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Information on EC 2.4.2.36 - NAD+-diphthamide ADP-ribosyltransferase and Organism(s) Homo sapiens

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.36 NAD+-diphthamide ADP-ribosyltransferase
IUBMB Comments
Diphtheria toxin and some other bacterial toxins catalyse this reaction, which inactivates translation elongation factor 2 (EF2). The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria. cf. EC 2.4.2.31 NAD(P)+---protein-arginine ADP-ribosyltransferase. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii.
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Word Map
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
cholera toxin, exotoxin a, adp-ribosyltransferase, mono-adp-ribosyltransferase, cholix toxin, cholix, ehtoxin-like, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
(adenosine diphosphoribose)transferase, nicotinamide adenine dinucleotide-elongation factor 2
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ADP-ribosyltransferase
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mono(ADPribosyl)transferase
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NAD(+)-diphthamide ADP-ribosyltransferase
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NAD-diphthamide ADP-ribosyltransferase
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NAD-diphthamide ADP-ribosyltransferase NAD-elongation factor 2 ADP-ribosyltransferase
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NAD:elongation factor 2-adenosine diphosphate ribose-transferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pentosyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
NAD+:diphthamide-[translation elongation factor 2] N-(ADP-D-ribosyl)transferase
Diphtheria toxin and some other bacterial toxins catalyse this reaction, which inactivates translation elongation factor 2 (EF2). The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria. cf. EC 2.4.2.31 NAD(P)+---protein-arginine ADP-ribosyltransferase. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii.
CAS REGISTRY NUMBER
COMMENTARY hide
52933-21-8
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