C, pH 7.5
0.8
2-oxoglutarate
-
recombinant mutant C166A, pH 7.5, 25°C
1
2-oxoglutarate
pH 7.5, 25°C, recombinant mutant E108K
1.1
2-oxoglutarate
pH 7.5, 25°C, recombinant wild-type enzyme
1.2
2-oxoglutarate
pH 7.5, 25°C, recombinant mutant A168G
1.25
2-oxoglutarate
-
cytoplasmic enzyme
1.33
2-oxoglutarate
-
cytoplasmic enzyme, in 0.05 M potassium phosphate buffer (pH 7.5) containing 0.9 mM L-aspartate, 2.7 mM 2-oxoglutarate, 0.1 mM NADH, and 1 U/ml malate dehydrogenase
1.4
2-oxoglutarate
-
pH 7.5, 35°C
1.47
2-oxoglutarate
-
enzyme from nonsynaptic mitochondrion, pH 7.8, 30°C
1.5
2-oxoglutarate
pH 7.5, 37°C
1.7
2-oxoglutarate
-
cytosolic isozyme
1.75
2-oxoglutarate
-
mitochondrial enzyme
1.95
2-oxoglutarate
-
enzyme from synaptic mitochondrion, pH 7.8, 30°C
1.95
2-oxoglutarate
-
mitochondrial enzyme, in 0.05 M potassium phosphate buffer (pH 7.5) containing 1.6 mM L-aspartate, 4 mM 2-oxoglutarate, 0.1 mM NADH, and 1 U/ml malate dehydrogenase
2.06
2-oxoglutarate
-
cytosolic isozyme, pH 6.8, 37°C
2.2
2-oxoglutarate
-
mitochondrial isozyme
2.4
2-oxoglutarate
wild-type, pH 8.0, 25°C
2.5
2-oxoglutarate
using L-aspartate as a cosubstrate, at pH 8.0 and 60°C
2.6
2-oxoglutarate
-
pH 8.0, 50°C
2.6
2-oxoglutarate
pH 8, cosubstrate: L-Asp, mutant enzyme A12T/P13T/N34D/T109S/G261A/S285G/A293D/N297S
3.2
2-oxoglutarate
pH 7.5, 37°C
6.9
2-oxoglutarate
-
mitochondrial isozyme, pH 8.0, 37°C
1.01
3,4-dimethoxyphenylpyruvate
-
mutant enzyme N165Y/R316H/A381T/P399L, at pH 8.0 and 40°C
-
10.32
3,4-dimethoxyphenylpyruvate
-
wild type enzyme, at pH 8.0 and 40°C
-
4.92
3-methoxyphenylpyruvate
-
mutant enzyme N165Y/R316H/A381T/P399L, at pH 8.0 and 40°C
11.56
3-methoxyphenylpyruvate
-
wild type enzyme, at pH 8.0 and 40°C
4.12
4-methoxyphenylpyruvate
-
mutant enzyme N165Y/R316H/A381T/P399L, at pH 8.0 and 40°C
10.14
4-methoxyphenylpyruvate
-
wild type enzyme, at pH 8.0 and 40°C
4.1
L-2-amino-4-methoxy-4-oxobutanoic acid
-
isozyme AAT2, 25°C
20.3
L-2-amino-4-methoxy-4-oxobutanoic acid
-
isozyme AAT1, 25°C
3.5
L-alanine
-
pH 7.5, 37°C
0.039
L-aspartate
at pH 7.4 and 30°C
0.09
L-aspartate
-
recombinant deletion mutant, pH 7.5, 25°C
0.108
L-aspartate
at pH 7.4 and 30°C
0.25
L-aspartate
-
recombinant premature isozyme pmAspAT, pH 7.5, 25°C
0.29
L-aspartate
-
recombinant mutant C166A, pH 7.5, 25°C
0.33
L-aspartate
-
recombinant mutant C166S, pH 7.5, 25°C
0.35
L-aspartate
-
cytoplasmic enzyme
0.36
L-aspartate
-
recombinant isozyme mAspAT, pH 7.5, 25°C
0.4
L-aspartate
-
mitochondrial isozyme, pH 7.4, 25°C
0.43
L-aspartate
-
cytoplasmic enzyme, in 0.05 M potassium phosphate buffer (pH 7.5) containing 0.9 mM L-aspartate, 2.7 mM 2-oxoglutarate, 0.1 mM NADH, and 1 U/ml malate dehydrogenase
0.5
L-aspartate
-
isozyme Asp-DEAE-2, pH 8.0
0.51
L-aspartate
-
mitochondrial isozyme
0.75
L-aspartate
-
mitochondrial enzyme
0.78
L-aspartate
-
mitochondrial enzyme, in 0.05 M potassium phosphate buffer (pH 7.5) containing 1.6 mM L-aspartate, 4 mM 2-oxoglutarate, 0.1 mM NADH, and 1 U/ml malate dehydrogenase
0.85
L-aspartate
-
isozyme Asp-DEAE-1, pH 8.0
1.2
L-aspartate
-
isozyme AAT-1, pH 8.0
1.3
L-aspartate
-
