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Information on EC 2.4.2.31 - NAD+-protein-arginine ADP-ribosyltransferase and Organism(s) Homo sapiens
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2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferaseIUBMB Comments
Protein mono-ADP-ribosylation is a reversible post-translational modification that plays a role in the regulation of cellular activities . Arginine residues in proteins act as acceptors. Free arginine, agmatine [(4-aminobutyl)guanidine], arginine methyl ester and guanidine can also do so. The enzyme from some, but not all, species can also use NADP+ as acceptor (giving rise to Nomega-[(2'-phospho-ADP)-D-ribosyl]-protein-L-arginine as the product), but more slowly [1,5]. The enzyme catalyses the NAD+-dependent activation of EC 4.6.1.1, adenylate cyclase. Some bacterial enterotoxins possess similar enzymic activities. (cf. EC 2.4.2.36 NAD+---diphthamide ADP-ribosyltransferase).
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Word Map
- 2.4.2.31
- angiotensin
- losartan
- arterial
-
renin-angiotensin
- hypertension
- subtype
-
blocker
- cardiovascular
- cardiac
- ventricular
- renin
- hypertrophy
-
ii-induced
-
angiotensin-converting
- agonist
-
hemodynamic
-
vasoconstriction
- valsartan
- bradykinin
-
angii
- candesartan
-
sympathetic
- angiotensinogen
-
antihypertensive
- aldosterone
-
nonpeptide
-
pressor
- aortic
- myocardial
-
systolic
-
normotensive
-
angii-induced
- medicine
- agriculture
- saralasin
- enalapril
-
aceis
-
conscious
- captopril
-
wistar-kyoto
-
baroreflex
-
renin-angiotensin-aldosterone
-
subfornical
-
natriuresis
-
ii-stimulated
-
angiotensin-1-7
-
intrarenal
- telmisartan
- angiotensin-ii
- olmesartan
-
ii-mediated
- irbesartan
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
at1, at2, iota toxin, rt6.1, rt6.2, mono(adp-ribosyl)transferase, arginine-specific adp-ribosyltransferase, nad:arginine adp-ribosyltransferase, arginine-specific mono-adp-ribosyltransferase, xopai, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
(adenosine diphosphoribose)transferase, nicotinamide adenine dinucleotide-arginine
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ADP-ribosyltransferase
ADPRT
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-
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alloantigen Rt6.1
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-
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alloantigen Rt6.2
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arginine specific ADP-ribosyltransferase
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-
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arginine specific mono-ADP-ribosyltransferase
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arginine-specific mono-ADP-ribosyltransferase
ART
AT1
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AT2
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Dombrock blood group carrier molecule
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mono(ADP-ribosyl)transferase
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NAD(P)+-arginine ADP-ribosyltransferase
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NAD+:arginine ADP-ribosyltransferase
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NAD+:arginine ecto-mono(ADP-ribosyl)transferase
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NAD+:L-arginine ADP-D-ribosyltransferase
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NAD-arginine ADP-ribosyltransferase
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NAD-arginine mono-ADP-ribosyltransferase B
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NAD-dependent ADPribosyltransferase
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NAD:arginine ADP-ribosyltransferase B
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RT6
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RT6.1
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RT6.2
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T-cell surface protein Rt6.1
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T-cell surface protein Rt6.2
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ADP-ribosyltransferase
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arginine-specific mono-ADP-ribosyltransferase
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ART
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pentosyl group transfer
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-
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-
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SYSTEMATIC NAME
IUBMB Comments
NAD+:protein-L-arginine ADP-D-ribosyltransferase
Protein mono-ADP-ribosylation is a reversible post-translational modification that plays a role in the regulation of cellular activities [4]. Arginine residues in proteins act as acceptors. Free arginine, agmatine [(4-aminobutyl)guanidine], arginine methyl ester and guanidine can also do so. The enzyme from some, but not all, species can also use NADP+ as acceptor (giving rise to Nomega-[(2'-phospho-ADP)-D-ribosyl]-protein-L-arginine as the product), but more slowly [1,5]. The enzyme catalyses the NAD+-dependent activation of EC 4.6.1.1, adenylate cyclase. Some bacterial enterotoxins possess similar enzymic activities. (cf. EC 2.4.2.36 NAD+---diphthamide ADP-ribosyltransferase).
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CAS REGISTRY NUMBER
COMMENTARY
81457-93-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
FGF-2 + NAD+
?
-
ADP-ribosylation of FGF-2 may provide an additional level of control of FGF-2 activity
-
-
?
human neutrophil peptide-1 + NAD+
Nomega-(ADP-D-ribosyl)-L-arginine-human neutrophil peptide-1 + nicotinamide
NAD+ + glucose-regulated protein of 78 kDa/immunoglobulin heavy-chainbinding protein L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-glucose-regulated protein of 78 kDa/immunoglobulin heavy-chainbinding protein-L-arginine
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-
-
?
NAD+ + protein L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine
-
-
-
-
?
P2X7(k) + NAD+
nicotinamide + ?
-
the P2X7(k) variant is sensitive to activation by ADP-ribosylation whereas the P2X7(a) variant is insensitive
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-
?
human neutrophil peptide-1 + NAD+
Nomega-(ADP-D-ribosyl)-L-arginine-human neutrophil peptide-1 + nicotinamide
-
human neutrophil peptide-1, HNP-1, from neutrophil cell surface, ADP-ribosylation of HNP-1 is primarily an activity of ART1 and occurs in inflammatory conditions and disease, lack of modified HNP-1 due to enzyme deficiency in the sputum leads to cystic fibrosis
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-
?
human neutrophil peptide-1 + NAD+
Nomega-(ADP-D-ribosyl)-L-arginine-human neutrophil peptide-1 + nicotinamide
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human neutrophil peptide-1, HNP-1, from neutrophil cell surface, isozyme ART1 shows high activity on Arg14 and Arg24, while isozymes ART3, ART4, ART5 are less or not active
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-
?
additional information
?
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-
enzyme is involved in posttranslational modification of proteins
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-
?
additional information
?
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substrate specificity, beta-defensin-1 is a poor substrate, overview
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
FGF-2 + NAD+
?
-
ADP-ribosylation of FGF-2 may provide an additional level of control of FGF-2 activity
-
-
?
human neutrophil peptide-1 + NAD+
Nomega-(ADP-D-ribosyl)-L-arginine-human neutrophil peptide-1 + nicotinamide
-
human neutrophil peptide-1, HNP-1, from neutrophil cell surface, ADP-ribosylation of HNP-1 is primarily an activity of ART1 and occurs in inflammatory conditions and disease, lack of modified HNP-1 due to enzyme deficiency in the sputum leads to cystic fibrosis
-
-
?
NAD+ + glucose-regulated protein of 78 kDa/immunoglobulin heavy-chainbinding protein L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-glucose-regulated protein of 78 kDa/immunoglobulin heavy-chainbinding protein-L-arginine
-
-
-
?
NAD+ + protein L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine
-
-
-
-
?
additional information
?
-
-
enzyme is involved in posttranslational modification of proteins
-
-
?
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38.
Acidosis
Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation.
Acidosis
Bicarbonate transport along the loop of Henle. II. Effects of acid-base, dietary, and neurohumoral determinants.
Acidosis
Effect of ANG II on pHi, [Ca2+]i, and contraction in rabbit ventricular myocytes from infarcted hearts.
Acidosis
Endocytotic uptake of HPMA-based polymers by different cancer cells: impact of extracellular acidosis and hypoxia.
Acidosis
The Role of MicroRNA Expression for Proliferation and Apoptosis of Tumor Cells: Impact of Hypoxia-Related Acidosis.
Acute Coronary Syndrome
Autoantibodies Targeting AT1 Receptor from Patients with Acute Coronary Syndrome Upregulate Proinflammatory Cytokines Expression in Endothelial Cells Involving NF-?B Pathway.
Acute Kidney Injury
Acute renal failure in 2K2C Goldblatt hypertensive rats during antihypertensive therapy: comparison of an angiotensin AT1 receptor antagonist and clonidine analogues.
Acute Kidney Injury
Angiotensin II type 1a receptor loss ameliorates chronic tubulointerstitial damage after renal ischemia reperfusion.
Acute Kidney Injury
AT1 receptor antagonism before ischemia prevents the transition of acute kidney injury to chronic kidney disease.
Acute Kidney Injury
Cisplatin-induced acute renal failure in mice is mediated by chymase-activated angiotensin-aldosterone system and interleukin-18.
Acute Kidney Injury
Protection of kidney function and tissue integrity by pharmacologic use of natriuretic peptides and neprilysin inhibitors.
Acute Kidney Injury
Variance of ACE and AT1 receptor gene does not influence the risk of neonatal acute renal failure.
Acute Kidney Injury
[Acute kidney failure and losartan: a recently observed event of antagonists of angiotensin II AT1 receptors]
Acute Lung Injury
Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury.
Acute Lung Injury
Angiotensin II type-1 receptor antagonist attenuates LPS-induced acute lung injury.
Acute Lung Injury
Apoptosis-dependent acute pulmonary injury after intratracheal instillation of angiotensin II.
Acute Lung Injury
Losartan, an antagonist of AT1 receptor for angiotensin II, attenuates lipopolysaccharide-induced acute lung injury in rat.
Adenocarcinoma
Alterations in Gene Expression of Components of the Renin-Angiotensin System and Its Related Enzymes in Lung Cancer.
Adenocarcinoma
Enhanced expression of angiotensin II receptor subtypes and angiotensin converting enzyme in medroxyprogesterone-induced mouse mammary adenocarcinomas.
Adenocarcinoma
Expression of NAD glycohydrolase activity by rat mammary adenocarcinoma cells transformed with rat T cell alloantigen RT6.2.
Adenocarcinoma
GdDO3NI, a nitroimidazole-based T1 MRI contrast agent for imaging tumor hypoxia in vivo.
Adenocarcinoma
Intracellular visualization of prostate cancer using magnetic resonance imaging.
Adenocarcinoma
Pilot study of angiotensin II receptor blocker in advanced hormone-refractory prostate cancer.
Adenocarcinoma
Real-time impedance assay to follow the invasive activities of metastatic cells in culture.
Adenocarcinoma
Synergistic inhibitory effect of high-intensity focused ultrasound combined with chemotherapy on Dunning adenocarcinoma.
Adenocarcinoma of Lung
Angiotensin II elevates cytosolic free calcium in human lung adenocarcinoma cells via activation of AT1 receptors.
Adenocarcinoma of Lung
Claudin-18: unexpected regulator of lung alveolar epithelial cell proliferation.
Adenocarcinoma of Lung
Identification of Sca-1+Abcg1+ bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
Adenocarcinoma of Lung
Transcription factor Etv5 is essential for the maintenance of alveolar type II cells.
Adenoma
Adrenal angiotensin II type 1 and type 2 receptors in Cushing's and Conn's syndromes.
Adenoma
Autoimmune mechanisms activating the angiotensin AT1 receptor in 'primary' aldosteronism.
Adenoma
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas.
Adenoma
PCR-SSCP analysis of the angiotensin II type 1 receptor gene in patients with aldosterone-producing adenomas.
Adenoma
Somatic mutations of the angiotensin II (AT1) receptor gene are not present in aldosterone-producing adenoma.
Adrenal Gland Neoplasms
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumors.
Adrenocortical Adenoma
Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals.
Adrenocortical Adenoma
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumors.
Albuminuria
Angiotensin II increases glomerular permeability by ?-arrestin mediated nephrin endocytosis.
Albuminuria
Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders.
Albuminuria
Deterioration of Kidney Function by the (Pro)renin Receptor Blocker Handle Region Peptide in Aliskiren-treated Diabetic Transgenic (mRen2)27 Rats.
Albuminuria
Differential effects of enalapril and irbesartan in experimental papillary necrosis.
Albuminuria
Monocyte infiltration and adhesion molecules in a rat model of high human renin hypertension.
Albuminuria
Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats.
Albuminuria
Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor.
Albuminuria
Renoprotective mechanisms of angiotensin II antagonism in experimental chronic renal failure.
Albuminuria
Restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin.
Albuminuria
Simultaneous angiotensin receptor blockade and glucagon-like peptide-1 receptor activation ameliorate albuminuria in obese insulin-resistant rats.
Alkalosis
Bicarbonate transport along the loop of Henle. II. Effects of acid-base, dietary, and neurohumoral determinants.
Alveolar Bone Loss
Protective effects of the angiotensin type 1 receptor antagonist losartan in infection-induced and arthritis-associated alveolar bone loss.
Alveolitis, Extrinsic Allergic
Telomere shortening and DNA damage in culprit cells of different types of progressive fibrosing interstitial lung disease.
Alzheimer Disease
Alterations in angiotensin AT1 and AT2 receptor subtype levels in brain regions from patients with neurodegenerative disorders.
Alzheimer Disease
Angiotensin II AT2 receptor oligomers mediate G-protein dysfunction in an animal model of Alzheimer disease.
Alzheimer Disease
Transient Mild Cerebral Ischemia Significantly Deteriorated Cognitive Impairment in a Mouse Model of Alzheimer's Disease via Angiotensin AT1 Receptor.
Amnesia
Role of central angiotensin receptors in scopolamine-induced impairment in memory, cerebral blood flow, and cholinergic function.
Anemia
Effects of an angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitors on burst forming units-erythroid in chronic hemodialysis patients.
Anemia
Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways.
Aneurysm
Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism.
Aneurysm
Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis.
Aneurysm
Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms.
Angina Pectoris
Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease.
Angina, Unstable
Agonistic autoantibodies against the angiotensin AT1 receptor increase in unstable angina patients after stent implantation.
Angioedema
Angioedema associated with angiotensin II receptor antagonists: challenging our knowledge of angioedema and its etiology.
Angioedema
Angiotensin II Receptor Blocker Neprilysin Inhibitor (ARNI): New Avenues in Cardiovascular Therapy.
Angioedema
Angiotensin II receptor blockers are safe in patients with prior angioedema related to angiotensin-converting enzyme inhibitors - a nationwide registry-based cohort study.
Angioedema
Antagonizing the angiotensin II subtype 1 receptor: a focus on olmesartan medoxomil.
Angioedema
Antihypertensive efficacy and tolerability of once daily losartan potassium compared with captopril in patients with mild to moderate essential hypertension.
Angioedema
Are patients who develop angioedema with ACE inhibition at risk of the same problem with AT1 receptor blockers?
Angioedema
Concomitant Angiotensin AT1 Receptor Antagonism and Neprilysin Inhibition Produces Omapatrilat-Like Antihypertensive Effects Without Promoting Tracheal Plasma Extravasation In The Rat.
Angioedema
Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI).
Anthrax
Immunological and functional comparison between Clostridium perfringens iota toxin, C. spiroforme toxin, and anthrax toxins.
Anthrax
Interactions of high-affinity cationic blockers with the translocation pores of B. anthracis, C. botulinum, and C. perfringens binary toxins.
Aortic Aneurysm
Angiotensin II induces an increase in MMP-2 expression in idiopathic ascending aortic aneurysm via AT1 receptor and JNK pathway.
Aortic Aneurysm
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
Aortic Aneurysm, Abdominal
Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis.
Aortic Aneurysm, Abdominal
AT2R (Angiotensin AT2 Receptor) Agonist, Compound 21, Prevents Abdominal Aortic Aneurysm Progression in the Rat.
Aortic Aneurysm, Abdominal
Cartilage oligomeric matrix protein is an endogenous ?-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury.
Aortic Aneurysm, Abdominal
Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury.
Aortic Aneurysm, Abdominal
PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism.
Aortic Aneurysm, Thoracic
PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism.
Aortic Coarctation
Decreased perfusion pressure modulates renin and ANG II type 1 receptor gene expression in the rat kidney.
Aortic Coarctation
Effects of des-aspartate-angiotensin I on the expression of angiotensin AT1 and AT2 receptors in ventricles of hypertrophic rat hearts.
Aortic Valve Stenosis
Angiotensin AT1 receptor inhibition. Effects on hypertrophic remodeling and ACE expression in rats with pressure-overload hypertrophy due to ascending aortic stenosis.
Aortic Valve Stenosis
Role of angiotensin AT1, and AT2 receptors in cardiac hypertrophy and disease.
Aortic Valve Stenosis
[Blockade of renin-angiotensin system attenuates cardiac remodeling in rats undergoing aortic stenosis]
Apnea
[Could the understanding of racial differences prevent idiosyncratic anesthetic reactions?]
Arrhythmias, Cardiac
On the local cardiac renin angiotensin system. Basic and clinical implications.
Arrhythmias, Cardiac
[Could the understanding of racial differences prevent idiosyncratic anesthetic reactions?]
Arteriosclerosis
Candesartan cilexetil reduces graft arteriosclerosis in aortic transplantation model in rat.
Arteriosclerosis
Insulin induces upregulation of vascular AT1 receptor gene expression by posttranscriptional mechanisms.
Arteriosclerosis
Interaction between insulin and AT1 receptor. Relevance for hypertension and arteriosclerosis.
Arteriosclerosis
Regulation of the angiotensin AT1 receptor expression by hypercholesterolemia.
Arteriosclerosis
[Significance of the angiotensin-II receptor AT1 in the pathogenesis of arterial hypertension and arteriosclerosis]
Arteriovenous Fistula
Arteriovenous fistula patency associated with angiotensin-converting enzyme I/D polymorphism and ACE inhibition or AT1 receptor blockade.
Arthritis
Effects of adjuvant-induced arthritis on the ventral prostate of rats treated with angiotensin AT1 receptor blocker.
Arthritis, Rheumatoid
Effects of adjuvant-induced arthritis on the ventral prostate of rats treated with angiotensin AT1 receptor blocker.
Arthritis, Rheumatoid
Mechanisms of the anti-inflammatory actions of the angiotensin type 1 receptor antagonist losartan in experimental models of arthritis.
Asthma
Effect of losartan, a type 1 angiotensin II receptor antagonist, on bronchial hyperresponsiveness to methacholine in patients with bronchial asthma.
Asthma
Role of angiotensin II type 1 (AT1) and type 2 (AT2) receptors in airway reactivity and inflammation in an allergic mouse model of asthma.
Asthma
Structural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma.
Asthma
The involvement of type 1a angiotensin II receptors in the regulation of airway inflammation in a murine model of allergic asthma.
Asthma
Type II alveolar epithelial cell-specific loss of RhoA exacerbates allergic airway inflammation through SLC26A4.
Astrocytoma
Expression of AT1 and AT2 angiotensin receptors in astrocytomas is associated with poor prognosis.
Ataxia Telangiectasia
Induction and rejoining of DNA double-strand breaks and interphase chromosome breaks after exposure to X rays in one normal and two hypersensitive human fibroblast cell lines.
Atherosclerosis
A/C1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure: the Ohasama Study.
Atherosclerosis
Alpha1-adrenergic plus angiotensin receptor blockade reduces atherosclerosis in apolipoprotein E-deficient mice.
Atherosclerosis
Angiotensin AT1 receptor antagonist irbesartan decreases lesion size, chemokine expression, and macrophage accumulation in apolipoprotein E-deficient mice.
Atherosclerosis
Angiotensin II activates nuclear transcription factor-kappaB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice.
Atherosclerosis
Angiotensin II and serotonin potentiate endothelin-1-induced vascular smooth muscle cell proliferation.
Atherosclerosis
Angiotensin II receptors and peritoneal dialysis-induced peritoneal fibrosis.
Atherosclerosis
Angiotensin II type 1 (AT1) receptor deficiency halts the progression of age-related atherosclerosis in hypercholesterolemia: molecular link between the AT1 receptor and hypercholesterolemia.
Atherosclerosis
Angiotensin II type 1 receptor expression in human coronary arteries with variable degrees of atherosclerosis.
Atherosclerosis
Angiotensin II, type 2 receptor is not involved in the angiotensin II-mediated pro-atherogenic process in ApoE-/- mice.
Atherosclerosis
Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications.
Atherosclerosis
Angiotensin type 1 receptor antagonism reverses abnormal coronary vasomotion in atherosclerosis.
Atherosclerosis
Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis.
Atherosclerosis
Blood pressure is the major driving force for plaque formation in aortic-constricted ApoE-/- mice.
Atherosclerosis
Bone marrow angiotensin AT2 receptor deficiency aggravates atherosclerosis development by eliminating macrophage liver X receptor-mediated anti-atherogenic actions.
Atherosclerosis
Comparison of the effects of AT1 receptor blockade and angiotensin converting enzyme inhibition on atherosclerosis.
Atherosclerosis
Compound 21 prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo.
Atherosclerosis
Counter-regulatory effects played by the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications.
Atherosclerosis
Deletion of angiotensin II type 2 receptor exaggerated atherosclerosis in apolipoprotein E-null mice.
Atherosclerosis
Deterioration of atherosclerosis in mice lacking angiotensin II type 1A receptor in bone marrow-derived cells.
Atherosclerosis
Differential effects of AT1 receptor and Ca2+ channel blockade on atherosclerosis, inflammatory gene expression, and production of reactive oxygen species.
Atherosclerosis
Differential phosphorylation of calreticulin affects AT1 receptor mRNA stability in VSMC.
Atherosclerosis
Effect of a common X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) on the occurrence of premature myocardial infarction and stenotic atherosclerosis requiring revascularization.
Atherosclerosis
Effect of combination of calcium antagonist, azelnidipine, and AT1 receptor blocker, olmesartan, on atherosclerosis in apolipoprotein E-deficient mice.
Atherosclerosis
Effect of long-term angiotensin II type I receptor antagonism on peripheral and coronary vasomotion.
Atherosclerosis
Effects of angiotensin II type 1 receptor blockade in ApoE-deficient mice with post-ischemic heart failure.
Atherosclerosis
Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of monocytes at the onset of atherosclerosis.
Atherosclerosis
Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis.
Atherosclerosis
Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage.
Atherosclerosis
Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor.
Atherosclerosis
Increased angiotensin II type 1 receptor expression in hypercholesterolemic atherosclerosis in rabbits.
Atherosclerosis
Induction of angiotensin converting enzyme and angiotensin II receptors in the atherosclerotic aorta of high-cholesterol fed Cynomolgus monkeys.
Atherosclerosis
Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice.
Atherosclerosis
Inhibitory effects of AT1 receptor blocker, olmesartan, and estrogen on atherosclerosis via anti-oxidative stress.
Atherosclerosis
Interaction between insulin and AT1 receptor. Relevance for hypertension and arteriosclerosis.
Atherosclerosis
Irbesartan but not amlodipine suppresses diabetes-associated atherosclerosis.
Atherosclerosis
Irbesartan, an angiotensin type 1 receptor inhibitor, regulates markers of inflammation in patients with premature atherosclerosis.
Atherosclerosis
Local angiotensin II-generating system in vascular tissues: the roles of chymase.
Atherosclerosis
Low-sodium diet induces atherogenesis regardless of lowering blood pressure in hypertensive hyperlipidemic mice.
Atherosclerosis
Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis.
Atherosclerosis
MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS axis functionality.
Atherosclerosis
Mildly oxidized low-density lipoprotein acts synergistically with angiotensin II in inducing vascular smooth muscle cell proliferation.
Atherosclerosis
PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism.
Atherosclerosis
Prevention of accelerated atherosclerosis by AT1 receptor blockade in experimental renal failure.
Atherosclerosis
Renin Angiotensin blockers and cardiac protection. From basis to clinical trials.
Atherosclerosis
Rosuvastatin attenuates atherosclerosis in rats via activation of scavenger receptor class B type I.
Atherosclerosis
Stimulation of the AT2 receptor reduced atherogenesis in ApoE(-/-)/AT1A(-/-) double knock out mice.
Atherosclerosis
The heterogenous nuclear riboprotein S1-1 regulates AT1 receptor gene expression via transcriptional and posttranscriptional mechanisms.
Atherosclerosis
The potential role of the angiotensin subtype 2 receptor in cardiovascular protection.
Atherosclerosis
Transcriptional suppression of rat angiotensin AT1a receptor gene expression by interferon-gamma in vascular smooth muscle cells.
Atherosclerosis
Transition from atherosclerosis to aortic aneurysm in humans coincides with an increased expression of RAS components.
Atrial Fibrillation
Angiotensin II potentiates the slow component of delayed rectifier K+ current via the AT1 receptor in guinea pig atrial myocytes.
Atrial Fibrillation
AT1 mutations and risk of atrial fibrillation based on genotypes from 71,000 individuals from the general population.
Atrial Fibrillation
Direct action of an angiotensin II receptor blocker on angiotensin II-induced left atrial conduction delay in spontaneously hypertensive rats.
Atrial Fibrillation
Does treatment of hypertension decrease the incidence of atrial fibrillation and cardioembolic stroke?
Atrial Fibrillation
Rationale and design of the GISSI-Atrial Fibrillation Trial: a randomized, prospective, multicentre study on the use of valsartan, an angiotensin II AT1-receptor blocker, in the prevention of atrial fibrillation recurrence.
Atrial Fibrillation
[Atrial fibrillation as end point of hypertension. Can antihypertensive therapy prevent it?]
Azotemia
Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis.
Bacterial Infections
Nonpeptide antagonists of AT1 receptor for angiotensin II delay the onset of acute respiratory distress syndrome.
Bartter Syndrome
Angiotensin II type 1 receptor gene abnormality in a patient with Bartter's syndrome.
Blister
Involvement of the angiotensin II type 2 receptor in apoptosis during human fetal adrenal gland development.
Bradycardia
AT2 and MAS (but not AT1) angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats.
Bradycardia
Brain angiotensin receptors and sympathoadrenal regulation during insulin-induced hypoglycemia.
Bradycardia
Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.
Bradycardia
Cardiovascular effects after the intracerebroventricular administration of peptide and nonpeptide angiotensin antagonists in Dahl salt-sensitive rats.
Bradycardia
Differential effects of angiotensin II on cardiorespiratory reflexes mediated by nucleus tractus solitarii - a microinjection study in the rat.
Bradycardia
Early Training-Induced Reduction of Angiotensinogen in Autonomic Areas-The Main Effect of Exercise on Brain Renin-Angiotensin System in Hypertensive Rats.
Bradycardia
[Angiotensin II Regulates Excitability and Contractile Functions of Myocardium and Smooth Muscles through Autonomic Nervous Transmission].
Brain Diseases
Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders.
Brain Diseases
Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis.
Brain Edema
Candesartan attenuates ischemic brain edema and protects the blood-brain barrier integrity from ischemia/reperfusion injury in rats.
Brain Edema
Losartan versus enalapril on cerebral edema and proteinuria in stroke-prone hypertensive rats.
Brain Edema
Pain threshold, learning and formation of brain edema in mice lacking the angiotensin II type 2 receptor.
Brain Injuries
Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury.
Brain Injuries
Angiotensin II Receptor 1 Blockage Limits Brain Damage and Improves Functional Outcome After Brain Injury in Aged Animals Despite Age-Dependent Reduction in AT1 Expression.
Brain Injuries
AT1 receptor blocker candesartan-induced attenuation of brain injury of rats subjected to chronic cerebral hypoperfusion.
Brain Injuries
Attenuation of stroke damage by angiotensin II type 2 receptor stimulation via peroxisome proliferator-activated receptor-gamma activation.
Brain Injuries
Beneficial effects of combination of valsartan and amlodipine on salt-induced brain injury in hypertensive rats.
Brain Injuries
Excess salt causes cerebral neuronal apoptosis and inflammation in stroke-prone hypertensive rats through angiotensin II-induced NADPH oxidase activation.
Brain Injuries
Losartan inhibits development of spontaneous recurrent seizures by preventing astrocyte activation and attenuating blood-brain barrier permeability following pilocarpine-induced status epilepticus.
Brain Injuries
Neuroprotective potential of azilsartan against cerebral ischemic injury: Possible involvement of mitochondrial mechanisms.
Brain Injuries
Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury.
Brain Injuries
Selective blockade of AT1 receptor attenuates impairment of hypotensive autoregulation and improves cerebral blood flow after brain injury in the newborn pig.
Brain Injuries, Traumatic
Angiotensin II Type 1 receptor deficiency protects against the impairment of blood-brain barrier in a mouse model of traumatic brain injury.
Brain Ischemia
Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury.
Brain Ischemia
Associations of renin-angiotensin system genetic polymorphisms and clinical course after aneurysmal subarachnoid hemorrhage.
Brain Ischemia
AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats.
Brain Ischemia
Blockade of Central Angiotensin II AT1 Receptor Protects the Brain from Ischemia/Reperfusion Injury in Normotensive Rats.
Brain Ischemia
BR 09-3 AT2R STIMULATION AND ITS EFFECT ON TARGET ORGAN DAMAGE: THERAPEUTIC IMPLICATIONS.
Brain Ischemia
Cerebral ischemia enhances vascular angiotensin AT1 receptor-mediated contraction in rats.
Brain Ischemia
Cerebral ischemia induced inflammatory response and altered glutaminergic function mediated through brain AT1 and not AT2 receptor.
Brain Ischemia
Intracisternal administration of Angiotensin II AT1 receptor antisense oligodeoxynucleotides protects against cerebral ischemia in spontaneously hypertensive rats.
Brain Ischemia
Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor.
Brain Ischemia
Neuroprotective potential of azilsartan against cerebral ischemic injury: Possible involvement of mitochondrial mechanisms.
Brain Ischemia
Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inhibition.
Brain Ischemia
Platelet-endothelial cell interaction in brain microvessels of angiotensin II type-2 receptor knockout mice following transient bilateral common carotid artery occlusion.
Brain Ischemia
Prevention and intervention studies with telmisartan, ramipril and their combination in different rat stroke models.
Brain Ischemia
Protective effect of candesartan in experimental ischemic stroke in the rat mediated by AT2 and AT4 receptors.
Brain Ischemia
Protective effect of irbesartan, an angiotensin II receptor antagonist, alone and in combination with aspirin on middle cerebral artery occlusion model of focal cerebral ischemia in rats.
Brain Ischemia
Protective mechanisms of the angiotensin II type 1 receptor blocker candesartan against cerebral ischemia: in-vivo and in-vitro studies.
Brain Ischemia
Stroke prevention with losartan in the context of other antihypertensive drugs.
Brain Ischemia
Sustained blockade of brain AT1 receptors before and after focal cerebral ischemia alleviates neurologic deficits and reduces neuronal injury, apoptosis, and inflammatory responses in the rat.
Brain Ischemia
Synergistic protective effects of erythropoietin and olmesartan on ischemic stroke survival and post-stroke memory dysfunctions in the gerbil.
Brain Ischemia
The calcium-channel blocker, azelnidipine, enhances the inhibitory action of AT1 receptor blockade on ischemic brain damage.
Brain Ischemia
The pathophysiologic role of the brain renin-angiotensin system in stroke protection: clinical implications.
