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Information on EC 2.4.1.174 - glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase and Organism(s) Danio rerio

for references in articles please use BRENDA:EC2.4.1.174
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EC Tree
IUBMB Comments
Requires Mn2+. Involved in the biosynthesis of chondroitin sulfate. Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core.
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This record set is specific for:
Danio rerio
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Word Map
The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Synonyms
csgalnact1, csgalnact2, chondroitin sulfate n-acetylgalactosaminyltransferase 1, galnact-ii, chondroitin n-acetylgalactosaminyltransferase-1, n-acetylgalactosaminet-ii, galnact-i, chondroitin beta1,4-n-acetylgalactosaminyltransferase-1, chondroitin n-acetylgalactosaminyltransferase-2, chondroitin sulfate n-acetylgalactosaminyltransferase 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin, I
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CSGalNAcT1
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CSGALNACT2
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glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase
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N-acetylgalactosaminyltransferase I
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uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-D-galactosamine:D-glucuronyl-(1->3)-beta-D-galactosyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
Requires Mn2+. Involved in the biosynthesis of chondroitin sulfate. Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core.
CAS REGISTRY NUMBER
COMMENTARY hide
96189-39-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan
UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
show the reaction diagram
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan
UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
show the reaction diagram
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?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
the CSGALNACT1 and CSGALNACT2 isozymes enzymes both have a GT7 catalytic domain with beta(1->4)-N-acetylgalactosaminyl transferase
metabolism
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A8M1NHC5_DANRE
540
1
62182
TrEMBL
Secretory Pathway (Reliability: 1)
A8E7C8_DANRE
540
0
62182
TrEMBL
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E7F6G2_DANRE
580
0
65636
TrEMBL
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene csgalnact1, DNA and amino acid sequence determination and analysis, phylogenetic analysis
gene csgalnact2, DNA and amino acid sequence determination and analysis, phylogenetic analysis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Filipek-Gorniok, B.; Holmborn, K.; Haitina, T.; Habicher, J.; Oliveira, M.B.; Hellgren, C.; Eriksson, I.; Kjellen, L.; Kreuger, J.; Ledin, J.
Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development
Dev. Dyn.
242
964-975
2013
Danio rerio (A8E7C8), Danio rerio (E7F6G2)
Manually annotated by BRENDA team