isozyme mAspAT, pH 8.0, 25°C
1.3
L-aspartate
-
25°C, pH 8.0
1.5
L-aspartate
-
isozyme AAT-2, including forms 2a, 2b and 2c, pH 8.0
1.5
L-aspartate
at pH 8.0 and 60°C
1.6
L-aspartate
pH 7.5, 25°C, recombinant mutant T84V
1.7
L-aspartate
-
isozyme AspAT-3, 25°C, pH 8.0
1.7
L-aspartate
wild-type, pH 8.0, 25°C
1.9
L-aspartate
-
wild-type, pH 8.4, 25°C
1.9
L-aspartate
-
mitochondrial isozyme, pH 8.0, 37°C
1.9
L-aspartate
pH 7.5, 25°C, recombinant wild-type enzyme
2
L-aspartate
-
pH 7.4, 25°C
2.1
L-aspartate
pH 7.5, 37°C
2.1 - 2.9
L-aspartate
-
pH 7.4, 30°C
2.2
L-aspartate
-
isozyme AAT-P1, pH 7.6, 25°C
2.2
L-aspartate
-
isozyme pAsp-AT, beta-form, pH 8.0, 25°C
2.3
L-aspartate
-
pH 8.3, 25°C
2.3
L-aspartate
-
isozyme pAsp-AT, gamma-form, pH 8.0, 25°C
2.34
L-aspartate
at pH 7.4 and 37°C
2.4
L-aspartate
-
isoenzyme AAT-1, pH 7.8, 37°C
2.53
L-aspartate
-
pH 7.8, 25°C
2.6
L-aspartate
-
isozyme AAT-P2, pH 7.6, 25°C
2.6
L-aspartate
-
isozyme pAsp-AT and cAspAT, alpha-form, pH 8.0, 25°C
2.8
L-aspartate
pH 7.5, 25°C, recombinant mutant E108K
3
L-aspartate
-
cytosolic isozyme, pH 7.4, 25°C
3
L-aspartate
-
isozyme cAspAT, gamma-form, pH 8.0, 25°C
3
L-aspartate
-
pH 8.0, 50°C
3.1
L-aspartate
pH 7.5, 25°C, mutant I33Q/Y214Q/R280Y
3.2
L-aspartate
-
isozyme cAspAT, beta-form, pH 8.0, 25°C
3.7
L-aspartate
-
pH 7.5, 37°C
3.7
L-aspartate
-
isoenzyme AAT-2, pH 7.8, 37°C
3.8
L-aspartate
pH 7.5, 25°C, recombinant mutant A168G
3.9
L-aspartate
-
cytosolic isozyme, pH 8.0, 37°C
4
L-aspartate
pH 7.5, 25°C, wild-type
4.6
L-aspartate
-
pH 7.5, 35°C
5
L-aspartate
-
pH 8.0, 45°C
6.5
L-aspartate
-
cytosolic isozyme
6.7
L-aspartate
pH 8.0, 45°C
6.8
L-aspartate
pH 7.5, 37°C
7.1
L-aspartate
allozyme AAT-3c, pH 7.5, 25°C
7.5
L-aspartate
-
isozyme AspAT-1, 25°C, pH 8.0
8.3
L-aspartate
allozyme AAT-2a, pH 7.5, 25°C
8.5
L-aspartate
allozyme AAT-2c, pH 7.5, 25°C
9.3
L-aspartate
allozyme AAT-3a, pH 7.5, 25°C
9.9
L-aspartate
allozyme AAT-2b, pH 7.5, 25°C
10
L-aspartate
allozyme AAT-3b, pH 7.5, 25°C
15.1
L-aspartate
-
isozyme AST II, 37°C, pH 7.5
22.5
L-aspartate
-
cytosolic isozyme, pH 6.8, 37°C
26
L-aspartate
pH 7.5, 37°C
37
L-aspartate
pH 7.5, 37°C
8.57
L-cysteine
at pH 7.4 and 30°C
20.62
L-cysteine
at pH 7.4 and 30°C
0.5
L-glutamate
-
cytoplasmic enzyme, in 0.05 M potassium phosphate buffer (pH 7.5) containing 0.9 mM L-aspartate, 2.7 mM 2-oxoglutarate, 0.1 mM NADH, and 1 U/ml malate dehydrogenase
0.58
L-glutamate
-
mitochondrial enzyme, in 0.05 M potassium phosphate buffer (pH 7.5) containing 1.6 mM L-aspartate, 4 mM 2-oxoglutarate, 0.1 mM NADH, and 1 U/ml malate dehydrogenase
0.75
L-glutamate
-
isozyme Asp-DEAE-2, pH 8.0
1.6
L-glutamate
-
isozyme Asp-DEAE-1, pH 8.0
3.88
L-glutamate
-
pH 7.8, 25°C
5.2
L-glutamate
pH 7.5, 25°C, mutant I33Q/Y214Q/R280Y
5.7
L-glutamate
-
pH 8.0, 45°C
7.5
L-glutamate
-
isozyme mAspAT, pH 8.0, 25°C
8
L-glutamate
pH 8.0, 45°C
8.2
L-glutamate
allozyme AAT-2b, pH 7.5, 25°C
8.3
L-glutamate
allozyme AAT-3a, pH 7.5, 25°C
12
L-glutamate
-
isozyme AAT-P2, pH 7.6, 25°C
12
L-glutamate
allozyme AAT-2a, pH 7.5, 25°C
12.2
L-glutamate
-
isozyme AspAT-3, 25°C, pH 8.0
13
L-glutamate
-
pH 8.0, 25°C