Brain Ischemia
The Promyelocytic Leukemia Zinc Finger (PLZF) Protein Exerts Neuroprotective Effects in Neuronal Cells and is Dysregulated in Experimental Stroke.
Brain Ischemia
Transient Mild Cerebral Ischemia Significantly Deteriorated Cognitive Impairment in a Mouse Model of Alzheimer's Disease via Angiotensin AT1 Receptor.
Breast Neoplasms
A Novel Cellular Model to Study Angiotensin II AT2 Receptor Function in Breast Cancer Cells.
Breast Neoplasms
Angiotensin II activates extracellular signal regulated kinases via protein kinase C and epidermal growth factor receptor in breast cancer cells.
Breast Neoplasms
Angiotensin II stimulation of Na+/K+ATPase activity and cell growth by calcium-independent pathway in MCF-7 breast cancer cells.
Breast Neoplasms
Anti-cancer actions of a recombinant antibody (R6313/G2) against the angiotensin II AT1 receptor.
Breast Neoplasms
Association between AT1 and AT2 angiotensin II receptor expression with cell proliferation and angiogenesis in operable breast cancer.
Breast Neoplasms
Challenging the roles of CD44 and lipolysis stimulated lipoprotein receptor in conveying Clostridium perfringens iota toxin cytotoxicity in breast cancer.
Breast Neoplasms
Correction to: Nongenomic oestrogen signalling in oestrogen receptor negative breast cancer cells: a role for the angiotensin II receptor AT1.
Breast Neoplasms
Effects of Angiotensin, vasopressin and aldosterone on proliferation of mcf-7 cells and their sensitivity to Doxorubicin.
Breast Neoplasms
G-protein coupled receptors of the renin-angiotensin system: new targets against breast cancer?
Breast Neoplasms
Glutamyl- but not aspartyl-aminopeptidase activity is modified in serum of N-methyl nitrosourea-induced rat mammary tumours.
Breast Neoplasms
Growth stimulatory angiotensin II type-1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma.
Breast Neoplasms
Nongenomic oestrogen signalling in oestrogen receptor negative breast cancer cells: a role for the angiotensin II receptor AT1.
Bronchopulmonary Dysplasia
Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture.
Carcinogenesis
Adrenal angiotensin II type 1 and type 2 receptors in Cushing's and Conn's syndromes.
Carcinogenesis
Analysis of the biological function of ELDF15 using an antisense recombinant expression vector.
Carcinogenesis
Angiotensin 1-7 inhibits angiotensin II-stimulated head and neck cancer progression.
Carcinogenesis
Angiotensin II type 2 receptor gene deficiency attenuates susceptibility to tobacco-specific nitrosamine-induced lung tumorigenesis: involvement of transforming growth factor-beta-dependent cell growth attenuation.
Carcinogenesis
Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals.
Carcinogenesis
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas.
Carcinoma
Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38.
Carcinoma
Angiotensin II receptor subtypes in the human renal cortex and renal cell carcinoma.
Carcinoma
Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice.
Carcinoma
Assessing p-Glycoprotein (Pgp) Activity In Vivo Utilizing (68)Ga-Schiff Base Complexes.
Carcinoma
AT1 angiotensin II receptor subtype in the human larynx and squamous laryngeal carcinoma.
Carcinoma
AT1 receptor and ACE mRNA are increased in chemically induced carcinoma of rat mammary gland.
Carcinoma
Decreasing the thresholds for electroporation by sensitizing cells with local cationic anesthetics and substances that decrease the surface negative electric charge.
Carcinoma
Differences between squamous cell carcinoma and keratoacanthoma in angiotensin type-1 receptor expression.
Carcinoma
Direct determination of intracellular daunorubicin in intact confluent monolayers of AT1 prostate carcinoma cells using a multiwell-multilabel counter.
Carcinoma
Extracellular Acidosis Modulates the Expression of Epithelial-Mesenchymal Transition (EMT) Markers and Adhesion of Epithelial and Tumor Cells.
Carcinoma
Functional Impact of Acidosis-Regulated MicroRNAs on the Migration and Adhesion of Tumor Cells.
Carcinoma
Growth stimulatory angiotensin II type-1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma.
Carcinoma
Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy.
Carcinoma
Immunohistochemical study of angiotensin receptors in human anagen hair follicles and basal cell carcinoma.
Carcinoma
Impact of the acidic environment on gene expression and functional parameters of tumors in vitro and in vivo.
Carcinoma
Inhibition of arginine ADP-ribosyltransferase 1 reduces the expression of poly(ADP-ribose) polymerase-1 in colon carcinoma.
Carcinoma
Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study.
Carcinoma
Measurement of Protein Synthesis: In Vitro Comparison of (68)Ga-DOTA-Puromycin, [ (3)H]Tyrosine, and 2-Fluoro-[ (3)H]tyrosine.
Carcinoma
Regulation of the RhoA/ROCK/AKT/?-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma.
Carcinoma
Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis.
Carcinoma
The Role of MicroRNA Expression for Proliferation and Apoptosis of Tumor Cells: Impact of Hypoxia-Related Acidosis.
Carcinoma
Tubb3 regulation by the Erk and Akt signaling pathways: a mechanism involved in the effect of arginine ADP-ribosyltransferase 1 (Art1) on apoptosis of colon carcinoma CT26 cells.
Carcinoma, Basal Cell
Immunohistochemical study of angiotensin receptors in human anagen hair follicles and basal cell carcinoma.
Carcinoma, Ductal
Growth stimulatory angiotensin II type-1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma.
Carcinoma, Ductal
p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer.
Carcinoma, Hepatocellular
Glucocorticoids regulate the expression of angiotensin AT1 receptors, in the human hepatoma cell line, PLC-PRF-5.
Carcinoma, Intraductal, Noninfiltrating
Growth stimulatory angiotensin II type-1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma.
Carcinoma, Intraductal, Noninfiltrating
p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer.
Carcinoma, Lewis Lung
Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis.
Carcinoma, Non-Small-Cell Lung
Angiotensin II elevates cytosolic free calcium in human lung adenocarcinoma cells via activation of AT1 receptors.
Carcinoma, Pancreatic Ductal
Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice.
Carcinoma, Renal Cell
Angiotensin II receptor subtypes in the human renal cortex and renal cell carcinoma.
Carcinoma, Squamous Cell
Differences between squamous cell carcinoma and keratoacanthoma in angiotensin type-1 receptor expression.
Carcinoma, Squamous Cell
The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology.
Cardiomegaly
A newly developed angiotensin II type 1 receptor antagonist, CS866, promotes regression of cardiac hypertrophy by reducing integrin beta1 expression.
Cardiomegaly
A novel mechanism of mechanical stress-induced angiotensin II type 1-receptor activation without the involvement of angiotensin II.
Cardiomegaly
Anabolic Steroid Associated To Physical Training Induces Deleterious Cardiac Effects.
Cardiomegaly
Ang-(1-7) is an endogenous ?-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy.
Cardiomegaly
Angiotensin AT1 receptor antagonism and protection against cardiovascular end-organ damage.
Cardiomegaly
Angiotensin AT1 receptor blockade fails to attenuate pressure-overload cardiac hypertrophy in fetal sheep.
Cardiomegaly
Angiotensin AT1 receptor-mediated attenuation of cardiac hypertrophy due to volume overload: involvement of endothelin.
Cardiomegaly
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
Cardiomegaly
Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload.
Cardiomegaly
Angiotensin II receptor expression and inhibition in the chronically hypoxic rat lung.
Cardiomegaly
Angiotensin II stimulation of left ventricular hypertrophy in adult rat heart. Mediation by the AT1 receptor.
Cardiomegaly
Angiotensin II type 2 receptor blockade partially negates antihypertrophic effects of type 1 receptor blockade on pressure-overload rat cardiac hypertrophy.
Cardiomegaly
Angiotensin II type I receptor antagonist inhibits the gene expression of transforming growth factor-beta 1 and extracellular matrix in cardiac and vascular tissues of hypertensive rats.
Cardiomegaly
AT1 receptor A/C1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy.
Cardiomegaly
AT1 receptor antagonist, TCV 116, does not prevent cardiac hypertrophy in salt-loaded Dahl salt-sensitive rats.
Cardiomegaly
AT1 receptor blockade is superior to conventional triple therapy in protecting against end-organ damage in Cyp1a1-Ren-2 transgenic rats with inducible hypertension.
Cardiomegaly
AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats.
Cardiomegaly
AT1 receptor density changes during development of hypertension in hyperinsulinemic rats.
Cardiomegaly
AT1 receptor participates in the cardiac hypertrophy induced by resistance training in rats.
Cardiomegaly
Attenuation of Angiotensin II-Induced Hypertension and Cardiac Hypertrophy in Transgenic Mice Overexpressing a Type 1 Receptor Mutant.
Cardiomegaly
Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6.
Cardiomegaly
Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats.
Cardiomegaly
Cardiac angiotensin II receptor populations during aortocaval fistulae, AII and beta adrenergic receptor blockade.
Cardiomegaly
Cardiac AT1 receptor-dependent and IGF1 receptor-independent signaling is activated by a single bout of resistance exercise.
Cardiomegaly
Cardiac collagen remodeling in the cardiomyopathic Syrian hamster and the effect of losartan.
Cardiomegaly
Cardiac hypertrophy and fibrosis in chronic L-NAME-treated AT2 receptor-deficient mice.
Cardiomegaly
Cardiac hypertrophy is associated with decreased eNOS expression in angiotensin AT2 receptor-deficient mice.
Cardiomegaly
Cardiac microvascular rarefaction in hyperthyroidism-induced left ventricle dysfunction.
Cardiomegaly
Cardiac senescence is associated with enhanced expression of angiotensin II receptor subtypes.
Cardiomegaly
Cardiac type-1 angiotensin II receptor status in deoxycorticosterone acetate-salt hypertension in rats.
Cardiomegaly
Chronic AT1 receptor blockade and angiotensin-converting enzyme (ACE) inhibition in (CHF 146) cardiomyopathic hamsters: effects on cardiac hypertrophy and survival.
Cardiomegaly
Comparative effects of chronic ACE inhibition and AT1 receptor blocked losartan on cardiac hypertrophy and renal function in hypertensive patients.
Cardiomegaly
Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat.
Cardiomegaly
Comparison of the angiotensin II type 1-receptor antagonist YM358 and the angiotensin-converting enzyme inhibitor enalapril in rats with cardiac volume overload.
Cardiomegaly
Contribution of local renin-angiotensin system to cardiac hypertrophy, phenotypic modulation, and remodeling in TGR (mRen2)27 transgenic rats.
Cardiomegaly
Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy.
Cardiomegaly
Effect of an ACE inhibitor and an AT1 receptor antagonist on cardiac hypertrophy.
Cardiomegaly
Effect of an angiotensin II receptor antagonist, TCV-116, on cardiac hypertrophy and coronary circulation in spontaneously hypertensive rats.
Cardiomegaly
Effect of an AT1 receptor antagonist (CV-11974) on angiotensin II-induced cardiomyocyte hypertrophy in vitro.
Cardiomegaly
Effect of AT2 blockade on cardiac hypertrophy as induced by high dietary salt in the proatrial natriuretic peptide (ANP) gene-disrupted mouse.
Cardiomegaly
Effects of an AT1 receptor antagonist, an ACE inhibitor and a calcium channel antagonist on cardiac gene expressions in hypertensive rats.
Cardiomegaly
Effects of angiotensin AT1 receptor antagonist on volume overload-induced cardiac gene expression in rats.
Cardiomegaly
Effects of angiotensin-converting enzyme inhibition and angiotensin II AT1 receptor antagonism on cardiac parameters in left ventricular hypertrophy.
Cardiomegaly
Effects of AT1 receptor blockade on blood pressure and the renin-angiotensin system in spontaneously hypertensive rats of the stroke prone strain.
Cardiomegaly
Effects of des-aspartate-angiotensin I on the expression of angiotensin AT1 and AT2 receptors in ventricles of hypertrophic rat hearts.
Cardiomegaly
Effects of the new angiotensin receptor antagonist dipotassium (Z)-2-[[5-ethyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl] methyl-1,3,4-thiadiazoline-2-ylidene]aminocarbonyl]-1-cy clopentencarbox ylate on experimental cardiac hypertrophy and acute left ventricular failure.
Cardiomegaly
Endothelin-1 and angiotensin II receptors in cells from rat hypertrophied heart. Receptor regulation and intracellular Ca2+ modulation.
Cardiomegaly
Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates ACE and AT1 receptor gene expression and signaling: role in cardiac hypertrophy.
Cardiomegaly
Genetically modified mouse models used for studying the role of the AT2 receptor in cardiac hypertrophy and heart failure.
Cardiomegaly
Guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart.
Cardiomegaly
High-density lipoprotein inhibits mechanical stress-induced cardiomyocyte autophagy and cardiac hypertrophy through angiotensin II type 1 receptor-mediated PI3K/Akt pathway.
Cardiomegaly
Isosorbide dinitrate inhibits mechanical stress-induced cardiac hypertrophy and autophagy through downregulation of angiotensin II type 1 receptor.
Cardiomegaly
Living high training low induces physiological cardiac hypertrophy accompanied by down-regulation and redistribution of the renin-angiotensin system.
Cardiomegaly
Loss-of-function polymorphic variants of the human angiotensin II type 1 receptor.
Cardiomegaly
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding.
Cardiomegaly
Overexpression of insulin-like growth factor-I in hearts of rats with isoproterenol-induced cardiac hypertrophy.
Cardiomegaly
Overexpression of the human angiotensin II type 1 receptor in the rat heart augments load induced cardiac hypertrophy.
Cardiomegaly
Rat angiotensin II (type 1A) receptor mRNA regulation and subtype expression in myocardial growth and hypertrophy.
Cardiomegaly
Regulation of atrial contraction by PKA and PKC during development and regression of eccentric cardiac hypertrophy.
Cardiomegaly
Role of angiotensin AT1 and AT2 receptors in cardiac hypertrophy and cardiac remodelling.
Cardiomegaly
Role of angiotensin AT1, and AT2 receptors in cardiac hypertrophy and disease.
Cardiomegaly
Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice.
Cardiomegaly
Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy.
Cardiomegaly
Solving the cardiac hypertrophy riddle: The angiotensin II-mechanical stress connection.
Cardiomegaly
Spironolactone Prevents Endothelial Nitric Oxide Synthase Uncoupling and Vascular Dysfunction Induced by ?-Adrenergic Overstimulation: Role of Perivascular Adipose Tissue.
Cardiomegaly
The Angiotensin II Type 1(AT1) Receptor and Cardiac Hypertrophy: Did We Have It Wrong All Along?
Cardiomegaly
The role of the AT1 angiotensin receptor in cardiac hypertrophy: angiotensin II receptor or stretch sensor?
Cardiomegaly
[Blockade of renin-angiotensin system attenuates cardiac remodeling in rats undergoing aortic stenosis]
Cardiomegaly
[Mechanisms underlying angiotensin II-independent activation of angiotensin II type 1 receptor].
Cardiomyopathies
Angiotensin II type 1a receptor mediates doxorubicin-induced cardiomyopathy.
Cardiomyopathies
Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice.
Cardiomyopathies
Angiotensin receptor type 1 mRNA in human right ventricular endomyocardial biopsies: downregulation in heart failure.
Cardiomyopathies
Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression.
Cardiomyopathies
Cardiac collagen remodeling in the cardiomyopathic Syrian hamster and the effect of losartan.
Cardiomyopathies
Impact of early life AT1 blockade on adult cardiac morpho-functional changes and the renin-angiotensin system in a model of neonatal high oxygen-induced cardiomyopathy.
Cardiomyopathies
Taurine may prevent diabetic rats from developing cardiomyopathy also by downregulating angiotensin II type2 receptor expression.
Cardiomyopathy, Dilated
Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice.
Cardiomyopathy, Dilated
Angiotensin receptor type 1 mRNA in human right ventricular endomyocardial biopsies: downregulation in heart failure.
Cardiomyopathy, Dilated
Angiotensin-converting enzyme inhibitors improve coronary flow reserve in dilated cardiomyopathy by a bradykinin-mediated, nitric oxide-dependent mechanism.
Cardiomyopathy, Dilated
AT1 and AT2 angiotensin receptor gene expression in human heart failure.
Cardiomyopathy, Dilated
Differential distribution of angiotensin AT2 receptors in the normal and failing human heart.
Cardiomyopathy, Dilated
Effects of losartan on the collagen degradative enzymes in hypertrophic and congestive types of cardiomyopathic hamsters.
Cardiomyopathy, Dilated
Impact of repeated intravenous bone marrow mesenchymal stem cells infusion on myocardial collagen network remodeling in a rat model of doxorubicin-induced dilated cardiomyopathy.
Cardiomyopathy, Dilated
Up-regulated expression of angiotensin II type 1 receptor gene in human pathologic hearts.
Cardiomyopathy, Dilated
Ventricular-specific expression of angiotensin II type 2 receptors causes dilated cardiomyopathy and heart failure in transgenic mice.
Cardiomyopathy, Hypertrophic
AT1 blockade abolishes left ventricular hypertrophy in heterozygous cMyBP-C null mice: role of FHL1.
Cardiomyopathy, Hypertrophic
AT1 receptor A/C1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy.
Cardiotoxicity
Mitochondrial ROS-induced ERK1/2 Activation and HSF2-mediated AT1 R Upregulation Are Required for Doxorubicin-induced Cardiotoxicity.
Cardiovascular Diseases
A novel mechanism of mechanical stress-induced angiotensin II type 1-receptor activation without the involvement of angiotensin II.
Cardiovascular Diseases
Angiotensin II and coronary artery disease, congestive heart failure, and sudden cardiac death.
Cardiovascular Diseases
Angiotensin II type 1 receptor A1166C gene polymorphism and essential hypertension in San Luis.
Cardiovascular Diseases
Angiotensin II type 2 receptor gene polymorphisms in cardiovascular disease.
Cardiovascular Diseases
Antibodies against AT1 receptors are associated with vascular endothelial and smooth muscle function impairment: protective effects of hydroxysafflor yellow A.
Cardiovascular Diseases
Apoptosis induction and inhibition of cellular proliferation by angiotensin II: possible implication and perspectives.
Cardiovascular Diseases
Are reactive oxygen species important mediators of vascular dysfunction?
Cardiovascular Diseases
Association between AT C573T polymorphism and cardiovascular risk factors in myocardial infarction.
Cardiovascular Diseases
Biphasic effects of angiotensin II and receptor antagonism on aggregability and protein kinase C phosphorylation in human platelets.
Cardiovascular Diseases
Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects.
Cardiovascular Diseases
Cartilage oligomeric matrix protein is an endogenous ?-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury.
Cardiovascular Diseases
Cells on a chip--the use of electric properties for highly sensitive monitoring of blood-derived factors involved in angiotensin II type 1 receptor signalling.
Cardiovascular Diseases
Central inhibition of AT1receptors by eprosartan--in vitro autoradiography in the brain.
Cardiovascular Diseases
Cerebroprotection mediated by angiotensin II: a hypothesis supported by recent randomized clinical trials.
Cardiovascular Diseases
Characterization of polymorphisms in the promoter of the human angiotensin II subtype 1 (AT1) receptor gene.
Cardiovascular Diseases
Des-aspartate-angiotensin I causes specific release of PGE2 and PGI2 in HUVEC via the angiotensin AT1 receptor and biased agonism.
Cardiovascular Diseases
In vitro pharmacology of a novel non-peptide angiotensin II-receptor antagonist, E4177.
Cardiovascular Diseases
Integration of multi-scale molecular modeling approaches with experiments for the in silico guided design and discovery of novel hERG-Neutral antihypertensive oxazalone and imidazolone derivatives and analysis of their potential restrictive effects on cell proliferation.
Cardiovascular Diseases
Loss-of-function polymorphic variants of the human angiotensin II type 1 receptor.
Cardiovascular Diseases
Management of hypertension: the advent of a new angiotensin II receptor antagonist.
Cardiovascular Diseases
Modulation by bradykinin and nitric oxide of angiotensin II-induced apoptosis in a vascular smooth muscle cell phenotype.
Cardiovascular Diseases
Molecular biology of angiotensin receptors and their role in human cardiovascular disease.
Cardiovascular Diseases
Multiple templates-based homology modeling enhances structure quality of AT1 receptor: validation by molecular dynamics and antagonist docking.
Cardiovascular Diseases
Negative feedback regulation of reactive oxygen species on AT1 receptor gene expression.
Cardiovascular Diseases
Neuroendocrine mechanisms of acupuncture in the treatment of hypertension.
Cardiovascular Diseases
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding.
Cardiovascular Diseases
Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
Cardiovascular Diseases
Pleiotropic Effects of Angiotensin II Receptor Signaling in Cardiovascular Homeostasis and Aging.
Cardiovascular Diseases
RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane.
Cardiovascular Diseases
Recent studies with eplerenone, a novel selective aldosterone receptor antagonist.
Cardiovascular Diseases
Role of angiotensin II AT1 receptor activation in cardiovascular diseases.
Cardiovascular Diseases
Running Exercise and Angiotensin II Type I Receptor Blocker Telmisartan Are Equally Effective in Preventing Angiotensin II-Mediated Vulnerable Atherosclerotic Lesions.
Cardiovascular Diseases
Safety and efficacy of eprosartan, a new angiotensin II receptor blocker.
Cardiovascular Diseases
Targeting the Angiotensin II Type 1 Receptor in Cerebrovascular Diseases: Biased Signaling Raises New Hopes.
Cardiovascular Diseases
The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans-inhibition.
Cardiovascular Diseases
The role of tyrosine phosphorylation in angiotensin II mediated intracellular signaling and cell growth.
Cardiovascular Diseases
[6]-Gingerol: A Novel AT1 Antagonist for the Treatment of Cardiovascular Disease.
Cardiovascular Diseases
[AT1 angiotensin receptor inhibition as a new therapeutic possibility]
Cardiovascular Diseases
[Candesartan cilexetil: pharmacological properties and protective effects against organ damage of a novel nonpeptide angiotensin II-receptor antagonist]
Cardiovascular Diseases
[Mechanisms underlying angiotensin II-independent activation of angiotensin II type 1 receptor].
Cardiovascular Diseases
[Prevention of progression and regression of target organ damage. Future strategies].
Cardiovascular Diseases
[Selective knockdown of Angiotensin II receptor subtype 1a in rat vascular smooth muscle cells by RNA interference]
Carotid Stenosis
Direct angiotensin II type 2 receptor stimulation by compound 21 prevents vascular dementia.
Cerebral Hemorrhage
Blockade of AT1 receptor reduces apoptosis, inflammation, and oxidative stress in normotensive rats with intracerebral hemorrhage.
Cerebral Infarction
Cerebroprotective effects of angiotensin II (AT 1) receptor antagonists?
Cerebrovascular Disorders
Effect of compound EXP-2528 on angiotensin II-induced E-selectin and VCAM-1 expression in rat brain microvascular endothelial cells in vitro.
Cerebrovascular Disorders
Targeting the Angiotensin II Type 1 Receptor in Cerebrovascular Diseases: Biased Signaling Raises New Hopes.
Cholera
Interspecies relationships among ADP-ribosylation factors (ARFs): evidence of evolutionary pressure to maintain individual identities.
Cholera
Intracellular inhibition of mono(ADP-ribosylation) by meta-iodobenzylguanidine: specificity, intracellular concentration and effects on glucocorticoid-mediated cell lysis.
Cholera
Two distinct pathways in the down-regulation of type-1 angiotension II receptor gene in rat glomerular mesangial cells.
Choriocarcinoma
Angiotensin II augmented migration and invasion of choriocarcinoma cells involves PI3K activation through the AT1 receptor.
Choriocarcinoma
Enhancement of aminopeptidase A expression during angiotensin II-induced choriocarcinoma cell proliferation through AT1 receptor involving protein kinase C- and mitogen-activated protein kinase-dependent signaling pathway.
Colitis
Implication of Clostridium difficile and Clostridium perfringens iota toxins in experimental lincomycin-associated colitis of rabbits.
Colitis
PD123319, angiotensin II type II receptor antagonist, inhibits oxidative stress and inflammation in 2, 4-dinitrobenzene sulfonic acid-induced colitis in rat and ameliorates colonic contractility.
Colorectal Neoplasms
Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway.
Congenital Abnormalities
AT2 R deficiency mediated podocyte loss via activation of ectopic hedgehog interacting protein (Hhip) gene expression.
Coronary Artery Disease
Angiotensin II type 1 receptor blockade restores angiotensin-(1-7)-induced coronary vasodilation in hypertrophic rat hearts.
Coronary Artery Disease
Angiotensin II type 1 receptor expression in human coronary arteries with variable degrees of atherosclerosis.
Coronary Artery Disease
Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphism in coronary disease and malignant ventricular arrhythmias.
Coronary Artery Disease
Dose-dependent regulation of NAD(P)H oxidase expression by angiotensin II in human endothelial cells: protective effect of angiotensin II type 1 receptor blockade in patients with coronary artery disease.
Coronary Artery Disease
Effects of AT1 receptor antagonism with candesartan on endothelial function in patients with hypertension and coronary artery disease.
Coronary Artery Disease
Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress: the EPAS trial.
Coronary Artery Disease
Expression of Renin-Angiotensin System on Dendritic Cells of Patients with Coronary Artery Disease.
Coronary Artery Disease
Growth response of human coronary smooth muscle cells to angiotensin II and influence of angiotensin AT1 receptor blockade.
Coronary Artery Disease
Localization of the angiotensin II receptor subtypes in the human atrium.
Coronary Artery Disease
The clinical significance of a common, functional, X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) in a cohort of 509 families with premature coronary artery disease.
Coronary Disease
[Association of angiotensin II receptor type 1 gene single nucleotide polymorphism with Chinese essential hypertension complicated with coronary heart disease]
Coronary Disease
[The involvement of the renin-angiotensin system gene polymorphisms in coronary heart disease]
Coronary Occlusion
Early and chronic captopril or Losartan therapy reduces infarct size and avoids congestive heart failure after myocardial infarction in rats.
Coronary Occlusion
Role of augmented expression of intermediate-conductance Ca2+-activated K+ channels in postischaemic heart.
Cough
Antihypertensive efficacy and tolerability of once daily losartan potassium compared with captopril in patients with mild to moderate essential hypertension.
Cough
Antihypertensive therapy targeted to the needs of the patient: focus on the renin-angiotensin system; older and newer agents.
Cough
Comparison of type 1 angiotensin II receptor blockers and angiotensin converting enzyme inhibitors in the treatment of hypertension.
Cough
Recent insight into therapy of congestive heart failure: focus on ACE inhibition and angiotensin-II antagonism.
Cough
The cough reflex is upregulated by lisinopril microinjected into the caudal nucleus tractus solitarii of the rabbit.
COVID-19
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium.
COVID-19
Autoantibodies against ACE2 and angiotensin type-1 receptors increase severity of COVID-19.
COVID-19
Characterization of ACE Inhibitors and AT1R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model.
COVID-19
RAAS Blockade and COVID-19: Mechanistic Modeling of Mas and AT1 Receptor Occupancy as Indicators of Pro-Inflammatory and Anti-Inflammatory Balance.
COVID-19
Renin-angiotensin-system inhibitors and all-cause mortality in patients with COVID-19: a systematic review and meta-analysis of observational studies.
COVID-19
Role of the Backbenchers of the Renin-Angiotensin System ACE2 and AT2 Receptors in COVID-19: Lessons From SARS.
COVID-19
Shape-based Machine Learning Models for the Potential Novel COVID-19 Protease Inhibitors Assisted by Molecular Dynamics Simulation
COVID-19
Single Cell RNA-seq Data Analysis Reveals the Potential Risk of SARS-CoV-2 Infection Among Different Respiratory System Conditions.
Cushing Syndrome
Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals.
Cystic Fibrosis
Human alveolar type II cells secrete and absorb liquid in response to local nucleotide signaling.
Cysts
FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury.
Cysts
Renal cyst growth is the main determinant for hypertension and concentrating deficit in Pkd1-deficient mice.
Dehydration
Differential regulation of angiotensinogen and AT1A receptor mRNA within the rat subfornical organ during dehydration.
Dehydration
Effects of dehydration and blockade of angiotensin II AT1 receptor on stress hormones and anti-oxidants in the one-humped camel.
Dehydration
Inhibitory effect of DUP-753 on the drinking responses of rats to central administration of noradrenaline and angiotensin II and to dehydration.
Dehydration
Neuroendocrine effects of dehydration in mice lacking the angiotensin AT1a receptor.
Dehydration
Responses to dehydration in the one-humped camel and effects of blocking the renin-angiotensin system.
Dehydration
Type 1A angiotensin II receptor is regulated differently in proximal and distal nephron segments.
Dehydration
Water deprivation upregulates ANG II AT1 binding and mRNA in rat subfornical organ and anterior pituitary.
Dementia
Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia.
Dementia
Evaluating the relationship of blood pressure, plasma angiotensin peptides and aldosterone with cognitive functions in patients with hypertension.
Dementia
Pleiotropic Effects of Angiotensin II Receptor Signaling in Cardiovascular Homeostasis and Aging.
Dementia, Vascular
Direct angiotensin II type 2 receptor stimulation by compound 21 prevents vascular dementia.
Diabetes Complications
Activation of AT2 receptors prevents diabetic complications in female db/db mice by NO-mediated mechanisms.
Diabetes Insipidus
Regulation of AQP2 in Collecting Duct : An emphasis on the Effects of Angiotensin II or Aldosterone.
Diabetes Mellitus
ANG II type I receptor antagonism improved nitric oxide production and enhanced eNOS and PKB/Akt expression in hearts from a rat model of insulin resistance.
Diabetes Mellitus
Counter-regulatory effects played by the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications.
Diabetes Mellitus
Deletion of AT2 Receptor Prevents SHP-1-Induced VEGF Inhibition and Improves Blood Flow Reperfusion in Diabetic Ischemic Hindlimb.
Diabetes Mellitus
Effects of candesartan cilexetil on glucose homeostasis. Multicenter Study Group.
Diabetes Mellitus
Elevation of [Ca2+]i of renal proximal tubular cells and down-regulation of mRNA of PTH-PTHrP, V1a and AT1 receptors in kidney of diabetic rats.
Diabetes Mellitus
Expression of Angiotensin II Type 1 Receptor in Rat Bladder Smooth Muscle Cells in Response to a Streptzotocin Induced Diabetes Mellitus Model.
Diabetes Mellitus
Renal AT1 receptor protein expression during the early stage of diabetes mellitus.
Diabetes Mellitus
Renal vascular responses to captopril and to candesartan in patients with type 1 diabetes mellitus.
