Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.5.1.108 - 2-(3-amino-3-carboxypropyl)histidine synthase and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC2.5.1.108
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
A [4Fe-4S] enzyme that modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical. The enzyme is present in archae and eukaryotes but not in eubacteria. The enzyme is a member of the 'AdoMet radical' (radical SAM) family and generates the 3-amino-3-carboxypropyl radical by an uncanonical clevage of S-adenosyl-L-methionine. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii. Part of diphthamide biosynthesis.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Synonyms
dph1-dph2, phdph2, more
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:L-histidine-[translation elongation factor 2] 2-[(3S)-3-amino-3-carboxypropyl]transferase
A [4Fe-4S] enzyme that modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical. The enzyme is present in archae and eukaryotes but not in eubacteria. The enzyme is a member of the 'AdoMet radical' (radical SAM) family and generates the 3-amino-3-carboxypropyl radical by an uncanonical clevage of S-adenosyl-L-methionine. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii. Part of diphthamide biosynthesis.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DPH1_HUMAN
443
0
48805
Swiss-Prot
Mitochondrion (Reliability: 5)
I3L1H5_HUMAN
427
0
46930
TrEMBL
other Location (Reliability: 5)
B3KQW7_HUMAN
199
0
22081
TrEMBL
other Location (Reliability: 4)
H0YCR5_HUMAN
262
0
27846
TrEMBL
other Location (Reliability: 2)
A0A6Q8JGF9_HUMAN
438
0
48134
TrEMBL
other Location (Reliability: 5)
B2RA29_HUMAN
363
0
40010
TrEMBL
Secretory Pathway (Reliability: 3)
B3KRB8_HUMAN
413
0
43994
TrEMBL
other Location (Reliability: 2)
I3L3X9_HUMAN
148
0
16277
TrEMBL
other Location (Reliability: 5)
B4DNK0_HUMAN
453
0
50246
TrEMBL
Mitochondrion (Reliability: 5)
U3KQN3_HUMAN
103
0
11267
TrEMBL
other Location (Reliability: 3)