13
L-glutamate
-
isozyme cAspAT, gamma-form, pH 8.0, 25°C
13.2
L-glutamate
-
isoenzyme AAT-2
14
L-glutamate
-
isozyme cAspAT, beta-form, pH 8.0, 25°C
14
L-glutamate
allozyme AAT-3c, pH 7.5, 25°C
15
L-glutamate
-
25°C, pH 8.0
16
L-glutamate
allozyme AAT-2c, pH 7.5, 25°C
17
L-glutamate
-
isozyme cAspAT, alpha-form, pH 8.0, 25°C
17
L-glutamate
allozyme AAT-3b, pH 7.5, 25°C
17.4
L-glutamate
-
isozyme AspAT-1, 25°C, pH 8.0
18
L-glutamate
-
isozyme pAspAT, gamma-form, pH 8.0, 25°C
18.5
L-glutamate
-
isozyme AAT-1, pH 8.0
19.4
L-glutamate
-
isozyme AAT-2, including forms 2a, 2b and 2c, pH 8.0
20
L-glutamate
-
isozyme pAspAT, beta-form, pH 8.0, 25°C
22
L-glutamate
-
isozyme AAT-P1, pH 7.6, 25°C
32
L-glutamate
-
isozyme pAspAT, alpha-form, pH 8.0, 25°C
37
L-glutamate
pH 7.5, 25°C, wild-type
105
L-Lys
-
mutant enzyme R292E/L18H
189
L-Lys
-
wild-type enzyme
6.9
L-methionine
pH 7.5, 37°C
56
L-methionine
pH 7.5, 37°C
1.1
L-phenylalanine
pH 7.5, 37°C
6.6
L-phenylalanine
pH 7.5, 37°C
2.3
L-tryptophan
pH 7.5, 37°C
5
L-tryptophan
-
pH 7.6, 25°C
5
L-tryptophan
-
L-glutamate, isoenzyme AAT-1
1.43
L-tyrosine
-
pH 7.6, 25°C
1.5
L-tyrosine
pH 7.5, 37°C
1.6
L-tyrosine
pH 7.5, 37°C
0.01
oxaloacetate
-
25°C, pH 8.0
0.017
oxaloacetate
pH 8.0, 30°C
0.02
oxaloacetate
-
isozyme AAT-P2, pH 7.6, 25°C
0.023
oxaloacetate
-
isozyme pAspAT, gamma-form, pH 8.0, 25°C
0.027
oxaloacetate
-
isozyme AAT-2, including forms 2a, 2b and 2c, pH 8.0
0.03
oxaloacetate
-
isozyme pAspAT, alpha-form, pH 8.0, 25°C
0.031
oxaloacetate
-
isozyme AAT-1, pH 8.0
0.032
oxaloacetate
-
pH 8.0, 45°C
0.033
oxaloacetate
-
isozyme pAspAT, beta-form, pH 8.0, 25°C
0.037
oxaloacetate
allozyme AAT-3a, pH 7.5, 25°C
0.039
oxaloacetate
allozyme AAT-2b, pH 7.5, 25°C
0.043
oxaloacetate
-
isoenzyme AAT-1
0.043
oxaloacetate
allozyme AAT-3c, pH 7.5, 25°C
0.044
oxaloacetate
-
pH 7.8, 25°C
0.045
oxaloacetate
-
isozyme Asp-DEAE-2, pH 8.0
0.048
oxaloacetate
-
isoenzyme AAT-2
0.049
oxaloacetate
-
pH 8.0, 25°C
0.052
oxaloacetate
allozyme AAT-2a, pH 7.5, 25°C
0.056
oxaloacetate
-
isozyme mAspAT, pH 8.0, 25°C
0.057
oxaloacetate
allozyme AAT-2c, pH 7.5, 25°C
0.057
oxaloacetate
allozyme AAT-3b, pH 7.5, 25°C
0.065
oxaloacetate
-
isozyme cAspAT, alpha-form, pH 8.0, 25°C
0.08
oxaloacetate
-
isozyme cAspAT, gamma-form, pH 8.0, 25°C
0.085
oxaloacetate
-
isozyme cAspAT, beta-form, pH 8.0, 25°C
0.1
oxaloacetate
-
isozyme Asp-DEAE-1, pH 8.0
0.1
oxaloacetate
-
isozyme AAT-P1, pH 7.6, 25°C
0.2
oxaloacetate
-
isozyme AspAT-1, 25°C, pH 8.0
0.32
oxaloacetate
-
isozyme AspAT-3, 25°C, pH 8.0
0.37
oxaloacetate
-
pH 7.6, 25°C
0.6
oxaloacetate
pH 8.0, 45°C
2.04
oxaloacetate
-
mitochondrial enzyme, in 0.05 M potassium phosphate buffer (pH 7.5) containing 1.6 mM L-aspartate, 4 mM 2-oxoglutarate, 0.1 mM NADH, and 1 U/ml malate dehydrogenase
2.45
oxaloacetate
-
cytoplasmic enzyme, in 0.05 M potassium phosphate buffer (pH 7.5) containing 0.9 mM L-aspartate, 2.7 mM 2-oxoglutarate, 0.1 mM NADH, and 1 U/ml malate dehydrogenase
0.92
phenylpyruvate
-
mutant enzyme N165Y/R316H/A381T/P399L, at pH 8.0 and 40°C
4.24
phenylpyruvate
-
wild type enzyme, at pH 8.0 and 40°C