Diabetes Mellitus
Role of renin angiotensin system inhibitors in cardiovascular and renal protection: a lesson from clinical trials.
Diabetes Mellitus
The effect of oral glucose loads on tissue metabolism during angiotensin II receptor and beta-receptor blockade in obese hypertensive subjects.
Diabetes Mellitus
[Are beta blockers no longer the medicines of choice for the treatment of hypertension?]
Diabetes Mellitus, Experimental
Kinins or nitric oxide, or both, are involved in the antitrophic effects of angiotensin converting enzyme inhibitors on diabetes-associated mesenteric vascular hypertrophy in the rat.
Diabetes Mellitus, Type 1
DR-BB rat thymus contains thymocyte populations predisposed to autoreactivity.
Diabetes Mellitus, Type 1
Elevation of [Ca2+]i of renal proximal tubular cells and down-regulation of mRNA of PTH-PTHrP, V1a and AT1 receptors in kidney of diabetic rats.
Diabetes Mellitus, Type 1
Expression of NAD glycohydrolase activity by rat mammary adenocarcinoma cells transformed with rat T cell alloantigen RT6.2.
Diabetes Mellitus, Type 1
Importance of donor-derived lymphocytes in the protection of pancreaticoduodenal or islet grafts from recurrent autoimmunity: a role for RT6+NKR-P1+ T cells.
Diabetes Mellitus, Type 1
Mono(ADP-ribosyl)transferase genes and diabetes in NOD mice. Is there a relationship?
Diabetes Mellitus, Type 1
Renal vascular responses to captopril and to candesartan in patients with type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
The effect of immunomodulators on prevention of autoimmune diabetes is stage dependent: FTY720 prevents diabetes at three different stages in the diabetes-resistant biobreeding rat.
Diabetes Mellitus, Type 1
The effects of valsartan on the accumulation of circulating and renal advanced glycation end products in experimental diabetes.
Diabetes Mellitus, Type 1
[Efficacy of valsartan in the treatment of persistent microalbuminuria in normotensive patients with type 1 diabetes]
Diabetes Mellitus, Type 2
ANG II type I receptor antagonism improved nitric oxide production and enhanced eNOS and PKB/Akt expression in hearts from a rat model of insulin resistance.
Diabetes Mellitus, Type 2
Angiotensin blockade improves cardiac and renal complications of type II diabetic rats.
Diabetes Mellitus, Type 2
Autoantibodies against ?1 receptor and AT1 receptor in type 2 diabetes patients with left ventricular dilatation.
Diabetes Mellitus, Type 2
Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes.
Diabetes Mellitus, Type 2
Genetic studies of the renin-angiotensin system in arterial hypertension associated with non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist.
Diabetes Mellitus, Type 2
Inhibiting angiotensin type 1 receptors as a target for diabetes.
Diabetes Mellitus, Type 2
Inhibition of cellular transdifferentiation by losartan minimizes but does not reverse type 2 diabetes-induced renal fibrosis.
Diabetes Mellitus, Type 2
Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats.
Diabetes Mellitus, Type 2
Regional variation in the prescribing for diabetes and use of secondary preventative therapies in Ireland.
Diabetes Mellitus, Type 2
Renin-angiotensin system inhibition prevents type 2 diabetes mellitus. Part 2. Overview of physiological and biochemical mechanisms.
Diabetes Mellitus, Type 2
Renoprotective effects of blockade of angiotensin II AT1 receptors in an animal model of type 2 diabetes.
Diabetes Mellitus, Type 2
Role of renin angiotensin system inhibitors in cardiovascular and renal protection: a lesson from clinical trials.
Diabetes Mellitus, Type 2
The angiotensin II receptor antagonist valsartan enhances lipoprotein lipase mass in preheparin serum in type 2 diabetes with hypertension.
Diabetes Mellitus, Type 2
The renin-angiotensin system and progression of renal disease: from hemodynamics to cell biology.
Diabetes Mellitus, Type 2
The role of angiotensin II antagonism in type 2 diabetes mellitus: a review of renoprotection studies.
Diabetes Mellitus, Type 2
[NAVIGATOR: A trial of prevention of cardiovascular complications and type 2 diabetes with valsartan and/or nateglinide]
Diabetes Mellitus, Type 2
[THE ROLE OF MARKER FIBROSIS ST2 AND ANGIOTENZINOGEN GENE POLYMORPHISM IN HEART FAILURE PROGRESSING IN PATIENTS WITH TYPE 2 DIABETES MELLITUS].
Diabetic Cardiomyopathies
Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression.
Diabetic Cardiomyopathies
AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase.
Diabetic Cardiomyopathies
Exposure of cardiomyocytes to angiotensin II induces over-activation of monoamine oxidase type A: Implications in heart failure.
Diabetic Cardiomyopathies
Significance of AT1 Receptor Independent Activation of Mineralocorticoid Receptor in Murine Diabetic Cardiomyopathy.
Diabetic Cardiomyopathies
Taurine may prevent diabetic rats from developing cardiomyopathy also by downregulating angiotensin II type2 receptor expression.
Diabetic Cardiomyopathies
[Research progress in relations between renin angiotensin system and diabetic cardiomyopathy].
Diabetic Nephropathies
Additive hypotensive and anti-albuminuric effects of angiotensin-converting enzyme inhibition and angiotensin receptor antagonism in diabetic spontaneously hypertensive rats.
Diabetic Nephropathies
Angiotensin II receptor type 1 gene expression in human glomerulonephritis and diabetes mellitus.
Diabetic Nephropathies
AT1 receptor antagonists: a challenge for ACE inhibitors in diabetic nephropathy.
Diabetic Nephropathies
AT2 receptor agonist Compound 21: A silver lining for diabetic nephropathy.
Diabetic Nephropathies
Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase.
Diabetic Nephropathies
Differential regulation of angiotensin converting enzyme 2 and nuclear factor-?B by angiotensin II receptor subtypes in type 2 diabetic kidney.
Diabetic Nephropathies
Early streptozotocin-diabetes mellitus downregulates rat kidney AT2 receptors.
Diabetic Nephropathies
KRH-594, a new angiotensin AT1 receptor antagonist, ameliorates nephropathy and hyperlipidaemia in diabetic spontaneously hypertensive rats.
Diabetic Nephropathies
Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist.
Diabetic Nephropathies
Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice.
Diabetic Nephropathies
Major role for ACE-independent intrarenal ANGII formation in type II diabetes.
Diabetic Nephropathies
Podocytes of AT2 Receptor Knockout Mice Are Protected from Angiotensin II-Mediated RAGE Induction.
Diabetic Nephropathies
Possible involvement of intracellular angiotensin II receptor in high-glucose-induced damage in renal proximal tubular cells.
Diabetic Nephropathies
Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats.
Diabetic Nephropathies
Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor.
Diabetic Nephropathies
The effects of angiotensin-II receptor blockers on podocyte damage and glomerular apoptosis in a rat model of experimental streptozotocin-induced diabetic nephropathy.
Diabetic Nephropathies
Time course of the antiproteinuric and antihypertensive effect of losartan in diabetic nephropathy.
Diabetic Nephropathies
Valsartan inhibited HIF-1? pathway and attenuated renal interstitial fibrosis in streptozotocin-diabetic rats.
Diabetic Nephropathies
[Efficacy of valsartan in the treatment of persistent microalbuminuria in normotensive patients with type 1 diabetes]
Diabetic Nephropathies
[Renoprotective effects of ACE inhibitors and AT1 antagonists on diabetic nephropathy beyond blood pressure control]
Diabetic Nephropathies
[Threatened diabetic nephropathy. Early administration of ACE inhibitors and AT1 blockers]
Diabetic Retinopathy
Diabetes and retinal vascular disorders: role of the reninangiotensin system.
Diabetic Retinopathy
Pharmacological and pharmacokinetic study of olmesartan medoxomil in animal diabetic retinopathy models.
Diabetic Retinopathy
Retinal expression of vascular endothelial growth factor is mediated by angiotensin type 1 and type 2 receptors.
Diphtheria
Modulation of diphthamide synthesis by 5'-deoxy-5'-methylthioadenosine in murine lymphoma cells.
Dupuytren Contracture
Angiotensin receptors in Dupuytren's disease: a target for pharmacological treatment?
Dupuytren Contracture
The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology.
Dysautonomia, Familial
[Could the understanding of racial differences prevent idiosyncratic anesthetic reactions?]
Dyskinesias
Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson's disease that increases with levodopa-induced dyskinesia.
Dyskinesias
Potential protective role of ACE-inhibitors and AT1 receptor blockers against levodopa-induced dyskinesias: a retrospective case-control study.
Embolism, Fat
Evidence for angiotensin mediation of the late histopathological effects of pulmonary fat embolism: Protection by losartan in a rat model.
Encephalitis
Chronic Brain Inflammation: The Neurochemical Basis for Drugs to Reduce Inflammation.
Endometriosis
Expression of angiotensin II type 1 (AT1) and angiotensin II type 2 (AT2) receptors in human granulosa-lutein (GL) cells: correlation with infertility diagnoses.
Endometriosis
The Expression of MAS1, an Angiotensin (1-7) Receptor, in the Eutopic Proliferative Endometria of Endometriosis Patients.
Endotoxemia
Involvement of central angiotensin II type 1 receptors in LPS-induced systemic vasopressin release and blood pressure regulation in rats.
Enteritis
Clostridium perfringens type E animal enteritis isolates with highly conserved, silent enterotoxin gene sequences.
Epidermolysis Bullosa Dystrophica
The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology.
Epilepsy
Effect of Combined Treatment with AT1 Receptor Antagonists and Tiagabine on Seizures, Memory and Motor Coordination in Mice.
Epilepsy
Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats.
Epilepsy
Inhibition of the renin-angiotensin system prevents seizures in a rat model of epilepsy.
Epilepsy
Long-Term Treatment with Losartan Attenuates Seizure Activity and Neuronal Damage Without Affecting Behavioral Changes in a Model of Co-morbid Hypertension and Epilepsy.
Epilepsy
The amygdala and intractable temporal lobe epilepsy: a quantitative magnetic resonance imaging study.
Epilepsy
The levels of renin-angiotensin related components are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy.
Epilepsy
The Potential Therapeutic Capacity of Inhibiting the Brain Renin-Angiotensin System in the Treatment of Co-Morbid Conditions in Epilepsy.
Epilepsy
The renin-angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis.
Epilepsy, Temporal Lobe
The levels of renin-angiotensin related components are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy.
Epilepsy, Temporal Lobe
The renin-angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis.
Essential Hypertension
825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension.
Essential Hypertension
A1166C variant of angiotensin II type 1 receptor gene is associated with severe hypertension in pregnancy independently of T235 variant of angiotensinogen gene.
Essential Hypertension
Angiotensin II AT1 receptor gene polymorphism and microalbuminuria in essential hypertension.
Essential Hypertension
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
Essential Hypertension
Angiotensin II type 1 receptor gene polymorphism is associated with increase of left ventricular mass but not with hypertension.
Essential Hypertension
Effect of AT1 receptor blockade on endothelial function in essential hypertension.
Essential Hypertension
Effect of losartan on haematology and haemorheology in elderly patients with essential hypertension: a pilot study.
Essential Hypertension
Effects of losartan on renal function in patients with essential hypertension.
Essential Hypertension
Effects of valsartan on left ventricular diastolic function in patients with mild or moderate essential hypertension: comparison with enalapril.
Essential Hypertension
Eprosartan provides safe and effective long-term maintenance of blood pressure control in patients with mild to moderate essential hypertension.
Essential Hypertension
Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension.
Essential Hypertension
Favourable effects on arterial wave reflection and pulse pressure amplification of adding angiotensin II receptor blockade in resistant hypertension.
Essential Hypertension
Genetic polymorphism of the renin-angiotensin system and organ damage in essential hypertension.
Essential Hypertension
Genome-wide scan of predisposing loci for increased diastolic blood pressure in Finnish siblings.
Essential Hypertension
Hypertension after renal transplantation and polymorphism of genes involved in essential hypertension: ACE, AGT, AT1 R and ecNOS.
Essential Hypertension
Influence of autoantibodies against AT1 receptor and AGTR1 polymorphisms on candesartan-based antihypertensive regimen: results from the study of optimal treatment in hypertensive patients with anti-AT1-receptor autoantibodies trial.
Essential Hypertension
Is there relationship between the A1166C polymorphism of the angiotensin II receptor AT1 and plasma renin activity, insulin resistance and reduction of blood pressure after angiotensin-converting enzyme inhibitor therapy?
Essential Hypertension
Lack of association between angiotensin II type 1 receptor gene polymorphism and hypertension in Japanese.
Essential Hypertension
Pharmacokinetics and blood pressure response of losartan in end-stage renal disease.
Essential Hypertension
Prolonged treatment with the AT1 receptor blocker, valsartan, increases small and large artery compliance in uncomplicated essential hypertension.
Essential Hypertension
Protection against ischemia: a physiological function of the renin-angiotensin system.
Essential Hypertension
Regression of left ventricular hypertrophy by AT1 receptor blockade in renal transplant recipients.
Essential Hypertension
Role of angiotensin II and endogenous vasodilators in the control of glomerular hemodynamics.
Essential Hypertension
The effects of eprosartan, an angiotensin II AT1 receptor antagonist, on uric acid excretion in patients with mild to moderate essential hypertension.
Essential Hypertension
[Association of angiotensin II receptor type 1 gene single nucleotide polymorphism with Chinese essential hypertension complicated with coronary heart disease]
Essential Hypertension
[The usefulness of a new class antihypertensive drug, angiotensin II receptor antagonist, for essential hypertension]
Fatty Liver
ACE Inhibition and AT1 Receptor Blockade Prevent Fatty Liver and Fibrosis in Obese Zucker Rats.
Fatty Liver
Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice.
Fatty Liver
Chronic angiotensin receptor activation promotes hepatic triacylglycerol accumulation during an acute glucose challenge in obese-insulin-resistant OLETF rats.
Fetal Growth Retardation
Angiotensin II type 1 receptor agonistic antibodies reflect fundamental alterations in the uteroplacental vasculature.
Fetal Growth Retardation
Cellular localization of AT1 receptor mRNA and protein in normal placenta and its reduced expression in intrauterine growth restriction. Angiotensin II stimulates the release of vasorelaxants.
Fetal Growth Retardation
Disrupted balance of angiogenic and antiangiogenic signalings in preeclampsia.
Fetal Growth Retardation
Influence of aerobic training on the reduced vasoconstriction to angiotensin II in rats exposed to intrauterine growth restriction: possible role of oxidative stress and AT2 receptor of angiotensin II.
Fetal Growth Retardation
Maternal treatment with agonistic autoantibodies against type-1 angiotensin II receptor in late pregnancy increases apoptosis of myocardial cells and myocardial susceptibility to ischemia-reperfusion injury in offspring rats.
Fibrosarcoma
[Effect of expression of exogenous PDGF-A chain on growth and transformation of CHO cells]
Glaucoma
Changes in Corneal Biomechanical Properties after Long-Term Topical Prostaglandin Therapy.
Glaucoma
Effect of CS-088, an angiotensin AT1 receptor antagonist, on intraocular pressure in glaucomatous monkey eyes.
Glioma
Angiotensin II type-2 (AT2) receptor-mediated inhibition of NMDA receptor signalling in neuronal cells.
Glioma
AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma.
Glioma
Blockage of angiotensin II type I receptor decreases the synthesis of growth factors and induces apoptosis in C6 cultured cells and C6 rat glioma.
Glioma
Induction of the angiotensin AT2 receptor subtype expression by differentiation of the neuroblastoma x glioma hybrid, NG-108-15.
Glioma
Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study.
Glioma
Transcriptional network analysis reveals that AT1 and AT2 angiotensin II receptors are both involved in the regulation of genes essential for glioma progression.
Glomerulonephritis
Nature and Mediators of Parietal Epithelial Cell Activation in Glomerulonephritides of Human and Rat.
Glomerulonephritis
[Are the antagonists of angiotensin II AT1 receptors protectors of the kidney?]
Glomerulonephritis, IGA
Supportive Versus Immunosuppressive Therapy of Progressive IgA nephropathy (STOP) IgAN trial: rationale and study protocol.
Glomerulosclerosis, Focal Segmental
Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats.
Glucose Intolerance
Angiotensin receptor and tumor necrosis factor-? activation contributes to glucose intolerance independent of systolic blood pressure in obese rats.
Glucose Intolerance
Epigenetic repression of AT2 receptor is involved in ? cell dysfunction and glucose intolerance of adult female offspring rats exposed to dexamethasone prenatally.
Glucose Intolerance
TAK-536, a new AT1 receptor blocker, improves glucose intolerance and adipocyte differentiation.
Granuloma
Sequential development of angiotensin receptors and angiotensin I converting enzyme during angiogenesis in the rat subcutaneous sponge granuloma.
Hallucinations
The amygdala and temporal lobe simple partial seizures: a prospective and quantitative MRI study.
Hartnup Disease
Accurate discrimination of Hartnup disorder from other aminoacidurias using a diagnostic ratio.
Hartnup Disease
[Hartnup disease is related to a mutation in the SL C6A19 gene coding for the B degrees AT1 aminoacid transporter]
Heart Block
Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block.
Heart Diseases
Local neurohumoral regulation in the transition to isolated diastolic heart failure in hypertensive heart disease: absence of AT1 receptor downregulation and 'overdrive' of the endothelin system.
Heart Diseases
Nitric oxide synthases and heart failure - lessons from genetically manipulated mice.
Heart Diseases
The A1166C polymorphism of the AT1 receptor gene is associated with collagen type I synthesis and myocardial stiffness in hypertensives.
Heart Diseases
Up-regulated expression of angiotensin II type 1 receptor gene in human pathologic hearts.
Heart Diseases
[Study of autoantibodies against the G-protein-coupled beta 2- and alpha 1-adrenergic and AT1 receptors in patients with primary hypertension]
Heart Diseases
[The role of DNA polymorphism in the renin-angiotensin system and the pathogenesis of cardiovascular diseases]
Heart Failure
A case series about the favorable effects of sacubitril/valsartan on anthracycline cardiomyopathy.
Heart Failure
ACE-inhibition and angiotensin II receptor blockers in chronic heart failure: pathophysiological consideration of the unresolved battle.
Heart Failure
Acute effects of E-3174, a human active metabolite of losartan, on the cardiovascular system in tachycardia-induced canine heart failure.
Heart Failure
Additive beneficial effects of the combination of a calcium channel blocker and an angiotensin blocker on a hypertensive rat-heart failure model.
Heart Failure
ADEPT: Addition of the AT1 receptor antagonist eprosartan to ACE inhibitor therapy in chronic heart failure trial: hemodynamic and neurohormonal effects.
Heart Failure
Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock.
Heart Failure
Angiotensin AT1 receptor inhibition in pacing induced heart failure: effects on left ventricular myocardial collagen content and composition.
Heart Failure
Angiotensin AT1 receptor inhibition, angiotensin-converting enzyme inhibition, and combination therapy with developing heart failure: cellular mechanisms of action.
Heart Failure
Angiotensin converting enzyme inhibition, AT1 receptor inhibition, and combination therapy with pacing induced heart failure: effects on left ventricular performance and regional blood flow patterns.
Heart Failure
Angiotensin II AT1 receptor antagonism prevents detrimental renal actions of acute diuretic therapy in human heart failure.
Heart Failure
Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders.
Heart Failure
Angiotensin II blockade [corrected] enhances baroreflex control of sympathetic outflow in heart failure.
Heart Failure
Angiotensin II potentiates the slow component of delayed rectifier K+ current via the AT1 receptor in guinea pig atrial myocytes.
Heart Failure
Angiotensin II receptor antagonists: an emerging new class of cardiovascular therapeutics.
Heart Failure
Angiotensin II receptor blockade prevents acute renal sodium retention induced by low levels of orthostatic stress.
Heart Failure
Angiotensin II type 1a receptor signals are involved in the progression of heart failure in MLP-deficient mice.
Heart Failure
Angiotensin II type 2 receptor deficiency exacerbates heart failure and reduces survival after acute myocardial infarction in mice.
Heart Failure
Angiotensin receptor type 1 mRNA in human right ventricular endomyocardial biopsies: downregulation in heart failure.
Heart Failure
Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications.
Heart Failure
Angiotensin subtype 1 rReceptor (AT1) blockade improves vasorelaxation in heart failure by up-regulation of endothelial nitric-oxide synthase via activation of the AT2 receptor.
Heart Failure
Apoptosis induction and inhibition of cellular proliferation by angiotensin II: possible implication and perspectives.
Heart Failure
AT1 angiotensin II receptor inhibition in pacing-induced heart failure: effects on left ventricular performance and regional blood flow patterns.
Heart Failure
AT1 receptor blocker azilsartan medoxomil normalizes plasma miR-146a and miR-342-3p in a murine heart failure model.
Heart Failure
AT1 receptor blocker, but not an ACE inhibitor, prevents kidneys from hypoperfusion during congestive heart failure in normotensive and hypertensive rats.
Heart Failure
AT1 receptor in paraventricular nucleus mediates the enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure.
Heart Failure
AT1 receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure.
Heart Failure
BLAST-AHF: insights into biased AT1 ligands and heart failure. Beginning of the end or end of the beginning?
Heart Failure
Blockade of AT1 receptors enhances baroreflex control of heart rate in conscious rabbits with heart failure.
Heart Failure
Blood pressure-independent renoprotection in diabetic rats treated with AT1 receptor-neprilysin inhibition compared with AT1 receptor blockade alone.
Heart Failure
Brain AT1 Receptor Activates the Sympathetic Nervous System through Toll-like Receptor 4 in Mice with Heart Failure.
Heart Failure
Captopril and angiotensin II receptor antagonist therapy in a pacing model of heart failure.
Heart Failure
Central AT1 receptors are involved in the enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure.
Heart Failure
Central inhibition of AT1receptors by eprosartan--in vitro autoradiography in the brain.
Heart Failure
Changes of renal AQP2, ENaC, and NHE3 in experimentally induced heart failure: response to angiotensin II AT1 receptor blockade.
Heart Failure
Chronic administration of angiotensin II receptor antagonist, TCV-116, in cardiomyopathic hamsters.
Heart Failure
Chronic AT1 receptor blockade and angiotensin-converting enzyme (ACE) inhibition in (CHF 146) cardiomyopathic hamsters: effects on cardiac hypertrophy and survival.
Heart Failure
Chronic AT1 receptor blockade normalizes NMDA-mediated changes in renal sympathetic nerve activity and NR1 expression within the PVN in rats with heart failure.
Heart Failure
Combined effects of angiotensin converting enzyme inhibition and angiotensin II receptor antagonism in conscious pigs with congestive heart failure.
Heart Failure
Comparison between angiotensin receptor antagonism and converting enzyme inhibition in heart failure. Differential acute effects according to the renin-angiotensin system activation.
Heart Failure
Comparison of type 1 angiotensin II receptor blockers and angiotensin converting enzyme inhibitors in the treatment of hypertension.
Heart Failure
Difficult cases in heart failure: Raison d'Ãtre behind ACE inhibitors and AT1 receptor combinations in chronic heart failure: chemical nuances or clinical significance?
Heart Failure
Diverse effects of AT1 receptor antagonists on normal blood pressure and regulatory system.
Heart Failure
Dose-related beneficial long-term hemodynamic and clinical efficacy of irbesartan in heart failure.
Heart Failure
Effects of ACE inhibitor, AT1 antagonist, and combined treatment in mice with heart failure.
Heart Failure
Effects of acute angiotensin II type 1 receptor antagonism and angiotensin converting enzyme inhibition on plasma fibrinolytic parameters in patients with heart failure.
Heart Failure
Effects of angiotensin II type 1 receptor blockade in ApoE-deficient mice with post-ischemic heart failure.
Heart Failure
Effects of angiotensin receptor antagonists in heart failure: clinical and experimental aspects.
Heart Failure
Effects of AT1 receptor antagonist therapy in patients with severe heart failure pretreated with angiotensin-converting enzyme inhibitors.
Heart Failure
Effects of long-term angiotensin II AT1 receptor blockade on survival, hemodynamics and cardiac remodeling in chronic heart failure in rats.
Heart Failure
From bedside to bench--meeting report of the 7th International Conference on cGMP "cGMP: generators, effectors and therapeutic implications" in Trier, Germany, from June 19th to 21st 2015.
Heart Failure
Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation.
Heart Failure
Genetically modified mouse models used for studying the role of the AT2 receptor in cardiac hypertrophy and heart failure.
Heart Failure
Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation.
Heart Failure
In heart failure with reduced ejection fraction patients' left ventricular global longitudinal strain is enhanced after 1-year therapy with sacubitril/valsartan compared with conventional therapy with angiotensin-converting enzyme-inhibitors or AT1 blockers: results from a retrospective cohort study.
Heart Failure
Initial white blood cell count is an independent risk factor for survival in patients with dilated cardiomyopathy.
Heart Failure
Interaction between AT1 and alpha1-adrenergic receptors in cardiomyopathic hamsters.
Heart Failure
Interaction Between AT1 Receptor and NF-?B in Hypothalamic Paraventricular Nucleus Contributes to Oxidative Stress and Sympathoexcitation by Modulating Neurotransmitters in Heart Failure.
Heart Failure
Interaction between cardiac sympathetic afferent reflex and chemoreflex is mediated by the NTS AT1 receptors in heart failure.
Heart Failure
Leptin, Galectin-3 and Angiotensin II Type 1 Receptor Polymorphism in Overweight and Obese Patients with Heart Failure - Role and Functional Interplay.
Heart Failure
Long-term combined therapy with an angiotensin type I receptor blocker and an angiotensin converting enzyme inhibitor prolongs survival in dilated cardiomyopathy.
Heart Failure
Losartan corrects abnormal frequency response of renal vasculature in congestive heart failure.
Heart Failure
Loss-of-function polymorphic variants of the human angiotensin II type 1 receptor.
Heart Failure
Mechanism of beta-adrenergic receptor upregulation induced by ACE inhibition in cultured neonatal rat cardiac myocytes: roles of bradykinin and protein kinase C.
Heart Failure
Mitochondrial ROS-induced ERK1/2 Activation and HSF2-mediated AT1 R Upregulation Are Required for Doxorubicin-induced Cardiotoxicity.
Heart Failure
Modulation of oxidative stress by a selective inhibition of angiotensin II type 1 receptors in MI rats.
Heart Failure
Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: I. Effects on left ventricular performance and neurohormonal systems.
Heart Failure
Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: II. Effects on myocyte contractile processes.
Heart Failure
Molecular biology of angiotensin receptors and their role in human cardiovascular disease.
Heart Failure
Molecular signaling mediated by angiotensin II type 1A receptor blockade leading to attenuation of renal dysfunction-associated heart failure.
Heart Failure
Myocardial bradykinin following acute angiotensin-converting enzyme inhibition, AT1 receptor blockade, or combined inhibition in congestive heart failure.
Heart Failure
Myogenic constriction is increased in mesenteric resistance arteries from rats with chronic heart failure: instantaneous counteraction by acute AT1 receptor blockade.
Heart Failure
Novel mechanism of angiotensin II-induced cardiac injury in hypertensive rats: the critical role of ASK1 and VEGF.
Heart Failure
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding.
Heart Failure
Olmesartan, a novel AT1 antagonist, suppresses cytotoxic myocardial injury in autoimmune heart failure.
Heart Failure
Recent insight into therapy of congestive heart failure: focus on ACE inhibition and angiotensin-II antagonism.
Heart Failure
Reduced atrial angiotensin receptor type 1 mRNA content in end-stage human heart failure: assessment by a novel quantitative PCR-ELISA technique.
Heart Failure
Regulation of the angiotensin receptor subtypes in cell cultures, animal models and human diseases.
Heart Failure
Renin-angiotensin system inhibition prevents type 2 diabetes mellitus. Part 2. Overview of physiological and biochemical mechanisms.
Heart Failure
Role of angiotensin II receptors in the regulation of vasomotor neurons in the ventrolateral medulla.
Heart Failure
Role of oxidant stress on AT1 receptor expression in neurons of rabbits with heart failure and in cultured neurons.
Heart Failure
Sacubitril and valsartan fixed combination to reduce heart failure events in post-acute myocardial infarction patients.
Heart Failure
Sensitization of the Angiotensin II AT1 Receptor Contributes to RKIP-Induced Symptoms of Heart Failure.
Heart Failure
Significance of timing of angiotensin AT1 receptor blockade in rats with myocardial infarction-induced heart failure.
Heart Failure
The Angiotensin II Type 1(AT1) Receptor and Cardiac Hypertrophy: Did We Have It Wrong All Along?
Heart Failure
The central vasopressinergic system in experimental left ventricular hypertrophy and dysfunction.
Heart Failure
The Protective Effects of Compound 21 and Valsartan in Isoproterenol-Induced Myocardial Injury in Rats.
Heart Failure
The Regulation of Central Angiotensin Type 1 Receptors and Sympathetic Outflow in Heart Failure.
Heart Failure
The role of angiotensin II AT1 receptor in the maintenance of hemodynamics in a canine model of coronary microembolization-induced heart failure.
Heart Failure
TNF-? in hypothalamic paraventricular nucleus contributes to sympathoexcitation in heart failure by modulating AT1 receptor and neurotransmitters.
Heart Failure
Use of angiotensin II antagonists in human heart failure: function of the subtype 1 receptor.
Heart Failure
Valsartan and coronary haemodynamics in early post-myocardial infarction in rats.
Heart Failure
Ventricular-specific expression of angiotensin II type 2 receptors causes dilated cardiomyopathy and heart failure in transgenic mice.
Heart Failure
[Candesartan cilexetil: pharmacological properties and protective effects against organ damage of a novel nonpeptide angiotensin II-receptor antagonist]
Heart Failure
[Distribution and function of angiotensin receptor subtypes in cardiovascular system]
Heart Failure
[ESC guidelines for therapy of heart failure. AT1 blockers are now also included]
Heart Failure
[Levosimendan: a new option in the pharmacologic management of cardiac insufficiency]
Heart Failure, Diastolic
AT1 receptor blocker added to ACE inhibitor provides benefits at advanced stage of hypertensive diastolic heart failure.
Heart Failure, Diastolic
Local neurohumoral regulation in the transition to isolated diastolic heart failure in hypertensive heart disease: absence of AT1 receptor downregulation and 'overdrive' of the endothelin system.
Heart Failure, Systolic
Combination treatment with a calcium channel blocker and an angiotensin blocker in a rat systolic heart failure model with hypertension.
Hepatitis B
A bivalent antihypertensive vaccine targeting L-type calcium channels and angiotensin AT1 receptors.
