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Information on EC 2.4.1.17 - glucuronosyltransferase and Organism(s) Gallus gallus

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.17 glucuronosyltransferase
IUBMB Comments
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
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Gallus gallus
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The taxonomic range for the selected organisms is: Gallus gallus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
ugt1a1, udp-glucuronosyltransferase, ugt2b7, ugt1a9, ugt1a6, ugt1a, ugt2b17, ugt1a4, udp-glucuronyltransferase, udpgt, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-naphthol glucuronyltransferase
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-
-
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1-naphthol-UDP-glucuronosyltransferase
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-
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17-OH steroid UDPGT
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-
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17beta-hydroxysteroid UDP-glucuronosyltransferase
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-
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3-OH androgenic UDPGT
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-
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3alpha-hydroxysteroid UDP-glucuronosyltransferase
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-
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4-hydroxybiphenyl UDP-glucuronosyltransferase
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-
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4-methylumbelliferone UDP-glucuronosyltransferase
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-
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4-nitrophenol UDP-glucuronosyltransferase
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-
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4-nitrophenol UDP-glucuronyltransferase
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-
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4-nitrophenol UDPGT
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-
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bile acid uridine 5'-diphosphoglucuronyltransferase
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bilirubin glucuronyltransferase
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bilirubin monoglucuronide glucuronyltransferase
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bilirubin UDP-glucuronosyltransferase
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bilirubin UDPglucuronosyltransferase
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bilirubin UDPGT
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bilirubin uridine diphosphoglucuronyltransferase
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ciramadol UDP-glucuronyltransferase
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estriol UDP-glucuronosyltransferase
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estrone UDP-glucuronosyltransferase
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glucuronosyltransferase, uridine diphospho-
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glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol
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glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl
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glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin
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glucuronosyltransferase, uridine diphosphoglucuronate-estradiol
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glucuronosyltransferase, uridine diphosphoglucuronate-estriol
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glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-
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glucuronyltransferase, uridine diphospho-GT
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morphine glucuronyltransferase
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p-hydroxybiphenyl UDP glucuronyltransferase
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p-nitrophenol UDP-glucuronosyltransferase
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p-nitrophenol UDP-glucuronyltransferase
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p-nitrophenylglucuronosyltransferase
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p-phenylphenol glucuronyltransferase
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phenyl-UDP-glucuronosyltransferase
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PNP-UDPGT
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UDP glucuronate-estradiol-glucuronosyltransferase
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UDP glucuronate-estriol glucuronosyltransferase
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UDP glucuronic acid transferase
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UDP glucuronosyltransferase
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UDP glucuronyltransferase
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UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase
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UDP-glucuronate-bilirubin glucuronyltransferase
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UDP-glucuronosyltransferase
UDP-glucuronyltransferase
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UDPGA transferase
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UDPGA-glucuronyltransferase
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UDPglucuronate beta-D-glucuronosyltransferase
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UDPglucuronosyltransferase
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UDPGT
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UGT1E
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isoform
uridine 5'-diphosphoglucuronyltransferase
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uridine diphosphate glucuronyltransferase
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uridine diphosphoglucuronate-bilirubin glucuronosyltransferase
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uridine diphosphoglucuronosyltransferase
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uridine diphosphoglucuronyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
CAS REGISTRY NUMBER
COMMENTARY hide
37205-52-0
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37277-52-4
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37277-66-0
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61969-98-0
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62213-43-8
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62213-47-2
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9030-08-4
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-hydroxypyrene + UDP-glucuronate
UDP + 1-hydroxypyrene-1-O-glucuronide
show the reaction diagram
-
-
-
-
?
4-nitrothiophenol + UDP-glucuronate
4-nitrothiophenyl thio-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
?
acetaminophen + UDP-glucuronate
UDP + ?
show the reaction diagram
-
-
-
-
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol-3-glucuronide
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
100 mM used in assay conditions
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Phenobarbital
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stimulation of the enzyme in cultured 11-day embryo liver
UDP-N-acetylglucosamine
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activation
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1137
1-hydroxypyrene
-
at pH 7.4 and 42°C
0.004951
acetaminophen
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at pH 7.4 and 42°C
0.00787
beta-estradiol
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at pH 7.4 and 42°C
additional information
additional information
-
effect of UDP-N-acetylglucosamine as activator
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
F1NMB3_CHICK
529
2
60643
TrEMBL
Secretory Pathway (Reliability: 1)
F1P1M1_CHICK
532
2
59520
TrEMBL
Secretory Pathway (Reliability: 1)
F1NQS8_CHICK
529
1
59881
TrEMBL
Secretory Pathway (Reliability: 1)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Illing, H.P.A.; Dutton, G.J.
Some properties of the uridine diphosphate glucuronyltransferase activity synthesizing thio-beta-D-glucuronides
Biochem. J.
131
139-147
1973
Gallus gallus, Mus musculus, Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Kawai, Y.K.; Shinya, S.; Ikenaka, Y.; Saengtienchai, A.; Kondo, T.; Darwish, W.S.; Nakayama, S.M.M.; Mizukawa, H.; Ishizuka, M.
Characterization of function and genetic feature of UDP-glucuronosyltransferase in avian species
Comp. Biochem. Physiol. C
217
5-14
2019
Gallus gallus, Meleagris gallopavo, Struthio camelus, Rattus norvegicus, Serinus canaria, Bubo virginianus, Haliaeetus albicilla, Spheniscus humboldti
Manually annotated by BRENDA team