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
Leptosphaeria michotii
-
-
-
additional information
additional information
-
-
-
additional information
additional information
dolphin
-
-
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
recombinant enzyme
-
additional information
additional information
-
mutants
-
additional information
additional information
-
recombinant enzyme, high temperature dependence of Km
-
additional information
additional information
-
wild-type and mutants
-
additional information
additional information
-
wild-type and mutants
-
additional information
additional information
wild-type and mutants
-
additional information
additional information
-
wild-type and mutants
-
additional information
additional information
steady-state kinetics analysis
-
additional information
additional information
-
steady-state kinetics analysis
-
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0.0072
(2-chloro-6-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)(2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)copper
Rattus norvegicus
-
at pH 7.5 and 37°C
0.0036
(2-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)(2-hydroxyethyl)(2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)cuprate(1-)
Rattus norvegicus
-
at pH 7.5 and 37°C
0.032
1-(2,4-dichlorophenyl)-3-[2-(1H-indol-3-yl)ethyl]urea
Homo sapiens
at 37°C, pH not specified in the publication
0.036
1-(4-chlorophenyl)-3-[2-(1H-indol-3-yl)ethyl]urea
Homo sapiens
at 37°C, pH not specified in the publication
0.034
1-biphenyl-2-yl-3-[2-(1H-indol-3-yl)ethyl]urea
Homo sapiens
at 37°C, pH not specified in the publication
0.1
1-[2-(1H-indol-3-yl)ethyl]-3-phenylurea
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.062
1-[2-(1H-indol-3-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]urea
Homo sapiens
at 37°C, pH not specified in the publication
0.039
1-[2-(1H-indol-3-yl)ethyl]-3-[4-(trifluoromethyl)phenyl]urea
Homo sapiens
at 37°C, pH not specified in the publication
0.1
4-(1H-indazol-4-yl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-(2-methylphenyl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-(3-methylphenyl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.039
4-(1H-indol-4-yl)-N-(3-phenoxyphenyl)piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-(4-methylphenyl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-(propan-2-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-(pyridazin-4-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-(pyridin-3-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-(pyrimidin-5-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.0113 - 0.085
4-(1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
0.1
4-(1H-indol-4-yl)-N-[2-(trifluoromethyl)phenyl]piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-[3-(methylcarbamoyl)phenyl]piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.014
4-(1H-indol-4-yl)-N-[3-(trifluoromethyl)phenyl]piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-[4-(methylcarbamoyl)phenyl]piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.016