Hepatitis C
Angiotensin II Activates IkappaB Kinase Phosphorylation of RelA at Ser(536) to Promote Myofibroblast Survival and Liver Fibrosis.
Hermanski-Pudlak Syndrome
AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies suppresses activation of YAP in alveolar epithelial type 2 cells.
Hermanski-Pudlak Syndrome
Gene-edited MLE-15 Cells as a Model for the Hermansky Pudlak Syndromes.
Hermanski-Pudlak Syndrome
In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids.
Herpes Simplex
Inhibition of transient gene expression with plasmids encoding herpes simplex virus type 1 UL55 and alpha genes.
Herpes Simplex
[Anti-idiotypic antibodies to the herpes simplex type-1 virus neutralize the virus' infectious activity]
Herpes Zoster
Agonist-induced phosphorylation of the endogenous AT1 angiotensin receptor in bovine adrenal glomerulosa cells.
Herpes Zoster
Angiotensin II dilates bovine adrenal cortical arterioles: role of endothelial nitric oxide.
Herpes Zoster
Angiotensin II stimulates both aldosterone secretion and DNA synthesis via type 1 but not type 2 receptors in bovine adrenocortical cells.
Herpes Zoster
Angiotensin II stimulates growth and steroidogenesis in zona fasciculata/reticularis cells from bovine adrenal cortex via the AT1 receptor subtype.
Herpes Zoster
Biochemical properties of the ovarian granulosa cell type 2-angiotensin II receptor.
Herpes Zoster
Characterization of a specific antibody to the rat angiotensin II AT1 receptor.
Herpes Zoster
Differential regulation of angiotensin II receptor subtypes in the adrenal gland: role of aldosterone.
Herpes Zoster
Distribution and functional significance of angiotensin-II AT1- and AT2-receptor subtypes in the rat adrenal gland.
Herpes Zoster
Effects of mineralocorticoid receptor gene disruption on the components of the renin-angiotensin system in 8-day-old mice.
Herpes Zoster
Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats.
Herpes Zoster
Immunocytochemical localization of angiotensin II receptor subtypes 1 and 2 in the porcine fetal, prepubertal and postpubertal ovary.
Herpes Zoster
Immunohistochemical Localization of AT1a, AT1b, and AT2 Angiotensin II Receptor Subtypes in the Rat Adrenal, Pituitary, and Brain with a Perspective Commentary.
Herpes Zoster
Influence of dietary sodium restriction on angiotensin II receptors in rat adrenals.
Herpes Zoster
Internalization of the type I angiotensin II receptor (AT1) is required for protein kinase C activation but not for inositol trisphosphate release in the angiotensin II stimulated rat adrenal zona glomerulosa cell.
Herpes Zoster
Localization of a novel non-peptide angiotensin II type 1 receptor antagonist, E4177, in rat adrenal glomerulosa.
Herpes Zoster
Locally generated angiotensin II in the adrenal gland regulates basal, corticotropin-, and potassium-stimulated aldosterone secretion.
Herpes Zoster
Multiple signal transduction systems regulate angiotensin II type 1 (AT1) receptor mRNA expression in bovine adrenocortical cells.
Herpes Zoster
Ontogeny and regulation of the AT1 and AT2 receptors in the ovine fetal adrenal gland.
Herpes Zoster
Role of angiotensin II receptor subtypes on the regulation of aldosterone secretion in the adrenal glomerulosa zone in the rat.
Herpes Zoster
The angiotensin AT2 receptor is present in the human fetal adrenal gland throughout the second trimester of gestation.
Hodgkin Disease
The Reed-Steinberg cell: molecular characterization by proteomic analysis with therapeutic implications.
Huntington Disease
Alterations in angiotensin AT1 and AT2 receptor subtype levels in brain regions from patients with neurodegenerative disorders.
Hydronephrosis
Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract.
Hyperaldosteronism
Angiotensin II type 1 receptor messenger RNA levels in human blood cells of patients with primary and secondary hypertension: reference to renin profile.
Hyperaldosteronism
Autoimmune mechanisms activating the angiotensin AT1 receptor in 'primary' aldosteronism.
Hyperaldosteronism
Influence of antihypertensive medication on aldosterone and renin concentration in the differential diagnosis of essential hypertension and primary aldosteronism.
Hyperaldosteronism
Somatic mutations of the angiotensin II (AT1) receptor gene are not present in aldosterone-producing adenoma.
Hyperalgesia
A new role for the renin-angiotensin system in the rat periaqueductal gray matter: angiotensin receptor-mediated modulation of nociception.
Hyperalgesia
Effect of subpressor dose of angiotensin II on pain-related behavior in relation with neuronal injury and activation of satellite glial cells in the rat dorsal root ganglia.
Hyperalgesia
Involvement of Spinal Angiotensin II System in Streptozotocin-Induced Diabetic Neuropathic Pain in Mice.
Hyperalgesia
Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system by regulating the dorsal root ganglion axon sprouting.
Hypercalcemia
Hypercalcemia stimulates expression of intrarenal phospholipase A2 and prostaglandin H synthase-2 in rats. Role of angiotensin II AT1 receptors.
Hypercholesterolemia
Angiotensin II AT1 receptor blockade improves renal perfusion in hypercholesterolemia.
Hypercholesterolemia
Angiotensin II type 1 (AT1) receptor deficiency halts the progression of age-related atherosclerosis in hypercholesterolemia: molecular link between the AT1 receptor and hypercholesterolemia.
Hypercholesterolemia
Angiotensin II type 1 receptor antagonism improves hypercholesterolemia-associated endothelial dysfunction.
Hypercholesterolemia
Hypercholesterolemia is associated with enhanced angiotensin AT1-receptor expression.
Hypercholesterolemia
Increased angiotensin II type 1 receptor expression in hypercholesterolemic atherosclerosis in rabbits.
Hypercholesterolemia
Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system.
Hypercholesterolemia
Regulation of the angiotensin AT1 receptor expression by hypercholesterolemia.
Hypercholesterolemia
Renin-angiotensin system at the crossroad of hypertension and hypercholesterolemia.
Hypercholesterolemia
Role of blood cell-associated AT1 receptors in the microvascular responses to hypercholesterolemia.
Hypercholesterolemia
Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men.
Hyperemia
Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals.
Hyperglycemia
Acute hyperglycemia rapidly stimulates VEGF mRNA translation in the kidney. Role of angiotensin type 2 receptor (AT2).
Hyperglycemia
Baseline glucose and left ventricular remodeling after acute myocardial infarction.
Hyperglycemia
Elevation of [Ca2+]i of renal proximal tubular cells and down-regulation of mRNA of PTH-PTHrP, V1a and AT1 receptors in kidney of diabetic rats.
Hyperglycemia
Local renal aldosterone system and its regulation by salt, diabetes, and angiotensin II type 1 receptor.
Hyperglycemia
The hyperglycemia induced by angiotensin II in rats is mediated by AT1 receptors.
Hyperhomocysteinemia
Synergism between AT1 receptor and hyperhomocysteinemia during vascular remodeling.
Hyperinsulinism
Effect of telmisartan, angiotensin II receptor antagonist, on metabolic profile in fructose-induced hypertensive, hyperinsulinemic, hyperlipidemic rats.
Hyperinsulinism
Insulin induces upregulation of vascular AT1 receptor gene expression by posttranscriptional mechanisms.
Hyperlipidemias
Combined effect of ACE inhibitor and exercise training on insulin resistance in type 2 diabetic rats.
Hyperphosphatemia
Measurement of serum electrolytes and phosphate after sodium phosphate colonoscopy bowel preparation: an evaluation.
Hypersensitivity
A Local Inflammatory Renin-Angiotensin System Drives Sensory Axon Sprouting in Provoked Vestibulodynia.
Hypersensitivity
Angiotensin II augments renal vasoconstriction via AT1 receptors in L-NAME-induced hypertensive rats.
Hypersensitivity
Angiotensin II pressor response in the L-NAME-induced hypertensive pithed rat: role of the AT1 receptor.
Hypersensitivity
Angiotensin II Receptor Type 2 Activation Is Required for Cutaneous Sensory Hyperinnervation and Hypersensitivity in a Rat Hind Paw Model of Inflammatory Pain.
Hypersensitivity
Efficacy and tolerability of angiotensin II type 1 receptor antagonists in dialysis patients using AN69 dialysis membranes.
Hypersensitivity
Nitric oxide: a physiological mediator of the type 2 (AT2) angiotensin receptor.
Hypersensitivity
Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor.
Hypersensitivity
The role of angiogenic, anti-angiogenic and vasoactive factors in pre-eclamptic African women: early- versus late-onset pre-eclampsia.
Hypersensitivity
Update: role of the angiotensin type-2 (AT(2)) receptor in blood pressure regulation.
Hypersensitivity
Upregulation of angiotensin II type 1 receptor gene expression in chronic renovascular hypertension.
Hypersensitivity
[Behavioral and Molecular Pharmacological Study of the Role of Angiotensin II in Spinal Pain Transmission].
Hypertension
(Pro)renin receptor knockdown in the paraventricular nucleus of the hypothalamus attenuates hypertension development and AT1 receptor-mediated calcium events.
Hypertension
A case of lithium intoxication induced by an antihypertensive angiotensin 1 subtype-specific angiotensin II receptor blocker in an elderly patient with bipolar disorder and hypertension.
Hypertension
A polymorphism in the gene for the angiotensin II type 1 receptor is not associated with hypertension.
Hypertension
A/C1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure: the Ohasama Study.
Hypertension
ABPM comparison of the antihypertensive profiles of the selective angiotensin II receptor antagonists telmisartan and losartan in patients with mild-to-moderate hypertension.
Hypertension
Absence of a pharmacokinetic interaction between losartan and hydrochlorothiazide.
Hypertension
ACE inhibitors versus AT1 blockers in the treatment of hypertension and syndrome X.
Hypertension
Activating autoantibodies to the angiotensin II type I receptor play an important role in mediating hypertension in response to adoptive transfer of CD4+ T lymphocytes from placental ischemic rats.
Hypertension
Activation of angiotensin type 2 (AT2) receptors prevents myocardial hypertrophy in Zucker diabetic fatty rats.
Hypertension
Activation of D4 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells.
Hypertension
Activation of ERK, JNK, Akt, and G-protein coupled signaling by hybrid angiotensin II AT1/bradykinin B2 receptors expressed in HEK-293 cells.
Hypertension
Activation of Renin-Angiotensin System Induces Osteoporosis Independently of Hypertension.
Hypertension
Activation of thiazide-sensitive co-transport by angiotensin II in the cyp1a1-Ren2 hypertensive rat.
Hypertension
Acute hypertension after nitric oxide synthase inhibition is mediated primarily by increased endothelin vasoconstriction.
Hypertension
Acute myocardial and vascular responses to specific angiotensin II antagonism in the spontaneously hypertensive rat.
Hypertension
Additive beneficial effects of the combination of a calcium channel blocker and an angiotensin blocker on a hypertensive rat-heart failure model.
Hypertension
Agonist-like activity of antibodies to angiotensin II receptor subtype 1 (AT1) from rats immunized with AT1 receptor peptide.
Hypertension
Agonistic autoantibodies against the angiotensin AT1 receptor increase in unstable angina patients after stent implantation.
Hypertension
Alpha-adrenergic systems mediate chronic central AII hypertension in rats fed high sodium chloride diet from weaning.
Hypertension
Alterations in sarcoplasmic reticulum and angiotensin II receptor type 1 gene expression in spontaneously hypertensive rat hearts.
Hypertension
Altered AT1 receptor regulation of ETB receptors in renal proximal tubule cells of spontaneously hypertensive rats.
Hypertension
Altered expression of vascular natriuretic peptide receptors in experimental hypertensive rats.
Hypertension
An effort to understand the molecular basis of hypertension through the study of conformational analysis of losartan and sarmesin using a combination of nuclear magnetic resonance spectroscopy and theoretical calculations.
Hypertension
An essential role for angiotensin II type 1a receptor in pregnancy-associated hypertension with intrauterine growth retardation.
Hypertension
Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock.
Hypertension
Angiotensin AT2 receptor agonist prevents salt-sensitive hypertension in obese Zucker rats.
Hypertension
Angiotensin gene polymorphism as a determinant of posttransplantation renal dysfunction and hypertension.
Hypertension
Angiotensin II activates nuclear transcription factor-kappaB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice.
Hypertension
Angiotensin II and alpha 1-adrenergic tone in chronic nitric oxide blockade-induced hypertension.
Hypertension
Angiotensin II and serotonin potentiate endothelin-1-induced vascular smooth muscle cell proliferation.
Hypertension
Angiotensin II AT1 receptor alters ACE2 activity, eNOS expression and CD44-hyaluronan interaction in rats with hypertension and myocardial fibrosis.
Hypertension
Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders.
Hypertension
Angiotensin II augments renal vasoconstriction via AT1 receptors in L-NAME-induced hypertensive rats.
Hypertension
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
Hypertension
Angiotensin II causes weight loss and decreases circulating insulin-like growth factor I in rats through a pressor-independent mechanism.
Hypertension
Angiotensin II pressor response in the L-NAME-induced hypertensive pithed rat: role of the AT1 receptor.
Hypertension
Angiotensin II receptor blockade in normotensive subjects: A direct comparison of three AT1 receptor antagonists.
Hypertension
Angiotensin II receptor blockade in TGR(mREN2)27: effects of renin-angiotensin-system gene expression and cardiovascular functions.
Hypertension
Angiotensin II regulation of AT1 and D3 dopamine receptors in renal proximal tubule cells of SHR.
Hypertension
Angiotensin II subtype AT1 receptor blockade prevents hypertension and renal insufficiency induced by chronic NO-synthase inhibition in rats.
Hypertension
Angiotensin II type 1 autoantibody induced hypertension during pregnancy is associated with renal endothelial dysfunction.
Hypertension
Angiotensin II type 1 receptor antagonist and angiotensin-converting enzyme inhibitor altered the activation of Cu/Zn-containing superoxide dismutase in the heart of stroke-prone spontaneously hypertensive rats.
Hypertension
Angiotensin II type 1 receptor antibodies in childhood kidney transplantation.
Hypertension
Angiotensin II type 1 receptor blockade by telmisartan prevents stress-induced impairment of memory via HPA axis deactivation and up-regulation of brain-derived neurotrophic factor gene expression.
Hypertension
Angiotensin II type 1 receptor blocker irbesartan ameliorates vascular function in spontaneously hypertensive rats regardless of oestrogen status.
Hypertension
Angiotensin II type 1 receptor gene A1166C polymorphism and essential hypertension in Chinese: a meta-analysis.
Hypertension
Angiotensin II type 1 receptor gene polymorphism is associated with increase of left ventricular mass but not with hypertension.
Hypertension
Angiotensin II type 1 receptor is involved in hypertension and vascular alterations caused by environmental toxicant hexachlorobenzene.
Hypertension
Angiotensin II type 1 receptor messenger RNA levels in human blood cells of patients with primary and secondary hypertension: reference to renin profile.
Hypertension
Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection.
Hypertension
Angiotensin II-dependent increased expression of Na+-glucose cotransporter in hypertension.
Hypertension
Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium.
Hypertension
Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide.
Hypertension
Angiotensin receptor blockade recovers hepatic UCP2 expression and aconitase and SDH activities and ameliorates hepatic oxidative damage in insulin resistant rats.
Hypertension
Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications.
Hypertension
Angiotensin type 1 receptor blockade prevents cardiac remodeling in mice with pregnancy-associated hypertension.
Hypertension
Angiotensin type 2 receptor-mediated phosphorylation of eNOS in the aortas of mice with 2-kidney, 1-clip hypertension.
Hypertension
Angiotensin Type-2 (AT-2)-Receptor activation reduces renal fibrosis in cyclosporine nephropathy: Evidence for blood-pressure independent effect.
Hypertension
Antagonizing the angiotensin II subtype 1 receptor: a focus on olmesartan medoxomil.
Hypertension
Antihypertensive effects of a mixed endothelin-A- and -B-receptor antagonist, J-104132, were augmented in the presence of an AT1 -receptor antagonist, MK-954.
Hypertension
Antisense inhibition of AT1 receptor mRNA and angiotensinogen mRNA in the brain of spontaneously hypertensive rats reduces hypertension of neurogenic origin.
Hypertension
Antisense oligonucleotide to AT1 receptor mRNA inhibits central angiotensin induced thirst and vasopressin.
Hypertension
Aortic collagen, aortic stiffness, and AT1 receptors in experimental and human hypertension.
Hypertension
Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: the Ohasama Study.
Hypertension
Association of AT1R polymorphism with hypertension risk: An update meta-analysis based on 28,952 subjects.
Hypertension
Association of renal injury with nitric oxide deficiency in aged SHR: prevention by hypertension control with AT1 blockade.
Hypertension
AT1 and TxA2/PGH2 receptors maintain hypertension throughout 2K,1C Goldblatt hypertension in the rat.
Hypertension
AT1 Angiotensin receptors-vascular and renal epithelial pathways for blood pressure regulation.
Hypertension
AT1 receptor antagonist treatment caused persistent arterial functional changes in young spontaneously hypertensive rats.
Hypertension
AT1 receptor antisense therapy transiently lowers blood pressure in Ren-2 transgenic rats.
Hypertension
AT1 receptor blockade in experimental myocardial ischemia/reperfusion.
Hypertension
AT1 receptor blockade is superior to conventional triple therapy in protecting against end-organ damage in Cyp1a1-Ren-2 transgenic rats with inducible hypertension.
Hypertension
AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats.
Hypertension
AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats.
Hypertension
AT1 receptor density changes during development of hypertension in hyperinsulinemic rats.
Hypertension
AT1 receptor mediated augmentation of intrarenal angiotensinogen in angiotensin II-dependent hypertension.
Hypertension
AT1 receptor-mediated augmentation of angiotensinogen, oxidative stress, and inflammation in ANG II-salt hypertension.
Hypertension
AT1 receptors mediate chronic central nervous system AII hypertension in rats fed high sodium chloride diet from weaning.
Hypertension
AT1 receptors mediate pressor responses induced by angiotensin II in the periaqueductal gray area of rats.
Hypertension
AT2 Receptor Activation Prevents Sodium Retention and Reduces Blood Pressure in Angiotensin II-Dependent Hypertension.
Hypertension
Autoantibodies to the angiotensin type I receptor in response to placental ischemia and tumor necrosis factor alpha in pregnant rats.
Hypertension
Beraprost Sodium, a Stable Analogue of PGI2, Inhibits the Renin-Angiotensin System in the Renal Tissues of Rats with Chronic Renal Failure.
Hypertension
Biphasic effects of angiotensin II and receptor antagonism on aggregability and protein kinase C phosphorylation in human platelets.
Hypertension
Blockade of AT1 receptor reduces apoptosis, inflammation, and oxidative stress in normotensive rats with intracerebral hemorrhage.
Hypertension
Blockade of AT1 receptors by specific antibody attenuated hypertension development in young spontaneously hypertensive rats.
Hypertension
Blood pressure and proteinuria after cessation of a brief renin-angiotensin system blockade in young and adult Lyon hypertensive rats.
Hypertension
BR 09-3 AT2R STIMULATION AND ITS EFFECT ON TARGET ORGAN DAMAGE: THERAPEUTIC IMPLICATIONS.
Hypertension
Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities.
Hypertension
Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice.
Hypertension
C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice.
Hypertension
Candesartan cilexetil on regular hemodialysis: inability to reduce excessive thirst, but good tolerance and efficacy in hypertensive patients.
Hypertension
Candesartan: a new-generation angiotensin II AT1 receptor blocker: pharmacology, antihypertensive efficacy, renal function, and renoprotection.
Hypertension
Cardiac hypertrophy and fibrosis in chronic L-NAME-treated AT2 receptor-deficient mice.
Hypertension
Cardiac microvascular rarefaction in hyperthyroidism-induced left ventricle dysfunction.
Hypertension
Cardiac sympathetic afferent reflex and its implications for sympathetic activation in chronic heart failure and hypertension.
Hypertension
Cardiac type-1 angiotensin II receptor status in deoxycorticosterone acetate-salt hypertension in rats.
Hypertension
Cardiovascular effects of angiotensin II in the rostral ventrolateral medulla: the push-pull hypothesis.
Hypertension
Cardiovascular effects of GR117289, a novel angiotensin AT1 receptor antagonist.
Hypertension
Caspase-dependent cell death mediates the early phase of aortic hypertrophy regression in losartan-treated spontaneously hypertensive rats.
Hypertension
Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension.
Hypertension
Central inhibition of AT1receptors by eprosartan--in vitro autoradiography in the brain.
Hypertension
Central Mineralocorticoid Receptors and the Role of Angiotensin II and Glutamate in the Paraventricular Nucleus of Rats With Angiotensin II-Induced Hypertension.
Hypertension
Cerebroventricular injection of angiotensin II antagonist: effects on blood pressure responses to central and systemic angiotensin II.
Hypertension
Changes in angiotensin AT1 receptor density during hypertension in fructose-fed rats.
Hypertension
Changes in endothelium-derived hyperpolarizing factor in hypertension and ageing: response to chronic treatment with renin-angiotensin system inhibitors.
Hypertension
Changes in protein and gene expression of angiotensin II receptors (AT1 and AT2) in aorta of diabetic and hypertensive rats.
Hypertension
Characterization of polymorphisms in the promoter of the human angiotensin II subtype 1 (AT1) receptor gene.
Hypertension
Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure.
Hypertension
Chronic effects of central and systemic administration of losartan on blood pressure and baroreceptor reflex in spontaneously hypertensive rats.
Hypertension
Chronic knockdown of the nucleus of the solitary tract AT1 receptors increases blood inflammatory-endothelial progenitor cell ratio and exacerbates hypertension in the spontaneously hypertensive rat.
Hypertension
Chronic production of angiotensin IV in the brain leads to hypertension that is reversible with an angiotensin II AT1 receptor antagonist.
Hypertension
Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension.
Hypertension
Combination treatment with a calcium channel blocker and an angiotensin blocker in a rat systolic heart failure model with hypertension.
Hypertension
Combined treatment with ibuprofen and the AT1 receptor antagonist candesartan in young spontaneously hypertensive rats.
Hypertension
Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. AT1 receptors in the kidney mediate the chronic hypertensive response to angiotensin II.
Hypertension
Comparison between chronic converting enzyme inhibition and AT1 blockade in mRen2 transgenic rats.
Hypertension
Comparison of circulating and local adipose tissue renin-angiotensin system in normotensive and hypertensive obese subjects.
Hypertension
Comparison of type 1 angiotensin II receptor blockers and angiotensin converting enzyme inhibitors in the treatment of hypertension.
Hypertension
Conformation and bioactivity. Design and discovery of novel antihypertensive drugs.
Hypertension
Contribution of renal angiotensin II type I receptor to gene expressions in hypertension-induced renal injury.
Hypertension
Control of renal sympathetic nerve activity by neurotransmitters in the spinal cord in Goldblatt hypertension.
Hypertension
Coordinate regulation of canine glomeruli and adrenal angiotensin receptors by dietary sodium manipulation.
Hypertension
Counter-regulatory effects played by the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications.
Hypertension
Curcumin Exerts its Anti-hypertensive Effect by Down-regulating the AT1 Receptor in Vascular Smooth Muscle Cells.
Hypertension
Deficiency of angiotensin type 2 receptor rescues obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissue.
Hypertension
Design, synthesis and antihypertensive evaluation of novel codrugs with combined angiotensin type 1 receptor antagonism and neprilysin inhibition.
Hypertension
Differential expression of AT1 receptors in the pituitary and adrenal gland of SHR and WKY.
Hypertension
Differential phosphorylation of calreticulin affects AT1 receptor mRNA stability in VSMC.
Hypertension
Differential regulation of renal angiotensin subtype AT1A and AT2 receptor protein in rats with angiotensin-dependent hypertension.
Hypertension
Direct analysis of valsartan or candesartan in human plasma and urines by on-line solid phase extraction coupled to electrospray tandem mass spectrometry.
Hypertension
Direct Renin Inhibition With Aliskiren Normalizes Blood Pressure in Cyp1a1-Ren2 Transgenic Rats With Inducible Angiotensin II-Dependent Malignant Hypertension.
Hypertension
Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI).
Hypertension
Distinct mechanisms of modulation of angiotensin II type I receptor gene expression in heart and aorta.
Hypertension
Does blockade of angiotensin II receptors offer clinical benefits over inhibition of angiotensin-converting enzyme?
Hypertension
Early and late haemodynamic and morphological effects of angiotensin II subtype 1 receptor blockade during genetic hypertension development.
Hypertension
Effect of an angiotensin II receptor antagonist, TCV-116, on cardiac hypertrophy and coronary circulation in spontaneously hypertensive rats.
Hypertension
Effect of AT1 receptor blockade on hepatic redox status in SHR: possible relevance for endothelial function?
Hypertension
Effect of chronic treatment with ME3221 on blood pressure and mortality in aged stroke-prone spontaneously hypertensive rats.
Hypertension
Effect of Combined Treatment with AT1 Receptor Antagonists and Tiagabine on Seizures, Memory and Motor Coordination in Mice.
Hypertension
Effect of sodium on blood pressure, cardiac hypertrophy, and angiotensin receptor expression in rats.
Hypertension
Effect of sodium on vasoconstriction and angiotensin II type 1 receptor mRNA expression in cold-induced hypertensive rats.
Hypertension
Effect of telmisartan, angiotensin II receptor antagonist, on metabolic profile in fructose-induced hypertensive, hyperinsulinemic, hyperlipidemic rats.
Hypertension
Effects and mechanism of irbesartan on tubulointerstitial fibrosis in 5/6 nephrectomized rats.
Hypertension
Effects of angiotensin type 2 receptor on secretion of the locus coeruleus in stress-induced hypertension rats.
Hypertension
Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats.
Hypertension
Effects of AT1 receptor antagonism with candesartan on endothelial function in patients with hypertension and coronary artery disease.
Hypertension
Effects of candesartan cilexetil in patients with systemic hypertension. Candesartan Cilexetil Study Investigators.
Hypertension
Effects of candesartan cilexetil on glucose homeostasis. Multicenter Study Group.
Hypertension
Effects of centrally administered losartan on deoxycorticosterone-salt hypertension rats.
Hypertension
Effects of changes in sodium balance on plasma and kidney angiotensin II levels in anesthetized and conscious Ren-2 transgenic rats.
Hypertension
Effects of dual angiotensin type 1 receptor/neprilysin inhibition vs. angiotensin type 1 receptor inhibition on target organ injury in the stroke-prone spontaneously hypertensive rat.
Hypertension
Effects of losartan on blood pressure, metabolic alterations, and vascular reactivity in the fructose-induced hypertensive rat.
Hypertension
Effects of losartan on blood pressure, oxidative stress, and nitrate/nitrite levels in the nitric oxide deficient hypertensive rats.
Hypertension
Effects of quinapril on expression of eNOS, ACE, and AT1 receptor in deoxycorticosterone acetate-salt hypertensive rats.
Hypertension
Efficacy and safety of telmisartan, a selective AT1 receptor antagonist, compared with enalapril in elderly patients with primary hypertension. TEES Study Group.
Hypertension
Elevated arterial pressure impairs autoregulation independently of AT(1) receptor activation.
Hypertension
Endogenous AT1 receptor-protein kinase C activity in the hypothalamus augments glutamatergic input and sympathetic outflow in hypertension.
Hypertension
Enhanced Angiotensin II type 1 receptor expression in leukocytes of patients with chronic kidney disease.
Hypertension
Enhanced platelet release of superoxide anion in systemic hypertension: role of AT1 receptors.
Hypertension
Enhanced pressor response to angiotensin III in spontaneously hypertensive rats: effects of losartan.
Hypertension
Eprosartan provides safe and effective long-term maintenance of blood pressure control in patients with mild to moderate essential hypertension.
Hypertension
Estrogen or the AT1 antagonist olmesartan reverses the development of profound hypertension in the congenic mRen2.Lewis rat.
Hypertension
Evaluation of three polymorphisms in the promoter region of the angiotensin II type I receptor gene.
Hypertension
Evidence for a causal role of the renin-angiotensin system in vascular dysfunction associated with insulin resistance.
Hypertension
Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension.
Hypertension
Exaggerated tubuloglomerular feedback activity in genetic hypertension is mediated by ANG II and AT1 receptors.
Hypertension
Expression and role of angiotensin II type 2 receptor in the kidney and mesangial cells of spontaneously hypertensive rats.
Hypertension
Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of monocytes at the onset of atherosclerosis.
Hypertension
Favourable effects on arterial wave reflection and pulse pressure amplification of adding angiotensin II receptor blockade in resistant hypertension.
Hypertension
Functional interaction of AT1 and AT2 receptors in fructose-induced insulin resistance and hypertension in rats.
Hypertension
Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant.
Hypertension
Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage.
Hypertension
Genetic inactivation of the B2 receptor in mice worsens two-kidney, one-clip hypertension: role of NO and the AT2 receptor.
Hypertension
Genetic studies of the renin-angiotensin system in arterial hypertension associated with non-insulin-dependent diabetes mellitus.
Hypertension
Haemodynamic effects of AT1 inhibition and Ca(2+)-channel blockade in hypertensive patients during isometric stress.
Hypertension
Hemodynamic and biochemical effects of the AT1 receptor antagonist irbesartan in hypertension.
Hypertension
High-salt intake accelerates functional and histological renal damage associated with renal tissue overexpression of (pro)renin receptors and AT1 receptors in spontaneously hypertensive rats.
Hypertension
Homology modeling, binding site identification and docking study of human angiotensin II type I (Ang II-AT1) receptor.
Hypertension
Human chymase expression in a mice induces mild hypertension with left ventricular hypertrophy.
Hypertension
Hypercholesterolemia blunts the oxidative stress elicited by hypertension in venules through angiotensin II type-2 receptors.
Hypertension
Hypersensitivity of the adrenal cortex to trophic and secretory effects of angiotensin II in Lyon genetically-hypertensive rats.
Hypertension
Hypertension after renal transplantation and polymorphism of genes involved in essential hypertension: ACE, AGT, AT1 R and ecNOS.
Hypertension
Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage.
Hypertension
Hypertension study in anesthetized rabbits: protocol proposal for AT1 antagonists screening.
Hypertension
Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats.
Hypertension
Identification of a cis-acting glucocorticoid responsive element in the rat angiotensin II type 1A promoter.
Hypertension
Identification of AT1 receptors on human platelets and decreased angiotensin II binding in hypertension.
Hypertension
Identification of reference genes for quantitative RT-PCR in ascending aortic aneurysms.
Hypertension
Identifying structural features related to the biological activity of a series of AT1 antagonists from fragment-based drug design.
