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Information on EC 2.5.1.72 - quinolinate synthase and Organism(s) Pseudomonas aeruginosa

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EC Tree
IUBMB Comments
An iron-sulfur protein that requires a [4Fe-4S] cluster for activity . Quinolinate synthase catalyses the second step in the de novo biosynthesis of NAD+ from aspartate in some bacteria, with EC 1.4.3.16 (L-aspartate oxidase) catalysing the first step and EC 2.4.2.19 [nicotinate-nucleotide diphosphorylase (carboxylating)] the third step. In Escherichia coli, two of the residues that are involved in the [4Fe-4S] cluster binding appear to undergo reversible disulfide-bond formation that regulates the activity of the enzyme .
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Pseudomonas aeruginosa
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The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
quinolinate synthase, quinolinate synthetase, sufe3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
quinolinate synthetase
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
glycerone phosphate:iminosuccinate alkyltransferase (cyclizing)
An iron-sulfur protein that requires a [4Fe-4S] cluster for activity [1]. Quinolinate synthase catalyses the second step in the de novo biosynthesis of NAD+ from aspartate in some bacteria, with EC 1.4.3.16 (L-aspartate oxidase) catalysing the first step and EC 2.4.2.19 [nicotinate-nucleotide diphosphorylase (carboxylating)] the third step. In Escherichia coli, two of the residues that are involved in the [4Fe-4S] cluster binding appear to undergo reversible disulfide-bond formation that regulates the activity of the enzyme [5].
CAS REGISTRY NUMBER
COMMENTARY hide
39434-08-7
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A8G6IZH0_PSEAI
352
0
38403
TrEMBL
-
A0A4P0TCT1_PSEAI
352
0
38353
TrEMBL
-
A0A431XFU0_PSEAI
352
0
38295
TrEMBL
-
A0A6B1YAP5_PSEAI
352
0
38448
TrEMBL
-
A0A367M5A0_PSEAI
352
0
38414
TrEMBL
-
A0A8G3NF28_PSEAI
352
0
38402
TrEMBL
-
A0A071L2J8_PSEAI
352
0
38418
TrEMBL
-
A0A8G4P1X9_PSEAI
352
0
38379
TrEMBL
-
A0A8G7BT07_PSEAI
352
0
38388
TrEMBL
-
A0A8G7RZS3_PSEAI
352
0
38402
TrEMBL
-
A0A8A4FZH9_PSEAI
352
0
38432
TrEMBL
-
A0A077JNH7_PSEAI
352
0
38432
TrEMBL
-
A0A2R3J2P5_PSEAI
352
0
38293
TrEMBL
-
A0A8G7CEQ0_PSEAI
352
0
38388
TrEMBL
-
A0A8G3YKZ2_PSEAI
352
0
38408
TrEMBL
-
A0A8G6K8U1_PSEAI
352
0
38432
TrEMBL
-
A0A8G7S6K1_PSEAI
352
0
38404
TrEMBL
-
A0A8I0ZI32_PSEAI
352
0
38402
TrEMBL
-