4-(1H-indol-4-yl)-N-[4-(trifluoromethyl)phenyl]piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.1
4-(3-methoxyphenyl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(5-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.046
4-(6-chloro-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.1
4-(6-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(7-chloro-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.041
4-(7-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.1
4-(methylsulfonyl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-acetyl-N-phenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
1.5
alpha-aminoadipate
Rattus norvegicus
-
IC50: 1.5 mM
0.078
aqua[2-([[3-bromo-6-(hydroxy-kappaO)cyclohexa-2,4-dien-1-yl]methylidene]amino-kappaN)benzoato(2-)-kappaO]cuprate(1-)
Rattus norvegicus
-
at pH 7.5 and 37°C
0.089
aqua[2-([[3-chloro-6-(hydroxy-kappaO)cyclohexa-2,4-dien-1-yl]methylidene]amino-kappaN)benzoato(2-)-kappaO]cuprate(1-)
Rattus norvegicus
-
at pH 7.5 and 37°C
0.3
aspartate
Rattus norvegicus
-
IC50: 0.3 mM
0.012
bis[4-chloro-2-[(phenylimino-kappaN)methyl]phenolato-kappaO]copper
Rattus norvegicus
-
at pH 7.5 and 37°C
0.017
bis[4-nitro-2-[(phenylimino-kappaN)methyl]phenolato-kappaO]copper
Rattus norvegicus
-
at pH 7.5 and 37°C
0.008
Cu2+
Rattus norvegicus
-
at pH 7.5 and 37°C
0.053
diaqua[2-chloro-6-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]-4-(hydroxymethyl)phenolato-kappaO](2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)copper
Rattus norvegicus
-
at pH 7.5 and 37°C
0.072
diaqua[3-([[2-(carboxy-kappaO)phenyl]imino-kappaN]methyl)-4-(hydroxy-kappaO)cyclohexa-1,5-dien-1-yl](hydroxy)oxoammoniumato(2-)copper
Rattus norvegicus
-
at pH 7.5 and 37°C
0.9
glutamate
Rattus norvegicus
-
IC50: 0.9 mM
0.1103
hesperidin
Rattus norvegicus
-
at pH 7.4 and 37°C
0.08529
hesperitin
Rattus norvegicus
-
at pH 7.4 and 37°C
0.069
hydroxylamine
Plasmodium falciparum
pH 8, 37°C
0.1
N,4-diphenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.076
N-(1,3-benzothiazol-5-yl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.056
N-(2,4-dichlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.1
N-(2-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.022
N-(3,5-dichlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.052
N-(3-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.043
N-(4-benzoylphenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0082
N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.1
N-phenyl-4-(propan-2-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
N-phenyl-4-(pyridin-4-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
N-phenyl-4-(quinolin-5-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
1
protein-binding copper complex 10
Rattus norvegicus
-
at pH 7.5 and 37°C
0.008
protein-binding copper complex 11
Rattus norvegicus
-
at pH 7.5 and 37°C
1
protein-binding copper complex 9
Rattus norvegicus
-
at pH 7.5 and 37°C
0.0113
4-(1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
at pH 7.4 and 37°C
0.085
4-(1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
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