Hypertension
IL-17-mediated oxidative stress is an important stimulator of AT1-AA and hypertension during pregnancy.
Hypertension
Immunohistochemical localization of angiotensin II receptor types 1 and 2 in the mesenteric artery from spontaneously hypertensive rats.
Hypertension
In silico identification of novel lead compounds with AT1 receptor antagonist activity: successful application of chemical database screening protocol.
Hypertension
In vitro pharmacology of a novel non-peptide angiotensin II-receptor antagonist, E4177.
Hypertension
In vivo and in vitro characterization of the novel antiarrhythmic agent SSR149744C: electrophysiological, anti-adrenergic, and anti-angiotensin II effects.
Hypertension
In vivo pharmacology of an angiotensin AT1 receptor antagonist with balanced affinity for AT2 receptors.
Hypertension
Increased AT1 receptor expression mediates vasoconstriction leading to hypertension in Snx1-/- mice.
Hypertension
Increased expression of vascular angiotensin II type 1A receptor gene in glucocorticoid-induced hypertension.
Hypertension
Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats.
Hypertension
Influence of active immunization against angiotensin AT1 or AT2 receptor on hypertension development in young and adult SHR.
Hypertension
Influence of arginine vasopressin receptors and angiotensin receptor subtypes on the water intake and arterial blood pressure induced by vasopressin injected into the lateral septal area of the rat.
Hypertension
Influence of autoantibodies against AT1 receptor and AGTR1 polymorphisms on candesartan-based antihypertensive regimen: results from the study of optimal treatment in hypertensive patients with anti-AT1-receptor autoantibodies trial.
Hypertension
Influence of irbesartan and enalapril on changes of renal function associated with the established phase of l-NAME hypertension.
Hypertension
INFLUENCE OF POLYMORPHISM OF GENES INVOLVED IN ARTERIAL HYPERTENSION: ANGIOTENSIN I CONVERTING ENZYME (ACE); ANGIOTENSINOGEN (AGT); AT1 RECEPTOR OF ANGIOTENSIN II (AT1-R); AND ENDOTHELIAL CONSTITUTIVE NO SYNTHASE (ecNOS); ON LONG TERM RESULTS AFTER RENAL TRANSPLANTATION.
Hypertension
Inhibition of NAD(P)H oxidase potentiates AT2 receptor agonist-induced natriuresis in Sprague-Dawley rats.
Hypertension
Insights into angiotensin II receptor function through AT2 receptor knockout mice.
Hypertension
Insulin induces upregulation of vascular AT1 receptor gene expression by posttranscriptional mechanisms.
Hypertension
Integration of multi-scale molecular modeling approaches with experiments for the in silico guided design and discovery of novel hERG-Neutral antihypertensive oxazalone and imidazolone derivatives and analysis of their potential restrictive effects on cell proliferation.
Hypertension
Interaction between insulin and AT1 receptor. Relevance for hypertension and arteriosclerosis.
Hypertension
Interaction of angiotensin II type 1 and D5 dopamine receptors in renal proximal tubule cells.
Hypertension
Interaction of mRNAs for angiotensin II type 1 and type 2 receptors to vascular remodeling in spontaneously hypertensive rats.
Hypertension
Intrarenal angiotensin II augmentation in angiotensin II dependent hypertension.
Hypertension
Intrarenal angiotensin II generation and renal effects of AT1 receptor blockade.
Hypertension
Intratubular, Intracellular, and Mitochondrial Angiotensin II/AT1 (AT1a) Receptor/NHE3 Signaling Plays a Critical Role in Angiotensin II-Induced Hypertension and Kidney Injury.
Hypertension
Investigation of angiotensin II/AT1 receptors with carbon-11-L-159,884: a selective AT1 antagonist.
Hypertension
Is there relationship between the A1166C polymorphism of the angiotensin II receptor AT1 and plasma renin activity, insulin resistance and reduction of blood pressure after angiotensin-converting enzyme inhibitor therapy?
Hypertension
Lack of association between angiotensin II type 1 receptor gene polymorphism and hypertension in Japanese.
Hypertension
Localization and functional properties of angiotensin II AT1 receptors in the kidney: focus on renomedullary interstitial cells.
Hypertension
Long-term prevention of hypertension and end-organ damage in Ren-2 transgenic rats is achieved only with persistent but not transient AT1 receptor blockade.
Hypertension
Long-Term Treatment with Losartan Attenuates Seizure Activity and Neuronal Damage Without Affecting Behavioral Changes in a Model of Co-morbid Hypertension and Epilepsy.
Hypertension
Losartan reduces the increased participation of cyclooxygenase-2-derived products in vascular responses of hypertensive rats.
Hypertension
Losartan renography for the detection of renal artery stenosis: comparison with captopril renography and evaluation of dose and timing.
Hypertension
Losartan, a selective inhibitor of subtype AT1 receptors for angiotensin II, inhibits the binding of N-formylmethionyl-leucyl-phenylalanine to neutrophil receptors.
Hypertension
Losartan-induced attenuation of blood pressure in L-NAME hypertensive rats is associated with reversal of the enhanced expression of Gi alpha proteins.
Hypertension
Loss-of-function polymorphic variants of the human angiotensin II type 1 receptor.
Hypertension
MALDI-TOF/MS-based label-free binding assay for angiotensin II type 1 receptor: application for novel angiotensin peptides.
Hypertension
Management of hypertension: the advent of a new angiotensin II receptor antagonist.
Hypertension
Mechanisms of acute neurovascular protection with AT1 blockade after stroke: Effect of prestroke hypertension.
Hypertension
Mesangial AT1/B2 receptor heterodimers contribute to angiotensin II hyperresponsiveness in experimental hypertension.
Hypertension
Mildly oxidized low-density lipoprotein acts synergistically with angiotensin II in inducing vascular smooth muscle cell proliferation.
Hypertension
Mineralocorticoid Receptor Activation Contributes to the Supine Hypertension of Autonomic Failure.
Hypertension
Moderate-intensity exercise and renin angiotensin system blockade improve the renovascular hypertension (2K1C)-induced gastric dysmotility in rats.
Hypertension
Modulating Role of Ang1-7 in Control of Blood Pressure and Renal Function in AngII-infused Hypertensive Rats.
Hypertension
Modulation of haemodynamics, endogeneous antioxidant enzymes, and pathophysiological changes by selective inhibition of angiotensin II type 1 receptors in pressureoverload rats.
Hypertension
Molecular biology of angiotensin receptors and their role in human cardiovascular disease.
Hypertension
Molecular mechanism of angiotensin II type I and type II receptors in cardiac hypertrophy of spontaneously hypertensive rats.
Hypertension
Multiple actions of angiotensin II in hypertension: benefits of AT1 receptor blockade.
Hypertension
Nitric oxide: a physiological mediator of the type 2 (AT2) angiotensin receptor.
Hypertension
Non-peptide angiotensin type 1 receptor antagonists in the treatment of hypertension.
Hypertension
Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inhibition.
Hypertension
Normalizing the expression of nitric oxide synthase by low-dose AT1 receptor antagonism parallels improved vascular morphology in hypertensive rats.
Hypertension
Novel dual action AT1 and ETA receptor antagonists reduce blood pressure in experimental hypertension.
Hypertension
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding.
Hypertension
Olmesartan improves endothelin-induced hypertension and oxidative stress in rats.
Hypertension
Optimum AT1 receptor-neprilysin inhibition has superior cardioprotective effects compared with AT1 receptor blockade alone in hypertensive rats.
Hypertension
Overexpression of the human angiotensin II type 1 receptor in the rat heart augments load induced cardiac hypertrophy.
Hypertension
Oxidative stress-induced renal angiotensin AT1 receptor upregulation causes increased stimulation of sodium transporters and hypertension.
Hypertension
Participation of 5-HT and AT1 Receptors within the Rostral Ventrolateral Medulla in the Maintenance of Hypertension in the Goldblatt 1 Kidney-1 Clip Model.
Hypertension
Peripheral administration of AT1 receptor blockers and pressor responses to central angiotensin II and sodium.
Hypertension
Persistent cardiovascular effects of chronic renin-angiotensin system inhibition following withdrawal in adult spontaneously hypertensive rats.
Hypertension
Perturbation of D1 dopamine and AT1 receptor interaction in spontaneously hypertensive rats.
Hypertension
Pharmacokinetic and pharmacodynamic interaction of single doses of valsartan and atenolol.
Hypertension
Pharmacologic profiles of KRH-594, a novel nonpeptide angiotensin II-receptor antagonist.
Hypertension
Pharmacological Potential of Exercise and RAS Vasoactive Peptides for Prevention of Diseases.
Hypertension
Physiopathological implications of P2X1 and P2X7 receptors in regulation of glomerular hemodynamics in angiotensin II-induced hypertension.
Hypertension
Position Paper of the Department of Hypertension of the Brazilian Society of Nephrology: Use of renin-angiotensin system blockers during the course of Covid-19 infection.
Hypertension
Postovariectomy hypertension is linked to increased renal AT1 receptor and salt sensitivity.
Hypertension
Pravastatin enhances beneficial effects of olmesartan on vascular injury of salt-sensitive hypertensive rats, via pleiotropic effects.
Hypertension
Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system.
Hypertension
Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats.
Hypertension
Prevention of diabetes and left ventricular hypertrophy with AT1 receptor blockade for hypertension.
Hypertension
Prolonged angiotensin II antagonism in spontaneously hypertensive rats. Hemodynamic and biochemical consequences.
Hypertension
Prolonged reduction of high blood pressure with an in vivo, nonpathogenic, adeno-associated viral vector delivery of AT1-R mRNA antisense.
Hypertension
Protective role of the angiotensin AT2 receptor in a renal wrap hypertension model.
Hypertension
Proximal Tubule-Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice.
Hypertension
Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension.
Hypertension
Quantitative localization of angiotensin II receptor subtypes in spontaneously hypertensive rats.
Hypertension
Recent insight into therapy of congestive heart failure: focus on ACE inhibition and angiotensin-II antagonism.
Hypertension
Recent progress in molecular and cell biological studies of angiotensin receptors.
Hypertension
Recent Updates on the Proximal Tubule Renin-Angiotensin System in Angiotensin II-Dependent Hypertension.
Hypertension
Regulation of angiotensin II type 1 receptor mRNA and protein in angiotensin II-induced hypertension.
Hypertension
Regulation of growth of the adrenal gland in DOC-salt hypertension. Role of angiotensin II receptor subtypes.
Hypertension
Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone.
Hypertension
Regulation of the angiotensin receptor subtypes in cell cultures, animal models and human diseases.
Hypertension
Relation of renin-angiotensin system gene polymorphisms and expressions with the efficacy of antihypertensive drugs.
Hypertension
Renal AT1 receptor: computerized quantification in spontaneously hypertensive rats and DOCA-salt rats.
Hypertension
Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor.
Hypertension
Renin-angiotensin system and fibronectin gene expression in Dahl Iwai salt-sensitive and salt-resistant rats.
Hypertension
Renin-angiotensin system inhibition prevents type 2 diabetes mellitus. Part 2. Overview of physiological and biochemical mechanisms.
Hypertension
Resistance to oxidative stress by chronic infusion of angiotensin II in mouse kidney is not mediated by the AT2 receptor.
Hypertension
Reversal of fructose-induced hypertension and insulin resistance by chronic losartan treatment is independent of AT2 receptor activation in rats.
Hypertension
Role of angiotensin AT1, and AT2 receptors in cardiac hypertrophy and disease.
Hypertension
Role of angiotensin II and bradykinin on aortic collagen following converting enzyme inhibition in spontaneously hypertensive rats.
Hypertension
Role of angiotensin II and endogenous vasodilators in the control of glomerular hemodynamics.
Hypertension
Role of angiotensin II AT1 receptor blockers in the treatment of arterial hypertension.
Hypertension
Role of anterior hypothalamic angiotensin II in the pathogenesis of salt sensitive hypertension in the spontaneously hypertensive rat.
Hypertension
Role of AT1 and AT2 receptor subtypes in salt-sensitive hypertension induced by sensory nerve degeneration.
Hypertension
Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR.
Hypertension
Role of bradykinin in renoprotective effects by angiotensin II type 1 receptor antagonist in salt-sensitive hypertension.
Hypertension
Role of IgM and angiotensin II Type I receptor autoantibodies in local complement activation in placental ischemia-induced hypertension in the rat.
Hypertension
Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis.
Hypertension
Role of paraventricular angiotensin AT1 receptors in salt-sensitive hypertension in mRen-2 transgenic rats.
Hypertension
Role of the angiotensin AT2 receptor in blood pressure regulation and therapeutic implications.
Hypertension
Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats.
Hypertension
Role of vascular smooth muscle PPAR? in regulating AT1 receptor signaling and angiotensin II-dependent hypertension.
Hypertension
Roles of angiotensin type 1 and 2 receptors in pregnancy-associated blood pressure change.
Hypertension
Roles of AT1 and AT2 receptors in the hypertensive Ren-2 gene transgenic rat kidney.
Hypertension
Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension.
Hypertension
Salt-sensitive hypertension in ANP knockout mice is prevented by AT1 receptor antagonist losartan.
Hypertension
Sex and salt intake dependent renin-angiotensin plasticity in the liver of the rat.
Hypertension
Sex Differences in the Renal Vascular Responses of AT1 and Mas Receptors in Two-Kidney-One-Clip Hypertension.
Hypertension
Strain-dependent effects of sub-chronically infused losartan against kainic acid-induced seizures, oxidative stress, and heat shock protein 72 expression.
Hypertension
Structural adaptation to ischemia in skeletal muscle: effects of blockers of the renin-angiotensin system.
Hypertension
Structural determinants for binding, activation, and functional selectivity of the angiotensin AT1 receptor.
Hypertension
Sulfatase 2 mediates, partially, the expression of endothelin-1 and the additive effect of Ang II-induced endothelin-1 expression by CXCL8 in vascular smooth muscle cells from spontaneously hypertensive rats.
Hypertension
Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor.
Hypertension
Target organ protection from a novel angiotensin II receptor (AT1) vaccine ATR12181 in spontaneously hypertensive rats.
Hypertension
Targeting of the renin-angiotensin system by antisense gene therapy: a possible strategy for the long-term control of hypertension.
Hypertension
Telmisartan has the strongest binding affinity to angiotensin II type 1 receptor: comparison with other angiotensin II type 1 receptor blockers.
Hypertension
Telmisartan mediates anti-inflammatory and not cognitive function through PPAR-? agonism via SARM and MyD88 signaling.
Hypertension
The angiotensin II AT1 receptor antagonist irbesartan prevents thromboxane A2-induced vasoconstriction in the rat hind-limb vascular bed in vivo.
Hypertension
The angiotensin II receptor antagonist valsartan enhances lipoprotein lipase mass in preheparin serum in type 2 diabetes with hypertension.
Hypertension
The Angiotensin II Type 1(AT1) Receptor and Cardiac Hypertrophy: Did We Have It Wrong All Along?
Hypertension
The angiotensin receptor antagonist, irbesartan, reduces renal injury in experimental chronic renal failure.
Hypertension
The clinical significance of a common, functional, X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) in a cohort of 509 families with premature coronary artery disease.
Hypertension
The compensatory renin-angiotensin system in the central regulation of arterial pressure: new avenues and new challenges.
Hypertension
The effects of novokinin, an AT2 agonist, on blood pressure, vascular responses, and levels of ADMA, NADPH oxidase, and Rho kinase in hypertension induced by NOS inhibition and salt.
Hypertension
The mechanism of signal transduction during vascular smooth muscle cell proliferation induced by autoantibodies against angiotensin AT1 receptor from hypertension.
Hypertension
The neurogenic origin of hypertension in SHR may be mediated by angiotensin II through a receptor different from AT1 and AT2.
Hypertension
The Role of AT1 Receptor-Mediated Salt Retention in Angiotensin II-Dependent Hypertension.
Hypertension
The tissue renin-angiotensin system in rats with fructose-induced hypertension: overexpression of type 1 angiotensin II receptor in adipose tissue.
Hypertension
The use of ultralow doses of antibodies to C-terminal fragment of angiotensin II AT1 receptor (kardos) in the therapy of arterial hypertension.
Hypertension
Time course of inhibition of hypertension by antisense oligonucleotides targeted to AT1 angiotensin receptor mRNA in spontaneously hypertensive rats.
Hypertension
Time course of losartan blockade of angiotensin II hypertension versus blockade of angiotensin II fast pressor effects.
Hypertension
Tissue transglutaminase-mediated AT1 receptor sensitization underlies pro-inflammatory cytokine LIGHT-induced hypertension.
Hypertension
Transcriptional suppression of rat angiotensin AT1a receptor gene expression by interferon-gamma in vascular smooth muscle cells.
Hypertension
Understanding electrostatic and steric requirements related to hypertensive action of AT(1) antagonists using molecular modeling techniques.
Hypertension
Up-regulation of Akt and eNOS induces vascular smooth muscle cell differentiation in hypertension in vivo.
Hypertension
Update: role of the angiotensin type-2 (AT(2)) receptor in blood pressure regulation.
Hypertension
Upregulation of angiotensin II type 1 receptor gene expression in chronic renovascular hypertension.
Hypertension
Upregulation of AT1 Receptor Mediates a Pressor Effect Through ROS-SAPK/JNK Signaling in Glutamatergic Neurons of Rostral Ventrolateral Medulla in Rats With Stress-Induced Hypertension.
Hypertension
Upregulation of AT2 receptor and iNOS impairs angiotensin II-induced contraction without endothelium influence in young normotensive diabetic rats.
Hypertension
Vaccination against the angiotensin type 1 receptor for the prevention of L-NAME-induced nephropathy.
Hypertension
Vascular angiotensin AT1 receptor neuromodulation in fetal programming of hypertension.
Hypertension
Vasodilation mediated by angiotensin II type 2 receptor is impaired in afferent arterioles of young spontaneously hypertensive rats.
Hypertension
Vitamin D deficiency aggravates nephrotoxicity, hypertension and dyslipidemia caused by tenofovir: role of oxidative stress and renin-angiotensin system.
Hypertension
Vulnerability to stress consequences induced by repeated social defeat in rats: Contribution of the angiotensin II type 1 receptor in cardiovascular alterations associated to low brain derived neurotrophic factor.
Hypertension
[Are the antagonists of angiotensin II AT1 receptors protectors of the kidney?]
Hypertension
[AT1 blocker or calcium antagonist in treatment of hypertension. What protects the heart better?]
Hypertension
[AT1 blocker therapy of hypertension in seniors. Added protection for cerebral blood vessels?]
Hypertension
[AT1 receptor antagonist lorsartan and organ protection. Managing hypertension a different way]
Hypertension
[Candesartan cilexetil: pharmacological properties and protective effects against organ damage of a novel nonpeptide angiotensin II-receptor antagonist]
Hypertension
[Clinical study of the month. The LIFE study: cardiovascular protection of hypertensive patients by losartan]
Hypertension
[Could the understanding of racial differences prevent idiosyncratic anesthetic reactions?]
Hypertension
[Effect of puerarin injection on the mRNA expressions of AT1 and ACE2 in spontaneous hypertension rats]
Hypertension
[Effects of angiotensin II receptor antagonist on insulin sensitivity and sympathetic activity in spontaneously hypertensive rats]
Hypertension
[Effects of RNA interference targeting angiotensin 1a receptor on the blood pressure and cardiac hypertrophy of rats with 2K1C hypertension]
Hypertension
[Fixed combination of AT1 blocker and diuretic. Stroke preventive combination for hypertension]
Hypertension
[Genetic predisposition to systemic complications of arterial hypertension in maintenance haemodialysis patients]
Hypertension
[German Hypertension League on the LIFE Study. New evaluation of AT1 receptor antagonists]
Hypertension
[Hypertrophy and ventricular remodeling in systemic arterial hypertension: role of AT1 receptors]
Hypertension
[Irbesartan--antihypertensive treatment in patients with heart failure and diabetes mellitus]
Hypertension
[Pathophysiological roles of angiotensin in the pathogenesis of hypertension and cardiovascular remodeling]
Hypertension
[Significance of the angiotensin-II receptor AT1 in the pathogenesis of arterial hypertension and arteriosclerosis]
Hypertension
[Study of autoantibodies against the G-protein-coupled beta 2- and alpha 1-adrenergic and AT1 receptors in patients with primary hypertension]
Hypertension
[The role of DNA polymorphism in the renin-angiotensin system and the pathogenesis of cardiovascular diseases]
Hypertension
[The usefulness of a new class antihypertensive drug, angiotensin II receptor antagonist, for essential hypertension]
Hypertension, Malignant
Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection.
Hypertension, Malignant
AT1 receptor blockade prevents the increase in blood pressure and the augmentation of intrarenal ANG II levels in hypertensive Cyp1a1-Ren2 transgenic rats fed with a high-salt diet.
Hypertension, Malignant
Autoantibodies against the angiotensin receptor (AT1) in patients with hypertension.
Hypertension, Malignant
Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat.
Hypertension, Malignant
The mechanism of signal transduction during vascular smooth muscle cell proliferation induced by autoantibodies against angiotensin AT1 receptor from hypertension.
Hypertension, Portal
Expression of angiotensin II type 1 receptor in human cirrhotic livers: Its relation to fibrosis and portal hypertension.
Hypertension, Pregnancy-Induced
Expression of angiotensin II receptor-like 1 in the placentas of pregnancy-induced hypertension.
Hypertension, Pregnancy-Induced
Roles of angiotensin type 1 and 2 receptors in pregnancy-associated blood pressure change.
Hypertension, Pulmonary
Angiotensin II and monocrotaline-induced pulmonary hypertension: effect of losartan (DuP 753), a nonpeptide angiotensin type 1 receptor antagonist.
Hypertension, Pulmonary
Angiotensin II receptor expression and inhibition in the chronically hypoxic rat lung.
Hypertension, Pulmonary
Chronic iron overload induces vascular dysfunction in resistance pulmonary arteries associated with right ventricular remodeling in rats.
Hypertension, Pulmonary
Evaluation of olmesartan medoxomil in the rat monocrotaline model of pulmonary hypertension.
Hypertension, Pulmonary
Lung angiotensin receptor binding characteristics during the development of monocrotaline-induced pulmonary hypertension.
Hypertension, Pulmonary
Modification of the pulmonary renin-angiotensin system and lung structural remodelling in congestive heart failure.
Hypertension, Pulmonary
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding.
Hypertension, Pulmonary
Selective Activation of At2 Receptor Attenuates Progression of Pulmonary Hypertension and Inhibits Cardiopulmonary Fibrosis.
Hypertension, Pulmonary
[Effects of estrogen on ACE-Ang II-AT1 axis in ovariectomy and hypoxic pulmonary hypertension rats].
Hypertension, Pulmonary
[Losartan prevents pulmonary hypertension induced by a thromboxane A2 analog]
Hypertension, Renal
Acute AT1 receptor blockade does not improve the depressed baroreflex in rats with chronic renal hypertension.
Hypertension, Renal
Angiotensin AT1 receptor blockade by specific antibody prevented two-kidney, one-clip renal hypertension in the rat.
Hypertension, Renal
Differential regulation of renal angiotensin subtype AT1A and AT2 receptor protein in rats with angiotensin-dependent hypertension.
Hypertension, Renovascular
ACE inhibition is superior to angiotensin receptor blockade for renography in renal artery stenosis.
Hypertension, Renovascular
Angiotensin II receptors in cardiac left ventricles of Dahl rats.
Hypertension, Renovascular
Angiotensin II type 1 receptor messenger RNA levels in human blood cells of patients with primary and secondary hypertension: reference to renin profile.
Hypertension, Renovascular
Angiotensin II-dependent increased expression of Na+-glucose cotransporter in hypertension.
Hypertension, Renovascular
Angiotensin type 2 receptor-mediated phosphorylation of eNOS in the aortas of mice with 2-kidney, 1-clip hypertension.
Hypertension, Renovascular
AT1 and TxA2/PGH2 receptors maintain hypertension throughout 2K,1C Goldblatt hypertension in the rat.
Hypertension, Renovascular
Genetic inactivation of the B2 receptor in mice worsens two-kidney, one-clip hypertension: role of NO and the AT2 receptor.
Hypertension, Renovascular
Reliability of captopril renography in patients under chronic therapy with angiotensin II (AT1) receptor antagonists.
Hypertension, Renovascular
The role of AT1 receptor-mediated reproductive function in renovascular hypertension in male rats.
Hypertension, Renovascular
Vaccarin alleviates hypertension and nephropathy in renovascular hypertensive rats.
Hyperthyroidism
Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem and propranolol.
Hyperthyroidism
Cardiac microvascular rarefaction in hyperthyroidism-induced left ventricle dysfunction.
Hyperthyroidism
Involvement of renin-angiotensin system in the reduced pressure natriuresis response of hyperthyroid rats.
Hypertriglyceridemia
Effect of telmisartan, angiotensin II receptor antagonist, on metabolic profile in fructose-induced hypertensive, hyperinsulinemic, hyperlipidemic rats.
Hypertrophy, Left Ventricular
Angiotensin AT1/AT2 receptors: regulation, signalling and function.
Hypertrophy, Left Ventricular
Angiotensin II receptor gene expression in hypertrophied left ventricles of rat hearts.
Hypertrophy, Left Ventricular
Angiotensin II stimulation of left ventricular hypertrophy in adult rat heart. Mediation by the AT1 receptor.
Hypertrophy, Left Ventricular
Angiotensin in the kidney: a key to understanding hypertension?
Hypertrophy, Left Ventricular
AT1 blockade abolishes left ventricular hypertrophy in heterozygous cMyBP-C null mice: role of FHL1.
Hypertrophy, Left Ventricular
Blockade of Angiotensin II Type 1 Receptor Improves the Arrhythmia Morbidity in Mice With Left Ventricular Hypertrophy.
Hypertrophy, Left Ventricular
Blood pressure lowering and renin-angiotensin system blockade.
Hypertrophy, Left Ventricular
Cardiac hypertrophy and fibrosis in chronic L-NAME-treated AT2 receptor-deficient mice.
Hypertrophy, Left Ventricular
Development of pressure overload induced cardiac hypertrophy is unaffected by long-term treatment with losartan.
Hypertrophy, Left Ventricular
Effect of combination of valsartan with benazepril on blood pressure and left ventricular hypertrophy in SHR.
Hypertrophy, Left Ventricular
Effects of angiotensin-converting enzyme inhibition and angiotensin II AT1 receptor antagonism on cardiac parameters in left ventricular hypertrophy.
Hypertrophy, Left Ventricular
Experimental evidence for effects of ramipril on cardiac and vascular hypertrophy beyond blood pressure reduction.
Hypertrophy, Left Ventricular
Human chymase expression in a mice induces mild hypertension with left ventricular hypertrophy.
Hypertrophy, Left Ventricular
Intronic ANG II type 2 receptor gene polymorphism 1675 G/A modulates receptor protein expression but not mRNA splicing.
Hypertrophy, Left Ventricular
Prevention of diabetes and left ventricular hypertrophy with AT1 receptor blockade for hypertension.
Hypertrophy, Left Ventricular
Regression of left ventricular hypertrophy by AT1 receptor blockade in renal transplant recipients.
Hypertrophy, Left Ventricular
The angiotensin AT2 receptor in left ventricular hypertrophy.
Hypertrophy, Left Ventricular
[Clinical study of the month. The LIFE study: cardiovascular protection of hypertensive patients by losartan]
Hypertrophy, Right Ventricular
Angiotensin AT1 receptor blockade fails to attenuate pressure-overload cardiac hypertrophy in fetal sheep.
Hypertrophy, Right Ventricular
Angiotensin II receptor expression and inhibition in the chronically hypoxic rat lung.
Hypertrophy, Right Ventricular
Evaluation of olmesartan medoxomil in the rat monocrotaline model of pulmonary hypertension.
Hypertrophy, Right Ventricular
Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27.
Hypoalbuminemia
Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis.
Hypoglycemia
AT1 and AT2 receptor blockade and epinephrine release during insulin-induced hypoglycemia.
Hypoglycemia
AT1 receptor blockade and the sympathoadrenal response to insulin-induced hypoglycemia in humans.
Hypoglycemia
Brain angiotensin receptors and sympathoadrenal regulation during insulin-induced hypoglycemia.
Hypoglycemia
The AT1 receptor autoantibody causes hypoglycemia in fetal rats via promoting the STT3A-GLUT1-glucose uptake axis in liver.
Hypokalemia
Low-dose angiotensin AT1 receptor ?-arrestin-biased ligand, TRV027, protects against cisplatin-induced nephrotoxicity.
Hypophosphatemia
Vitamin D deficiency aggravates nephrotoxicity, hypertension and dyslipidemia caused by tenofovir: role of oxidative stress and renin-angiotensin system.
Hypophosphatemia, Familial
Vitamin D deficiency aggravates nephrotoxicity, hypertension and dyslipidemia caused by tenofovir: role of oxidative stress and renin-angiotensin system.
Hypotension
Angiotensin II AT2 receptor stimulation increases cerebrovascular resistance during hemorrhagic hypotension in rats.
Hypotension
Anomalous effects of losartan on aminopeptidase-induced reductions of blood pressure in SHR.
Hypotension
Antihypertensive effect of a standardized aqueous extract of Cecropia glaziovii Sneth in rats: an in vivo approach to the hypotensive mechanism.
Hypotension
Effects of acute AT1 receptor blockade by candesartan on arterial pressure and renal function in rats.
Hypotension
Endogenous angiotensin II in the paraventricular nucleus regulates arterial pressure during hypotension in rat, a single-unit study.
Hypotension
Peroxisome proliferator-activated receptor alpha activation attenuated angiotensin type 1-mediated but enhanced angiotensin type 2-mediated hemodynamic effects to angiotensin II in the rat.
Hypotension
Renal responses of the nonclipped kidney of two-kidney/one-clip Goldblatt hypertensive rats to type 1 angiotensin II receptor blockade with candesartan.
Hypotension
Role of the angiotensin AT2 receptor in blood pressure regulation and therapeutic implications.
Hypotension
Selective blockade of AT1 receptor attenuates impairment of hypotensive autoregulation and improves cerebral blood flow after brain injury in the newborn pig.
Hypotension
The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension.
Hypoxia, Brain
Beneficial effects of combination of valsartan and amlodipine on salt-induced brain injury in hypertensive rats.
Idiopathic Pulmonary Fibrosis
Culture of human alveolar epithelial type II cells by sprouting.
Idiopathic Pulmonary Fibrosis
Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis.
Idiopathic Pulmonary Fibrosis
Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture.
Idiopathic Pulmonary Fibrosis
Telomere shortening and DNA damage in culprit cells of different types of progressive fibrosing interstitial lung disease.
