Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.4.2.14 - amidophosphoribosyltransferase and Organism(s) Mus musculus

for references in articles please use BRENDA:EC2.4.2.14
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.14 amidophosphoribosyltransferase
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Mus musculus
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
amidophosphoribosyltransferase, glutamine phosphoribosylpyrophosphate amidotransferase, phosphoribosyl pyrophosphate amidotransferase, amido phosphoribosyltransferase, phosphoribosylamidotransferase, 5-phosphoribosyl-1-pyrophosphate amidotransferase, gpatase, glutamine phosphoribosyl pyrophosphate amidotransferase, gprat, 5'-phosphoribosylpyrophosphate amidotransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5'-phosphoribosylpyrophosphate amidotransferase
-
-
-
-
5-phosphoribosyl-1-pyrophosphate amidotransferase
-
-
-
-
5-phosphoribosylpyrophosphate amidotransferase
-
-
-
-
5-phosphororibosyl-1-pyrophosphate amidotransferase
-
-
-
-
alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase
-
-
-
-
amidotransferase, phosphoribosyl pyrophosphate
-
-
-
-
ATASE
-
-
-
-
glutamine 5-phosphoribosylpyrophosphate amidotransferase
-
-
-
-
glutamine phosphoribosylpyrophosphate amidotransferase
-
-
-
-
glutamine ribosylpyrophosphate 5-phosphate amidotransferase
-
-
-
-
GPAT
-
-
-
-
GPATase
-
-
-
-
phosphoribose pyrophosphate amidotransferase
-
-
-
-
phosphoribosyl pyrophosphate amidotransferase
-
-
-
-
phosphoribosyldiphosphate 5-amidotransferase
-
-
-
-
phosphoribosylpyrophosphate glutamyl amidotransferase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
5-phospho-beta-D-ribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
-
CAS REGISTRY NUMBER
COMMENTARY hide
9031-82-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate
show the reaction diagram
-
-
-
?
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
L-glutamate + 5-phospho-beta-D-ribosylamine + diphosphate
show the reaction diagram
-
first reaction in de-novo pathway of purine biosynthesis
-
?
NH3 + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
5-phospho-beta-D-ribosylamine + diphosphate
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
L-glutamate + 5-phospho-beta-D-ribosylamine + diphosphate
show the reaction diagram
-
first reaction in de-novo pathway of purine biosynthesis
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
4Fe-4S-cluster
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
AMP
-
competitive vs. 5-phospho-alpha-D-ribose 1-diphosphate, noncompetitive vs. glutamine
piritrexim
-
noncompetitive vs. 5-phospho-alpha-D-ribose 1-diphosphate, binds with positive cooperativity at 2 allosteric sites of an inactive dimer
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.57
5-phospho-alpha-D-ribose 1-diphosphate
-
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.04
AMP
-
-
0.066
piritrexim
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
L1210 leukemia cells
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PUR1_MOUSE
517
0
57403
Swiss-Prot
other Location (Reliability: 2)
Q3UGA8_MOUSE
558
0
62038
TrEMBL
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
127000
-
liver small form
292000
-
liver, large form
additional information
OXIDATION STABILITY
ORGANISM
UNIPROT
LITERATURE
amido- and aminotransferase activity is lost after exposure to oxygen
-
489754
oxygen sensitive enzyme
-
489754
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Holmes, E.W.
Kinetic, physical, and regulatory properties of amidophosphoribosyltransferase
Adv. Enzyme Regul.
19
215-231
1981
Bacillus subtilis, Cricetulus griseus, Columba livia, Escherichia coli, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Schoettle, S.L.; Crisp, L.B.; Szabados, E.; Christopherson, R.I.
Mechanisms of inhibition of amido phosphoribosyltransferase from mouse L1210 leukemia cells
Biochemistry
36
6377-6383
1997
Mus musculus
Manually annotated by BRENDA team