Infarction, Middle Cerebral Artery
Angiotensin II type-2 receptor stimulation prevents neural damage by transcriptional activation of methyl methanesulfonate sensitive 2.
Infarction, Middle Cerebral Artery
Ischemic injury in experimental stroke depends on angiotensin II.
Infarction, Middle Cerebral Artery
Sustained blockade of brain AT1 receptors before and after focal cerebral ischemia alleviates neurologic deficits and reduces neuronal injury, apoptosis, and inflammatory responses in the rat.
Infections
Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury.
Infections
Detection of angiotensin ii type i-receptor antibodies in transplant glomerulopathy.
Infections
G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor.
Infections
Plant eR genes that encode photorespiratory enzymes confer resistance against disease.
Infections
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.
Infections
Rapid expression of recombinant proteins in modified CHO cells using the baculovirus system.
Infections
Shape-based Machine Learning Models for the Potential Novel COVID-19 Protease Inhibitors Assisted by Molecular Dynamics Simulation
Infections
Single Cell RNA-seq Data Analysis Reveals the Potential Risk of SARS-CoV-2 Infection Among Different Respiratory System Conditions.
Infections
Telmisartan, an AT1 receptor blocker and a PPAR gamma activator, alleviates liver fibrosis induced experimentally by Schistosoma mansoni infection.
Infections
The expression of human brain vascular smooth muscle cell AT receptor after the UL83 gene of HCMV inhibition by small interfering RNAs.
Infertility, Male
Angiotensin II regulates testicular peritubular cell function via AT1 receptor: a specific situation in male infertility.
Infertility, Male
Decreased angiotensin receptor 1 expression in?±?AT1 Knockout mice testis results in male infertility and GnRH reduction.
Influenza, Human
Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury.
Influenza, Human
Insights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regenerating Cells and by Lung Proteomics.
Influenza, Human
Mesenchyme-free expansion and transplantation of adult alveolar progenitor cells: steps toward cell-based regenerative therapies.
Influenza, Human
N-linked glycosylation is required for optimal AT1a angiotensin receptor expression in COS-7 cells.
Insulin Resistance
ACE inhibitors versus AT1 blockers in the treatment of hypertension and syndrome X.
Insulin Resistance
Activation of AT2 receptors prevents diabetic complications in female db/db mice by NO-mediated mechanisms.
Insulin Resistance
Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity.
Insulin Resistance
ANG II type I receptor antagonism improved nitric oxide production and enhanced eNOS and PKB/Akt expression in hearts from a rat model of insulin resistance.
Insulin Resistance
Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue.
Insulin Resistance
Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice.
Insulin Resistance
Angiotensin II Type 2 Receptor Inhibits Vascular Intimal Proliferation With Activation of PPAR?.
Insulin Resistance
Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice.
Insulin Resistance
Angiotensin receptor blockade improves cardiac mitochondrial activity in response to an acute glucose load in obese insulin resistant rats.
Insulin Resistance
Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats.
Insulin Resistance
Anti-inflammatory and metabolic effects of candesartan in hypertensive patients.
Insulin Resistance
AT1 Receptor Blockade Attenuates Insulin Resistance and Myocardial Remodeling in Rats with Diet-Induced Obesity.
Insulin Resistance
BLOCKADE OF THE RENIN-ANGIOTENSIN SYSTEM IMPROVES INSULIN RECEPTOR SIGNALING AND INSULIN-STIMULATED SKELETAL MUSCLE GLUCOSE TRANSPORT IN BURN INJURY.
Insulin Resistance
Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders.
Insulin Resistance
Comparison of type 1 angiotensin II receptor blockers and angiotensin converting enzyme inhibitors in the treatment of hypertension.
Insulin Resistance
Differential effects of ACE-inhibition and angiotensin II antagonism on fibrinolysis and insulin sensitivity in hypertensive postmenopausal women.
Insulin Resistance
Effects of losartan on blood pressure, metabolic alterations, and vascular reactivity in the fructose-induced hypertensive rat.
Insulin Resistance
Evidence for a causal role of the renin-angiotensin system in vascular dysfunction associated with insulin resistance.
Insulin Resistance
Evidence for functional expression of vascular angiotensin II type 2 receptors in patients with insulin resistance.
Insulin Resistance
Functional interaction of AT1 and AT2 receptors in fructose-induced insulin resistance and hypertension in rats.
Insulin Resistance
Hepatic structural enhancement and insulin resistance amelioration due to AT1 receptor blockade.
Insulin Resistance
Improved Insulin Sensitivity after Long-Term Treatment with AT1 Blockers Is Not Associated with PPAR? Target Gene Regulation.
Insulin Resistance
Insulin resistance induces a segmental difference in thoracic and abdominal aorta: differential expression of AT1 and AT2 receptors.
Insulin Resistance
Is there relationship between the A1166C polymorphism of the angiotensin II receptor AT1 and plasma renin activity, insulin resistance and reduction of blood pressure after angiotensin-converting enzyme inhibitor therapy?
Insulin Resistance
Reversal of fructose-induced hypertension and insulin resistance by chronic losartan treatment is independent of AT2 receptor activation in rats.
Insulin Resistance
Simultaneous angiotensin receptor blockade and glucagon-like peptide-1 receptor activation ameliorate albuminuria in obese insulin-resistant rats.
Insulin Resistance
The role of the renin-angiotensin system in the development of insulin resistance in skeletal muscle.
Insulin Resistance
Valsartan, independently of AT1 receptor or PPAR?, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.
Insulin Resistance
[Effects of angiotensin II receptor antagonist on insulin sensitivity and sympathetic activity in spontaneously hypertensive rats]
Insulin Resistance
[Treatment of hypertension in patients with diabetes mellitus and lower limb ischemia]
Intermittent Claudication
Structural adaptation to ischemia in skeletal muscle: effects of blockers of the renin-angiotensin system.
Iron Overload
Chronic iron overload induces vascular dysfunction in resistance pulmonary arteries associated with right ventricular remodeling in rats.
Iron Overload
[Effect of iron overload on experimental immunological liver injury in rats and the role of angiotensin]
Ischemic Attack, Transient
Deterioration of cognitive function after transient cerebral ischemia with amyloid-? infusion-possible amelioration of cognitive function by AT2 receptor activation.
Ischemic Contracture
Angiotensin II subtype 1 (AT1) receptors contribute to ischemic contracture and regulate chemomechanical energy transduction in isolated transgenic rat (alphaMHC-hAT1)594-17 hearts.
Ischemic Stroke
Cerebral ischemia enhances vascular angiotensin AT1 receptor-mediated contraction in rats.
Ischemic Stroke
Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant.
Ischemic Stroke
Ischemia Induced Brain Damage Is Enhanced in Human Renin and Angiotensinogen Double Transgenic Mice.
Ischemic Stroke
Neuroprotective effects of AT1 receptor antagonists after experimental ischemic stroke: what is important?
Ischemic Stroke
Protective effect of candesartan in experimental ischemic stroke in the rat mediated by AT2 and AT4 receptors.
Keloid
Detection of Angiotensin II and AT1 Receptor Concentrations in Keloid and Hypertrophic Scar.
Keratoacanthoma
Differences between squamous cell carcinoma and keratoacanthoma in angiotensin type-1 receptor expression.
Kidney Diseases
Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes.
Kidney Diseases
Regulation of TRPC6 ion channels in podocytes - Implications for focal segmental glomerulosclerosis and acquired forms of proteinuric diseases.
Kidney Diseases
[Are the antagonists of angiotensin II AT1 receptors protectors of the kidney?]
Kidney Diseases
[The significance of angiotensin-converting enzyme inhibitors genotype for ACEi response in patients with chronic allograft nephropathy]
Kidney Failure, Chronic
Angiotensin II AT1 receptor blockade changes expression of renal sodium transporters in rats with chronic renal failure.
Kidney Failure, Chronic
AT1 receptor up-regulation in intestine in chronic renal failure is segment specific.
Kidney Failure, Chronic
Effects of losartan and captopril on endothelin-1 production in blood vessels and glomeruli of rats with reduced renal mass.
Kidney Failure, Chronic
Increased colonic sodium absorption in rats with chronic renal failure is partially mediated by AT1 receptor agonism.
Kidney Failure, Chronic
Metabolic reprogramming by N-acetyl-seryl-aspartyl-lysyl-proline protects against diabetic kidney disease.
Kidney Failure, Chronic
The renin-angiotensin system and progression of renal disease: from hemodynamics to cell biology.
Kidney Failure, Chronic
[ACE and AT1 inhibitors in used in the progression of chronic renal failure]
Kidney Failure, Chronic
[Different effect of angiotensin convertase inhibitors and AT1 receptor blockers on renal function in patients with chronic renal failure: report of two cases]
Leiomyoma
Type 2 angiotensin II receptor is expressed in human myometrium and uterine leiomyoma and is down-regulated during pregnancy.
Leiomyosarcoma
Activation of intracellular angiotensin AT2 receptors induces rapid cell death in human uterine leiomyosarcoma cells.
Leiomyosarcoma
Activation of the cell membrane angiotensin AT2 receptors in human leiomyosarcoma cells induces differentiation and apoptosis by a PPAR? - dependent mechanism.
Leukemia
Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction.
Liddle Syndrome
Quantitative trait loci for blood pressure exist near the IGF-1, the Liddle syndrome, the angiotensin II-receptor gene and the renin loci in man.
Liver Cirrhosis
Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis.
Liver Cirrhosis
AT1 receptor antagonist Candesartan in selected cirrhotic patients: effect on portal pressure and liver fibrosis markers.
Liver Cirrhosis
Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice.
Liver Cirrhosis
Expression of angiotensin II type 1 receptor in human cirrhotic livers: Its relation to fibrosis and portal hypertension.
Liver Cirrhosis
Potential antifibrotic effects of at1 receptor antagonist, losartan, and/or praziquantel on acute and chronic experimental liver fibrosis induced by schistosoma mansoni.
Liver Cirrhosis
Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats.
Liver Cirrhosis
Telmisartan, an AT1 receptor blocker and a PPAR gamma activator, alleviates liver fibrosis induced experimentally by Schistosoma mansoni infection.
Liver Diseases
Chronic angiotensin receptor activation promotes hepatic triacylglycerol accumulation during an acute glucose challenge in obese-insulin-resistant OLETF rats.
Liver Diseases
Pharmacokinetics and safety of candesartan cilexetil in subjects with normal and impaired liver function.
Liver Failure
Angiotensin II type 1 receptor antagonist improves the prognosis in rats displaying liver cirrhosis induced by a choline-deficient diet.
Lung Diseases
A SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.
Lung Diseases
Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes.
Lung Diseases
Heterogeneous groups of alveolar type II cells in lung homeostasis and repair.
Lung Diseases
In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids.
Lung Diseases
Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease.
Lung Diseases
Oxidized Ferric and Ferryl Forms of Hemoglobin Trigger Mitochondrial Dysfunction and Injury in Alveolar Type I Cells.
Lung Diseases
Regulation of alveolar type 2 stem/progenitor cells in lung injury and regeneration.
Lung Diseases
Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture.
Lung Diseases, Interstitial
A SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.
Lung Diseases, Interstitial
Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice.
Lung Injury
A Cellular Pathway Involved in Clara Cell to Alveolar Type II Cell Differentiation after Severe Lung Injury.
Lung Injury
Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration.
Lung Injury
Angiocrine Sphingosine-1-Phosphate Activation of S1PR2-YAP Signaling Axis in Alveolar Type II Cells Is Essential for Lung Repair.
Lung Injury
Angiotensin II is related to the acute aortic dissection complicated with lung injury through mediating the release of MMP9 from macrophages.
Lung Injury
Angiotensin II receptor antagonists in the treatment and prevention of radiation nephropathy.
Lung Injury
Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury.
Lung Injury
Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells.
Lung Injury
Bone Marrow-Derived VSELs Engraft as Lung Epithelial Progenitor Cells after Bleomycin-Induced Lung Injury.
Lung Injury
Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice.
Lung Injury
Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis.
Lung Injury
FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury.
Lung Injury
Fraction of MHCII and EpCAM expression characterizes distal lung epithelial cells for alveolar type 2 cell isolation.
Lung Injury
Impact of Regulatory T Cells on Type 2 Alveolar Epithelial Cell Transcriptomes during Resolution of Acute Lung Injury and Contributions of IFN-?.
Lung Injury
Losartan attenuated lipopolysaccharide-induced lung injury by suppression of lectin-like oxidized low-density lipoprotein receptor-1.
Lung Injury
Losartan, a selective antagonist of AT1 receptor, attenuates seawater inhalation induced lung injury via modulating JAK2/STATs and apoptosis in rat.
Lung Injury
Protein Expression Profile of Rat Type Two Alveolar Epithelial Cells During Hyperoxic Stress and Recovery.
Lung Injury
Regulation of alveolar type 2 stem/progenitor cells in lung injury and regeneration.
Lung Injury
Serum-Free Differentiation of Murine Embryonic Stem Cells into Alveolar Type II Epithelial Cells.
Lung Injury
Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture.
Lung Injury
The common ABCA3E292V variant disrupts AT2 cell quality control and increases susceptibility to lung injury and aberrant remodeling.
Lung Injury
The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury.
Lung Neoplasms
A precision-guided MWNT mediated reawakening the sunk synergy in RAS for anti-angiogenesis lung cancer therapy.
Lung Neoplasms
Angiotensin II elevates cytosolic free calcium in human lung adenocarcinoma cells via activation of AT1 receptors.
Lung Neoplasms
Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis.
Lung Neoplasms
Mutationally-activated PI3'-kinase-? promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase.
Lymphoma
An 18-kDa domain of a glycosylphosphatidylinositol-linked NAD:arginine ADP-ribosyltransferase possesses NAD glycohydrolase activity.
Lymphopenia
Expression of NAD glycohydrolase activity by rat mammary adenocarcinoma cells transformed with rat T cell alloantigen RT6.2.
Macular Degeneration
Cuticular drusen associated with aneurysmal type 1 neovascularization (polypoidal choroidal vasculopathy).
Marfan Syndrome
Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism.
Marfan Syndrome
Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications.
Marfan Syndrome
AT1 receptor antagonism to reduce aortic expansion in Marfan syndrome: lost in translation or in need of different interpretation?
Marfan Syndrome
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
Melanoma
AT1 receptors activation enhances the expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 melanoma cells.
Melanoma
Diagnostic accuracy of whole slide imaging for cutaneous, soft tissue, and melanoma sentinel lymph node biopsies with and without immunohistochemistry.
Melanoma
Inhibition of angiotensin II receptor 1 limits tumor-associated angiogenesis and attenuates growth of murine melanoma.
Melanoma
The Angiotensin II Type 1 Receptor Antagonist Losartan Affects NHE1-Dependent Melanoma Cell Behavior.
Memory Disorders
A Comparative Study on the Memory-Enhancing Actions of Oral Renin-Angiotensin System Altering Drugs in Scopolamine-Treated Mice.
Memory Disorders
Candesartan improves memory decline in mice: involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin.
Metabolic Diseases
Characterization in mice of the resident mesenchymal niche maintaining AT2 stem cell proliferation in homeostasis and disease.
Metabolic Syndrome
A mechanism underlying hypertensive occurrence in the metabolic syndrome: cooperative effect of oxidative stress and calcium accumulation in vascular smooth muscle cells.
Metabolic Syndrome
Angiotensin II and 1-7 during aging in Metabolic Syndrome rats. Expression of AT1, AT2 and Mas receptors in abdominal white adipose tissue.
Metabolic Syndrome
Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue.
Metabolic Syndrome
Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats.
Metabolic Syndrome
Coronary arteriolar vasoconstriction to angiotensin II is augmented in prediabetic metabolic syndrome via activation of AT1 receptors.
Metabolic Syndrome
Interaction between insulin and AT1 receptor. Relevance for hypertension and arteriosclerosis.
Metabolic Syndrome
Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats.
Muscle Weakness
Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging-Related Muscle Weakness in Male Mice.
Muscular Disorders, Atrophic
Losartan restores skeletal muscle remodeling and protects against disuse atrophy in sarcopenia.
Muscular Dystrophies, Limb-Girdle
In dystrophic hamsters losartan affects control of ventilation and dopamine D1 receptor density.
Mydriasis
[Could the understanding of racial differences prevent idiosyncratic anesthetic reactions?]
Myocardial Infarction
ACE inhibitor suppresses cardiac remodeling after myocardial infarction by regulating dendritic cells and AT2 receptor-mediated mechanism in mice.
Myocardial Infarction
Activation of angiotensin type 2 (AT2) receptors prevents myocardial hypertrophy in Zucker diabetic fatty rats.
Myocardial Infarction
Aliskiren and Valsartan reduce myocardial AT1 receptor expression and limit myocardial infarct size in diabetic mice.
Myocardial Infarction
Angiotensin AT2 receptor deficiency after myocardial infarction: its effects on cardiac function and fibrosis depend on the stimulus.
Myocardial Infarction
Angiotensin blockade inhibits SIF DNA binding activities via STAT3 after myocardial infarction.
Myocardial Infarction
Angiotensin II receptor binding following myocardial infarction in the rat.
Myocardial Infarction
Angiotensin II receptor blockade and myocardial fibrosis of the infarcted rat heart.
Myocardial Infarction
Angiotensin II via AT1 receptor accelerates arterial thrombosis in renovascular hypertensive rats.
Myocardial Infarction
Angiotensin receptors alter myocardial infarction-induced remodeling of the guinea pig cardiac plexus.
Myocardial Infarction
Antagonism of the renin-angiotensin-aldosterone system and collagen metabolism in cardiac fibroblasts.
Myocardial Infarction
Antioxidant effect of valsartan in experimental model of myocardial infarction.
Myocardial Infarction
Association between AT C573T polymorphism and cardiovascular risk factors in myocardial infarction.
Myocardial Infarction
AT1 receptor blockade alters metabolic, functional and structural proteins after reperfused myocardial infarction: detection using proteomics.
Myocardial Infarction
AT1 receptor blockade for the prevention of cardiovascular events after myocardial infarction.
Myocardial Infarction
AT1 receptor blockade in experimental myocardial ischemia/reperfusion.
Myocardial Infarction
AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction in rats.
Myocardial Infarction
AT1 receptor blockade limits myocardial injury and upregulates AT2 receptors during reperfused myocardial infarction.
Myocardial Infarction
AT1 receptor blockade prevents cardiac dysfunction after myocardial infarction in rats.
Myocardial Infarction
AT2 receptor and apoptosis during AT1 receptor blockade in reperfused myocardial infarction in the rat.
Myocardial Infarction
AT2 receptor blockade reduces cardiac interstitial cell DNA synthesis and cardiac function after rat myocardial infarction.
Myocardial Infarction
Atrial expression of the CCN1 and CCN2 proteins in chronic heart failure.
Myocardial Infarction
Blood pressure lowering and renin-angiotensin system blockade.
Myocardial Infarction
BR 09-3 AT2R STIMULATION AND ITS EFFECT ON TARGET ORGAN DAMAGE: THERAPEUTIC IMPLICATIONS.
Myocardial Infarction
Cardiac c-kit+AT2+ Cell Population is Increased in Response to Ischemic Injury and Supports Cardiomyocyte Performance.
Myocardial Infarction
Cardiac hypertrophy is associated with decreased eNOS expression in angiotensin AT2 receptor-deficient mice.
Myocardial Infarction
Cardioprotection after angiotensin II type 1 blockade involves angiotensin II type 2 receptor expression and activation of protein kinase C-epsilon in acutely reperfused myocardial infarction in the dog. Effect of UP269-6 and losartan on AT1 and AT2-receptor expression and IP3 receptor and PKCepsilon proteins.
Myocardial Infarction
Cardioprotective role of AT2 receptor in postinfarction left ventricular remodeling.
Myocardial Infarction
CCN1 expression in interleukin-6 deficient mouse kidney in experimental model of heart failure.
Myocardial Infarction
Combination therapy with angiotensin converting enzyme inhibition and AT1 receptor inhibitor on ventricular remodeling after myocardial infarction in rats.
Myocardial Infarction
Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat.
Myocardial Infarction
Differential effects of angiotensin AT1 and AT2 receptors on the expression, translation and function of the Na+-H+ exchanger and Na+-HCO3- symporter in the rat heart after myocardial infarction.
Myocardial Infarction
Dual ACE-inhibition and angiotensin II AT1 receptor antagonism with curcumin attenuate maladaptive cardiac repair and improve ventricular systolic function after myocardial infarctionin rat heart.
Myocardial Infarction
Effect of ANG II on pHi, [Ca2+]i, and contraction in rabbit ventricular myocytes from infarcted hearts.
Myocardial Infarction
Effect of AT1 receptor blockade on cardiac collagen remodeling after myocardial infarction.
Myocardial Infarction
Effect of chronic blockade of angiotensin II-receptor subtypes on aortic compliance in rats with myocardial infarction.
Myocardial Infarction
Effect of Early vs Late AT1 Receptor Blockade with Losartan on Post-Myocardial Infarction Ventricular Remodeling in Rabbits.
Myocardial Infarction
Effect of losartan and captopril on expression of cardiac angiotensin II AT1 receptor mRNA in rats following myocardial infarction.
Myocardial Infarction
Effects of angiotensin-converting enzyme inhibition and angiotensin II AT1 receptor antagonism on cardiac parameters in left ventricular hypertrophy.
Myocardial Infarction
Effects of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on beta-adrenoceptor signaling in heart failure produced by myocardial Infarction in rabbits: reversal of altered expression of beta-adrenoceptor kinase and G i alpha.
Myocardial Infarction
Effects of AT1 receptor blockade after myocardial infarct on myocardial fibrosis, stiffness, and contractility.
Myocardial Infarction
Effects of losartan on haemodynamic parameters and angiotensin receptor mRNA levels in rat heart after myocardial infarction.
Myocardial Infarction
Efficacy of angiotensin-converting enzyme inhibition and AT1 receptor blockade on cardiac pump performance after myocardial infarction in rats.
Myocardial Infarction
Expression of Renin-Angiotensin System on Dendritic Cells of Patients with Coronary Artery Disease.
Myocardial Infarction
Increased expression of glomerular AT1 receptors in rats with myocardial infarction.
Myocardial Infarction
Increases in brain and cardiac AT1 receptor and ACE densities after myocardial infarct in rats.
Myocardial Infarction
Influence of myocardial infarction on changes in the expression of angiotensin type 1 receptor in the rat prostate.
Myocardial Infarction
Influence of the angiotensin II AT1 receptor antagonist irbesartan on ischemia/reperfusion injury in the dog heart.
Myocardial Infarction
Inhibition by angiotensin II type 1 receptor antagonist of cardiac phenotypic modulation after myocardial infarction.
Myocardial Infarction
Interaction of AT1 receptors and V1a receptors-mediated effects in the central cardiovascular control during the post-infarct state.
Myocardial Infarction
Mineralocorticoid and AT1 receptors in the paraventricular nucleus contribute to sympathetic hyperactivity and cardiac dysfunction in rats post myocardial infarct.
Myocardial Infarction
Myocardial angiotensin II receptor expression and ischemia-reperfusion injury.
Myocardial Infarction
Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone.
Myocardial Infarction
Relationship between remodeling and function of left ventricle and angiotensin II AT1 receptor expression after myocardial infarction in rats.
Myocardial Infarction
Renin-angiotensin system and associated gene polymorphisms in myocardial infarction in young South African Indians.
Myocardial Infarction
Retraction notice to Dual ACE-inhibition and angiotensin II AT1 receptor antagonism with curcumin attenuate maladaptive cardiac repair and improve ventricular systolic function after myocardial infarction in rat heart [Eur.J.Pharmacol.January(2015)2230].
Myocardial Infarction
Role of ACE inhibition or AT1 blockade in the remodeling following myocardial infarction.
Myocardial Infarction
Role of angiotensin AT1 and AT2 receptors in cardiac hypertrophy and cardiac remodelling.
Myocardial Infarction
Role of AT2 receptors in the cardioprotective effect of AT1 antagonists in mice.
Myocardial Infarction
Role of intracardiac renin-angiotensin-aldosterone system in extracellular matrix remodeling.
Myocardial Infarction
Suppression of Ventricular Arrhythmias After Myocardial Infarction by AT1 Receptor Blockade: Role of the AT2 Receptor and Casein Kinase 2/Kir2.1 Pathway. Editorial to: "Valsartan Upregulates Kir2.1 in Rats Suffering from Myocardial Infarction Via Casein Kinase 2" by Xinran Li et al.
Myocardial Infarction
Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction.
Myocardial Infarction
The angiotensin II type 1 receptor gene polymorphism is associated with coronary artery vasoconstriction.
Myocardial Infarction
The bradykinin B1 receptor contributes to the cardioprotective effects of AT1 blockade after experimental myocardial infarction.
Myocardial Infarction
The genotype interactions of methylenetetrahydrofolate reductase and renin-angiotensin system genes are associated with myocardial infarction.
Myocardial Infarction
The paradoxical association of common polymorphisms of the renin-angiotensin system genes with risk of myocardial infarction.
Myocardial Infarction
The potential role of the angiotensin subtype 2 receptor in cardiovascular protection.
Myocardial Infarction
The Protective Role of AT2 and B1 Receptors in Kinin B2 Receptor Knockout Mice with Myocardial Infarction.
Myocardial Infarction
Up-regulated expression of angiotensin II type 1 receptor gene in human pathologic hearts.
Myocardial Infarction
[Changes in expression of angiotensin subtype AT1A and AT2 receptors in rats during cardiac remodeling following myocardial infarction]
Myocardial Infarction
[Distribution and function of angiotensin receptor subtypes in cardiovascular system]
Myocardial Infarction
[Effects of combination therapy with angiotensin I-converting enzyme inhibitor and angiotensin 1 receptor antagonist on ventricular remodeling and expression of endothelial nitric oxide synthase]
Myocardial Infarction
[The role of DNA polymorphism in the renin-angiotensin system and the pathogenesis of cardiovascular diseases]
Myocardial Ischemia
Angiotensin II type 1 receptor blockade abolishes specific K(ATP)channel gene expression in rats with myocardial ischemia.
Myocardial Ischemia
Coupling of angiotensin II AT1 receptors to neuronal NHE activity and carrier-mediated norepinephrine release in myocardial ischemia.
Myocardial Ischemia
Differential distribution of angiotensin AT2 receptors in the normal and failing human heart.
Myocardial Ischemia
Effects of acute and chronic angiotensin receptor blockade on myocardial vascular blood volume and perfusion in a pig model of coronary microembolization.
Myocardial Ischemia
Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease.
Myocardial Ischemia
Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction.
Myocardial Stunning
Attenuation of myocardial stunning by the AT1 receptor antagonist candesartan.
nad+-protein-arginine adp-ribosyltransferase deficiency
AT1-receptor-deficiency induced atheroprotection in diabetic mice is partially mediated via PPARgamma.
nad+-protein-arginine adp-ribosyltransferase deficiency
Deficiency of angiotensin type 2 receptor rescues obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissue.
Neoplasm Metastasis
Angiotensin II type 1A receptor signaling facilitates tumor metastasis formation through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells.
Neoplasm Metastasis
AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells.
Neoplasm Metastasis
Functional Impact of Acidosis-Regulated MicroRNAs on the Migration and Adhesion of Tumor Cells.
Neoplasms
A precision-guided MWNT mediated reawakening the sunk synergy in RAS for anti-angiogenesis lung cancer therapy.
Neoplasms
ACE2/Angiotensin-(1-7)/Mas receptor axis in human cancer: Potential role for pediatric tumors.
Neoplasms
Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38.
Neoplasms
Actin filament organization of the Dunning R3327 rat prostatic adenocarcinoma system: correlation with metastatic potential.
Neoplasms
Activation of the cell membrane angiotensin AT2 receptors in human leiomyosarcoma cells induces differentiation and apoptosis by a PPAR? - dependent mechanism.
Neoplasms
Adrenal angiotensin II type 1 and type 2 receptors in Cushing's and Conn's syndromes.
Neoplasms
Altered TGF-?/? signaling drives cooperation between breast cancer cell populations.
Neoplasms
Angiotensin II receptor blocker: possibility of antitumor agent for prostate cancer.
Neoplasms
Angiotensin II receptor subtypes on adrenal adenoma in primary hyperaldosteronism.
Neoplasms
Angiotensin II receptor type 1 gene expression in human glomerulonephritis and diabetes mellitus.
Neoplasms
Angiotensin II Type 1 Receptor (AT1) Knockdown Impairs Interleukin (IL)-1?-Induced Cytokines in Human Periodontal Fibroblasts.
Neoplasms
Angiotensin II type 1 receptor expression in two cases of juxtaglomerular cell tumor: correlation to negative feedback of renin secretion by angiotensin II.
Neoplasms
Angiotensin II type 1 receptor messenger RNA levels in human blood cells of patients with primary and secondary hypertension: reference to renin profile.
Neoplasms
Angiotensin II type 1A receptor signaling facilitates tumor metastasis formation through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells.
Neoplasms
Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury.
Neoplasms
Angiotensin II type 2 receptor gene deficiency attenuates susceptibility to tobacco-specific nitrosamine-induced lung tumorigenesis: involvement of transforming growth factor-beta-dependent cell growth attenuation.
Neoplasms
Angiotensin II Type 2 Receptor Inhibits Vascular Intimal Proliferation With Activation of PPAR?.
Neoplasms
Angiotensin receptors in hormone-independent prostate cancer cell line DU145: presence of two variants of angiotensin type 1 receptor.
Neoplasms
Angiotensin type 1a receptor signaling-dependent induction of vascular endothelial growth factor in stroma is relevant to tumor-associated angiogenesis and tumor growth.
Neoplasms
Anti-cancer actions of a recombinant antibody (R6313/G2) against the angiotensin II AT1 receptor.
Neoplasms
ART1 promotes starvation-induced autophagy: a possible protective role in the development of colon carcinoma.
Neoplasms
Association between AT1 and AT2 angiotensin II receptor expression with cell proliferation and angiogenesis in operable breast cancer.
Neoplasms
AT1 angiotensin II receptor subtype in the human larynx and squamous laryngeal carcinoma.
Neoplasms
AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells.
Neoplasms
Blockage of angiotensin II type I receptor decreases the synthesis of growth factors and induces apoptosis in C6 cultured cells and C6 rat glioma.
Neoplasms
Chronic ethanol ingestion increases expression of the angiotensin II type 2 (AT2) receptor and enhances tumor necrosis factor-alpha- and angiotensin II-induced cytotoxicity via AT2 signaling in rat alveolar epithelial cells.
Neoplasms
Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor.
Neoplasms
Decreased binding sites of angiotensin II in rat LY-80 and AH109A tumour and human gastric cancer using quantitative in vitro autoradiography.
Neoplasms
Dermatan carriers for neovascular transport targeting, deep tumor penetration and improved therapy.
Neoplasms
Differential sensitivity of three sublines of the rat Dunning prostate tumor system R3327 to radiation and/or local tumor hyperthermia.
Neoplasms
Differentiation-stage specific expression of oncoprotein 18 in human and rat prostatic adenocarcinoma.
Neoplasms
Dynamic oxygen challenge evaluated by NMR T1 and T2*--insights into tumor oxygenation.
Neoplasms
Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers.
Neoplasms
Effects of orthotopic implantation of rat prostate tumour cells upon components of the N-acylethanolamine and monoacylglycerol signalling systems: an mRNA study.
Neoplasms
Expression of AT1 and AT2 angiotensin receptors in astrocytomas is associated with poor prognosis.
Neoplasms
Expression of ras proto-oncogenes in the Dunning R3327 rat prostatic adenocarcinoma system.
Neoplasms
Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4.
Neoplasms
Feasibility study of cavitation-induced liposomal doxorubicin release in an AT2 Dunning rat tumor model.
Neoplasms
Functional Impact of Acidosis-Regulated MicroRNAs on the Migration and Adhesion of Tumor Cells.
Neoplasms
GdDO3NI, a nitroimidazole-based T1 MRI contrast agent for imaging tumor hypoxia in vivo.
Neoplasms
Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals.
Neoplasms
High-grade tumours promote growth of other less-malignant tumours in the same prostate.
Neoplasms
Highly aggressive rat prostate tumors rapidly precondition regional lymph nodes for subsequent metastatic growth.
Neoplasms
Identification of Sca-1+Abcg1+ bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
Neoplasms
Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy.
Neoplasms
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumors.
Neoplasms
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas.
Neoplasms
Immunohistochemical study of angiotensin receptors in human anagen hair follicles and basal cell carcinoma.
Neoplasms
Immunohistochemical study of angiotensin receptors in normal human sweat glands and eccrine poroma.
Neoplasms
Impact of stroma on the growth, microcirculation, and metabolism of experimental prostate tumors.
Neoplasms
Inhibition of the renin-angiotensin system downregulates tissue factor and vascular endothelial growth factor in human breast carcinoma cells.
Neoplasms
Losartan and Vitamin D Inhibit Colonic Tumor Development in a Conditional Apc-Deleted Mouse Model of Sporadic Colon Cancer.
Neoplasms
MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS axis functionality.
Neoplasms
Measurement of hypoxia-related parameters in three sublines of a rat prostate carcinoma using dynamic (18)F-FMISO-Pet-Ct and quantitative histology.
Neoplasms
Measurement of Protein Synthesis: In Vitro Comparison of (68)Ga-DOTA-Puromycin, [ (3)H]Tyrosine, and 2-Fluoro-[ (3)H]tyrosine.
Neoplasms
Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma.
Neoplasms
Mutationally-activated PI3'-kinase-? promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase.
Neoplasms
Nitric oxide-dependent down-regulation of angiotensin II type 2 receptors during experimental sepsis.
Neoplasms
PAK1-cofilin phosphorylation mediates human lung adenocarcinoma cells migration induced by apelin-13.
Neoplasms
PCR-SSCP analysis of the angiotensin II type 1 receptor gene in patients with aldosterone-producing adenomas.
Neoplasms
Pharmacology and new perspectives of angiotensin II receptor blocker in prostate cancer treatment.
Neoplasms
Pleiotropic Effects of Angiotensin II Receptor Signaling in Cardiovascular Homeostasis and Aging.
Neoplasms
Possible roles of tumor necrosis factor-? and angiotensin II type 1 receptor on high glucose-induced damage in renal proximal tubular cells.
Neoplasms
Pre-treatment with angiotensin-(1-7) inhibits tumor growth via autophagy by downregulating PI3K/Akt/mTOR signaling in human nasopharyngeal carcinoma xenografts.
Neoplasms
Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells.
Neoplasms
Regulation of alveolar type 2 stem/progenitor cells in lung injury and regeneration.
Neoplasms
Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis.
Neoplasms
Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP.
Neoplasms
The Angiotensin II Type 1 Receptor Antagonist Losartan Affects NHE1-Dependent Melanoma Cell Behavior.
Neoplasms
The effects of angiotensin peptides and angiotensin receptor antagonists on the cell growth and angiogenic activity of GH3 lactosomatotroph cells in vitro.
Neoplasms
The Role of MicroRNA Expression for Proliferation and Apoptosis of Tumor Cells: Impact of Hypoxia-Related Acidosis.
Neoplasms
Therapeutic efficacy of the combination of doxorubicin-loaded liposomes with inertial cavitation generated by confocal ultrasound in AT2 Dunning rat tumour model.
Neoplasms
Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells.
Neoplasms
Tumor necrosis factor-alpha-induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis.
Neoplasms
Whole slide imaging equivalency and efficiency study: experience at a large academic center.
Neoplasms
[Role of AT2 receptors on angiotensin II-induced tumor necrosis factor alpha and interleukin 1 beta secretion in adult rat cardiac fibroblasts]
Nephritis
Angiotensin II type I receptor antagonist suppresses proteinuria and glomerular lesions in experimental nephritis.
Nephritis
Renoprotective mechanisms of angiotensin II antagonism in experimental chronic renal failure.
Nephrosclerosis
Angiotensin II formation in the kidney and nephrosclerosis in Ren-2 hypertensive rats.
Nephrosclerosis
Effects of angiotensin inhibitors on renal injury and angiotensin receptor expression in early hypertensive nephrosclerosis.
Nephrosis
Addition of AT1 blocker fails to overcome resistance to ACE inhibition in adriamycin nephrosis.
Nephrosis
Involvement of angiotensin II in development of spontaneous nephrosis in Dahl salt-sensitive rats.
Nervous System Diseases
What have we learned about the kallikrein-kinin and renin-angiotensin systems in neurological disorders?
Neuralgia
Angiotensin II Type 2-Receptor: New Clinically Validated Target in the Treatment of Neuropathic Pain.
Neuralgia
Effect of subpressor dose of angiotensin II on pain-related behavior in relation with neuronal injury and activation of satellite glial cells in the rat dorsal root ganglia.
Neuralgia
Mechanisms Involved in Superiority of Angiotensin Receptor Blockade over ACE Inhibition in Attenuating Neuropathic Pain Induced in Rats.
Neuralgia
Propofol inhibits expression of angiotensin II receptor type 2 in dorsal root ganglion neurons.
Neuralgia
Selective small molecule angiotensin II type 2 receptor antagonists for neuropathic pain: preclinical and clinical studies.
Neuralgia
Small Molecule Angiotensin II Type 2 Receptor (AT2 R) Antagonists as Novel Analgesics for Neuropathic Pain: Comparative Pharmacokinetics, Radioligand Binding, and Efficacy in Rats.
Neuralgia
The Characterization of AT1 Expression in the Dorsal Root Ganglia After Chronic Constriction Injury.
Neuralgia, Postherpetic
Angiotensin II Type 2-Receptor: New Clinically Validated Target in the Treatment of Neuropathic Pain.
Neuralgia, Postherpetic
Selective small molecule angiotensin II type 2 receptor antagonists for neuropathic pain: preclinical and clinical studies.
Neuroblastoma
Angiotensin II AT2 receptors are functionally coupled to protein tyrosine dephosphorylation in N1E-115 neuroblastoma cells.
Neuroblastoma
Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase.
Neuroblastoma
Angiotensin II type-2 (AT2) receptor-mediated inhibition of NMDA receptor signalling in neuronal cells.
Neuroblastoma
AT1 angiotensin receptors mobilize intracellular calcium in a subclone of NG108-15 neuroblastoma cells.
Neuroblastoma
Biochemical characterization of two distinct angiotensin AT2 receptor populations in murine neuroblastoma N1E-115 cells.
Neuroblastoma
Cloning and expression of angiotensin II type 2 (AT2) receptors from murine neuroblastoma N1E-115 cells: evidence for AT2 receptor heterogeneity.
Neuroblastoma
Differentiation of NG108-15 neuroblastoma cells by serum starvation or dimethyl sulfoxide results in marked differences in angiotensin II receptor subtype expression.
Neuroblastoma
Identification and characterization of functional angiotensin II receptors in human neuroblastoma cells.
Neuroblastoma
Induction of the angiotensin AT2 receptor subtype expression by differentiation of the neuroblastoma x glioma hybrid, NG-108-15.
Neuroblastoma
Intracerebroventricular administration of AT1 receptor antisense oligonucleotides inhibits the behavioral actions of angiotensin II.
Neuroblastoma
Molecular and functional characterization of angiotensin II AT2 receptor in neuroblastoma N1E-115 cells.
Neurodegenerative Diseases
Alterations in angiotensin AT1 and AT2 receptor subtype levels in brain regions from patients with neurodegenerative disorders.
Neurodegenerative Diseases
The Renin-Angiotensin System and the Neurodegenerative Diseases: a brief review.
Neuroinflammatory Diseases
Angiotensin Receptor Blockade Modulates NF?B and STAT3 Signaling and Inhibits Glial Activation and Neuroinflammation Better than Angiotensin-Converting Enzyme Inhibition.
Neurologic Manifestations
Sustained blockade of brain AT1 receptors before and after focal cerebral ischemia alleviates neurologic deficits and reduces neuronal injury, apoptosis, and inflammatory responses in the rat.
Neuromyelitis Optica
Angiotensin AT2 receptor-induced interleukin-10 attenuates neuromyelitis optica spectrum disorder-like pathology.
Non-alcoholic Fatty Liver Disease
Chronic angiotensin receptor activation promotes hepatic triacylglycerol accumulation during an acute glucose challenge in obese-insulin-resistant OLETF rats.
Obesity
ANG II type I receptor antagonism improved nitric oxide production and enhanced eNOS and PKB/Akt expression in hearts from a rat model of insulin resistance.
Obesity
Angiotensin II impairs glucose utilization in obese Zucker rats by increasing HPA activity via an adrenal-dependent mechanism.
Obesity
Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice.
Obesity
AT1 Receptor Blockade Attenuates Insulin Resistance and Myocardial Remodeling in Rats with Diet-Induced Obesity.
Obesity
Deficiency of angiotensin type 2 receptor rescues obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissue.
Obesity
Elevated AT1 receptor protein but lower angiotensin II-binding in adipose tissue of rats with monosodium glutamate-induced obesity.
Obesity
Evidence of changes in alpha-1/AT1 receptor function generated by diet-induced obesity.
Obesity
Genetic Contributions to Childhood Obesity: Association of Candidate Gene Polymorphisms and Overweight/Obesity in Korean Preschool Children.
Obesity
Lack of weight gain after angiotensin AT1 receptor blockade in diet-induced obesity is partly mediated by an angiotensin-(1-7)/Mas-dependent pathway.
Obesity
Low number of insulin receptors but high receptor protein content in adipose tissue of rats with monosodium glutamate-induced obesity.
Obesity
Obese female SHHF/Mcc-fa(cp) rats resist antihypertensive effects of renin-angiotensin system inhibition.
Obesity
Obesity and aging affects skeletal muscle renin-angiotensin system and myosin heavy chain proportions in pre-diabetic Zucker rats.
Obesity
Prevention of metabolic disorders and reproductive performance deficits by the blockade of Angiotensin II AT1 receptor in female rats fed with cafeteria diet.
Obesity
Simultaneous angiotensin receptor blockade and glucagon-like peptide-1 receptor activation ameliorate albuminuria in obese insulin-resistant rats.
Obesity
Simultaneous GLP-1 receptor activation and angiotensin receptor blockade increase natriuresis independent of altered arterial pressure in obese OLETF rats.
Obesity
Suppression of Inflammatory Cardiac Cytokine Network in Rats with Untreated Obesity and Pre-Diabetes by AT2 Receptor Agonist NP-6A4.
Obesity
Telmisartan prevents development of obesity and normalizes hypothalamic lipid droplets.
Obesity
[Blockade of AT1 receptor of Angiotensin II reduces the number of antral follicles in female rats with obesity induced by cafeteria diet].
Obesity, Abdominal
Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue.
Osteoporosis
Activation of Renin-Angiotensin System Induces Osteoporosis Independently of Hypertension.
Osteoporosis
Pleiotropic Effects of Angiotensin II Receptor Signaling in Cardiovascular Homeostasis and Aging.
Osteoporosis, Postmenopausal
Chronic treatment with angiotensin AT1 receptor antagonists reduced serum but not bone TGF-beta1 levels in ovariectomized rats.
Overnutrition
Postnatal early overnutrition dysregulates the intrarenal renin-angiotensin system and extracellular matrix-linked molecules in juvenile male rats.
Overweight
Association of angiotensin II type 1 receptor polymorphism with resistant essential hypertension.
Overweight
Genetic Contributions to Childhood Obesity: Association of Candidate Gene Polymorphisms and Overweight/Obesity in Korean Preschool Children.
Overweight
Leptin, Galectin-3 and Angiotensin II Type 1 Receptor Polymorphism in Overweight and Obese Patients with Heart Failure - Role and Functional Interplay.
Overweight
Overexpression of the renin-angiotensin system in human visceral adipose tissue in normal and overweight subjects.
Pancreatic Neoplasms
Angiotensin II activates MAP kinase and NF-kappaB through angiotensin II type I receptor in human pancreatic cancer cells.
Pancreatic Neoplasms
Angiotensin II type 1 receptor expression in human pancreatic cancer and growth inhibition by angiotensin II type 1 receptor antagonist.
Pancreatic Neoplasms
Angiotensin II type 1 receptor mRNA and its protein expression in human pancreatic cancer cell lines.
Pancreatic Neoplasms
Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice.
Pancreatitis
Angiotensin II signaling through the AT1a and AT1b receptors does not have a role in the development of cerulein induced chronic pancreatitis in the mouse.
Pancreatitis
The effect of anti-hypertensive drugs on the obstructive pancreatitis in rats.
Pancreatitis
The role of the pancreatic renin-angiotensin system in acinar digestive enzyme secretion and in acute pancreatitis.
Parkinson Disease
Alterations in angiotensin AT1 and AT2 receptor subtype levels in brain regions from patients with neurodegenerative disorders.
Parkinson Disease
Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson's disease that increases with levodopa-induced dyskinesia.
Parkinson Disease
Angiotensin AT2 receptor stimulation inhibits activation of NADPH oxidase and ameliorates oxidative stress in rotenone model of Parkinson's disease in CATH.a cells.
Parkinson Disease
Angiotensin II type 1 receptors may not influence response of spinal autonomic neurons to axonal damage.
Parkinson Disease
Involvement of microglial RhoA/Rho-Kinase pathway activation in the dopaminergic neuron death. Role of angiotensin via angiotensin type 1 receptors.
Parkinsonian Disorders
Effects of Telmisartan, an AT1 receptor antagonist, on mitochondria-specific genes expression in a mouse MPTP model of Parkinsonism.
Parkinsonian Disorders
The angiotensin converting enzyme inhibitor captopril protects nigrostriatal dopamine neurons in animal models of parkinsonism.
peptidyl-dipeptidase a deficiency
Tubuloglomerular feedback: mechanistic insights from gene-manipulated mice.
Periodontitis
AT1 receptor antagonism promotes bone loss attenuation in experimental periodontitis, block inflammatory mediators, upregulate antioxidant enzymes and bone formation markers.
Peripheral Nervous System Diseases
The Characterization of AT1 Expression in the Dorsal Root Ganglia After Chronic Constriction Injury.
Peritoneal Fibrosis
Angiotensin II induces fibronectin expression in human peritoneal mesothelial cells via ERK1/2 and p38 MAPK.
Peritoneal Neoplasms
Local angiotensin II-generation in human gastric cancer: Correlation with tumor progression through the activation of ERK1/2, NF-kappaB and survivin.
Pheochromocytoma
Analysis of the role of N-glycosylation in cell-surface expression and binding properties of angiotensin II type-2 receptor of rat pheochromocytoma cells.
Pheochromocytoma
Angiotensin II induces peroxisome proliferator-activated receptor gamma in PC12W cells via angiotensin type 2 receptor activation.
Pheochromocytoma
Angiotensin II subtype 2 receptor activation inhibits insulin-induced phosphoinositide 3-kinase and Akt and induces apoptosis in PC12W cells.
Pheochromocytoma
Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20.
Pheochromocytoma
Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis.
Pheochromocytoma
Characterization of biochemical responses of angiotensin II (AT2) binding sites in the rat pheochromocytoma PC12W cells.
Pheochromocytoma
Effects of growth factors on cell proliferation and angiotensin II type 2 receptor number and mRNA in PC12W and R3T3 cells.
Pheochromocytoma
Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals.
Pheochromocytoma
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumors.
Pheochromocytoma
Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor.
Pheochromocytoma
Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.
Pheochromocytoma
Nitric oxide-dependent down-regulation of angiotensin II type 2 receptors during experimental sepsis.
Pheochromocytoma
Protein tyrosine phosphatase inhibition by angiotensin II in rat pheochromocytoma cells through type 2 receptor, AT2.
Pheochromocytoma
Recognition of tissue- and subtype-specific modulation of angiotensin II receptors using antibodies against AT1 and AT2 receptors.
Pheochromocytoma
Repression of c-fos and c-jun gene expression is not part of AT2 receptor coupled signal transduction.
Pheochromocytoma
The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells.
Pituitary Neoplasms
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas.
Plant Diseases
Plant eR genes that encode photorespiratory enzymes confer resistance against disease.
Pneumonia
Agonists of MAS oncogene and angiotensin II type 2 receptors attenuate cardiopulmonary disease in rats with neonatal hyperoxia-induced lung injury.
Pneumonia
Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury.
Pneumonia
Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis.
Pneumonia
Insights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regenerating Cells and by Lung Proteomics.
Pneumonia
Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice.
Polycystic Kidney Diseases
AT1 Receptor Antagonism Improves Structural, Functional and Biomechanical Properties in Resistance Arteries in a Rodent Chronic Kidney Disease Model.
Polycystic Kidney, Autosomal Dominant
[Progression of autosomic dominant polycystic kidney disease. Influence of endothelial NO synthase (ecNOS) and renin angiotensin system gene polymorphisms]
Polycystic Ovary Syndrome
Expression of angiotensin II type 1 (AT1) and angiotensin II type 2 (AT2) receptors in human granulosa-lutein (GL) cells: correlation with infertility diagnoses.
Polycythemia
Losartan, an angiotensin II type 1 receptor antagonist, lowers hematocrit in posttransplant erythrocytosis.
Polyuria
Regulation of AQP2 in Collecting Duct : An emphasis on the Effects of Angiotensin II or Aldosterone.
Porphyria, Acute Intermittent
[Could the understanding of racial differences prevent idiosyncratic anesthetic reactions?]
Pre-Eclampsia
1166C mutation of angiotensin II type 1 receptor gene is correlated with umbilical blood flow velocimetry in women with preeclampsia.
Pre-Eclampsia
Agonist autoantibodies against the angiotensin AT1 receptor in renal and hypertensive disorders.
Pre-Eclampsia
Agonistic antibodies directed at the angiotensin II, AT1 receptor in preeclampsia.
Pre-Eclampsia
Agonistic autoantibodies against the angiotensin AT1 receptor increase in unstable angina patients after stent implantation.
Pre-Eclampsia
Agonistic autoantibodies directed against the angiotensin II AT1 receptor in patients with preeclampsia.
Pre-Eclampsia
Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia.
Pre-Eclampsia
Angiotensin II type 1 receptor agonistic antibodies reflect fundamental alterations in the uteroplacental vasculature.
Pre-Eclampsia
Angiotensin type 1 receptor autoantibody from preeclamptic patients induces human fetoplacental vasoconstriction.
Pre-Eclampsia
Antibodies from preeclamptic patients stimulate increased intracellular Ca2+ mobilization through angiotensin receptor activation.
Pre-Eclampsia
Association studies suggest a key role for endothelin-1 in the pathogenesis of preeclampsia and the accompanying renin-angiotensin-aldosterone system suppression.
Pre-Eclampsia
Beta-Arrestin1 Prevents Preeclampsia by Downregulation of Mechanosensitive AT1-B2 Receptor Heteromers.
Pre-Eclampsia
Contractility of placental vascular smooth muscle cells in response to stimuli produced by the placenta: roles of ACE vs. non-ACE and AT1 vs. AT2 in placental vessel cells.
Pre-Eclampsia
Disrupted balance of angiogenic and antiangiogenic signalings in preeclampsia.
Pre-Eclampsia
Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia.
Pre-Eclampsia
Elevated Transglutaminase Activity Triggers Angiotensin Receptor Activating Autoantibody Production and Pathophysiology of Preeclampsia.
Pre-Eclampsia
Exposure to AT1 receptor autoantibodies during pregnancy increases susceptibility of the maternal heart to postpartum ischemia-reperfusion injury in rats.
Pre-Eclampsia
High-cholesterol diet during pregnancy induces maternal vascular dysfunction in mice: potential role for oxidized LDL-induced LOX-1 and AT1 receptor activation.
Pre-Eclampsia
Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1.
Pre-Eclampsia
Identification of a Novel Agonist-Like Autoantibody in Preeclamptic Patients.
Pre-Eclampsia
Is parvovirus B19 the cause for autoimmunity against the angiotensin II type receptor?
Pre-Eclampsia
Limited AT1 Receptor Internalization Is a Novel Mechanism Underlying Sustained Vasoconstriction Induced by AT1 Receptor Autoantibody From Preeclampsia.
Pre-Eclampsia
Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human trophoblast cells.
Pre-Eclampsia
Murine pre-eclampsia induced by unspecific activation of the immune system correlates with alterations in the eNOS and AT1 receptor expression in the kidneys and placenta.
Pre-Eclampsia
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor.
Pre-Eclampsia
The angiotensin II type I receptor contributes to impaired cerebral blood flow autoregulation caused by placental ischemia in pregnant rats.
Pre-Eclampsia
The mechanism of signal transduction during vascular smooth muscle cell proliferation induced by autoantibodies against angiotensin AT1 receptor from hypertension.
Pre-Eclampsia
The renin-angiotensin-aldosterone system in pre-eclampsia: the delicate balance between good and bad.
Pre-Eclampsia
The role of AT1 angiotensin receptor activation in the pathogenesis of preeclampsia.
Pre-Eclampsia
Vascular Contraction and Preeclampsia. Downregulation of the Angiotensin Receptor 1 by Hemopexin In Vitro.
Pregnancy Complications
High-cholesterol diet during pregnancy induces maternal vascular dysfunction in mice: potential role for oxidized LDL-induced LOX-1 and AT1 receptor activation.
Primary Ovarian Insufficiency
Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome.
Prostatic Hyperplasia
Autoantibodies Directed Against the Endothelin A Receptor in Patients With Benign Prostatic Hyperplasia.
Prostatic Neoplasms
A comparison of the effects of Angiotensin IV on androgen-dependent and androgen-independent prostate cancer cell lines.
Prostatic Neoplasms
Albendazole exerts antiproliferative effects on prostate cancer cells by inducing reactive oxygen species generation.
Prostatic Neoplasms
Angiotensin II receptor blocker: possibility of antitumor agent for prostate cancer.
Prostatic Neoplasms
Effects of orthotopic implantation of rat prostate tumour cells upon components of the N-acylethanolamine and monoacylglycerol signalling systems: an mRNA study.
Prostatic Neoplasms
Expression and role of the angiotensin II AT2 receptor in human prostate tissue: In search of a new therapeutic option for prostate cancer.
Prostatic Neoplasms
Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4.
Prostatic Neoplasms
Functional Impact of Acidosis-Regulated MicroRNAs on the Migration and Adhesion of Tumor Cells.
Prostatic Neoplasms
High-grade tumours promote growth of other less-malignant tumours in the same prostate.
Prostatic Neoplasms
Immunohistochemical detection of angiotensin AT 1 and AT 2 receptors in prostate cancer.
Prostatic Neoplasms
Impact of the Tumor Microenvironment on the Expression of Inflammatory Mediators in Cancer Cells.
Prostatic Neoplasms
Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study.
Prostatic Neoplasms
Pharmacology and new perspectives of angiotensin II receptor blocker in prostate cancer treatment.
Prostatic Neoplasms
Synergistic inhibitory effect of high-intensity focused ultrasound combined with chemotherapy on Dunning adenocarcinoma.
Prostatic Neoplasms
Synthesis, anti-hypertensive effect of a novel angiotensin II AT1 receptor antagonist and its anti-tumor activity in prostate cancer.
Prostatic Neoplasms
[Renin-angiotensin system (RAS) as new molecular therapeutic targets in prostate cancer].
Proteinuria
Angiotensin-converting enzyme is upregulated in the proximal tubules of rats with intense proteinuria.
Proteinuria
Anti-inflammatory effects of AT1 receptor blockade provide end-organ protection in stroke-prone rats independently from blood pressure fall.
Proteinuria
AT1 receptor antagonists: a challenge for ACE inhibitors in diabetic nephropathy.
Proteinuria
Blood pressure and proteinuria after cessation of a brief renin-angiotensin system blockade in young and adult Lyon hypertensive rats.
Proteinuria
Chronic angiotensin II infusion but not bradykinin blockade abolishes the antiproteinuric response to angiotensin-converting enzyme inhibition in established adriamycin nephrosis.
Proteinuria
Cyclosporine A responsive congenital nephrotic syndrome with single heterozygous variants in NPHS1, NPHS2, and PLCE1.
Proteinuria
Deterioration of Kidney Function by the (Pro)renin Receptor Blocker Handle Region Peptide in Aliskiren-treated Diabetic Transgenic (mRen2)27 Rats.
Proteinuria
Differential effects of angiotensin II type-1 receptor antisense oligonucleotides on renal function in spontaneously hypertensive rats.
Proteinuria
Effect of angiotensin II type 1 receptor blocker on 12-lipoxygenase activity and slit diaphragm protein expression in type 2 diabetic rat glomeruli.
Proteinuria
Enhanced Urinary Angiotensinogen Excretion in Cyp1a1-Ren2 Transgenic Rats With Inducible ANG II-Dependent Malignant Hypertension.
Proteinuria
Losartan versus enalapril on cerebral edema and proteinuria in stroke-prone hypertensive rats.
Proteinuria
Persistent proteinuria up-regulates angiotensin II type 2 receptor and induces apoptosis in proximal tubular cells.
Proteinuria
Regulation of TRPC6 ion channels in podocytes - Implications for focal segmental glomerulosclerosis and acquired forms of proteinuric diseases.
Proteinuria
Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis.
Proteinuria
Supportive Versus Immunosuppressive Therapy of Progressive IgA nephropathy (STOP) IgAN trial: rationale and study protocol.
Proteinuria
Targeted deletion of angiotensin II type 1A receptor does not protect mice from progressive nephropathy of overload proteinuria.
Proteinuria
Vaccination against the angiotensin type 1 receptor for the prevention of L-NAME-induced nephropathy.
Proteinuria
[Are the antagonists of angiotensin II AT1 receptors protectors of the kidney?]
Proteinuria
[IgA nephropathy. Significance of immunoglobulin A glycosylation in pathogenesis and clinical presentation]
Proteinuria
[Irbesartan--antihypertensive treatment in patients with heart failure and diabetes mellitus]
Proteinuria
[Present opinions on use of ketoanalog essential aminoacids in a conservative treatment of chronic renal insufficiency]
Psoriasis
Telmisartan Lowers Elevated Blood Pressure in Psoriatic Mice without Attenuating Vascular Dysfunction and Inflammation.
Pulmonary Disease, Chronic Obstructive
Distribution of type-1 and type-2 angiotensin receptors in the normal human lung and in lungs from patients with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Testosterone replacement therapy and hospitalization rates in men with COPD.
Pulmonary Fibrosis
Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice.
Pulmonary Fibrosis
AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies suppresses activation of YAP in alveolar epithelial type 2 cells.
Pulmonary Fibrosis
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
Pulmonary Fibrosis
Early lung injury contributes to lung fibrosis via AT1 receptor in rats.
Pulmonary Fibrosis
Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis.
Pulmonary Fibrosis
Impact of Olmesartan Medoxomil on Amiodarone- Induced Pulmonary Toxicity in Rats: Focus on Transforming Growth Factor-ßeta-1.
Pulmonary Fibrosis
LRRK2 plays essential roles in maintaining lung homeostasis and preventing the development of pulmonary fibrosis.
Pulmonary Fibrosis
Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis.
Pulmonary Fibrosis
Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist.
Pulmonary Fibrosis
Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis.
Pulmonary Fibrosis
Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis.
Pulmonary Fibrosis
Telomere shortening and DNA damage in culprit cells of different types of progressive fibrosing interstitial lung disease.
Renal Artery Obstruction
Reliability of captopril renography in patients under chronic therapy with angiotensin II (AT1) receptor antagonists.
Renal Insufficiency
Angiotensin II subtype AT1 receptor blockade prevents hypertension and renal insufficiency induced by chronic NO-synthase inhibition in rats.
Renal Insufficiency
Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications.
Renal Insufficiency
AT1 receptor blockade improves vasorelaxation in experimental renal failure.
Renal Insufficiency
Does blockade of angiotensin II receptors offer clinical benefits over inhibition of angiotensin-converting enzyme?
Renal Insufficiency
Effect of angiotensin II type 1 receptor blockade on conduit artery tone in subtotally nephrectomized rats.
Renal Insufficiency
Fetal toxic effects of angiotensin II receptor antagonists: case report and follow-up after birth.
Renal Insufficiency
KRH-594, a new angiotensin AT1 receptor antagonist, prevents end-organ damage in stroke-prone spontaneously hypertensive/Izm rats.
Renal Insufficiency
Pharmacological inhibition of TRPV4 channels protects against ischemia-reperfusion-induced renal insufficiency in neonatal pigs.
Renal Insufficiency
Prevention of accelerated atherosclerosis by AT1 receptor blockade in experimental renal failure.
Renal Insufficiency
Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat.
Renal Insufficiency
Renoprotection and renin-angiotensin system blockade in diabetes mellitus.
Renal Insufficiency
The effect of different antihypertensive drugs on cavernous tissue in experimental chronic renal insufficiency.
Renal Insufficiency
[Effects of Jianpi Qinghua Recipe on angiotensin II/NADPH oxidase pathway in 5/6 nephrectomized rats].
Renal Insufficiency, Chronic
Adjunctive therapy with statins reduces residual albuminuria/proteinuria and provides further renoprotection by downregulating the angiotensin II-AT1 pathway in hypertensive nephropathy.
Renal Insufficiency, Chronic
Angiotensin II receptor type 1 gene expression in human glomerulonephritis and diabetes mellitus.
Renal Insufficiency, Chronic
Angiotensin II stimulates MCP-1 production in rat glomerular endothelial cells via NAD(P)H oxidase-dependent nuclear factor-kappa B signaling.
Renal Insufficiency, Chronic
Angiotensin II type 1a receptor loss ameliorates chronic tubulointerstitial damage after renal ischemia reperfusion.
Renal Insufficiency, Chronic
Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice.
Renal Insufficiency, Chronic
Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis.
Renal Insufficiency, Chronic
AT1 antagonism and renin inhibition in mice: pivotal role of targeting angiotensin II in chronic kidney disease.
Renal Insufficiency, Chronic
AT1 receptor antagonism before ischemia prevents the transition of acute kidney injury to chronic kidney disease.
Renal Insufficiency, Chronic
AT1 Receptor Antagonism Improves Structural, Functional and Biomechanical Properties in Resistance Arteries in a Rodent Chronic Kidney Disease Model.
Renal Insufficiency, Chronic
Effect of Shenxinning decoction on ventricular remodeling in AT1 receptor-knockout mice with chronic renal insufficiency.
Renal Insufficiency, Chronic
Enhanced Angiotensin II type 1 receptor expression in leukocytes of patients with chronic kidney disease.
Renal Insufficiency, Chronic
Heme oxygenase-1 inducer hemin attenuates the progression of remnant kidney model.
Renal Insufficiency, Chronic
Pleiotropic Effects of Angiotensin II Receptor Signaling in Cardiovascular Homeostasis and Aging.
Renal Insufficiency, Chronic
Protection of kidney function and tissue integrity by pharmacologic use of natriuretic peptides and neprilysin inhibitors.
Renal Insufficiency, Chronic
Treatment with enalapril and not diltiazem ameliorated progression of chronic kidney disease in rats, and normalized renal AT1 receptor expression as measured with PET imaging.
Reperfusion Injury
Aliskiren Reduces Myocardial Ischemia-Reperfusion Injury by a Bradykinin B2 Receptor- and Angiotensin AT2 Receptor-Mediated Mechanism.
Reperfusion Injury
Angiotensin II in paraventricular nucleus contributes to sympathoexcitation in renal ischemia-reperfusion injury by AT1 receptor and oxidative stress.
Reperfusion Injury
Angiotensin II type 1 receptor antagonist protects ventricular and coronary endothelial function after 24-hour heart preservation.
Reperfusion Injury
Cardioprotective effects of rosiglitazone are associated with selective overexpression of type 2 angiotensin receptors and inhibition of p42/44 MAPK.
Reperfusion Injury
Effect of angiotensin II type 2 receptor blockade on activation of mitogen-activated protein kinases after ischemia-reperfusion in isolated working rat hearts.
Reperfusion Injury
Exposure to AT1 receptor autoantibodies during pregnancy increases susceptibility of the maternal heart to postpartum ischemia-reperfusion injury in rats.
Reperfusion Injury
Microvascular responses to aldosterone in hamster cheek pouch microcirculation.
Reperfusion Injury
Myocardial angiotensin II receptor expression and ischemia-reperfusion injury.
Reperfusion Injury
The preventive effect of captopril or enalapril on reperfusion injury of the kidney of rats is independent of angiotensin II AT1 receptors.
Reperfusion Injury
Tissue kallikrein is involved in the cardioprotective effect of AT1-receptor blockade in acute myocardial ischemia.
Respiratory Distress Syndrome
Nonpeptide antagonists of AT1 receptor for angiotensin II delay the onset of acute respiratory distress syndrome.
Respiratory Distress Syndrome
Proteasome dysfunction in alveolar type 2 epithelial cells is associated with acute respiratory distress syndrome.
Respiratory Distress Syndrome
Transcription factor Etv5 is essential for the maintenance of alveolar type II cells.
Retinal Diseases
Retinal expression of vascular endothelial growth factor is mediated by angiotensin type 1 and type 2 receptors.
Retinal Neovascularization
Angiotensin II induces expression of the Tie2 receptor ligand, angiopoietin-2, in bovine retinal endothelial cells.
Retinal Neovascularization
Dual effect of angiotensin-converting enzyme inhibition on angiogenesis in type 1 diabetic mice.
Retinopathy of Prematurity
The vasoneuronal effects of AT1 receptor blockade in a rat model of retinopathy of prematurity.
Sarcoma, Avian
Inhibition of transient gene expression with plasmids encoding herpes simplex virus type 1 UL55 and alpha genes.
Schistosomiasis mansoni
Telmisartan, an AT1 receptor blocker and a PPAR gamma activator, alleviates liver fibrosis induced experimentally by Schistosoma mansoni infection.
Seizures
Adenosine-angiotensin II interactions in pentylenetetrazol seizure threshold in mice.
Seizures
Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock.
Seizures
Antiepileptogenic and neuroprotective effects of losartan in kainate model of temporal lobe epilepsy.
Seizures
Combined treatment with gabapentin and drugs affecting the renin-angiotensin system against electroconvulsions in mice.
Seizures
Effect of ACE inhibitors and AT1 receptor antagonists on pentylenetetrazole-induced convulsions in mice.
Seizures
Effect of Combined Treatment with AT1 Receptor Antagonists and Tiagabine on Seizures, Memory and Motor Coordination in Mice.
Seizures
Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats.
Seizures
Effects of non-peptide angiotensin II-receptor antagonists on pentylenetetrazol kindling in mice.
Seizures
Inhibition of the renin-angiotensin system prevents seizures in a rat model of epilepsy.
Seizures
Long-Term Treatment with Losartan Attenuates Seizure Activity and Neuronal Damage Without Affecting Behavioral Changes in a Model of Co-morbid Hypertension and Epilepsy.
Seizures
The amygdala and temporal lobe simple partial seizures: a prospective and quantitative MRI study.
Seizures
The renin-angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis.
Seizures, Febrile
The amygdala and intractable temporal lobe epilepsy: a quantitative magnetic resonance imaging study.
Sepsis
Angiotensin II receptor type 1 blockade improves hyporesponsiveness to vasopressors in septic shock.
Sepsis
Nitric oxide-dependent down-regulation of angiotensin II type 2 receptors during experimental sepsis.
Shock, Septic
Nitric oxide-dependent down-regulation of angiotensin II type 2 receptors during experimental sepsis.
Silicosis
Influence of the interaction between Ac?SDKP and Ang II on the pathogenesis and development of silicotic fibrosis.
Skin Diseases
Telmisartan Lowers Elevated Blood Pressure in Psoriatic Mice without Attenuating Vascular Dysfunction and Inflammation.
Skin Diseases
The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology.
Sleep Apnea Syndromes
Up-regulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia.
Spasm
[Could the understanding of racial differences prevent idiosyncratic anesthetic reactions?]
Squamous Cell Carcinoma of Head and Neck
Angiotensin 1-7 inhibits angiotensin II-stimulated head and neck cancer progression.
Starvation
Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: an in vitro gene transfer study.
Starvation
Differentiation of NG108-15 neuroblastoma cells by serum starvation or dimethyl sulfoxide results in marked differences in angiotensin II receptor subtype expression.
Starvation
Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis.
Status Epilepticus
Angiotensin II and its receptor in activated microglia enhanced neuronal loss and cognitive impairment following pilocarpine-induced status epilepticus.
Status Epilepticus
Antiepileptogenic and neuroprotective effects of losartan in kainate model of temporal lobe epilepsy.
Status Epilepticus
Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats.
Status Epilepticus
Strain-dependent effects of sub-chronically infused losartan against kainic acid-induced seizures, oxidative stress, and heat shock protein 72 expression.
Stomach Neoplasms
Local angiotensin II-generation in human gastric cancer: Correlation with tumor progression through the activation of ERK1/2, NF-kappaB and survivin.
Stomach Ulcer
Angiotensin II AT1 receptor blockade prevents gastric ulcers during cold-restraint stress.
Stomach Ulcer
Anti-inflammatory effects of angiotensin II AT1 receptor antagonism prevent stress-induced gastric injury.
Stroke
Acute effects of E-3174, a human active metabolite of losartan, on the cardiovascular system in tachycardia-induced canine heart failure.
Stroke
Age-adjusted stroke incidence increase: could angiotensin AT1 receptor antagonists enhance stroke prevention?
Stroke
Angiotensin AT1 receptor antagonism and protection against cardiovascular end-organ damage.
Stroke
Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke.
Stroke
Angiotensin AT2 receptor stimulation increases survival in gerbils with abrupt unilateral carotid ligation.
Stroke
Angiotensin AT2 receptor-mediated neuroprotection and nitric oxide-bioavailability in stroke.
Stroke
Angiotensin II via AT1 receptor accelerates arterial thrombosis in renovascular hypertensive rats.
Stroke
Biphasic effects of angiotensin II and receptor antagonism on aggregability and protein kinase C phosphorylation in human platelets.
Stroke
Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities.
Stroke
Cerebroprotection mediated by angiotensin II: a hypothesis supported by recent randomized clinical trials.
Stroke
Clinical experience with the use of angiotensin receptor blockers in patients with cardiovascular, cerebrovascular and renal diseases.
Stroke
Comparison between single and combined treatment with candesartan and pioglitazone following transient focal ischemia in rat brain.
Stroke
Critical role of angiotensin II in excess salt-induced brain oxidative stress of stroke-prone spontaneously hypertensive rats.
Stroke
Direct Stimulation of Angiotensin II Type 2 Receptor Initiated After Stroke Ameliorates Ischemic Brain Damage.
Stroke
Does treatment of hypertension decrease the incidence of atrial fibrillation and cardioembolic stroke?
Stroke
Effects of angiotensin-converting enzyme inhibition and angiotensin II AT1 receptor antagonism on cardiac parameters in left ventricular hypertrophy.
Stroke
Effects of AT1 receptor blockade on blood pressure and the renin-angiotensin system in spontaneously hypertensive rats of the stroke prone strain.
Stroke
Frequency of angiotensin II type 1 receptor gene polymorphism in Turkish acute stroke patients.
Stroke
Losartan's protective effects in stroke-prone spontaneously hypertensive rats persist durably after treatment withdrawal.
Stroke
Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-gamma activation in diabetic mice.
Stroke
Mechanisms of acute neurovascular protection with AT1 blockade after stroke: Effect of prestroke hypertension.
Stroke
Neuroprotective effects of candesartan against cerebral ischemia in spontaneously hypertensive rats.
Stroke
Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inhibition.
Stroke
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding.
Stroke
Possible pathophysiologic mechanisms supporting the superior stroke protection of angiotensin receptor blockers compared to angiotensin-converting enzyme inhibitors: clinical and experimental evidence.
Stroke
Prevention and intervention studies with telmisartan, ramipril and their combination in different rat stroke models.
Stroke
Synergistic protective effects of erythropoietin and olmesartan on ischemic stroke survival and post-stroke memory dysfunctions in the gerbil.
Stroke
The Renin-Angiotensin System and the Cerebrovascular Diseases: Experimental and Clinical Evidence.
Stroke
[Atrial fibrillation as end point of hypertension. Can antihypertensive therapy prevent it?]
Stroke
[Fixed combination of AT1 blocker and diuretic. Stroke preventive combination for hypertension]
Stroke, Lacunar
Gene polymorphism of the renin-angiotensin system associates with risk for lacunar infarction. The Ohasama study.
Subarachnoid Hemorrhage
Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage.
Tachycardia
AT1 and AT2 Receptors in the Prelimbic Cortex Modulate the Cardiovascular Response Evoked by Acute Exposure to Restraint Stress in Rats.
Tachycardia
AT2 and MAS (but not AT1) angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats.
Tachycardia
Cardiac microvascular rarefaction in hyperthyroidism-induced left ventricle dysfunction.
Tachycardia
In vivo and in vitro characterization of the novel antiarrhythmic agent SSR149744C: electrophysiological, anti-adrenergic, and anti-angiotensin II effects.
Tachycardia
Role of angiotensin II in reflex tachycardia during hypotension caused by a calcium channel blocker.
Tachycardia, Sinus
Role of angiotensin II in reflex tachycardia during hypotension caused by a calcium channel blocker.
Tachycardia, Ventricular
Angiotensin II Effects on Ischemic Focal Ventricular Tachycardia are Predominantly Mediated Through Myocardial AT2 Receptor.
Thromboembolism
Novel Vasopressors in the Treatment of Vasodilatory Shock: A Systematic Review of Angiotensin II, Selepressin, and Terlipressin.
Thrombosis
Angiotensin II via AT1 receptor accelerates arterial thrombosis in renovascular hypertensive rats.
Thrombosis
Imidapril, an angiotensin-converting enzyme inhibitor, inhibits thrombosis via reduction in aortic plasminogen activator inhibitor type-1 levels in spontaneously hypertensive rats.
Thrombosis
The acute prothrombotic effect of aldosterone in rats is partially mediated via angiotensin II receptor type 1.
Ureteral Obstruction
Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction.
Ureteral Obstruction
Antiarrhythmic effect linked to melatonin cardiorenal protection involves AT1 reduction and Hsp70-VDR increase.
Ureteral Obstruction
AT1 receptor blockade prevents interstitial and glomerular apoptosis but not fibrosis in pigs with neonatal induced partial unilateral ureteral obstruction.
Ureteral Obstruction
Effect of losartan pretreatment on kidney lipid content after unilateral obstruction in rats.
Ureteral Obstruction
Regulation of angiotensin II AT1 and AT2 receptors in neonatal ureteral obstruction.
Ureteral Obstruction
Regulation of renal growth factors and clusterin by AT1 receptors during neonatal ureteral obstruction.
Ureteral Obstruction
Stimulating Type 1 Angiotensin Receptors on T Lymphocytes Attenuates Renal Fibrosis.
Ureteral Obstruction
Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis.
Urethral Obstruction
Angiotensin II and bladder obstruction in the rat: influence on hypertrophic growth and contractility.
Urinary Bladder Neck Obstruction
Effect of the Renin-Angiotensin System on the Obstructed Bladder.
Uveitis
Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats.
Vascular Calcification
AT2 receptor stimulation inhibits phosphate-induced vascular calcification.
Vascular Calcification
Roles and possible mechanisms of autoantibodies against the angiotensin AT1 receptor in vascular calcification of rats.
Vascular Diseases
Angiotensin II activates nuclear transcription factor-kappaB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice.
Vascular Diseases
Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications.
Vascular Diseases
Calcium channel blocker azelnidipine enhances vascular protective effects of AT1 receptor blocker olmesartan.
Vascular Diseases
Effects of valsartan and valeryl 4-hydroxy valsartan on human platelets: a possible additional mechanism for clinical benefits.
Vascular Diseases
Fluvastatin enhances the inhibitory effects of a selective angiotensin II type 1 receptor blocker, valsartan, on vascular neointimal formation.
Vascular Diseases
Influence of oxidized low-density lipoprotein on vascular angiotensin II receptor expression.
Vascular Ring
Angiotensin-(1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide.
Vascular Ring
Autoantibodies isolated from preeclamptic patients induce endothelial dysfunction via interaction with the angiotensin II AT1 receptor.
Vascular Ring
Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
Vascular System Injuries
Angiotensin II type 1 receptor blockade inhibits the expression of immediate-early genes and fibronectin in rat injured artery.
Vascular System Injuries
BR 09-3 AT2R STIMULATION AND ITS EFFECT ON TARGET ORGAN DAMAGE: THERAPEUTIC IMPLICATIONS.
Vascular System Injuries
Calcium channel blocker azelnidipine enhances vascular protective effects of AT1 receptor blocker olmesartan.
Vascular System Injuries
Cartilage oligomeric matrix protein is an endogenous ?-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury.
Vascular System Injuries
CV-11974, the active metabolite of TCV-116 (Candesarten), inhibits the synergistic or additive effect of different growth factors on angiotensin II-induced proliferation of vascular smooth muscle cells.
Vascular System Injuries
Deletion of angiotensin II type 1 receptor gene or scavenge of superoxide prevents chronic alcohol-induced aortic damage and remodeling.
Vascular System Injuries
Effects of subtype-selective and balanced angiotensin II receptor antagonists in a porcine coronary artery model of vascular restenosis.
Vascular System Injuries
Interferon regulatory factor-1 exerts inhibitory effect on neointimal formation after vascular injury.
Vascular System Injuries
Pravastatin enhances beneficial effects of olmesartan on vascular injury of salt-sensitive hypertensive rats, via pleiotropic effects.
Vascular System Injuries
Prevention of vascular injury by combination of an AT1 receptor blocker, olmesartan, with various calcium antagonists.
Vascular System Injuries
Renal and vascular injury induced by exogenous angiotensin II is AT1 receptor-dependent.
Vascular System Injuries
Renin-angiotensin system modulates oxidative stress-induced endothelial cell apoptosis in rats.
Vascular System Injuries
Role of angiotensin II-regulated apoptosis through distinct AT1 and AT2 receptors in neointimal formation.
Vascular System Injuries
Role of the angiotensin II type 2 receptor in arterial remodeling after wire injury in mice.
Vascular System Injuries
Sex difference in vascular injury and the vasoprotective effect of valsartan are related to differential AT2 receptor expression.
Vascular System Injuries
[Distribution and function of angiotensin receptor subtypes in cardiovascular system]
Venous Thrombosis
Antithrombotic activity of losartan in two kidney, one clip hypertensive rats. A study on the mechanism of action.
Venous Thrombosis
Effects of drugs affecting the renin-angiotensin system on venous thrombosis in normotensive rats.
Venous Thrombosis
Losartan inhibits experimental venous thrombosis in spontaneously hypertensive rats.
Ventricular Dysfunction
Angiotensin II receptor blockade and myocardial fibrosis of the infarcted rat heart.
Ventricular Dysfunction
Selective downregulation of the angiotensin II AT1-receptor subtype in failing human ventricular myocardium.
Ventricular Dysfunction, Left
Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphism in coronary disease and malignant ventricular arrhythmias.
Ventricular Dysfunction, Left
Effect of angiotensin II type 2 receptor blockade on activation of mitogen-activated protein kinases after ischemia-reperfusion in isolated working rat hearts.
Vesico-Ureteral Reflux
Angiotensin II type 2 receptor gene is not responsible for familial vesicoureteral reflux.
Vulvodynia
A Local Inflammatory Renin-Angiotensin System Drives Sensory Axon Sprouting in Provoked Vestibulodynia.
Whooping Cough
Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis.
Whooping Cough
Angiotensin AT1 receptors in Clone 9 rat liver cells: Ca2+ signaling and c-fos expression.
Whooping Cough
Angiotensin II inhibits calcium and M current channels in rat sympathetic neurons via G proteins.
Whooping Cough
Angiotensin II receptor coupling to phospholipase D is mediated by the betagamma subunits of heterotrimeric G proteins in vascular smooth muscle cells.
Whooping Cough
Angiotensin II stimulation of Na-H antiporter activity is cAMP independent in OKP cells.
Whooping Cough
Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube formation of human endothelial cells.
Whooping Cough
Angiotensin II type 2 receptor stimulation increases the rate of NG108-15 cell migration via actin depolymerization.
Whooping Cough
Characterization of PD 121981- and CGP 42112-induced unmasking of low concentration effects of angiotensin II in rabbit abdominal aorta.
Whooping Cough
Dual effects of angiotensin II on calcium currents in neonatal rat nodose neurons.
Whooping Cough
Expression and regulation of G alpha q and G alpha 11 mRNAs and proteins in bovine adrenal cells.
Whooping Cough
Hormonal regulation of mitogen-activated protein kinase activity in bovine adrenocortical cells: cross-talk between phosphoinositides, adenosine 3',5'-monophosphate, and tyrosine kinase receptor pathways.
Whooping Cough
Hydrophobicity and subunit interactions of rod outer segment proteins investigated using Triton X-114 phase partitioning.
Whooping Cough
Identification and characterization of functional angiotensin II receptors in human neuroblastoma cells.
Whooping Cough
Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.
Whooping Cough
Regulation by growth factors of angiotensin II type-1 receptor and the alpha subunit of Gq and G11 in bovine adrenal cells.
Whooping Cough
Regulation of vascular proteoglycan synthesis by angiotensin II type 1 and type 2 receptors.
Whooping Cough
Selective antagonism of the AT1 receptor inhibits the effect of angiotensin II on DNA and protein synthesis of rat proximal tubular cells.
Whooping Cough
Sequential activation of MAP kinase cascade by angiotensin II in opossum kidney cells.
Whooping Cough
Subcellular mechanisms of angiotensin II and arginine vasopressin activation of area postrema neurons.
Whooping Cough
The bradykinin B2 receptor couples less efficiently than the angiotensin AT1 receptor to the G protein Gq in transiently transfected COS-7 cells.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
ART3, fragment; gene ART3, two splicing variants different in the 5'-UTR
SwissProt
brenda
ART3, fragments; gene ART3, two splicing variants different in the 5'-UTR
SwissProt
brenda
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
epithelial cells lining human airways and cells, isozyme ART1, bronchoalveolar lavage fluid
brenda
additional information
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
on epithelial cells lining human airways and cells, isozyme ART1
brenda
-
the enzyme is likely to be linked to the cell surface via a glycosylphosphatidylinositol
brenda
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
-
in contrast to its avian orthologue the mammalian ART4 is a acatalytic mono-ADP-ribosyltransferase
physiological function
-
ADP-ribosylation of the P2X7(k) but not the P2X7(a) variant induces stable Ca2+ signals
physiological function
-
the enzyme is involved in angiogenesis in cases of colorectal cancer and plays an important role in the invasion of colorectal cancer cells and the metastasis of colorectal cancer
physiological function
-
the enzyme is involved in the action by bacterial toxins as well as in tumorigenesis
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). NAR1_HUMAN
327
0
36335
Swiss-Prot
Secretory Pathway (Reliability: 1)
NAR3_HUMAN
389
1
43923
Swiss-Prot
Secretory Pathway (Reliability: 1)
NAR4_HUMAN
314
0
35878
Swiss-Prot
Secretory Pathway (Reliability: 3)
NAR5_HUMAN
291
0
32054
Swiss-Prot
Secretory Pathway (Reliability: 1)
A8K6J7_HUMAN
314
0
35865
TrEMBL
Secretory Pathway (Reliability: 3)
Q5IRA6_HUMAN
53
0
5825
TrEMBL
Mitochondrion (Reliability: 3)
A0A0U5FP74_HUMAN
236
0
27448
TrEMBL
other Location (Reliability: 2)
H7C3U2_HUMAN
151
0
17007
TrEMBL
other Location (Reliability: 2)
A0A3P3YW42_HUMAN
236
0
27470
TrEMBL
other Location (Reliability: 2)
E7ER42_HUMAN
174
0
20134
TrEMBL
Secretory Pathway (Reliability: 1)
C3W8I1_HUMAN
236
0
27478
TrEMBL
other Location (Reliability: 2)
Q3KZ27_HUMAN
30
1
3180
TrEMBL
Secretory Pathway (Reliability: 4)
H7C2G2_HUMAN
273
0
31511
TrEMBL
Secretory Pathway (Reliability: 1)
E9PGR5_HUMAN
107
0
12411
TrEMBL
Secretory Pathway (Reliability: 1)
A0A024RDB9_HUMAN
378
1
42742
TrEMBL
Secretory Pathway (Reliability: 1)
H7C1W0_HUMAN
264
0
29075
TrEMBL
other Location (Reliability: 1)
B4DHX3_HUMAN
368
0
41983
TrEMBL
Secretory Pathway (Reliability: 1)
A0A024RCD1_HUMAN
292
0
32155
TrEMBL
Secretory Pathway (Reliability: 1)
A0A166IZP3_HUMAN
236
0
27478
TrEMBL
other Location (Reliability: 2)
A0A3P3YWJ5_HUMAN
236
0
27505
TrEMBL
other Location (Reliability: 2)
Q3KZ25_HUMAN
273
0
31510
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3P3YWC4_HUMAN
236
0
27508
TrEMBL
other Location (Reliability: 2)
Q3KZ26_HUMAN
29
0
3337
TrEMBL
other Location (Reliability: 4)
A0A6C0M8C7_HUMAN
250
0
28566
TrEMBL
Secretory Pathway (Reliability: 3)
A0A3P3YWC5_HUMAN
236
0
27491
TrEMBL
other Location (Reliability: 2)
Q3KZ28_HUMAN
314
0
35818
TrEMBL
Secretory Pathway (Reliability: 3)
D3YNY8_HUMAN
236
0
27535
TrEMBL
other Location (Reliability: 2)
A0A3P3YWF0_HUMAN
236
0
27452
TrEMBL
other Location (Reliability: 2)
C3W8I0_HUMAN
236
0
27479
TrEMBL
other Location (Reliability: 2)
E7ESB3_HUMAN
201
0
23092
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3P3ZJX7_HUMAN
236
0
27504
TrEMBL
other Location (Reliability: 2)
A0A024RDG4_HUMAN
367
1
41515
TrEMBL
Secretory Pathway (Reliability: 1)
E7EX61_HUMAN
129
0
14998
TrEMBL
Secretory Pathway (Reliability: 1)
A1Z625_HUMAN
236
0
27418
TrEMBL
other Location (Reliability: 2)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
the crystal structure of human ARTD15/PARP16 is shown. ARTD15 features an alpha-helical domain that packs against its transferase domain without making direct contact with the NAD+-binding crevice or the donor loop
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
DELTA278-322
a deletion mutant lacking the region encompassing the putative transmembrane domain (aminoacids 278-322) shows a diffuse, cytosolic localization compared with full length ARTD15
Y187R/K242E
-
double mutant contains the R-S-EXE motif, but displays no activity, thus additional residues besides the intact R-S-EXE motif are involved in catalyzing the enzymatic reaction
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of isozymes ART1, ART3, ART4, ART5, ART2.2 in Escherichia coli, isozyme ART1synthesized in Escherichia coli, glycosylphosphatidylinositol-anchored ART1 released with phosphatidylinositol-specific phospholipase C from transfected NMU cells, or ART1 expressed endogenously on C2C12 myotubes modifiy arginine 14 on HNP-1 with a secondary site on arginine 24
-
gene ART3, DNA and amino acid sequence determination and analysis, structural analysis of the untranslated regions, splicing variants differing in the 5'-UTR, genomic organization, expression analysis, recombinant expression in HEK-293T cells
wild-type and mutants cloned into the pcDNA3.1/Zeo (+) plasmid, expression in C-33A cells
-
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme expression is activated during the endoplasmic reticulum stress response
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Okazaki, I.J.; Kim, H.J.; Moss, J.
Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase
J. Biol. Chem.
271
22052-22057
1996
Gallus gallus, Oryctolagus cuniculus, Homo sapiens, Mus musculus (P70352), Mus musculus
brenda
Jones, E.M.; Baird, A.
Cell-surface ADP-ribosylation of fibroblast growth factor-2 by an arginine-specific ADP-ribosyltransferase
Biochem. J.
323
173-177
1997
Bos taurus, Homo sapiens
-
brenda
Donnelly, L.E.; Rendell, N.B.; Murray, S.; Allport, J.R.; Lo, G.; Kefalas, P.; Taylor, G.W.; MacDermot, J.
Arginine-specific mono(ADP-ribosyl)transferase activity on the surface of human polymorphonuclear neutrophil leukocytes
Biochem. J.
315
635-641
1996
Homo sapiens
-
brenda
Moss, J.; Balducci, E.; Cavanaugh, E.; Kim, H.J.; Konczalik, P.; Lesma, E.A.; Okazaki, I.J.; Park, M.; Shoemaker, M.; Stevens, L.A.; Zolkiewska, A.
Characterization of NAD:arginine ADP-ribosyltransferases
Mol. Cell. Biochem.
193
109-113
1999
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Okazaki, I.J.; Kim, H.J.; Moss, J.
Molecular cloning and characterization of lymphocyte and muscle ADP-ribosyltransferases
Adv. Exp. Med. Biol.
419
129-136
1997
Oryctolagus cuniculus, Homo sapiens, Mus musculus
brenda
Friedrich, M.; Grahnert, A.; Klein, C.; Tschoep, K.; Engeland, K.; Hauschildt, S.
Genomic organization and expression of the human mono-ADP-ribosyltransferase ART3 gene
Biochim. Biophys. Acta
1759
270-280
2006
Homo sapiens (Q5J1L0), Homo sapiens (Q5J1P8), Homo sapiens (Q5J1Q0)
brenda
Paone, G.; Stevens, L.A.; Levine, R.L.; Bourgeois, C.; Steagall, W.K.; Gochuico, B.R.; Moss, J.
ADP-ribosyltransferase-specific modification of human neutrophil peptide-1
J. Biol. Chem.
281
17054-17060
2006
Homo sapiens, Mus musculus
brenda
Grahnert, A.; Richter, S.; Siegert, F.; Berndt, A.; Hauschildt, S.
The orthologue of the "acatalytic" mammalian ART4 in chicken is an arginine-specific mono-ADP-ribosyltransferase
BMC Mol. Biol.
9
86
2008
Homo sapiens, Gallus gallus (B6RDZ5), Gallus gallus
brenda
Karlberg, T.; Thorsell, A.G.; Kallas, A.; Schueler, H.
Crystal structure of human ADP-ribose transferase ARTD15/PARP16 reveals a novel putative regulatory domain
J. Biol. Chem.
287
24077-24081
2012
Homo sapiens (Q8N5Y8), Homo sapiens
brenda
Di Paola, S.; Micaroni, M.; Di Tullio, G.; Buccione, R.; Di Girolamo, M.
PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ss1
PLoS ONE
7
e37352
2012
Homo sapiens (Q8N5Y8), Homo sapiens
brenda
Schwarz, N.; Drouot, L.; Nicke, A.; Fliegert, R.; Boyer, O.; Guse, A.H.; Haag, F.; Adriouch, S.; Koch-Nolte, F.
Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation
PLoS ONE
7
e41269
2012
Homo sapiens
brenda
Mashimo, M.; Kato, J.; Moss, J.
Structure and function of the ARH family of ADP-ribosyl-acceptor hydrolases
DNA Repair
23
88-94
2014
Homo sapiens
brenda
Fabrizio, G.; Di Paola, S.; Stilla, A.; Giannotta, M.; Ruggiero, C.; Menzel, S.; Koch-Nolte, F.; Sallese, M.; Di Girolamo, M.
ARTC1-mediated ADP-ribosylation of GRP78/BiP: a new player in endoplasmic-reticulum stress responses
Cell. Mol. Life Sci.
72
1209-1225
2015
Homo sapiens (P52961), Homo sapiens
brenda
Yang, L.; Xiao, M.; Li, X.; Tang, Y.; Wang, Y.L.
Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway
Int. J. Mol. Med.
37
734-742
2016
Homo sapiens
brenda
EXTERNAL LINKS (specific for EC-Number 2.4.2.31)
Transporter Classification Database (TCDB): 1.C.106.4.2
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
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